Diagnostic accuracy of PCR alone compared to galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis: A systematic review

Journal of Clinical Microbiology

Volumn 50, Issue 11, 2012, Pages 3652-3658

  Avni, Tomer ^a   Levy, Itzhak ^b,c   Sprecher, Hannah ^d,e   Yahav, Dafna ^a   Leibovici, Leonard ^a,c   Paul, Mical ^a,c  

^a RABIN MEDICAL CENTER   (Israel)

^b Schneider Medical Center   (Israel)

^c TEL AVIV UNIVERSITY   (Israel)

^d Microbiology Laboratory   (Israel)

^e TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; GALACTOMANNAN;

BRONCHOSCOPY; CASE CONTROL STUDY; COHORT ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; HUMAN; INTERMETHOD COMPARISON; LUNG ASPERGILLOSIS; LUNG LAVAGE; OPTICAL DENSITY; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; REVIEW; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW;

BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CLINICAL LABORATORY TECHNIQUES; HUMANS; IMMUNOASSAY; INVASIVE PULMONARY ASPERGILLOSIS; MANNANS; MYCOLOGY; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY;

EID: 84867533256     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00942-12     Document Type: Review

References (46)

1. Altman DG, Bland JM. 1994. Diagnostic tests 2: predictive values. BMJ 309:102. (Pubitemid 24216428)
2. Ascioglu M, De Pauw B, Bennett JE. 1999. Analysis of definitions used in clinical research on invasive fungal infections (IFI): consensus proposal for new, standardized definitions, abstr 1639. 39th Intersci. Conf. Antimicrob. Agents Chemother., San Francisco, CA.
3. Ascioglu S, et al. 2002. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin. Infect. Dis. 34:7-14. (Pubitemid 33152659)
4. Bodey G, et al. 1992. Fungal infections in cancer patients: an international autopsy survey. Eur. J. Clin. Microbiol. Infect. Dis. 11:99-109.
5. Bretagne S, Costa JM. 2005. Towards a molecular diagnosis of invasive aspergillosis and disseminated candidosis. FEMS Immunol. Med. Microbiol. 45:361-368. (Pubitemid 41247773)
6. Bretagne S, et al. 1995. Detection of Aspergillus species DNA in bronchoalveolar lavage samples by competitive PCR. J. Clin. Microbiol. 33:1164-1168.
7. Buchheidt D, et al. 2001. Detection of Aspergillus species in blood and bronchoalveolar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results. Clin. Infect. Dis. 33:428-435. (Pubitemid 32709572)
8. Bustin SA, et al. 2009. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55:611-622.
9. Caillot D, et al. 1997. Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J. Clin. Oncol. 15:139-147. (Pubitemid 27020567)
10. The Cochrane Collaboration. 2011. Review Manager (RevMan) version 5.1. The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark.
11. De Pauw B, et al. 2008. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin. Infect. Dis. 46:1813-1821.
12. Diagnostic Test Accuracy Working Group. Handbook for DTA Reviews. The Cochrane Collaboration. http://srdta.cochrane.org/handbook-dta-reviews. Accessed 5 September 2012.
13. Einsele H, et al. 1998. Prediction of invasive pulmonary aspergillosis from colonisation of lower respiratory tract before marrow transplantation. Lancet 352:1443. (Pubitemid 28510884)
14. EORTC International Antimicrobial Therapy Cooperative Group. 1989. Empiric antifungal therapy in febrile granulocytopenic patients. Am. J. Med. 86:668-672.
15. Frealle E, et al. 2009. Diagnosis of invasive aspergillosis using bronchoalveolar lavage in haematology patients: influence of bronchoalveolar lavage human DNA content on real-time PCR performance. Eur. J. Clin. Microbiol. Infect. Dis. 28:223-232.
16. Girmenia C, et al. 27 September 2011, posting date. New category of probable invasive pulmonary aspergillosis in haematological patients. Clin. Microbiol. Infect. doi:10.1111/j.1469-0691.2011.03685.x.
17. Groll AH, et al. 1996. Trends in the postmortem epidemiology of invasive fungal infections at a university hospital. J. Infect. 33:23-32. (Pubitemid 26289847)
18. Guo YL, et al. 2010. Accuracy of BAL galactomannan in diagnosing invasive aspergillosis: a bivariate metaanalysis and systematic review. Chest 138:817-824.
19. Hadrich I, et al. 2011. Comparison of PCR-ELISA and real-time PCR for invasive aspergillosis diagnosis in patients with hematological malignancies. Med. Mycol. 49:489-494.
20. Hayette MP, et al. 2001. Detection of Aspergillus species DNA by PCR in bronchoalveolar lavage fluid. J. Clin. Microbiol. 39:2338-2340.
21. Jones ME, et al. 1998. PCR-ELISA for the early diagnosis of invasive pulmonary aspergillus infection in neutropenic patients. J. Clin. Pathol. 51:652-656. (Pubitemid 28423722)
22. Khot PD, Ko DL, Hackman RC, Fredricks DN. 2008. Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. BMC Infect. Dis. 8:73.
23. Leeflang MM, et al. 2008. Galactomannan detection for invasive aspergillosis in immunocompromized patients. Cochrane Database Syst. Rev. 2008:CD007394. doi:10.1002/14651858.CD007394.
24. Luong ML, et al. 2011. Comparison of an Aspergillus real-time polymerase chain reaction assay with galactomannan testing of bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in lung transplant recipients. Clin. Infect. Dis. 52:1218-1226.
25. Melchers WJ, et al. 1994. General primer-mediated PCR for detection of Aspergillus species. J. Clin. Microbiol. 32:1710-1717. (Pubitemid 24189561)
26. Mengoli C, Cruciani M, Barnes RA, Loeffler J, Donnelly JP. 2009. Use of PCR for diagnosis of invasive aspergillosis: systematic review and metaanalysis. Lancet Infect. Dis. 9:89-96.
27. Musher B, et al. 2004. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J. Clin. Microbiol. 42:5517-5522. (Pubitemid 39664330)
28. Orsi CF, et al. 2012. Performance of 2 commercial real-time polymerase chain reaction assays for the detection of Aspergillus and pneumocystis DNA in bronchoalveolar lavage fluid samples from critical care patients. Diagn. Microbiol. Infect. Dis. 73:138-143.
29. Raad I, et al. 2002. Diagnosis of invasive pulmonary aspergillosis using polymerase chain reaction-based detection of aspergillus in BAL. Chest 121:1171-1176. (Pubitemid 34280439)
30. Rantakokko-Jalava K, et al. 2003. Semiquantitative detection by realtime PCR of Aspergillus fumigatus in bronchoalveolar lavage fluids and tissue biopsy specimens from patients with invasive aspergillosis. J. Clin. Microbiol. 41:4304-4311. (Pubitemid 37099700)
31. Reinwald M, et al. 2012. Therapy with antifungals decreases the diagnostic performance of PCR for diagnosing invasive aspergillosis in bronchoalveolar lavage samples of patients with haematological malignancies. J. Antimicrob. Chemother. 67:2260-2267.
32. Roselló E, et al. 2011. Evaluation of MycAssay Aspergillus molecular diagnostic test and automated EZ1 DNA extraction for detecting Aspergillus spp. DNA in bronchoalveolar samples of patients with risk factors for pulmonary invasive aspergillosis, abstr P1942. 21st Eur. Congress Clin. Microbiol. Infect. Dis., Milano, Italy. http://www.poster-submission.com/search/ select/26.
33. Sanguinetti M, et al. 2003. Comparison of real-time PCR, conventional PCR, and galactomannan antigen detection by enzyme-linked immunosorbent assay using bronchoalveolar lavage fluid samples from hematology patients for diagnosis of invasive pulmonary aspergillosis. J. Clin. Microbiol. 41:3922-3925. (Pubitemid 36994742)
34. Shahid M, Malik A, Bhargava R. 2008. Bronchogenic carcinoma and secondary aspergillosis - common yet unexplored: evaluation of the role of bronchoalveolar lavage-polymerase chain reaction and some nonvalidated serologic methods to establish early diagnosis. Cancer 113:547-558.
35. Skladny H, et al. 1999. Specific detection of Aspergillus species in blood and bronchoalveolar lavage samples of immunocompromised patients by two-step PCR. J. Clin. Microbiol. 37:3865-3871.
36. Spiess B, et al. 2003. Development of a LightCycler PCR assay for detection and quantification of Aspergillus fumigatus DNA in clinical samples from neutropenic patients. J. Clin. Microbiol. 41:1811-1818. (Pubitemid 36576496)
37. Spreadbury C, Holden D, Aufauvre-Brown A, Bainbridge B, Cohen J. 1993. Detection of Aspergillus fumigatus by polymerase chain reaction. J. Clin. Microbiol. 31:615-621. (Pubitemid 23059877)
38. Sun W, et al. 2011. Evaluation of PCR on bronchoalveolar lavage fluid for diagnosis of invasive aspergillosis: a bivariate metaanalysis and systematic review. PLoS One 6:e28467. doi:10.1371/journal.pone.0028467.
39. Tang CM, Holden DW, Aufauvre-Brown A, Cohen J. 1993. The detection of Aspergillus spp. by the polymerase chain reaction and its evaluation in bronchoalveolar lavage fluid. Am. Rev. Respir. Dis. 148:1313-1317.
40. Tarrand JJ, et al. 2003. Diagnosis of invasive septate mold infections. A correlation of microbiological culture and histologic or cytologic examination. Am. J. Clin. Pathol. 119:854-858. (Pubitemid 37047847)
41. Torelli R, et al. 2011. Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay. J. Clin. Microbiol. 49:4273-4278.
42. Tuon FF. 2007. A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples. Rev. Iberoam. Micol. 24:89-94. (Pubitemid 47025141)
43. Verweij PE, et al. 1995. Comparison of antigen detection and PCR assay using bronchoalveolar lavage fluid for diagnosing invasive pulmonary aspergillosis in patients receiving treatment for hematological malignancies. J. Clin. Microbiol. 33:3150-3153.
44. von Eiff M, et al. 1995. Pulmonary aspergillosis: early diagnosis improves survival. Respiration 62:341-347.
45. White PL, et al. 2010. Aspergillus PCR: one step closer to standardization. J. Clin. Microbiol. 48:1231-1240.
46. Whiting PF, et al. 2011. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann. Intern. Med. 155:529-536.