Behavioral effects of tryptophan depletion in seasonal affective disorder associated with the serotonin transporter gene?

Psychiatry Research

Volumn 85, Issue 3, 1999, Pages 241-246

  Lenzinger, Elisabeth ^a   Neumeister, Alexander ^a   Praschak Rieder, Nicole ^a   Fuchs, Karoline ^b   Gerhard, Elisabeth ^b   Willeit, Mattheus ^a   Sieghart, Werner ^b   Kasper, Siegfried F ^a   Hornik, Kurt ^c   N Aschauer, Harald ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b University Hospital for Psychiatry   (Austria)

^c VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Chronobiology; Depressive disorder; Genetics; Variable number tandem repeat polymorphism

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER; SODIUM; TRYPTOPHAN;

ADULT; AFFECTIVE NEUROSIS; AGED; ALLELE; ARTICLE; BEHAVIOR; CHRONOBIOLOGY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENOTYPE; HAMILTON SCALE; HUMAN; MALE; PATHOGENESIS; PRIORITY JOURNAL; RELAPSE; SEROTONIN UPTAKE; SEROTONINERGIC TRANSMISSION; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AFFECT; AGED; CARRIER PROTEINS; CIRCADIAN RHYTHM; DNA; FATIGUE; FEMALE; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEASONAL AFFECTIVE DISORDER; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ADJUSTMENT; STATISTICS, NONPARAMETRIC; TANDEM REPEAT SEQUENCES; TRYPTOPHAN;

EID: 0033594127     PISSN: 01651781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-1781(99)00009-8     Document Type: Article

References (22)

1. American Psychiatric Association, 1994. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. American Psychiatric Press, Washington, DC.
2. Brewerton T.D., Berrettini W.H., Nurnberger J.I. Jr., Linnoila M. Analysis of seasonal fluctuations of CSF monoamine metabolites and neuropeptides in normal controls. Psychiatry Research. 23:1988;257-265.
3. Carlsson A., Svennerholm L., Winblad B. Seasonal and circadian monoamine variation in human brains examined post mortem. Acta Psychiatrica Scandinavica. 61((Suppl. 280)):1980;75-83.
4. Collier D.A., Sham P.C. The usual suspects: tyrosine hydroxylase and the serotonin transporter in affective disorders. Molecular Psychiatry. 3:1988;103-105.
5. Collier D.A., Stober G., Li T., Catalano M., DiBella T. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry. 1:1996;453-460.
6. Fernstrom J.D. Effects of the diet on brain neurotransmitters. Metabolism. 26:1977;207-223.
7. Hamilton M. Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology. 6:1967;278-296.
8. Kasper, S., Neumeister, A., Rieder, N., Ruhrmann, S., Heelmann, B., 1996. Serotonergic mechanisms in the pathophysiology and treatment of seasonal affective disorder. In: Biologic Effects of Light. Walter de Gruyter and Co., Berlin-New York.
9. Kasper S., Wehr T.A., Bartko J.J., Gaist P.A., Rosenthal N.E. Epidemiological findings of seasonal changes in mood and behavior: a telephone survey of Montgomery County, Maryland. Archives of General Psychiatry. 46:1989;823-833.
10. Kasper S., Wehr T.A., Rosenthal N.E. Saisonal abhngige Depressionsformen I. Grundlagen und Klinische Beschreibung des Syndroms. Nervenarzt. 59:1988;191-199.
11. Kasper S., Wehr T.A., Rosenthal N.E. Saisonal abhngige. Depressionsformen II. Beeinflussung durch Phototherapie und biologische Ergebnisse. Nervenarzt. 59:1988;200-214.
12. 3H-paroxetine to blood platelets in healthy volunteers: indications for a gender difference. Biological Psychiatry. 28:1990;509-517.
13. Lam R.W., Zis A.P., Grewal A., Delgado P.L., Charney D.S., Krystal J.H. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Archives of General Psychiatry. 53:1996;41-44.
14. Lesch K.P., Balling U., Gross J., Strauss K., Wolozin B.I., Murphy D.L., Riederer P. Organization of the serotonin transporter gene. Journal of Neural Transmission (General Section). 95:1994;157-162.
15. Madden P.A., Heath A.C., Rosenthal N.E., Martin N.G. Seasonal changes in mood and behavior. Archives of General Psychiatry. 63:1996;44-55.
16. Neumeister A., Praschak-Rieder N., Hesselmann B., Rao M.-L., Glück J., Kasper S. Effects of tryptophan depletion on drug-free patients with seasonal affective disorder during a stable response to bright light therapy. Archives of General Psychiatry. 55:1997;524-530.
17. Rosenthal N.E., Genhart M., Jacobsen F.M., Skewerer R.G., Wehr T.A. Seasonal affective disorder: relevance for treatment, and research in bulimia. Annals of the New York Academy of Sciences. 499:1987;216-230.
18. Rosenthal N.E., Mazzanti C.M., Barnett R.L., Hardin T.A., Turner E.H., Larn C.K., Ozaki N., Goldman D. Role of serotonin transporter promoter repeat length polymorphism (5-HTTLPR) in seasonality and seasonal affective disorder. Molecular Psychiatry. 3:1998;175-177.
19. Rosenthal N.E., Sack D.A., Gillin J.C., Lewy A.J., Goodwin F.K., Davenport Y., Mueller P.S., Newsome D.A., Wehr T.A. Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy. Archives of General Psychiatry. 41:1984;72-80.
20. Ruhrmann S., Kasper S., Hawellek B., Martinez B., Höflich G., Möller H.J. Fluoxetine as a treatment alternative to light therapy in seasonal affective disorder (SAD). Pharmacopsychiatry. 26:1993;193.
21. Wehr T.A., Rosenthal N.E. Seasonality and affective illness. American Journal of Psychiatry. 146:1989;829-839.
22. Wehr T.A., Sack D.A., Rosenthal N.E. Seasonal affective disorder with summer depression and winter hypomania. American Journal of Psychiatry. 144:1987;1602-1603.