-
1
-
-
33747777758
-
P P A R γ as a new therapeutic target in inf ammator y bowel diseases
-
Dubuquoy L, Rou sseaux C, Turu X et al.P P A R γ as a new therapeutic target in inf ammator y bowel diseases. Gut 2006; 55:1341-1349
-
(2006)
Gut
, vol.55
, pp. 1341-1349
-
-
Dubuquoy, L.1
Rousseaux, C.2
Turu, X.3
-
2
-
-
0033793133
-
Peroxiso me pro liferato r-activated receptors (PPARs):nuclear receptors at the crossroads between lipid metabolism and infammation
-
Chinetti G, Fruchart JC, Staels B. Peroxiso me pro liferato r-activated receptors (PPARs):nuclear receptors at the crossroads between lipid metabolism and infammation. Infamm Res 2000; 49:497-505.
-
(2000)
Infamm Res
, vol.49
, pp. 497-505
-
-
Chinetti, G.1
Fruchart, J.C.2
Staels, B.3
-
3
-
-
34548069753
-
Dif erential expression, distribution, and function of PPAR-gamma in the proximal and distal colon
-
Su W, Bush CR, Necela BM et al. Dif erential expression, distribution, and function of PPAR-gamma in the proximal and distal colon. Physiol Genomics 2007;30:342-353
-
(2007)
Physiol Genomics
, vol.30
, pp. 342-353
-
-
Su, W.1
Bush, C.R.2
Necela, B.M.3
-
4
-
-
34447287540
-
13-Oxo-ODE is an endogenous ligand for PPARγ in human colonic epithelial cells
-
DOI 10.1016/j.bcp.2007.05.027, PII S0006295207003383
-
Altmann R, Hausmann M, Spottl T et al. 13-Oxo-ODE is an endogenous ligand for PPARy in human colonic epithelial cells. Biochem Pharmacol 2007;74:612-622 (Pubitemid 47042013)
-
(2007)
Biochemical Pharmacology
, vol.74
, Issue.4
, pp. 612-622
-
-
Altmann, R.1
Hausmann, M.2
Spottl, T.3
Gruber, M.4
Bull, A.W.5
Menzel, K.6
Vogl, D.7
Herfarth, H.8
Scholmerich, J.9
Falk, W.10
Rogler, G.11
-
5
-
-
0038460253
-
PPARy and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-y target genes in macrophages
-
Welch JS, Ricote M, Akiyama TE et al. PPARy and PPAR8 negatively regulate specific subsets of lipopolysaccharide and IFN-y target genes in macrophages. Proc Natl Acad Sci USA 2003;100:6712-6717
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6712-6717
-
-
Welch, J.S.1
Ricote, M.2
Akiyama, T.E.3
-
6
-
-
0031888958
-
PPAR-γ agonists inhibit production of monocyte infammatory cytokines
-
Jiang C, Ting AT, Seed B. PPAR-γ agonists inhibit production of monocyte infammatory cytokines. Nature 1998;391:82-86
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
7
-
-
34247556499
-
The role of PPARy on restoration of colonic homeostasis after experimental stress-induced infammation and dysfunction
-
Ponferrada A, Caso JR, Alou L et al. The role of PPARy on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. Gastroenterology 2007;132:1791-1803
-
(2007)
Gastroenterology
, vol.132
, pp. 1791-1803
-
-
Ponferrada, A.1
Caso, J.R.2
Alou, L.3
-
8
-
-
0031886864
-
The peroxisome proliferator-activated recep-tor-yis a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM et al. The peroxisome proliferator-activated recep-tor-yis a negative regulator of macrophage activation. Nature 1998;391:79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
-
9
-
-
0035794293
-
Attenuation of colon inf ammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor y (PPARy) heterodimer. A basis for new therapeutic strategies
-
Desreumaux P, Dubuquoy L, Nutten S et al. Attenuation of colon inf ammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor y (PPARy) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001;193:827-838
-
(2001)
J Exp Med
, vol.193
, pp. 827-838
-
-
Desreumaux, P.1
Dubuquoy, L.2
Nutten, S.3
-
10
-
-
0036743165
-
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a T 2 cytokine response and prevent acute colitis
-
Saubermann LJ, Nakajima A, Wada K et al. Peroxisome proliferator- activated receptor gamma agonist ligands stimulate a T 2 cytokine response and prevent acute colitis. Infamm Bowel Dis 2002;8:330-339
-
(2002)
Infamm Bowel Dis
, vol.8
, pp. 330-339
-
-
Saubermann, L.J.1
Nakajima, A.2
Wada, K.3
-
11
-
-
33746159991
-
Peroxisome proliferator activated receptor y in colonic epithelial cells protects against experimental inf ammatory bowel disease
-
Adachi M, Kurotani R, Morimura K et al. Peroxisome proliferator activated receptor y in colonic epithelial cells protects against experimental inf ammatory bowel disease. Gut 2006; 55:1104-1113
-
(2006)
Gut
, vol.55
, pp. 1104-1113
-
-
Adachi, M.1
Kurotani, R.2
Morimura, K.3
-
12
-
-
38649114372
-
4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor y agonist alleviates the symptoms of DSS-induced colitis
-
Yamamoto K, Ninomiya Y, Iseki M et al. 4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor y agonist alleviates the symptoms of DSS-induced colitis. Biochem Biophys Res Commun 2008;367:566-572
-
(2008)
Biochem Biophys Res Commun
, vol.367
, pp. 566-572
-
-
Yamamoto, K.1
Ninomiya, Y.2
Iseki, M.3
-
13
-
-
0038185266
-
A novel PPAR y gene therapy to control inf ammation associated with inf ammatory bowel disease in a murine model
-
Katayama K, Wada K, Nakajima A et al. A novel PPAR y gene therapy to control inf ammation associated with inf ammatory bowel disease in a murine model. Gastroenterology 2003; 124:1315-1324
-
(2003)
Gastroenterology
, vol.124
, pp. 1315-1324
-
-
Katayama, K.1
Wada, K.2
Nakajima, A.3
-
14
-
-
34249099761
-
The PPARy agonist rosiglitazone impairs colonic infammation in mice with experimental colitis
-
Ramakers JD, Verstege MI, Tuijls G et al. The PPARy agonist rosiglitazone impairs colonic infammation in mice with experimental colitis. J Clin Immunol 2007;27:275-283
-
(2007)
J Clin Immunol
, vol.27
, pp. 275-283
-
-
Ramakers, J.D.1
Verstege, M.I.2
Tuijls, G.3
-
15
-
-
0037847511
-
Impaired expression of peroxisome proliferator-activated receptor y in ulcerative colitis
-
Dubuquoy L, Jansson EA, Deeb et al. Impaired expression of peroxisome proliferator-activated receptor y in ulcerative colitis. Gastroenterology 2003;124:1265-1276
-
(2003)
Gastroenterology
, vol.124
, pp. 1265-1276
-
-
Dubuquoy, L.1
Jansson, E.A.2
Deeb3
-
16
-
-
0037960082
-
Is there a role for PPARy in IBD? Yes, no, maybe
-
Wu GD. Is there a role for PPARy in IBD? Yes, no, maybe. Gastroenterology 2003;124:1538-1542
-
(2003)
Gastroenterology
, vol.124
, pp. 1538-1542
-
-
Wu, G.D.1
-
17
-
-
39749114544
-
Rosiglitazone for active ulcerative colitis: A randomized placebo-controlled trial
-
Lewis JD, Lichtenstein GR, Deren JJ et al. Rosiglitazone for active ulcerative colitis: A randomized placebo-controlled trial. Gastroenterology 2008;134:688-695
-
(2008)
Gastroenterology
, vol.134
, pp. 688-695
-
-
Lewis, J.D.1
Lichtenstein, G.R.2
Deren, J.J.3
-
18
-
-
39849093143
-
A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis
-
Liang HL, Ouyang Q. A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis. World J Gastroenterol 2008; 14:114-119
-
(2008)
World J Gastroenterol
, vol.14
, pp. 114-119
-
-
Liang, H.L.1
Ouyang, Q.2
-
19
-
-
34250212715
-
Ef ect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen SE, Wolski K. Ef ect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007; 356:2457-2471
-
(2007)
N Engl J Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
20
-
-
54849425755
-
Editorial, the Lancet. Rosiglitazone no longer recommended
-
Editorial, The Lancet. Rosiglitazone no longer recommended. Lancet 2009 372 1520.
-
(2009)
Lancet
, vol.372
, pp. 1520
-
-
-
21
-
-
0028338424
-
Course of ulcerative colitis:analysis of changes in disease activity over years
-
Langholz E, Munkholm P, Davidsen M et al. Course of ulcerative colitis:analysis of changes in disease activity over years. Gastroenterology 1994;107:3-11.
-
(1994)
Gastroenterology
, vol.107
, pp. 3-11
-
-
Langholz, E.1
Munkholm, P.2
Davidsen, M.3
-
22
-
-
0033883458
-
A simple method to establish short-term cultures of normal human colonic epithelial cells from endoscopic biopsy specimens. Comparison of isolation methods, assessment of viability and metabolic activity
-
Pedersen G, Saermark T, Giese B et al. A simple method to establish short-term cultures of normal human colonic epithelial cells from endoscopic biopsy specimens. Comparison of isolation methods, assessment of viability and metabolic activity. Scand J Gastroenterol 2000; 35:772-780
-
(2000)
Scand J Gastroenterol
, vol.35
, pp. 772-780
-
-
Pedersen, G.1
Saermark, T.2
Giese, B.3
-
23
-
-
0036288520
-
Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inf ammatory bowel disease
-
Brynskov J, Foegh P, Pedersen G et al. Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inf ammatory bowel disease. Gut 2002; 51:37-43.
-
(2002)
Gut
, vol.51
, pp. 37-43
-
-
Brynskov, J.1
Foegh, P.2
Pedersen, G.3
-
24
-
-
0025778925
-
36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO
-
Laborda J. 36B4 cDNA used as an estradiol-independent mRNA control is the cDNA for human acidic ribosomal phosphoprotein PO. Nucleic Acids Res 1991; 19:3998.
-
(1991)
Nucleic Acids Res
, vol.19
, pp. 3998
-
-
Laborda, J.1
-
25
-
-
0035839608
-
Target genes of peroxisome proliferator-activated receptor y in colorectal cancer cells
-
Gupta RA, Brockman JA, Sarraf P et al. Target genes of peroxisome proliferator-activated receptor y in colorectal cancer cells. J Biol Chem 2001;276:29681-29687
-
(2001)
J Biol Chem
, vol.276
, pp. 29681-29687
-
-
Gupta, R.A.1
Brockman, J.A.2
Sarraf, P.3
-
26
-
-
13244279846
-
Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas
-
Matthiessen MW, Pedersen G, Albrektsen T et al. Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas. Scand J Gastroenterol 2005;40:198-205.
-
(2005)
Scand J Gastroenterol
, vol.40
, pp. 198-205
-
-
Matthiessen, M.W.1
Pedersen, G.2
Albrektsen, T.3
-
27
-
-
0034526855
-
Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inf ammatory bowel disease
-
Pedersen G, Saermark T, Bendtzen K et al. Cultures of human colonic epithelial cells isolated from endoscopical biopsies from patients with inf ammatory bowel disease. Efect of IFNy, TNFa and IL-1P on viability, butyrate oxidation and IL-8 secretion. Autoimmunity 2000; 32:255-263
-
(2000)
Efect of IFNy, TNFa and IL-1P on Viability, Butyrate Oxidation and IL-8 Secretion. Autoimmunity
, vol.32
, pp. 255-263
-
-
Pedersen, G.1
Saermark, T.2
Bendtzen, K.3
-
28
-
-
33847179443
-
A review of activity indices and efcacy end points for clinical trials of medical therapy in adults with ulcerative colitis
-
D'Haens G, Sandborn WJ, Feagan BG et al. A review of activity indices and efcacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132:763-786
-
(2007)
Gastroenterology
, vol.132
, pp. 763-786
-
-
D'Haens, G.1
Sandborn, W.J.2
Feagan, B.G.3
-
29
-
-
0023521441
-
Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study
-
Schroeder KW, Tremaine WJ, Ilstrup DM. Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colitis. A randomized study. N Engl J Med 1987; 317:1625-1629
-
(1987)
N Engl J Med
, vol.317
, pp. 1625-1629
-
-
Schroeder, K.W.1
Tremaine, W.J.2
Ilstrup, D.M.3
-
31
-
-
0037303555
-
Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells
-
Perner A, Andresen L, Pedersen G et al. Superoxide production and expression of NAD(P)H oxidases by transformed and primary human colonic epithelial cells. Gut 2003;52:231-236
-
(2003)
Gut
, vol.52
, pp. 231-236
-
-
Perner, A.1
Andresen, L.2
Pedersen, G.3
-
32
-
-
22344440495
-
Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium
-
Pedersen G, Andresen L, Matthiessen MW et al. Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium. Clin Exp Immunol 2005;141:298-306.
-
(2005)
Clin Exp Immunol
, vol.141
, pp. 298-306
-
-
Pedersen, G.1
Andresen, L.2
Matthiessen, M.W.3
-
33
-
-
0031694577
-
Activation of the peroxisome proliferator-activated receptor y promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
-
Lefebvre AM, Chen I, Desreumaux P et al. Activation of the peroxisome proliferator-activated receptor y promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998;4:1053-1057
-
(1998)
Nat Med
, vol.4
, pp. 1053-1057
-
-
Lefebvre, A.M.1
Chen, I.2
Desreumaux, P.3
-
34
-
-
0032880826
-
Peroxisome proliferator-activated receptor gamma is induced during dif erentiation of colon epithelium cells
-
Lefebvre M, Paulweber B, Fajas L et al. Peroxisome proliferator-activated receptor gamma is induced during dif erentiation of colon epithelium cells. J Endocrinol 1999;162:331-340
-
(1999)
J Endocrinol
, vol.162
, pp. 331-340
-
-
Lefebvre, M.1
Paulweber, B.2
Fajas, L.3
-
35
-
-
64049095625
-
Regulation of epithelial- mecenchymal IL-1 signaling by PPARp/8 is essential for skin homeostasis and wound healing
-
Chong HC, Tan MJ, Philippe V et al. Regulation of epithelial- mecenchymal IL-1 signaling by PPARp/8 is essential for skin homeostasis and wound healing. J Cell Biol 2009;184:817-831
-
(2009)
J Cell Biol
, vol.184
, pp. 817-831
-
-
Chong, H.C.1
Tan, M.J.2
Philippe, V.3
-
36
-
-
0034742533
-
PPARy and inf ammatory bowel disease: A new therapeutic target for ulcerative colitis and Crohn's disease
-
Wada K, Nakajima A, Blumberg RS. PPARy and inf ammatory bowel disease: A new therapeutic target for ulcerative colitis and Crohn's disease. Trends Mol Med 2001;7:329-331
-
(2001)
Trends Mol Med
, vol.7
, pp. 329-331
-
-
Wada, K.1
Nakajima, A.2
Blumberg, R.S.3
-
37
-
-
0033060675
-
Downregulation of peroxisome proliferator-activated receptor y expression by inf ammatory cytokines and its reversal by thiazolidinediones
-
Tanaka T, Itoh H, Doi K et al. Downregulation of peroxisome proliferator-activated receptor y expression by inf ammatory cytokines and its reversal by thiazolidinediones. Diabetologia 1999;42:702-10.
-
(1999)
Diabetologia
, vol.42
, pp. 702-10
-
-
Tanaka, T.1
Itoh, H.2
Doi, K.3
-
38
-
-
33846174641
-
Tumor necrosis factor and interleukin 1 decrease RXRa, PPARa, PPARy, LXRa, and the coactivators SRC-1, PGC-1a, and PGC-1fS in liver cells
-
Kim MS, Sweeney TR, Shigenaga JK et al. Tumor necrosis factor and interleukin 1 decrease RXRa, PPARa, PPARy, LXRa, and the coactivators SRC-1, PGC-1a, and PGC-1fS in liver cells. Metabolism 2007;56:267-279
-
(2007)
Metabolism
, vol.56
, pp. 267-279
-
-
Kim, M.S.1
Sweeney, T.R.2
Shigenaga, J.K.3
-
39
-
-
1942487847
-
Tumor necrosis factor-a inhibits peroxisome proliferator-activated receptor y activity at a posttranslational level in hepatic stellate cells
-
Sung CK, She H, Xiong S et al. Tumor necrosis factor-a inhibits peroxisome proliferator-activated receptor y activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2004; 286:G722-9.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Sung, C.K.1
She, H.2
Xiong, S.3
-
40
-
-
0035831494
-
Interferon-y-induced regulation of peroxisome proliferator-activated receptor y and STATs in adipocytes
-
Waite KJ, Floyd ZE, Arbour-Reily P et al. Interferon-y-induced regulation of peroxisome proliferator-activated receptor y and STATs in adipocytes. J Biol Chem 2001;276:7062-7068
-
(2001)
J Biol Chem
, vol.276
, pp. 7062-7068
-
-
Waite, K.J.1
Floyd, Z.E.2
Arbour-Reily, P.3
-
41
-
-
0027451455
-
Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1P by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
-
Reinecker HC, Stefen M, Witthoef T et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1P by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993;94:174-181
-
(1993)
Clin Exp Immunol
, vol.94
, pp. 174-181
-
-
Reinecker, H.C.1
Stefen, M.2
Witthoef, T.3
-
42
-
-
0026514203
-
Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inf ammatory bowel disease
-
Brynskov J, Tvede N, Andersen CB et al. Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inf ammatory bowel disease. Gut 1992;33:55-58
-
(1992)
Gut
, vol.33
, pp. 55-58
-
-
Brynskov, J.1
Tvede, N.2
Andersen, C.B.3
-
43
-
-
33749338666
-
Clinical guidelines for the medical management of lef -sided ulcerative colitis and ulcerative proctitis:summary statement
-
Regueiro M, Lofus EV Jr, teinhart AH et al. Clinical guidelines for the medical management of lef -sided ulcerative colitis and ulcerative proctitis:summary statement. Infamm Bowel Dis 2006;12:972-978
-
(2006)
Infamm Bowel Dis
, vol.12
, pp. 972-978
-
-
Regueiro, M.1
Lofus Jr., E.V.2
Teinhart, A.H.3
|