Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

Nephrology Dialysis Transplantation

Volumn 25, Issue 7, 2010, Pages 2187-2194

  Leuenroth, Stephanie J ^a   Bencivenga, Natasha ^a   Chahboune, Halima ^a   Hyder, Fahmeed ^a,b   Crews, Craig M ^a,c  

^a YALE UNIVERSITY   (United States)

^b Yale University   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ADPKD; polycystic; triptolide

Indexed keywords

CRE RECOMBINASE; INTERFERON; PLACEBO; POLYCYSTIN 1; TRIPTOLIDE; ALKYLATING AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DITERPENE; EPOXIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRASE; MYXOVIRUS RESISTANCE PROTEIN; PHENANTHRENE DERIVATIVE; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; DRUG DOSE INCREASE; DRUG EFFECT; ENZYME INACTIVATION; FEMALE; GENE DELETION; KIDNEY FUNCTION; KIDNEY POLYCYSTIC DISEASE; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; UREA NITROGEN BLOOD LEVEL; AGING; ANIMAL; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECTS; GENETICS; KIDNEY; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; TIME;

AGING; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DITERPENES; EPOXY COMPOUNDS; GTP-BINDING PROTEINS; INTEGRASES; KIDNEY; MICE; MICE, MUTANT STRAINS; MUTATION; MYXOVIRUS RESISTANCE PROTEINS; PHENANTHRENES; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; TIME FACTORS; TRPP CATION CHANNELS;

EID: 77954337045     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp777     Document Type: Article

References (17)

1. Nauli SM, Alenghat FJ, Luo Y et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003; 33: 129-137
2. Yamaguchi T, Hempson SJ, Reif GA et al. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells. J Am Soc Nephrol 2006; 17: 178-187
3. Boulter C, Mulroy S, Webb S et al. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc Natl Acad Sci USA 2001; 98: 12174-12179
4. Lantinga-van Leeuwen IS, Leonhard WN, van der Wal A et al. Kidney-specific inactivation of the Pkd1 gene induces rapid cyst formation in developing kidneys and a slow onset of disease in adult mice. Hum Mol Genet 2007; 16: 3188-3196
5. Lu W, Peissel B, Babakhanlou H et al. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet 1997; 17: 179-181
6. Piontek K, Menezes LF, Garcia-Gonzalez MA et al. A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1. Nat Med 2007; 13: 1490-1495
7. Piontek KB, Huso DL, Grinberg A et al. A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol 2004; 15: 3035-3043
8. Shibazaki S, Yu Z, Nishio S et al. Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inac-tivation of Pkd1. Hum Mol Genet 2008; 17: 1505-1516
9. Starremans PG, Li X, Finnerty PE et al. A mouse model for polycys-tic kidney disease through a somatic in-frame deletion in the 5' end of Pkd1. Kidney Int 2008; 73: 1394-1405
10. Takakura A, Contrino L, Beck AWet al. Pkd1 inactivation induced in adulthood produces focal cystic disease. J Am Soc Nephrol 2008; 19: 2351-2363
11. Kuhn R, Schwenk F, Aguet M et al. Inducible gene targeting in mice. Science 1995; 269: 1427-1429
12. Schneider A, Zhang Y, Guan Y et al. Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice. Am J Physiol Renal Physiol 2003; 284: F411-F417
13. Leuenroth SJ, Okuhara D, Shotwell JD et al. Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci USA 2007; 104: 4389-4394
14. Leuenroth SJ, Bencivenga N, Igarashi P et al. Triptolide reduces cy-stogenesis in a model of ADPKD. J Am Soc Nephrol 2008; 19: 1659-1662
15. Lu H, Hachida M, Enosawa S et al. Immunosuppressive effect of triptolide in vitro. Transplant Proc 1999; 31: 2056-2057
16. Qiu D, Zhao G, Aoki Y et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nu-clear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 1999; 274: 13443-13450
17. Everson GT, Taylor MR, Doctor RB. Polycystic disease of the liver. Hepatology 2004; 40: 774-782