Risk of dementia associated with the ApoE ε4 allele and falls causing head injury without explicit traumatic brain injury

Acta Neurologica Scandinavica

Volumn 118, Issue 3, 2008, Pages 153-158

  Luukinen, H ^a   Jokelainen, J ^a   Kervinen, K ^a   Kesaniemi Y A ^a   Winqvist, S ^b   Hillbom, M ^b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Ageing; ApoE 4; Dementia; Fall accident; Head injury

Indexed keywords

APOLIPOPROTEIN E;

AGED; ALLELE; ARTICLE; CONFIDENCE INTERVAL; DEMENTIA; DEPENDENT VARIABLE; DISEASE ASSOCIATION; EDUCATIONAL STATUS; FALLING; FEMALE; FOLLOW UP; HAZARD RATIO; HEAD INJURY; HUMAN; LACERATION; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; RISK FACTOR; SKIN BRUISING; SUTURING METHOD; TRAUMATIC BRAIN INJURY; WOUND;

ACCIDENTAL FALLS; AGE OF ONSET; AGED; ALLELES; APOLIPOPROTEIN E4; BRAIN INJURIES; CRANIOCEREBRAL TRAUMA; DEMENTIA; FEMALE; HUMANS; MALE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 49649122043     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2008.00994.x     Document Type: Article

References (31)

1. Luukinen H, Viramo P, Koski K, Laippala P, Kivelä S-L. Head injuries and cognitive decline among older adults. A population-based study. Neurology 1999 52 : 557 62.
2. Luukinen H, Viramo P, Herala M et al. Fall-related brain injuries and the risk of dementia in elderly people: a population-based study. Eur J Neurol 2005 12 : 86 92.
3. Poirer J. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease. Trends Neurosci 1994 17 : 525 30.
4. Holtzmann DM, Pitas RE, Kilbridge J et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Proc Nat Acad Sci USA 1995 92 : 9480 4.
5. Jordan B, Relkin NR, Ravdin L, Jacobs AR, Bennett A, Gandy S. Apolipoprotein E epsilon 4 associated with chronic traumatic brain injury in boxing. JAMA 1997 278 : 136 40.
6. Kutner KC, Erlanger DM, Tsai J, Jordan B, Relkin NR. Lower cognitive performance of football players possessing apolipoprotein E ε4. Neurosurgery 2000 47 : 651 8.
7. Luukinen H, Koski K, Hiltunen L, Kivelä S-L. Incidence rate of falls in an aged population in northern Finland. J Clin Epidemiol 1994 47 : 843 50.
8. Folstein MF, Folstein SE, Mchugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975 12 : 189 98.
9. Ehnholm C, Lukka M, Kuusi T, Nikkilä E, Utermann G. Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations. J Lipid Res 1986 27 : 227 35.
10. American Psychiatric Association. Diagnostic and statistical manual of mental disorders (DSM-IV). Washington DC : American Psychiatric Association, 1994.
11. Morris JC, Heyman A, Mohs RC et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part 1. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989 39 : 1159 65.
12. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984 141 : 1356 64.
13. Luukinen H, Koski K, Honkanen R, Kivelä S-L. Incidence of injury-causing falls among older adults by place of residence: a population-based study. J Am Geriatr Soc 1995 43 : 871 6.
14. Luukinen H, Koski K, Honkanen R, Kivelä S-L. Rapid increase of severe head injuries due to indoor falls with age among the elderly - a population-based study. J Am Geriatr Soc 1999 47 : 1451 2.
15. Vos PE, Battistin L, Birbamer G et al. EFNS guidelines on mild traumatic brain injury: report of an EFNS task force. Eur J Neurol 2002 9 : 207 19.
16. De Kruijk JR, Twinstra A, Leffers P. Diagnostic criteria and differential diagnosis of mild traumatic brain injury. Brain Inj 2001 15 : 99 106.
17. Van Doom C, Gruber-Baldini AL, Zimmerman S et al. Dementia is a risk factor for falls and fall injuries among nursing home residents. J Am Geriatr Soc 2003 51 : 1213 18.
18. Commenges D, Letenneur L, Joly P, Alioum A, Dartigues JR. Modelling age specific risk: application to dementia. Stat Med 1998 17 : 1973 88.
19. Fleminger S, Oliver DL, Lovestone S, Rabe-Hesketh S, Giora A. Head injury as a risk factor for Alzheimer's disease: the evidence 10 years on; a partial replication. J Neurol Neurosurg Psychiatry 2003 74 : 857 62.
20. Launer LJ, Andersen K, Dewey ME et al. Rates and risk factors for dementia and Alzheimer's disease. Results from EURODEM pooled analyses. Neurology 1999 52 : 78 84.
21. Schofield PW, Tang M, Marder K et al. Alzheimer's disease after remote head injury: an incidence study. J Neurol Neurosurg Psychiatry 1997 62 : 119 24.
22. Nemetz PN, Leibson C, Naessens JM et al. Traumatic brain injury and time of onset of Alzheimer's disease: a population based study. Am J Epidemiol 1999 149 : 32 40.
23. Plassman BL, Havlik RJ, Steffens DC et al. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias. Neurology 2000 55 : 1158 66.
24. Mazzucchi A, Cattelani R, Missale G, Gugliotta M, Brianti R, Parma M. Head-injured subjects aged over 50 years: correlations between variables of trauma and neuropsychological follow-up. J Neurol 1992 239 : 256 60.
25. Katzman R, Galasko DR, Saitoh T et al. Apolipoprotein-ε4 and head trauma: synergistic or additive risks? Neurology 1996 46 : 889 91.
26. Mayeux R, Ottman R, Maestre G et al. Synergistic effect of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease. Neurology 1995 45 : 555 7.
27. Nicoll JAR, Roberts GW, Graham DI. Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury. Nat Med 1995 1 : 135 7.
28. Jennet B. Epidemiology of head injury. J Neurol Neurosurg Psychiatry 1996 60 : 362 9.
29. Aevarsson O, Skoog I. Dementia disorders in a birth cohort followed from age 85 to 88: the influence of mortality, refusal rate, and diagnostic change on prevalence. Int Psychogeriatr 1997 9 : 11 23.
30. Juva K, Verkkoniemi A, Viramo P et al. Apolipoprotein E, cognitive function, and dementia in a general population aged 85 and over. Int Psychogeriatr 2000 12 : 379 87.
31. Skoog I, Nilsson L, Palmertz B, Andreasson LA, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med 1993 328 : 153 8.