Differential Mitochondrial Toxicity Screening and Multi-Parametric Data Analysis

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Tsiper, Maria V ^a   Sturgis, Jennifer ^c   Avramova, Larisa V ^a   Parakh, Shilpa ^a   Fatig, Raymond ^b   Juan García, Ana ^c   Li, Nianyu ^e   Rajwa, Bartek ^a   Narayanan, Padma ^e   Qualls, C W ^e   Robinson, J Paul ^c,d   Davisson, V Jo ^b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d PURDUE UNIVERSITY   (United States)

^e AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTIMYCIN A1; BORTEZOMIB; CHLORPROMAZINE; CINNARIZINE; CLOZAPINE; ERLOTINIB; FLUINDOSTATIN; FLUOXETINE; GALACTOSE; GEFITINIB; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; INDINAVIR; IONOMYCIN; KETOCONAZOLE; LOPINAVIR; MASITINIB; METFORMIN; NIMODIPINE; OLIGOMYCIN; PARACETAMOL; PENTAMIDINE; PHENFORMIN; PIOGLITAZONE; PRAVASTATIN; ROFECOXIB; SIMVASTATIN; UNINDEXED DRUG;

ARTICLE; CELL FUNCTION; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CELL STRUCTURE; CELLULAR PARAMETERS; CELLULAR STRESS RESPONSE; CLUSTER ANALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; CYTOLOGY; CYTOTOXICITY; DATA ANALYSIS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HUMAN; HUMAN CELL; MEASUREMENT; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL TOXICITY; MULTI PARAMETRIC DATA ANALYSIS; MULTI PARAMETRIC HIGH CONTENT SCREENING; PARAMETRIC TEST; PHENOTYPE; QUANTITATIVE ANALYSIS; SENSITIZATION; SIMULATION; STATISTICAL ANALYSIS; TOXICITY TESTING;

EID: 84867557326     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045226     Document Type: Article

References (28)

1. Pieczenik SR, Neustadt J, (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83: 84-92.
2. Wallace DC, (2005) A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine. Annual Review of Genetics 39: 359-407.
3. Brand MD, Nicholls DG, (2011) Assessing mitochondrial dysfunction in cells. Biochemical Journal 435: 297-312.
4. Dykens JA, Jamieson JD, Marroquin LD, Nadanaciva S, Xu JJ, et al. (2008) In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone. Toxicological Sciences 103: 335-345.
5. Nadanaciva S, Will Y, (2009) Current concepts in drug-induced mitochondrial toxicity. Current Protocols in Toxicology/Editorial Board, Mahin D Maines (editor-in-Chief) [et Al] Chapter 2: Unit 2.15-Unit 12.15.
6. Wouters KA, Kremer LCM, Miller TL, Herman EH, Lipshultz SE, (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. British Journal of Haematology 131: 561-578.
7. Popelova O, Sterba M, Haskova P, Simunek T, Hroch M, et al. (2009) Dexrazoxane-afforded protection against chronic anthracycline cardiotoxicity in vivo: effective rescue of cardiomyocytes from apoptotic cell death. Br J Cancer 101: 792-802.
8. Kroemer G, Galluzzi L, Brenner C, (2007) Mitochondrial membrane permeabilization in cell death. Physiol Rev 87: 99-163.
9. Mehta R, Chan K, Lee O, Tafazoli S, O'Brien PJ (2008) Drug-Associated Mitochondrial Toxicity. Drug-Induced Mitochondrial Dysfunction: John Wiley & Sons, Inc. pp. 71-126.
10. Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, et al. (2010) Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nature Biotechnology.
11. Marroquin LD, Hynes J, Dykens JA, Jamieson JD, Will Y, (2007) Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants. Toxicological Sciences 97: 539-547.
12. Will Y, Dykens JA, Nadanaciva S, Hirakawa B, Jamieson J, et al. (2008) Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells. Toxicological Sciences 106: 153-161.
13. Abraham VC, Towne DL, Waring JF, Warrior U, Burns DJ, (2008) Application of a High-Content Multiparameter Cytotoxicity Assay to Prioritize Compounds Based on Toxicity Potential in Humans. Journal of Biomolecular Screening 13: 527-537.
14. O'Brien PJ, Irwin W, Diaz D, Howard-Cofield E, Krejsa CM, et al. (2006) High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening. Archives of Toxicology 80: 580-604.
15. O'Brien PJ (2007) High Content Analysis of Sublethal Cytotoxicity in Human HepG2 Hepatocytes for Assessing Potential and Mechanism for Chemical- and Drug-Induced Human Toxicity. High Content Screening: John Wiley & Sons, Inc. pp. 293-316.
16. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, et al. (2004) Multidimensional Drug Profiling By Automated Microscopy. Science 306: 1194-1198.
17. Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, et al. (2008) Large-scale chemical dissection of mitochondrial function. Nat Biotechnol 26: 343-351.
18. Young DW, Bender A, Hoyt J, McWhinnie E, Chirn G-W, et al. (2007) Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nature Chemical Biology 4: 59-68.
19. Scaduto RC Jr, Grotyohann LW, (1999) Measurement of Mitochondrial Membrane Potential Using Fluorescent Rhodamine Derivatives. Biophysical Journal 76: 469-477.
20. Derdak Z, Mark NM, Beldi G, Robson SC, Wands JR, et al. (2008) The mitochondrial uncoupling protein-2 promotes chemoresistance in cancer cells. Cancer research 68: 2813-2819.
21. Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA, (2009) Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nature Reviews Drug Discovery 8: 567-578.
22. Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, et al. (2011) Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proc Natl Acad Sci U S A 108: E771-780.
23. Le SB, Holmuhamedov EL, Narayanan VL, Sausville EA, Kaufmann SH, (2006) Adaphostin and other anticancer drugs quench the fluorescence of mitochondrial potential probes. Cell Death Differ 13: 151-159.
24. Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, et al. (2007) High-throughput screening assays for the identification of chemical probes. Nature Chemical Biology 3: 466-479.
25. Denus Sd, Spinler SA, Miller K, Peterson AM, (2004) Statins and Liver Toxicity: A Meta-Analysis. Pharmacotherapy 24: 584-591.
26. Jones P, Kafonek S, Laurora I, Hunninghake D, (1998) Comparative Dose Efficacy Study of Atorvastatin Versus Simvastatin, Pravastatin, Lovastatin, and Fluvastatin in Patients With Hypercholesterolemia (The CURVES Study). The American Journal of Cardiology 81: 582-587.
27. Kaufmann P, Torok M, Zahno A, Waldhauser KM, Brecht K, et al. (2006) Toxicity of statins on rat skeletal muscle mitochondria. Cell Mol Life Sci 63: 2415-2425.
28. Kubota T, Fujisaki K, Itoh Y, Yano T, Sendo T, et al. (2004) Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. Biochemical Pharmacology 67: 2175-2186.