Genetics and outcomes after traumatic brain injury (TBI): What do we know about pediatric TBI?

Journal of Pediatric Rehabilitation Medicine

Volumn 5, Issue 3, 2012, Pages 217-231

  Kurowski, Brad ^a   Martin, Lisa J ^a   Wade, Shari L ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Brain injuries; child; epidemiology; genes; genetic polymorphism; humans; pediatric

Indexed keywords

APOLIPOPROTEIN E4;

ALLELE; ARTICLE; BRAIN PERFUSION; CHILDHOOD INJURY; DISEASE ASSOCIATION; ETHNICITY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; GLASGOW OUTCOME SCALE; HUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; STUDY DESIGN; TRAUMATIC BRAIN INJURY;

ADULT; APOLIPOPROTEINS E; BRAIN INJURIES; CHILD; GENETIC ASSOCIATION STUDIES; GENETIC MARKERS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS;

EID: 84867539114     PISSN: 18745393     EISSN: 18758894     Source Type: Journal    
DOI: 10.3233/PRM-2012-0214     Document Type: Article

References (95)

1. Faul M, Xu L, Wald M, VG C. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002 - 2006. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control [Internet]. 2010.
2. Fowke JH. Issues in the design of molecular and genetic epidemiologic studies. J Prev Med Public Health. 2009;42(6):343-8.
3. McAllisterTW.Genetic factorsmodulating outcome after neurotrauma. PM R. 2010;2(12 Suppl 2):S241-52.
4. Dardiotis E, Fountas KN, Dardioti M, Xiromerisiou G, Kapsalaki E, Tasiou A, et al. Genetic association studies in patients with traumatic brain injury. Neurosurg Focus. 2010;28(1):E9.
5. Blackman JA, Worley G, Strittmatter WJ. Apolipoprotein E and brain injury: Implications for children. Developmental medicine and child neurology. 2005;47(1):64-70.
6. Zhou W, Xu D, Peng X, Zhang Q, Jia J, Crutcher KA. Metaanalysis of APOE4 allele and outcome after traumatic brain injury. Journal of neurotrauma. 2008;25(4):279-90.
7. Hadjigeorgiou GM, Paterakis K, Dardiotis E, Dardioti M, Aggelakis K, Tasiou A, et al. IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury. Neurology. 2005;65(7):1077-82.
8. Hoh NZ, Wagner AK, Alexander SA, Clark RB, Beers SR, Okonkwo DO, et al.BCL2 genotypes: Functional and neurobehavioral outcomes after severe traumatic brain injury. Journal of neurotrauma. 2010;27(8):1413-27.
9. Uzan M, Tanriverdi T, Baykara O, Kafadar A, Sanus GZ, Tureci E, et al. Association between interleukin-1 beta (IL- 1beta) gene polymorphism and outcome after head injury: An early report. Acta Neurochir (Wien). 2005;147(7):715-20; discussion 20.
10. Martinez-Lucas P, Moreno-Cuesta J, Garcia-Olmo DC, Sanchez-Sanchez F, Escribano-Martinez J, del Pozo AC, et al. Relationship between the Arg72Pro polymorphism of p53 and outcome for patients with traumatic brain injury. Intensive Care Med. 2005;31(9):1168-73.
11. Lipsky RH, SparlingMB, Ryan LM,XuK, Salazar AM,Goldman D, et al. Association of COMT Val158Met genotype with executive functioning following traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2005;17(4):465-71.
12. McAllister TW, Flashman LA, Harker Rhodes C, Tyler AL, Moore JH, Saykin AJ, et al. Single nucleotide polymorphisms inANKK1and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: A replication and extension study. Brain Inj. 2008;22(9):705-14.
13. McAllister TW, Flashman LA, McDonald BC, Saykin AJ. Mechanisms of working memory dysfunction after mild and moderate TBI: Evidence from functional MRI and neurogenetics. Journal of neurotrauma. 2006;23(10):1450-67.
14. McAllister TW, Flashman LA, Sparling MB, Saykin AJ. Working memory deficits after traumatic brain injury: Catecholaminergic mechanisms and prospects for treatment - a review. Brain Inj. 2004;18(4):331-50.
15. McAllister TW, Rhodes CH, Flashman LA, McDonald BC, Belloni D, Saykin AJ. Effect of the dopamine D2 receptor T allele on response latency after mild traumatic brain injury. Am J Psychiatry. 2005;162(9):1749-51.
16. YuW,Wulf A, Yesupriya A, Clyne M, Khoury MJ, Gwinn M. HuGE Watch: Tracking trends and patterns of published studies of genetic association and human genome epidemiology in near-real time. Eur J Hum Genet. 2008;16(9):1155-8.
17. YuW, Clyne M, KhouryMJ, Gwinn M. Phenopedia and Genopedia: Disease-centered and gene-centered views of the evolving knowledge of human genetic associations. Bioinformatics. 2010;26(1):145-6.
18. Yu W, Clyne M, Dolan SM, Yesupriya A, Wulf A, Liu T, et al. GAPscreener: An automatic tool for screening human genetic association literature in PubMed using the support vector machine technique. BMC Bioinformatics. 2008;9:205.
19. Quinn TJ, Smith C, Murray L, Stewart J, Nicoll JA, Graham DI. There is no evidence of an association in children and teenagers between the apolipoprotein E epsilon4 allele and post-traumatic brain swelling. Neuropathol Appl Neurobiol. 2004;30(6):569-75.
20. Moran LM, Taylor HG, Ganesalingam K, Gastier-Foster JM, Frick J, Bangert B, et al. Apolipoprotein E4 as a predictor of outcomes in pediatric mild traumatic brain injury. Journal of neurotrauma. 2009;26(9):1489-95.
21. Lo TY, Jones PA, Chambers IR, Beattie TF, Forsyth R,Mendelow AD, et al.Modulating effect of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma. Child's nervous system : ChNS : Official journal of the International Society for Pediatric Neurosurgery. 2009;25(1):47-54.
22. Brichtova E, Kozak L. Apolipoprotein E genotype and traumatic brain injury in children-association with neurological outcome. Child's nervous system : ChNS : Official journal of the International Society for Pediatric Neurosurgery. 2008;24(3):349-56.
23. Teasdale GM, Murray GD, Nicoll JAR. The association between APOE epsilon 4, age and outcome after head injury: A prospective cohort study. Brain : A journal of neurology. 2005;128:2556-61.
24. Pruthi N, Chandramouli BA, Kuttappa TB, Rao SL, Subbakrishna DK, Abraham MP, et al. Apolipoprotein E polymorphism and outcome after mild to moderate traumatic brain injury: A study of patient population in India. Neurol India. 2010;58(2):264-9.
25. Shadli RM, Pieter MS, Yaacob MJ, Rashid FA. APOE genotype and neuropsychological outcome in mild-tomoderate traumatic brain injury: A pilot study. Brain Inj. 2011;25(6):596-603.
26. Chamelian L, Reis M, Feinstein A. Six-month recovery from mild to moderate Traumatic Brain Injury: The role of APOEepsilon4 allele. Brain : A journal of neurology. 2004;127(Pt 12):2621-8.
27. Liberman JN, StewartWF,WesnesK, Troncoso J.Apolipoprotein E epsilon 4 and short-term recovery from predominantly mild brain injury. Neurology. 2002;58(7):1038-44.
28. Sundstrom A, Nilsson LG, CrutsM,AdolfssonR,Van Broeckhoven C, Nyberg L. Fatigue before and after mild traumatic brain injury: Pre-post-injury comparisons in relation to Apolipoprotein E. Brain Inj. 2007;21(10):1049-54.
29. Sundstrom A, Nilsson LG, CrutsM,AdolfssonR,Van Broeckhoven C, Nyberg L. Increased risk of dementia following mild head injury for carriers but not for non-carriers of the APOE epsilon4 allele. Int Psychogeriatr. 2007;19(1):159-65.
30. Kristman VL, Tator CH, Kreiger N, Richards D, Mainwaring L, Jaglal S, et al. Does the apolipoprotein epsilon 4 allele predispose varsity athletes to concussion? A prospective cohort study. Clinical journal of sport medicine : Official journal of the Canadian Academy of Sport Medicine. 2008;18(4):322-8.
31. Terrell TR, Bostick RM, Abramson R, Xie D, Barfield W, Cantu R, et al. APOE, APOE promoter, and Tau genotypes and risk for concussion in college athletes. Clinical journal of sport medicine : Official journal of the Canadian Academy of Sport Medicine. 2008;18(1):10-7.
32. Tierney RT, Mansell JL, Higgins M, McDevitt JK, Toone N, Gaughan JP, et al. Apolipoprotein E genotype and concussion in college athletes. Clinical journal of sport medicine : Official journal of the Canadian Academy of Sport Medicine. 2010;20(6):464-8.
33. Harding DR, Dhamrait S, Whitelaw A, Humphries SE, Marlow N, Montgomery HE. Does interleukin-6 genotype influence cerebral injury or developmental progress after preterm birth? Pediatrics. 2004;114(4):941-7.
34. Henskens LH, Kroon AA, van Boxtel MP, Hofman PA, de Leeuw PW. Associations of the angiotensin II type 1 receptor A1166C and the endothelial NO synthase G894T gene polymorphisms with silent subcortical white matter lesions in essential hypertension. Stroke. 2005;36(9):1869-73.
35. Lawford BR, Mc DYR, Noble EP, Kann B, Arnold L, Rowell J, et al. D2 dopamine receptor gene polymorphism: Paroxetine and social functioning in posttraumatic stress disorder. Eur Neuropsychopharmacol. 2003;13(5):313-20.
36. Qureischie H, Heun R, Popp J, Jessen F, Maier W, Schmitz S, et al. Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions. Journal of neural transmission (Vienna, Austria : 1996). 2009;116(4):467-72.
37. Rao R, Rosati A, Liberini P, Gipponi S, Venturelli E, Sapia E, et al. Cerebrovascular risk factors and MRI abnormalities in migraine. Neurol Sci. 2008;29 Suppl 1:S144-5.
38. Tang J, Zhao J, Zhao Y, Wang S, Chen B, Zeng W. Apolipoprotein E epsilon4 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage. Surg Neurol. 2003;60(5):391-6; discussion 6-7.
39. McDonagh DL, Mathew JP, White WD, Phillips-Bute B, Laskowitz DT, Podgoreanu MV, et al. Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology. 2010;112(4):852- 9.
40. Krueger F, Pardini M, Huey ED, Raymont V, Solomon J, Lipsky RH, et al. The role of the Met66 brain-derived neurotrophic factor allele in the recovery of executive functioning after combat-related traumatic brain injury. J Neurosci. 2011;31(2):598-606.
41. Alexander S, KerrME, Kim Y, Kamboh MI, Beers SR, Conley YP.Apolipoprotein E4 allele presence and functional outcome after severe traumatic brain injury. Journal of neurotrauma. 2007;24(5):790-7.
42. Anderson GD, Temkin NR, Dikmen SS, Diaz-Arrastia R, Machamer JE, Farhrenbruch C, et al. Haptoglobin phenotype and apolipoprotein E polymorphism: Relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury. Epilepsy Behav. 2009;16(3):501-6.
43. Ariza M, Pueyo R, Matarin Mdel M, Junque C, Mataro M, Clemente I, et al. Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury. Journal of neurology, neurosurgery, and psychiatry. 2006;77(10):1191-3.
44. Ashman TA, Cantor JB, Gordon WA, Sacks A, Spielman L, Egan M, et al. A comparison of cognitive functioning in older adults with and without traumatic brain injury. J Head Trauma Rehabil. 2008;23(3):139-48.
45. Chiang MF, Chang JG, Hu CJ. Association between apolipoprotein E genotype and outcome of traumatic brain injury. Acta Neurochir (Wien). 2003;145(8):649-53; discussion 53-4.
46. Diaz-Arrastia R, GongY, Fair S, Scott KD, GarciaMC, Carlile MC, et al. Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Arch Neurol. 2003;60(6):818-22.
47. Han SD, Drake AI, Cessante LM, Jak AJ, Houston WS, Delis DC, et al. Apolipoprotein E and traumatic brain injury in a military population: Evidence of a neuropsychological compensatory mechanism? Journal of neurology, neurosurgery, and psychiatry. 2007;78(10):1103-8.
48. Han SD, Suzuki H, Drake AI, Jak AJ, Houston WS, Bondi MW. Clinical, cognitive, and genetic predictors of change in job status following traumatic brain injury in a military population. J Head Trauma Rehabil. 2009;24(1):57-64.
49. Hiekkanen H, Kurki T, Brandstack N, Kairisto V, Tenovuo O. MRI changes and ApoE genotype, a prospective 1-year follow-up of traumatic brain injury: A pilot study. Brain Inj. 2007;21(12):1307-14.
50. Hiekkanen H, Kurki T, Brandstack N, Kairisto V, Tenovuo O. Association of injury severity, MRI-results and ApoE genotype with 1-year outcome in mainly mild TBI: A preliminary study. Brain Inj. 2009;23(5):396-402.
51. Isoniemi H, Tenovuo O, Portin R, Himanen L, Kairisto V. Outcome of traumatic brain injury after three decades- relationship to ApoE genotype. Journal of neurotrauma. 2006;23(11):1600-8.
52. Jellinger KA, Paulus W, Wrocklage C, Litvan I. Traumatic brain injury as a risk factor forAlzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype. BMC Neurol. 2001;1:3.
53. Jellinger KA, Paulus W, Wrocklage C, Litvan I. Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease. Eur J Neurol. 2001;8(6):707- 10.
54. Jiang Y, Sun X, Gui L,Xia Y, TangW, Cao Y, et al. Correlation between APOE -491AA promoter in epsilon4 carriers and clinical deterioration in early stage of traumatic brain injury. Journal of neurotrauma. 2007;24(12):1802-10.
55. Jiang Y, Sun X, Xia Y, Tang W, Cao Y, Gu Y. Effect of APOE polymorphisms on early responses to traumatic brain injury. Neurosci Lett. 2006;408(2):155-8.
56. Jiang Y SX, Gui L, Tang WY, Zhen LP, Gu YJ, Wu HT. Lack of association between apolipoprotein E promoters in epsilon4 carriers and worsening on computed tomography in early stage of traumatic brain injury. Acta Neurochir Suppl. 2008;105:233-6.
57. Kerr ME, Ilyas Kamboh M, Yookyung K, Kraus MF, Puccio AM, DeKosky ST, et al. Relationship between apoE4 allele and excitatory amino acid levels after traumatic brain injury. Crit Care Med. 2003;31(9):2371-9.
58. Koponen S, Taiminen T, Kairisto V, Portin R, Isoniemi H, Hinkka S, et al. APOE-epsilon4 predicts dementia but not other psychiatric disorders after traumatic brain injury. Neurology. 2004;63(4):749-50.
59. Lendon CL, Harris JM, Pritchard AL, Nicoll JA, Teasdale GM, Murray G. Genetic variation of the APOE promoter and outcome after head injury. Neurology. 2003;61(5):683-5.
60. Luukinen H, Jokelainen J, Kervinen K, Kesaniemi YA, Winqvist S, Hillbom M. Risk of dementia associated with theApoE epsilon4 allele and falls causing head injury without explicit traumatic brain injury. Acta Neurol Scand. 2008;118(3):153-8.
61. Mauri M SE, Bono G, Cittadella R, Quattrone A, Boller F, Nappi G. Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairement. Funct Neurol. 2006;21(4):223- 8.
62. Miller MA, Conley Y, Scanlon JM, Ren D, Ilyas Kamboh M, Niyonkuru C, et al. APOE genetic associations with seizure development after severe traumatic brain injury. Brain Inj. 2010;24(12):1468-77.
63. Nathoo N, Chetry R, van Dellen JR, Connolly C, Naidoo R. Apolipoprotein E polymorphism and outcome after closed traumatic brain injury: Influence of ethnic and regional differences. J Neurosurg. 2003;98(2):302-6.
64. Noe E, Ferri J, Colomer C, Moliner B, Chirivella J. APOE genotype and verbal memory recovery during and after emergence from post-traumatic amnesia. Brain Inj. 2010;24(6):886-92.
65. Ost M, Nylen K, Csajbok L, Blennow K, Rosengren L, Nellgard B. ApolipoproteinE polymorphismand gender difference in outcome after severe traumatic brain injury. Acta Anaesthesiol Scand. 2008;52(10):1364-9.
66. Ponsford J, Rudzki D, Bailey K, NgKT. Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury. Neurology. 2007;68(8):619-20.
67. Rapoport M, Wolf U, Herrmann N, Kiss A, Shammi P, Reis M, et al. Traumatic brain injury, Apolipoprotein E-epsilon4, and cognition in older adults: A two-year longitudinal study. J Neuropsychiatry Clin Neurosci. 2008;20(1):68-73.
68. Smith C, Graham DI, Murray LS, Stewart J, Nicoll JA. Association of APOE e4 and cerebrovascular pathology in traumatic brain injury. Journal of neurology, neurosurgery, and psychiatry. 2006;77(3):363-6.
69. Tanriverdi F, Taheri S, Ulutabanca H, Caglayan AO, Ozkul Y, DundarM, et al. Apolipoprotein E3/E3 genotype decreases the risk of pituitary dysfunction after traumatic brain injury due to various causes: Preliminary data. Journal of neurotrauma. 2008;25(9):1071-7.
70. Olivecrona M, Wildemyr Z, Koskinen LO. The apolipoprotein E epsilon4 allele and outcome in severe traumatic brain injury treated by an intracranial pressure-targeted therapy. J Neurosurg. 2010;112(5):1113-9.
71. Willemse-van Son AH, Ribbers GM, Hop WC, van Duijn CM, Stam HJ. Association between apolipoprotein-epsilon4 and long-term outcome after traumatic brain injury. Journal of neurology, neurosurgery, and psychiatry. 2008;79(4):426-30.
72. Krupa M, Moskala M, Goscinski I, Traczewski W, Polak J, Sado M. [Association of apoE polymorphism and treatment outcome in patients with traumatic brain injury]. Neurol Neurochir Pol. 2003;37(6):1223-9.
73. Ariza M, Matarin MD, Junque C, Mataro M, Clemente I, Moral P, et al. Influence of Angiotensin-converting enzyme polymorphism on neuropsychological subacute performance in moderate and severe traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2006;18(1):39-44.
74. Chan F, Lanctot KL, Feinstein A, Herrmann N, Strauss J, Sicard T, et al. The serotonin transporter polymorphisms and major depression following traumatic brain injury. Brain Inj. 2008;22(6):471-9.
75. Chuang PY, Conley YP, Poloyac SM, Okonkwo DO, Ren D, Sherwood PR, et al. Neuroglobin genetic polymorphisms and their relationship to functional outcomes after traumatic brain injury. Journal of neurotrauma. 2010;27(6):999-1006.
76. Johnson VE, Murray L, Raghupathi R, Stewart J, Nicoll JA, MacKinnon MA, et al. No evidence for the presence of apolipoprotein epsilon4, interleukin-lalpha allele 2 and interleukin-1beta allele 2 cause an increase in programmed cell death following traumatic brain injury in humans. Clin Neuropathol. 2006;25(6):255-64.
77. Johnson VE, Stewart W, Graham DI, Stewart JE, Praestgaard AH, Smith DH. A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury. Journal of neurotrauma. 2009;26(8):1197-202.
78. Lanctot KL, Rapoport MJ, Chan F, Rajaram RD, Strauss J, Sicard T, et al. Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury. Brain Inj. 2010;24(7-8):959-69.
79. Romeiro RR, Romano-Silva MA, De Marco L, Teixeira AL, Jr., Correa H. Can variation in aquaporin 4 gene be associated with different outcomes in traumatic brain edema? Neurosci Lett. 2007;426(2):133-4.
80. Sarnaik AA, Conley YP, Okonkwo DO, Barr TL, Fink EL, Szabo C, et al. Influence of PARP-1 polymorphisms in patients after traumatic brain injury. Journal of neurotrauma. 2010;27(3):465-71.
81. Tanriverdi T, Uzan M, Sanus GZ, Baykara O, Is M, Ozkara C, et al. Lack of association between the IL1A gene (-889) polymorphism and outcome after head injury. Surg Neurol. 2006;65(1):7-10; discussion
82. Wagner AK, Miller MA, Scanlon J, Ren D, Kochanek PM, Conley YP. Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI. Epilepsy Res. 2010;90(3):259-72.
83. Wagner AK, Ren D, Conley YP,Ma X, Kerr ME, Zafonte RD, et al. Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury. J Neurosurg. 2007;106(4):538-47.
84. Dalla Libera AL, Regner A, de Paoli J, Centenaro L, Martins TT, Simon D. IL-6 polymorphism associated with fatal outcome in patients with severe traumatic brain injury. Brain Inj. 2011;25(4):365-9.
85. Kurowski B, Martin L, Yeates K, Taylor H, Wade S. Influence of Catecholamine-Related Polymorphisms on Executive Functioning 12 months after Early Childhood TBI. Am J Phys Med and Rehab. 2012;91(3):285-86.
86. Duhaime AC, Gean AD, Haacke EM, Hicks R, Wintermark M, Mukherjee P, et al. Common data elements in radiologic imaging of traumatic brain injury. Arch Phys Med Rehabil. 2010;91(11):1661-6.
87. Haacke EM, Duhaime AC, Gean AD, Riedy G, Wintermark M, Mukherjee P, et al. Common data elements in radiologic imaging of traumatic brain injury. J Magn Reson Imaging. 2010;32(3):516-43.
88. Maas AI, Harrison-Felix CL, Menon D, Adelson PD, Balkin T, Bullock R, et al. Common data elements for traumatic brain injury: Recommendations from the interagency working group on demographics and clinical assessment. Arch Phys Med Rehabil. 2010;91(11):1641-9.
89. Manley GT, Diaz-Arrastia R, Brophy M, Engel D, Goodman C, Gwinn K, et al. Common data elements for traumatic brain injury: Recommendations from the biospecimens and biomarkers working group. Arch Phys Med Rehabil. 2010;91(11):1667-72.
90. Whyte J, Vasterling J,Manley GT. Common data elements for research on traumatic brain injury and psychological health: Current status and future development. Arch Phys Med Rehabil. 2010;91(11):1692-6.
91. Wilde EA, Whiteneck GG, Bogner J, Bushnik T, Cifu DX, Dikmen S, et al. Recommendations for the use of common outcome measures in traumatic brain injury research. Arch Phys Med Rehabil. 2010;91(11):1650-60 e17.
92. McCauley SR, Wilde EA, Anderson VA, Bedell G, Beers SR, Campbell TF, et al. Recommendations for the use of common outcome measures in pediatric traumatic brain injury research. Journal of neurotrauma. 2012;29(4):678-705.
93. Stover PJ, HarlanWR, Hammond JA, Hendershot T, Hamilton CM. PhenX: A toolkit for interdisciplinary genetics research. Curr Opin Lipidol. 2010;21(2):136-40.
94. Plomin R, Davis OS. The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA. Journal of child psychology and psychiatry, and allied disciplines. 2009;50(1-2):63-71.
95. Kohane IS. Using electronic health records to drive discovery in disease genomics. Nature reviews Genetics. 2011;12(6):417-28.