Treatment of distal ulcerative colitis with short-chain fatty acid enemas. A placebo-controlled trial

Digestive Diseases and Sciences

Volumn 41, Issue 11, 1996, Pages 2254-2259

  Scheppach, Wolfgang ^a   Bartram, H P ^a   Richter, F ^a   Muller J G ^a   Greinwald, K ^a,b   Tauschel, H D ^a,b   Gierend, M ^a,c   Weber, A ^a,c   Hegemann, D ^a,d   Kubetzko, W ^a,e   Rabast, U ^a,f   Schutz E ^a,g   Raedsch, R ^a,h   Britsch, R ^a,i   Rehmann, I H ^a,j   Otto, P ^a,k   Judmaier, G ^a,l   Press, A G ^a,m   Wordehoff D ^a,n   Mlitz, H ^a,o   Stein, J ^a,p   Schmidt, C ^a,q   more..

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Dr Falk Pharma   (Germany)

^c Medicomp GmbH   (Germany)

^d Frino Comp   (Germany)

^e Vitalis Klinik   (Germany)

^f Elisabeth Krankenhaus   (Germany)

^g Gastroenterological Practice   (Germany)

^h ST JOSEFS HOSPITAL   (Germany)

ⁱ Gastroenterology Group Practice   (Germany)

^j Gastroenterological Practice   (Germany)

^k Krankenhaus Grossburgwedel   (Germany)

^l UNIVERSITY OF INNSBRUCK   (Austria)

^m UNIVERSITY OF GÖTTINGEN   (Germany)

ⁿ Ehem Medizinische Klinik   (Germany)

^o Gastroenterological Practice   (Germany)

^p GOETHE UNIVERSITY   (Germany)

^q UNIVERSITY OF BONN   (Germany)

more..

Author keywords

Butyrate; Enemas; Short chain fatty acids; Ulcerative colitis

Indexed keywords

ENEMA; PLACEBO; SHORT CHAIN FATTY ACID;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENDOSCOPY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTAL DRUG ADMINISTRATION; STATISTICAL ANALYSIS; ULCERATIVE COLITIS;

EID: 0029846450     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02071409     Document Type: Article

References (16)

1. Cummings JH, Macfarlane GT: The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 70:443-459, 1991
2. Roetiiger WEW: Metabolic basis of starvation diarrhoea: implications for treatment. Lancet 1:1082-1084. 1986
3. Roediger WEW: The starved colon-diminished mucosal nutrition, diminished absorption, and colitis. Dis Colon Rectum 33:858-862, 1990
4. Harig JM, Soergel KH, Komorowski RA, Wood CM: Treatment of diversion colitis with short-chain fatty acid irrigation. N Engl J Med 320:23-28, 1989
5. Roediger WEW: What sequence of pathogenetic events leads to acute ulcerative colitis? Dis Colon Rectum 31:482-487, 1988
6. Scheppach W, Bartram P, Richter F: Management of diversion colitis, pouchitis and distal ulcerative colitis. In Physiological and Clinical Aspects of Short-Chain Fatty Acids. JH Cummings, JL Rombeau, T Sakata (eds). Cambridge, Cambridge University Press, 1995, pp 353-360
7. Breuer RI, Buto SK, Christ ML, Bean J, Vernia P, Paoluzi P, Di Paolo MC, Caprilli R: Rectal irrigation with short-chain fatty acids for distal ulcerative colitis. Preliminary report. Dig Dis Sci 36:185-187, 1991
8. Senagore AJ, MacKeigan JM, Seheider M, Ebrom JS: Short-chain fatty acid enemas: A cost-effective alternative in the treatment of nonspecific proctosigmoiditis. Dis Colon Rectum 35:923-927, 1992
9. Vernia P, Marcheggiano A, Caprilli R, Frieri G, Corrao G, Valpiani D, Di Paolo MC, Paoluzi P, Torsoli A: Short-chain fatly acid topical treatment in distal ulcerative colitis. Aliment Pharmacol Ther 9:309-313, 1995
10. Scheppach W, Sommer H, Kirchner T, Paganelli G-M, Burtram P, Christl S, Richter F, Dusel G, Kasper H: Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gustroenterology 103:51-56, 1992
11. Steinhart AH, Hiruki T, Brzezinski A, Baker JP: Treatment of left-sided ulcerulive colitis with butyrate enemas: A controlled trial. Aliment Pharmacol Ther (in press)
12. Sutherland LR, Martin F, Greer S, Robinson M, Greenberger N, Saibil F, Martin T, Sparr J, Prokipchuk E, Borgen L: 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis. Gastroenterology 92:1894-1898, 1987
13. Thomas L (ed): Labor und Diagnose. Marburg, Medizinische Verlagsgesellschaft, 1991
14. Sutherland LR, Martin F: 5-Aminosalicylic acid enemas in treatment of distal ulcerative colitis and proctitis in Canada. Dig Dis Sci 32:64S-66S, 1987
15. Sandborn WJ, Tremaine WJ, Schroeder KW, Batts KP, Lawson GM, Steiner BL, Harrison JM, Zinsmeister AR: A placebo-controlled trial of cyclosporin enemas for mildly to moderately active left-sided ulcerutive colitis. Gastroenterology 106:1429-1435, 1994
16. Roediger WEW: Role of anaerobic bacteria in the metabolic welfare of the colonic mucosa in man. Gut 21:793-798. 1980