메뉴 건너뛰기




Volumn 18, Issue 25, 2012, Pages 3677-3684

Vascular protection to increase the safety of tissue plasminogen activator for stroke

Author keywords

Blood brain barrier; Hemorrhagic transformation (HT); Ischemic stroke; Matrix metalloproteinases (MMPs); Thrombolysis; Tissue plasminogen activator (tPA); Vascular protection

Indexed keywords

3 [3 (4 AMIDINOBENZAMIDO)PROPIONAMIDO] 2 (4 ETHYLBENZENESULFONAMIDO)PROPIONIC ACID; ACTIVATED PROTEIN C; ALBUMIN; CASPASE 8; DISUFENTON SODIUM; ESTRADIOL; GELATINASE A; GELATINASE B; LIPOCORTIN 2; LOW DENSITY LIPOPROTEIN RECEPTOR; MATRILYSIN; MELATONIN; NEUROSERPIN; SCAVENGER; STROMELYSIN; TACROLIMUS; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

EID: 84867563380     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212802002779     Document Type: Review
Times cited : (21)

References (88)
  • 1
    • 20744447947 scopus 로고    scopus 로고
    • Stroke epidemiology in the developing world
    • Feigin VL. Stroke epidemiology in the developing world. Lancet 2005; 365: 2160-1.
    • (2005) Lancet , vol.365 , pp. 2160-2161
    • Feigin, V.L.1
  • 2
    • 0343118114 scopus 로고    scopus 로고
    • The NINDS t-pa stroke study group: Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke
    • The NINDS t-pa stroke study group: Intracerebral hemorrhage after intravenous t-pa therapy for ischemic stroke. Stroke 1997; 28: 2109-18.
    • (1997) Stroke , vol.28 , pp. 2109-2118
  • 3
    • 34748912364 scopus 로고    scopus 로고
    • Acute ischemic stroke treatment in 2007
    • Goldstein LB. Acute ischemic stroke treatment in 2007. Circulation 2007; 116: 1504-14.
    • (2007) Circulation , vol.116 , pp. 1504-1514
    • Goldstein, L.B.1
  • 4
    • 34347397407 scopus 로고    scopus 로고
    • Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: A review of the risk factors
    • Lansberg MG, Albers GW, Wijman CA. Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: a review of the risk factors. Cerebrovasc Dis 2007; 24: 1-10.
    • (2007) Cerebrovasc Dis , vol.24 , pp. 1-10
    • Lansberg, M.G.1    Albers, G.W.2    Wijman, C.A.3
  • 5
    • 77957984928 scopus 로고    scopus 로고
    • Thrombolysis with plasmin: Implications for stroke treatment
    • Marder VJ, Jahan R, Gruber T, Goyal A, Arora V. Thrombolysis with plasmin: implications for stroke treatment. Stroke 2010; 41: S45-9.
    • (2010) Stroke , vol.41
    • Marder, V.J.1    Jahan, R.2    Gruber, T.3    Goyal, A.4    Arora, V.5
  • 6
    • 0028783948 scopus 로고
    • Tissue Plasminogen Activator For Acute Ischemic Stroke
    • The National Institute of Neurological Disorder and Stroke rt-PA Stroke Study Group
    • Tissue Plasminogen Activator For Acute Ischemic Stroke. The National Institute of Neurological Disorder and Stroke rt-PA Stroke Study Group. NEJM 1995; 333(24): 1581-7.
    • (1995) NEJM , vol.333 , Issue.24 , pp. 1581-1587
  • 7
    • 52649165720 scopus 로고    scopus 로고
    • Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
    • Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke. NEJM 2008; 359(13): 1317-1329.
    • (2008) NEJM , vol.359 , Issue.13 , pp. 1317-1329
    • Hacke, W.1    Kaste, M.2    Bluhmki, E.3
  • 8
    • 0034161611 scopus 로고    scopus 로고
    • Use of tissue-type plasminogen activator for acute ischemic stroke: The Cleveland area experience
    • Katzan IL, Furlan AJ, Lloyd LE, et al. Use of tissue-type plasminogen activator for acute ischemic stroke: the Cleveland area experience. JAMA 2000; 283(9):1151-8.
    • (2000) JAMA , vol.283 , Issue.9 , pp. 1151-1158
    • Katzan, I.L.1    Furlan, A.J.2    Lloyd, L.E.3
  • 9
    • 49849089117 scopus 로고    scopus 로고
    • Early Disruption of the Blood-Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke
    • Kastrup A, Groschel K, Ringer TM, Redcker C, et al. Early Disruption of the Blood-Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke. Stroke 2008; 39: 2385-7.
    • (2008) Stroke , vol.39 , pp. 2385-2387
    • Kastrup, A.1    Groschel, K.2    Ringer, T.M.3    Redcker, C.4
  • 10
    • 0028125919 scopus 로고
    • Factors related to intracranial hematoma formation in patients receiving tPA for acute ischemic stroke
    • Levy DE, Brott TG, C HE, Marler JR, Sheppard GL, Barsan W, Broderick JP. Factors related to intracranial hematoma formation in patients receiving tPA for acute ischemic stroke. Stroke 1994; 25: 291-7.
    • (1994) Stroke , vol.25 , pp. 291-297
    • Levy, D.E.1    Brott, T.G.2    He, C.3    Marler, J.R.4    Sheppard, G.L.5    Barsan, W.6    Broderick, J.P.7
  • 11
    • 0027516225 scopus 로고
    • Acute Hypertension After Stroke; the Scientific Basis for Treatment Decisions
    • Powers WJ. Acute Hypertension After Stroke; the Scientific Basis for Treatment Decisions. Neurology 1993; 43: 461-7.
    • (1993) Neurology , vol.43 , pp. 461-467
    • Powers, W.J.1
  • 12
    • 7344252993 scopus 로고    scopus 로고
    • Hypertension and its treatment in the NINDS rt-PA Stroke Trial
    • Brott T, Lu M, Kothari R, et al. Hypertension and its treatment in the NINDS rt-PA Stroke Trial. Stroke 1998; 29: 1504-9.
    • (1998) Stroke , vol.29 , pp. 1504-1509
    • Brott, T.1    Lu, M.2    Kothari, R.3
  • 13
    • 0037056360 scopus 로고    scopus 로고
    • Admission glucose level and clinical outcomes in the NINDS rt-PA stroke trial
    • Bruno A, Levine SR, Frankel MR, et al. Admission glucose level and clinical outcomes in the NINDS rt-PA stroke trial. Neurology 2002; 59: 699-74.
    • (2002) Neurology , vol.59 , pp. 699-774
    • Bruno, A.1    Levine, S.R.2    Frankel, M.R.3
  • 14
    • 74049125986 scopus 로고    scopus 로고
    • Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation
    • EPITHET Investigators
    • Butcher K, Christensen S, Parsons M, et al. EPITHET Investigators. Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation. Stroke 2010; 41(1): 72-7.
    • (2010) Stroke , vol.41 , Issue.1 , pp. 72-77
    • Butcher, K.1    Christensen, S.2    Parsons, M.3
  • 15
    • 70350524024 scopus 로고    scopus 로고
    • Pre-Tissue Plasminogen Activator Blood Pressure Levels and Risk of Symptomatic Intracerebral Hemorrhage
    • Tsivgoulis, G, Fey, JL, Flaster, M, et al. Pre-Tissue Plasminogen Activator Blood Pressure Levels and Risk of Symptomatic Intracerebral Hemorrhage. Stroke 2009; 40: 3631-3634.
    • (2009) Stroke , vol.40 , pp. 3631-3634
    • Tsivgoulis, G.1    Fey, J.L.2    Flaster, M.3
  • 16
    • 0035856413 scopus 로고    scopus 로고
    • Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: The PROACT II trial
    • Kase CS, Furlan AJ, Wechsler LR, et al. Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trial. Neurology 2001; 57(9): 1603-10.
    • (2001) Neurology , vol.57 , Issue.9 , pp. 1603-1610
    • Kase, C.S.1    Furlan, A.J.2    Wechsler, L.R.3
  • 17
    • 65349175045 scopus 로고    scopus 로고
    • Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis
    • Canadian Alteplase for Stroke Effectiveness Study Investigators
    • Poppe AY, Majumdar SR, Jeerakathil T, Ghali W, Buchan AM, Hill MD. Canadian Alteplase for Stroke Effectiveness Study Investigators. Admission hyperglycemia predicts a worse outcome in stroke patients treated with intravenous thrombolysis. Diabetes Care 2009; 32(4): 617-22.
    • (2009) Diabetes Care , vol.32 , Issue.4 , pp. 617-622
    • Poppe, A.Y.1    Majumdar, S.R.2    Jeerakathil, T.3    Ghali, W.4    Buchan, A.M.5    Hill, M.D.6
  • 18
    • 39649107984 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator as a therapeutic target in stroke
    • Gravanis I, Tsirka SE. Tissue-type plasminogen activator as a therapeutic target in stroke. Expert Opin Ther Targets 2008; 12(2): 159-70.
    • (2008) Expert Opin Ther Targets , vol.12 , Issue.2 , pp. 159-170
    • Gravanis, I.1    Tsirka, S.E.2
  • 19
    • 0028275022 scopus 로고
    • Localization of tissue plasminogen activator in the endothelium of a limited number of vessels
    • Levin EG, del Zoppo GJ. Localization of tissue plasminogen activator in the endothelium of a limited number of vessels. Am J Pathol 1994; 144(5): 855-61.
    • (1994) Am J Pathol , vol.144 , Issue.5 , pp. 855-861
    • Levin, E.G.1    del Zoppo, G.J.2
  • 20
    • 77952547253 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator
    • Jin R, Yang G, Li G. Molecular insights and therapeutic targets for blood-brain barrier disruption in ischemic stroke: critical role of matrix metalloproteinases and tissue-type plasminogen activator. Neurobiol Dis 2010; 38(3): 376-85.
    • (2010) Neurobiol Dis , vol.38 , Issue.3 , pp. 376-385
    • Jin, R.1    Yang, G.2    Li, G.3
  • 21
    • 48249103532 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: Therapeutic strategies
    • Adibhatla RM, Hatcher JF. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol Disord Drug Targets 2008; 7(3): 243-53.
    • (2008) CNS Neurol Disord Drug Targets , vol.7 , Issue.3 , pp. 243-253
    • Adibhatla, R.M.1    Hatcher, J.F.2
  • 22
    • 0031021357 scopus 로고    scopus 로고
    • An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus
    • Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus. J Neurosci 1997; 17(2): 543-52.
    • (1997) J Neurosci , vol.17 , Issue.2 , pp. 543-552
    • Tsirka, S.E.1    Rogove, A.D.2    Bugge, T.H.3    Degen, J.L.4    Strickland, S.5
  • 23
    • 0038334811 scopus 로고    scopus 로고
    • Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury
    • Siao CJ, Fernandez SR, Tsirka SE. Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury. J Neurosci 2003; 23(8): 3234-42.
    • (2003) J Neurosci , vol.23 , Issue.8 , pp. 3234-3242
    • Siao, C.J.1    Fernandez, S.R.2    Tsirka, S.E.3
  • 24
    • 0034746189 scopus 로고    scopus 로고
    • The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling
    • Nicole O, Docagne F, Ali C, et al. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 2001; 7(1): 59-64.
    • (2001) Nat Med , vol.7 , Issue.1 , pp. 59-64
    • Nicole, O.1    Docagne, F.2    Ali, C.3
  • 25
    • 11144258914 scopus 로고    scopus 로고
    • Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
    • Liu D, Cheng T, Guo H, et al. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med 2004; 10(12): 1379-83.
    • (2004) Nat Med , vol.10 , Issue.12 , pp. 1379-1383
    • Liu, D.1    Cheng, T.2    Guo, H.3
  • 26
    • 0029088484 scopus 로고
    • Excitotoxininduced neuronal degeneration and seizure are mediated by tissue plasminogen activator
    • Tsirka SE, Gualandris A, Amaral DG, Strickland S. Excitotoxininduced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 1995; 377(6547): 340-4.
    • (1995) Nature , vol.377 , Issue.6547 , pp. 340-344
    • Tsirka, S.E.1    Gualandris, A.2    Amaral, D.G.3    Strickland, S.4
  • 27
    • 77950935919 scopus 로고    scopus 로고
    • Blood-brain barrier permeability and tPA-mediated neurotoxicity
    • Abu Fanne R, Nassar T, Yarovoi S, et al. Blood-brain barrier permeability and tPA-mediated neurotoxicity. Neuropharmacology 2010; 58(7): 972-80.
    • (2010) Neuropharmacology , vol.58 , Issue.7 , pp. 972-980
    • Abu, F.R.1    Nassar, T.2    Yarovoi, S.3
  • 28
    • 0031951510 scopus 로고    scopus 로고
    • Tissue plasminogen activator (tPA) increases neuronal damage after local cerebral ischemia in wild-type and tPA-deficient mice
    • Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 1998; 4(2): 228-31.
    • (1998) Nat Med , vol.4 , Issue.2 , pp. 228-231
    • Wang, Y.F.1    Tsirka, S.E.2    Strickland, S.3    Stieg, P.E.4    Soriano, S.G.5    Lipton, S.A.6
  • 29
    • 0033545965 scopus 로고    scopus 로고
    • Role of plasminogen system components in focal cerebral ischemic infarction: A gene targeting and gene transfer study in mice
    • Nagai N, De Mol M, Lijnen HR, Carmeliet P, Collen D. Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. Circulation 1999; 99(18): 2440-4.
    • (1999) Circulation , vol.99 , Issue.18 , pp. 2440-2444
    • Nagai, N.1    de Mol, M.2    Lijnen, H.R.3    Carmeliet, P.4    Collen, D.5
  • 30
    • 0031459856 scopus 로고    scopus 로고
    • Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia
    • Clark AW, Krekoski CA, Bou SS, Chapman KR, Edwards DR. Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia. Neurosci Lett 1997; 238(1-2): 53-6.
    • (1997) Neurosci Lett , vol.238 , Issue.1-2 , pp. 53-56
    • Clark, A.W.1    Krekoski, C.A.2    Bou, S.S.3    Chapman, K.R.4    Edwards, D.R.5
  • 31
    • 34447633015 scopus 로고    scopus 로고
    • Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice
    • Suzuki Y, Nagai N, Umemura K, Collen D, Lijnen HR. Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in mice. J Thromb Haemost 2007; 5(8): 1732-9.
    • (2007) J Thromb Haemost , vol.5 , Issue.8 , pp. 1732-1739
    • Suzuki, Y.1    Nagai, N.2    Umemura, K.3    Collen, D.4    Lijnen, H.R.5
  • 33
    • 20344373695 scopus 로고    scopus 로고
    • Multiple roles for MMPs and TIMPs in cerebral ischemia
    • Cunningham LA, Wetzel M, Rosenberg GA. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 2005; 50(4): 329-39.
    • (2005) Glia , vol.50 , Issue.4 , pp. 329-339
    • Cunningham, L.A.1    Wetzel, M.2    Rosenberg, G.A.3
  • 34
    • 0036460593 scopus 로고    scopus 로고
    • Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia
    • Rivera S, Ogier C, Jourquin J, et al. Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia. Eur J Neurosci 2002; 15(1): 19-32.
    • (2002) Eur J Neurosci , vol.15 , Issue.1 , pp. 19-32
    • Rivera, S.1    Ogier, C.2    Jourquin, J.3
  • 35
    • 0035478029 scopus 로고    scopus 로고
    • Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia
    • Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci 2001; 21(19): 7724-32.
    • (2001) J Neurosci , vol.21 , Issue.19 , pp. 7724-7732
    • Asahi, M.1    Wang, X.2    Mori, T.3
  • 36
    • 0842327251 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia
    • Lee SR, Tsuji K, Lo EH. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci 2004; 24(3): 671-8.
    • (2004) J Neurosci , vol.24 , Issue.3 , pp. 671-678
    • Lee, S.R.1    Tsuji, K.2    Lo, E.H.3
  • 37
    • 0037224938 scopus 로고    scopus 로고
    • Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke
    • Castellanos M, Leira R, Serena J, et al. Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003; 34(1): 40-6.
    • (2003) Stroke , vol.34 , Issue.1 , pp. 40-46
    • Castellanos, M.1    Leira, R.2    Serena, J.3
  • 38
    • 0037418038 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke
    • Montaner J, Molina CA, Monasterio J, et al Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 2003; 107(4): 598-603.
    • (2003) Circulation , vol.107 , Issue.4 , pp. 598-603
    • Montaner, J.1    Molina, C.A.2    Monasterio, J.3
  • 39
    • 33645744014 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in delayed cortical responses after stroke
    • Zhao BQ, Wang S, Kim HY, et al. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med 2006; 12(4): 441-5.
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 441-445
    • Zhao, B.Q.1    Wang, S.2    Kim, H.Y.3
  • 40
    • 0842289222 scopus 로고    scopus 로고
    • tPA and proteolysis in the neurovascular unit
    • Lo EH, Broderick JP, Moskowitz MA. tPA and proteolysis in the neurovascular unit. Stroke 2004; 35(2): 354-6.
    • (2004) Stroke , vol.35 , Issue.2 , pp. 354-356
    • Lo, E.H.1    Broderick, J.P.2    Moskowitz, M.A.3
  • 41
    • 0036843258 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: Mechanical versus embolic focal ischemia in spontaneously hypertensive rats
    • Aoki T, Sumii T, Mori T, Wang X, Lo EH. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke 2002; 33(11): 2711-7.
    • (2002) Stroke , vol.33 , Issue.11 , pp. 2711-2717
    • Aoki, T.1    Sumii, T.2    Mori, T.3    Wang, X.4    Lo, E.H.5
  • 42
    • 0036195260 scopus 로고    scopus 로고
    • Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats
    • Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke 2002; 33(3): 831-6.
    • (2002) Stroke , vol.33 , Issue.3 , pp. 831-836
    • Sumii, T.1    Lo, E.H.2
  • 43
    • 0142137232 scopus 로고    scopus 로고
    • Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
    • Wang X, Lee SR, Arai K, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med 2003; 9(10): 1313-7.
    • (2003) Nat Med , vol.9 , Issue.10 , pp. 1313-1317
    • Wang, X.1    Lee, S.R.2    Arai, K.3    Tsuji, K.4    Rebeck, G.W.5    Lo, E.H.6
  • 44
    • 0345824713 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein
    • Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DK, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest 2003; 112(10): 1533-40.
    • (2003) J Clin Invest , vol.112 , Issue.10 , pp. 1533-1540
    • Yepes, M.1    Sandkvist, M.2    Moore, E.G.3    Bugge, T.H.4    Strickland, D.K.5    Lawrence, D.A.6
  • 45
    • 0035046073 scopus 로고    scopus 로고
    • The LDL receptor gene family: (un)expected signal transducers in the brain
    • Herz J. The LDL receptor gene family: (un)expected signal transducers in the brain. Neuron 2001; 29(3): 571-81.
    • (2001) Neuron , vol.29 , Issue.3 , pp. 571-581
    • Herz, J.1
  • 46
    • 26844507074 scopus 로고    scopus 로고
    • Low density lipoprotein receptorrelated proteins (LRPs), Alzheimer's and cognition
    • Harris-White ME, Frautschy SA. Low density lipoprotein receptorrelated proteins (LRPs), Alzheimer's and cognition. Curr Drug Targets CNS Neurol Disord 2005; 4(5): 469-80.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , Issue.5 , pp. 469-480
    • Harris-White, M.E.1    Frautschy, S.A.2
  • 47
    • 34547598295 scopus 로고    scopus 로고
    • Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke
    • Strbian D, Karjalainen-Lindsberg ML, Kovanen PT, Tatlisumak T, Lindsberg PJ. Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circulation 2007; 116(4): 411-8.
    • (2007) Circulation , vol.116 , Issue.4 , pp. 411-418
    • Strbian, D.1    Karjalainen-Lindsberg, M.L.2    Kovanen, P.T.3    Tatlisumak, T.4    Lindsberg, P.J.5
  • 48
    • 3042828639 scopus 로고    scopus 로고
    • Pharmacology of caffeinol in embolized rabbits: Clinical rating scores and intracerebral hemorrhage incidence
    • Lapchak PA, Song D, Wei J, Zivin JA. Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence. Exp Neurol 2004; 188(2): 286-91.
    • (2004) Exp Neurol , vol.188 , Issue.2 , pp. 286-291
    • Lapchak, P.A.1    Song, D.2    Wei, J.3    Zivin, J.A.4
  • 49
    • 3042706276 scopus 로고    scopus 로고
    • Lost in translation: Taking neuroprotection from animal models to clinical trials
    • Hoyte L, Kaur J, Buchan AM. Lost in translation: taking neuroprotection from animal models to clinical trials. Exp Neurol 2004; 188(2): 200-4.
    • (2004) Exp Neurol , vol.188 , Issue.2 , pp. 200-204
    • Hoyte, L.1    Kaur, J.2    Buchan, A.M.3
  • 50
    • 39749139407 scopus 로고    scopus 로고
    • Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion
    • Schatlo B, Henning EC, Pluta RM, et al. Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion. J Cereb Blood Flow Metab 2008; 28(3): 482-9.
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.3 , pp. 482-489
    • Schatlo, B.1    Henning, E.C.2    Pluta, R.M.3
  • 51
    • 80054975030 scopus 로고    scopus 로고
    • Interactions between nitrous oxide and tissue plasminogen activator in a rat model of thromboembolic stroke
    • Haelewyn B, David HN, Colloc'H N, Colomb DG Jr, Risso JJ, Abraini JH. Interactions between nitrous oxide and tissue plasminogen activator in a rat model of thromboembolic stroke. Anesthesiology 2011; 115(5): 1044-53.
    • (2011) Anesthesiology , vol.115 , Issue.5 , pp. 1044-1053
    • Haelewyn, B.1    David, H.N.2    Colloc'H, N.3    Colomb Jr., D.G.4    Risso, J.J.5    Abraini, J.H.6
  • 52
    • 80054805311 scopus 로고    scopus 로고
    • Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC
    • Pfeilschifter W, Spitzer D, Pfeilschifter J, Steinmetz H, Foerch C. Warfarin Anticoagulation Exacerbates the Risk of Hemorrhagic Transformation after rt-PA Treatment in Experimental Stroke: Therapeutic Potential of PCC. PLoS One 2011; 6(10): e26087.
    • (2011) PLoS One , vol.6 , Issue.10
    • Pfeilschifter, W.1    Spitzer, D.2    Pfeilschifter, J.3    Steinmetz, H.4    Foerch, C.5
  • 54
    • 70949095435 scopus 로고    scopus 로고
    • Recombinant human erythropoietin in the treatment of acute ischemic stroke
    • Ehrenreich H, Weissenborn K, Prange H, et al. Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke. 2009; 40: e647-56.
    • (2009) Stroke , vol.40
    • Ehrenreich, H.1    Weissenborn, K.2    Prange, H.3
  • 55
    • 77951765198 scopus 로고    scopus 로고
    • Combination of tissueplasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice
    • Zechariah A, ElAli A, Hermann DM. Combination of tissueplasminogen activator with erythropoietin induces blood-brain barrier permeability, extracellular matrix disaggregation, and DNA fragmentation after focal cerebral ischemia in mice. Stroke 2010; 41(5): 1008-12.
    • (2010) Stroke , vol.41 , Issue.5 , pp. 1008-1012
    • Zechariah, A.1    Elali, A.2    Hermann, D.M.3
  • 56
    • 0035149749 scopus 로고    scopus 로고
    • Reactive oxygen radicals in signaling and damage in the ischemic brain
    • Chan PH. Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab 2001; 21: 2-14.
    • (2001) J Cereb Blood Flow Metab , vol.21 , pp. 2-14
    • Chan, P.H.1
  • 57
    • 33744815599 scopus 로고    scopus 로고
    • Evaluating therapeutic targets for reperfusion related brain hemorrhage
    • Maier CM, Hsieh L, Crandall T, Narasimhan P, Chan PH Evaluating therapeutic targets for reperfusion related brain hemorrhage. Ann Neurol 2006; 59: 929-38.
    • (2006) Ann Neurol , vol.59 , pp. 929-938
    • Maier, C.M.1    Hsieh, L.2    Crandall, T.3    Narasimhan, P.4    Chan, P.H.5
  • 58
    • 22844448204 scopus 로고    scopus 로고
    • Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: Evaluation in a rat thromboembolic stroke model
    • Kano T, Harada T, Katayama Y. Attenuation of extravasation of tissue plasminogen activator by the free radical scavenger, edaravone: evaluation in a rat thromboembolic stroke model. Neurol Res 2005; 27(5): 499-502.
    • (2005) Neurol Res , vol.27 , Issue.5 , pp. 499-502
    • Kano, T.1    Harada, T.2    Katayama, Y.3
  • 59
    • 63949085383 scopus 로고    scopus 로고
    • Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain
    • Yamashita T, Kamiya T, Deguchi K, et al. Dissociation and protection of the neurovascular unit after thrombolysis and reperfusion in ischemic rat brain. J Cereb Blood Flow Metab 2009; 29: 715-25.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 715-725
    • Yamashita, T.1    Kamiya, T.2    Deguchi, K.3
  • 60
    • 0034073442 scopus 로고    scopus 로고
    • Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats
    • Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 2000; 20(3): 452-7.
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.3 , pp. 452-457
    • Asahi, M.1    Asahi, K.2    Wang, X.3    Lo, E.H.4
  • 61
    • 0035148402 scopus 로고    scopus 로고
    • Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6- tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: Combination studies with the thrombolytic tissue plasminogen activator
    • Lapchak PA, Chapman DF, Zivin JA. Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6- tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 2001; 32(1): 147-53.
    • (2001) Stroke , vol.32 , Issue.1 , pp. 147-153
    • Lapchak, P.A.1    Chapman, D.F.2    Zivin, J.A.3
  • 62
    • 33644772082 scopus 로고    scopus 로고
    • Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice
    • Chen TY, Lee MY, Chen HY, et al. Melatonin attenuates the postischemic increase in blood-brain barrier permeability and decreases hemorrhagic transformation of tissue-plasminogen activator therapy following ischemic stroke in mice. J Pineal Res 2006; 40(3): 242-50.
    • (2006) J Pineal Res , vol.40 , Issue.3 , pp. 242-250
    • Chen, T.Y.1    Lee, M.Y.2    Chen, H.Y.3
  • 63
    • 0036281174 scopus 로고    scopus 로고
    • Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: Combination studies with tissue plasminogen activator
    • Lapchak PA, Araujo DM, Song D, Wei J, Purdy R, Zivin JA. Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator. Stroke 2002; 33(6): 1665-70.
    • (2002) Stroke , vol.33 , Issue.6 , pp. 1665-1670
    • Lapchak, P.A.1    Araujo, D.M.2    Song, D.3    Wei, J.4    Purdy, R.5    Zivin, J.A.6
  • 64
    • 0036098259 scopus 로고    scopus 로고
    • Neuroprotective effects of the spin trap agent disodium-[(tertbutylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: Combination studies with the thrombolytic tissue plasminogen activator
    • Lapchak PA, Araujo DM, Song D, Wei J, Zivin JA. Neuroprotective effects of the spin trap agent disodium-[(tertbutylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Stroke 2002; 33(5): 1411-5.
    • (2002) Stroke , vol.33 , Issue.5 , pp. 1411-1415
    • Lapchak, P.A.1    Araujo, D.M.2    Song, D.3    Wei, J.4    Zivin, J.A.5
  • 65
    • 3042706259 scopus 로고    scopus 로고
    • Coadministration of NXY059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores
    • Lapchak PA, Song D, Wei J, Zivin JA. Coadministration of NXY059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores. Exp Neurol 2004; 188(2): 279-85.
    • (2004) Exp Neurol , vol.188 , Issue.2 , pp. 279-285
    • Lapchak, P.A.1    Song, D.2    Wei, J.3    Zivin, J.A.4
  • 66
    • 32144453826 scopus 로고    scopus 로고
    • NXY-059 for acute ischemic stroke
    • Lees KR, Zivin JA, Ashwood T, et al. NXY-059 for acute ischemic stroke. N Engl J Med 2006; 354: 588-600.
    • (2006) N Engl J Med , vol.354 , pp. 588-600
    • Lees, K.R.1    Zivin, J.A.2    Ashwood, T.3
  • 67
    • 34547795720 scopus 로고    scopus 로고
    • NXY-059 for the treatment of acute ischemic stroke
    • Shuaib A, Lees KR, Lyden P, et al. NXY-059 for the treatment of acute ischemic stroke. N Engl J Med 2007; 357: 562-71.
    • (2007) N Engl J Med , vol.357 , pp. 562-571
    • Shuaib, A.1    Lees, K.R.2    Lyden, P.3
  • 68
    • 70349248385 scopus 로고    scopus 로고
    • Minocycline and tissue-type plasminogen activator for stroke: Assessment of interaction potential
    • Machado LS, Sazonova IY, Kozak A, et al. Minocycline and tissue-type plasminogen activator for stroke: assessment of interaction potential. Stroke 2009; 40(9): 3028-33.
    • (2009) Stroke , vol.40 , Issue.9 , pp. 3028-3033
    • Machado, L.S.1    Sazonova, I.Y.2    Kozak, A.3
  • 69
    • 34547793659 scopus 로고    scopus 로고
    • Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia
    • Rosenberg GA, Yang Y. Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg Focus 2007; 22: E4.
    • (2007) Neurosurg Focus , vol.22
    • Rosenberg, G.A.1    Yang, Y.2
  • 70
    • 24644519846 scopus 로고    scopus 로고
    • Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia
    • Tsuji K, Aoki T, Tejima E, et al. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke 2005; 36: 1954-9.
    • (2005) Stroke , vol.36 , pp. 1954-1959
    • Tsuji, K.1    Aoki, T.2    Tejima, E.3
  • 71
    • 0033666754 scopus 로고    scopus 로고
    • Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke
    • Lapchak PA, Chapman DF, Zivin JA. Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke 2000; 31(12): 3034-40.
    • (2000) Stroke , vol.31 , Issue.12 , pp. 3034-3040
    • Lapchak, P.A.1    Chapman, D.F.2    Zivin, J.A.3
  • 72
    • 49349107936 scopus 로고    scopus 로고
    • Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats
    • Copin JC, Merlani P, Sugawara T, Chan PH, Gasche Y. Delayed matrix metalloproteinase inhibition reduces intracerebral hemorrhage after embolic stroke in rats. Exp Neurol 2008; 213(1): 196-201.
    • (2008) Exp Neurol , vol.213 , Issue.1 , pp. 196-201
    • Copin, J.C.1    Merlani, P.2    Sugawara, T.3    Chan, P.H.4    Gasche, Y.5
  • 73
    • 58149357102 scopus 로고    scopus 로고
    • Extension of the thrombolytic time window with minocycline in experimental stroke
    • Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke 2008; 39(12): 3372-7.
    • (2008) Stroke , vol.39 , Issue.12 , pp. 3372-3377
    • Murata, Y.1    Rosell, A.2    Scannevin, R.H.3    Rhodes, K.J.4    Wang, X.5    Lo, E.H.6
  • 74
    • 79955729003 scopus 로고    scopus 로고
    • Minocycline Development for Acute Ischemic Stroke
    • Fagan SC, Cronic LE, Hess DC. Minocycline Development for Acute Ischemic Stroke. Transl Stroke Res 2011; 2(2): 202-8.
    • (2011) Transl Stroke Res , vol.2 , Issue.2 , pp. 202-208
    • Fagan, S.C.1    Cronic, L.E.2    Hess, D.C.3
  • 75
    • 33947543221 scopus 로고    scopus 로고
    • Recombinant Desmodus rotundus salivary plasminogen activator crosses the bloodbrain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects
    • López-Atalaya JP, Roussel BD, Ali C, et al. Recombinant Desmodus rotundus salivary plasminogen activator crosses the bloodbrain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects. Stroke 2007; 38(3): 1036-43.
    • (2007) Stroke , vol.38 , Issue.3 , pp. 1036-1043
    • López-Atalaya, J.P.1    Roussel, B.D.2    Ali, C.3
  • 76
    • 70350462242 scopus 로고    scopus 로고
    • Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein
    • Suzuki Y, Nagai N, Yamakawa K, Kawakami J, Lijnen HR, Umemura K. Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein. Blood 2009; 114(15): 3352-8.
    • (2009) Blood , vol.114 , Issue.15 , pp. 3352-3358
    • Suzuki, Y.1    Nagai, N.2    Yamakawa, K.3    Kawakami, J.4    Lijnen, H.R.5    Umemura, K.6
  • 78
    • 33947579557 scopus 로고    scopus 로고
    • Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage
    • Strbian D, Tatlisumak T, Abo Ramadan U, Lindsberg PJ. Mast cell blocking reduces brain edema and hematoma volume and improves outcome after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2007; 27: 795-802.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 795-802
    • Strbian, D.1    Tatlisumak, T.2    Abo, R.U.3    Lindsberg, P.J.4
  • 79
    • 84856506320 scopus 로고    scopus 로고
    • Cilostazol Reduces the Risk of Hemorrhagic Infarction After Administration of Tissue-Type Plasminogen Activator in a Murine Stroke Model
    • doi: 10.1161/STROKEAHA.111.635417
    • Kasahara Y, Nakagomi T, Matsuyama T, Stern D, Taguchi A. Cilostazol Reduces the Risk of Hemorrhagic Infarction After Administration of Tissue-Type Plasminogen Activator in a Murine Stroke Model. Stroke 2011; doi: 10.1161/STROKEAHA.111.635417.
    • (2011) Stroke
    • Kasahara, Y.1    Nakagomi, T.2    Matsuyama, T.3    Stern, D.4    Taguchi, A.5
  • 80
    • 0036142821 scopus 로고    scopus 로고
    • The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke
    • Lapchak PA, Araujo DM, Song D, Zivin JA. The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke. Stroke 2002; 33(1): 147-52.
    • (2002) Stroke , vol.33 , Issue.1 , pp. 147-152
    • Lapchak, P.A.1    Araujo, D.M.2    Song, D.3    Zivin, J.A.4
  • 81
    • 62549091955 scopus 로고    scopus 로고
    • Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats
    • Tang J, Li YJ, Mu J, Li Q, Yang DY, Xie P. Albumin ameliorates tissue plasminogen activator-mediated blood-brain barrier permeability and ischemic brain injury in rats. Neurol Res 2009; 31(2): 189-94.
    • (2009) Neurol Res , vol.31 , Issue.2 , pp. 189-194
    • Tang, J.1    Li, Y.J.2    Mu, J.3    Li, Q.4    Yang, D.Y.5    Xie, P.6
  • 82
    • 77953229376 scopus 로고    scopus 로고
    • Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke
    • Zhu H, Fan X, Yu Z, et al. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab 2010; 30(6): 1137-46.
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.6 , pp. 1137-1146
    • Zhu, H.1    Fan, X.2    Yu, Z.3
  • 84
    • 33750704292 scopus 로고    scopus 로고
    • Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
    • Cheng T, Petraglia AL, Li Z, et al. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med 2006; 12(11): 1278-85.
    • (2006) Nat Med , vol.12 , Issue.11 , pp. 1278-1285
    • Cheng, T.1    Petraglia, A.L.2    Li, Z.3
  • 85
    • 80053289143 scopus 로고    scopus 로고
    • 17β-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia
    • Li M, Zhang Z, Sun W, Koehler RC, Huang J. 17β-estradiol attenuates breakdown of blood-brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia. Neurobiol Dis 2011; 44(3): 277-83.
    • (2011) Neurobiol Dis , vol.44 , Issue.3 , pp. 277-283
    • Li, M.1    Zhang, Z.2    Sun, W.3    Koehler, R.C.4    Huang, J.5
  • 86
    • 77249127108 scopus 로고    scopus 로고
    • Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke
    • Liu R, Liu Q, He S, Simpkins JW, Yang SH. Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther 2010; 332(3): 1006-12.
    • (2010) J Pharmacol Exp Ther , vol.332 , Issue.3 , pp. 1006-1012
    • Liu, R.1    Liu, Q.2    He, S.3    Simpkins, J.W.4    Yang, S.H.5
  • 87
    • 0037031298 scopus 로고    scopus 로고
    • Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke
    • Zhang Z, Zhang L, Yepes M, et al. Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Circulation 2002; 106(6): 740-5.
    • (2002) Circulation , vol.106 , Issue.6 , pp. 740-745
    • Zhang, Z.1    Zhang, L.2    Yepes, M.3
  • 88
    • 58549083332 scopus 로고    scopus 로고
    • Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model
    • Maeda M, Furuichi Y, Noto T, Matsuoka N, Mutoh S, Yoneda Y. Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model. Brain Res 2009; 1254: 99-108.
    • (2009) Brain Res , vol.1254 , pp. 99-108
    • Maeda, M.1    Furuichi, Y.2    Noto, T.3    Matsuoka, N.4    Mutoh, S.5    Yoneda, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.