Estrogen and telomerase in human peripheral blood mononuclear cells

Molecular and Cellular Endocrinology

Volumn 364, Issue 1-2, 2012, Pages 83-88

  Benko, Ann L ^a   Olsen, Nancy J ^a   Kovacs, William J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Estrogen; T lymphocytes; Telomerase

Indexed keywords

ESTRADIOL; ESTROGEN; MESSENGER RNA; T LYMPHOCYTE RECEPTOR; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE;

ADULT; CELLS, CULTURED; ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; RNA, MESSENGER; SEX FACTORS; TELOMERASE;

EID: 84867554274     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2012.08.012     Document Type: Article

References (23)

1. Blackburn E.H. Telomere states and cell fates. Nature 2000, 408:53-56.
2. Calado R.T., Yewdell W.T., Wilkerson K.L., Regal J.A., Kajigaya S., Stratakis C.A., Young N.S. Sex hormones, acting on the Tert gene, increase telomerase activity in human primary hematopoietic cells. Blood 2009, 114:2236-2243.
3. Choi J., Fauce S.R., Effros R.B. Reduced telomerase activity in human T lymphocytes exposed to cortisol. Brain Behav. Immun. 2008, 22:600-605.
4. Effros R.B., Dagarag M., Spaulding C., Man J. The role of Cd8+ T-cell replicative senescence in human aging. Immunol. Rev. 2005, 205:147-157.
5. Feldman H.A., Longcope C., Derby C.A., Johannes C.B., Araujo A.B., Coviello A.D., Bremner W.J., McKinlay J.B. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J. Clin. Endocrinol. Metab. 2002, 87:589-598.
6. Greider C.W. Telomere length regulation. Annu. Rev. Biochem. 1996, 65:337-365.
7. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
8. Harman S.M., Metter E.J., Tobin J.D., Pearson J., Blackman M.R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore longitudinal study of aging. J. Clin. Endocrinol. Metab. 2001, 86:724-731.
9. Hohensinner P.J., Goronzy J.J., Weyand C.M. Telomere dysfunction, autoimmunity and aging. Aging Dis. 2011, 2:524-537.
10. Kim N.W., Piatyszek M.A., Prowse K.R., Harley C.B., West M.D., Ho P.L., Coviello G.M., Wright W.E., Weinrich S.L., Shay J.W. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266:2011-2015.
11. Kovacs W.J., Olsen N.J. Androgen receptors in human thymocytes. J. Immunol. 1987, 139:490-493.
12. Kyo S., Takakura M., Kohama T., Inoue M. Telomerase activity in human endometrium. Cancer Res. 1997, 57:610-614.
13. Kyo S., Takakura M., Kanaya T., Zhuo W., Fujimoto K., Nishio Y., Orimo A., Inoue M. Estrogen activates telomerase. Cancer Res. 1999, 59:5917-5921.
14. Liu K., Hodes R.J., Weng N. Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (Htert) protein but is associated with Htert phosphorylation and nuclear translocation. J. Immunol. 2001, 166:4826-4830.
15. Meeker A.K., Sommerfeld H.J., Coffey D.S. Telomerase is activated in the prostate and seminal vesicles of the castrated rat. Endocrinology 1996, 137:5743-5746.
16. Misiti S., Nanni S., Fontemaggi G., Cong Y.S., Wen J., Hirte H.W., Piaggio G., Sacchi A., Pontecorvi A., Bacchetti S., Farsetti A. Induction of Htert expression and telomerase activity by estrogens in human ovary epithelium cells. Mol. Cell. Biol. 2000, 20:3764-3771.
17. Olsen N.J., Kovacs W.J. Evidence that androgens modulate human thymic T cell output. J. Investig. Med. 2011, 59:32-35.
18. Olsen N.J., Watson M.B., Henderson G.S., Kovacs W.J. Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology 1991, 129:2471-2476.
19. Olsen N.J., Olson G., Viselli S.M., Gu X., Kovacs W.J. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology 2001, 142:1278-1283.
20. Shay J.W., Wright W.E. Telomerase activity in human cancer. Curr. Opin. Oncol. 1996, 8:66-71.
21. Weng N.P., Levine B.L., June C.H., Hodes R.J. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 1996, 183:2471-2479.
22. Weng N.P., Hathcock K.S., Hodes R.J. Regulation of telomere length and telomerase in T and B Cells: a mechanism for maintaining replicative potential. Immunity 1998, 9:151-157.
23. Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., Shay J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 1996, 18:173-179.