The adult asthmatic

Clinical Reviews in Allergy and Immunology

Volumn 43, Issue 1-2, 2012, Pages 138-155

  Zeki, Amir A ^a   Kenyon, Nicholas J ^a   Yoneda, Ken ^a   Louie, Samuel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adult onset asthma; Asthma cluster(s); Controller medication; COPD; Drug safety; Guidelines; Heterogenous; Investigational therapies; Late onset asthma; New paradigm; Novel treatments; Patient compliance; Phenotype; Severe asthma; Statin; Step down therapy; Step up therapy; Subphenotype

Indexed keywords

AZITHROMYCIN; BECLOMETASONE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE PLUS FORMOTEROL; CLARITHROMYCIN; CORTICOSTEROID; ESOMEPRAZOLE; FLUTICASONE; HISTONE DEACETYLASE 2; IMMUNOGLOBULIN E; INTERLEUKIN 6; INTERLEUKIN 8; IPRATROPIUM BROMIDE; ITRACONAZOLE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MEPOLIZUMAB; MINOCYCLINE; MONTELUKAST; NITRIC OXIDE; OMALIZUMAB; RANTES; ROFLUMILAST; SALBUTAMOL; SALMETEROL; TIOTROPIUM BROMIDE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; ZAFIRLUKAST; ZILEUTON;

ADAPTIVE IMMUNITY; ADD ON THERAPY; AGING; ANAPHYLAXIS; ANTIINFLAMMATORY ACTIVITY; ANXIETY DISORDER; ARTICLE; ASTHMA; ATOPY; BRONCHIAL THERMOPLASTY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CHRONOBIOLOGY; DEPRESSION; DRUG EFFICACY; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; GASTROESOPHAGEAL REFLUX; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HORMONE SUBSTITUTION; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; LOW DRUG DOSE; LUNG FUNCTION; LUNG FUNCTION TEST; NEOPLASM; NONHUMAN; OBESITY; PATIENT COMPLIANCE; PATIENT SAFETY; POWDER INHALER; PREVALENCE; PRICK TEST; PROMOTER REGION; QUALITY OF LIFE; RADIOFREQUENCY ABLATION; RESIDUAL VOLUME; RISK FACTOR; SEX DIFFERENCE; SLEEP DISORDER; SMOKING; SOCIAL STATUS; STRESS; TH1 CELL; TH2 CELL; TOTAL LUNG CAPACITY; TREATMENT RESPONSE; TREMOR; UNSPECIFIED SIDE EFFECT; URTICARIA; VITAL CAPACITY;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; ANTI-ASTHMATIC AGENTS; ASTHMA; FEMALE; HUMANS; MALE; MIDDLE AGED; YOUNG ADULT;

EID: 84867530805     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-011-8260-4     Document Type: Article

References (78)

1. Anderson G (2008) Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 372:1107-1119
2. Moore WC, Meyer DA, Wenzel SE et al (2010) Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med 181:315-323
3. Martinez FD (2009) The origins of asthma and chronic obstructive pulmonary disease in early life. Proc Am Thorac Soc 6:272-277
4. Martin RJ, Szefler SJ, King TS et al (2007) The predicting response to inhaled corticosteroid efficacy (PRICE) trial. J Allergy Clin Immunol 119:73-80 (Pubitemid 46037824)
5. Braman S (2006) The global burden of asthma. Chest 130:4S-12S (Pubitemid 44107231)
6. Gibson PG, McDonald VM, Marks GB (2010) Asthma in older adults. Lancet 376:803-813
7. Buffels J, Degryse J, Heyrman J et al (2004) Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study. Chest 125:1394-1399 (Pubitemid 38501355)
8. Abramson M, Matheson M, Wharton C et al (2002) Prevalence of respiratory symptoms related to chronic obstructive pulmonary disease and asthma among middle aged and older adults. Respirology 7(4):325-331
9. Soriano JB, Davis KJ, Coleman B et al (2003) The proportional venn diagram of obstructive lung disease: two approximations from the United States and the United Kingdom. Chest 124:474-481 (Pubitemid 37000122)
10. Bochenska-Marciniak M, Kupczyk M, Gorski P et al (2001) Prevalence of atopy and the diagnostic value of skin prick tests in asthmatics over the age of 60. J Allergy Clin Immunol 107(2): A862
11. Mediaty A, Neuber K (2005) Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis. Immunity & Ageing 2:9-14
12. Huss K, Naumann PL, Mason PJ et al (2001) Asthma severity, atopic status, allergen exposure, and quality of life in elderly persons. Ann Allergy, Asthma, & Immun 86(5):524-530 (Pubitemid 32487851)
13. Tattersfield AE, Postma DS, Barnes PJ et al (1999) Exacerbations of asthma: a descriptive study of 425 severe exacerbations. The FACET International Study Group. Am J Respir Crit Care Med 160:594-599 (Pubitemid 29380678)
14. Siroux V, Curt F, Oryszczyn MP et al (2004) Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy. J Allergy Clin Immunol 114:491-498 (Pubitemid 39194918)
15. Barr RG, Wentowski CC, Grodstein F et al (2004) Prospective study of postmenopausal hormone use and newly diagnosed asthma and chronic obstructive pulmonary disease. Arch Intern Med 164:379-386 (Pubitemid 38240701)
16. Gakia E, Papatheodorou G, Ischakia E et al (2007) Leukotriene E4 in urine in patients with asthma and COPD - the effect of smoking habit. Respir Med 101(4):826-832
17. Mastronarde JG, Anthonisen NR, Castro M et al (2009) Efficacy of esomeprazole for treatment of poorly controlled asthma: the American Lung Association Asthma Clinical Research Centers. N Engl J Med 360(15):1487-1499
18. Gunnbjornsdottir MI, Omenaas E, Gislason T et al (2004) Obesity and nocturnal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 24:116-121 (Pubitemid 39036125)
19. Beuther DA, Weiss ST, Sutherland ER (2006) Obesity and asthma. Am J Respir Crit Care Med 174:112-119 (Pubitemid 44015383)
20. Hizawa N, Yamaguchi E, Konno S et al (2002) A functional polymorphism in the RANTES gene promotor is associated with the development of late-onset asthma. Am J Respir Crit Care Med 166:686-690 (Pubitemid 34971851)
21. van Diemen CC, Postma DS, Vonk JM et al (2005) A disintegrin and metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med 172:329-333 (Pubitemid 41026143)
22. Raby BA, Van Steen K, Celedon JC et al (2005) CAMP Research Group. Paternal history of asthma and airway responsiveness in children with asthma. Am J Respir Crit Care Med 172:552-558 (Pubitemid 41232965)
23. Melen E, Bruce S, Doekes G et al (2005) Haplotypes of G protein-coupled receptor 154 are associated with childhood allergy and asthma. Am J Respir Crit Care Med 171:1089-1095 (Pubitemid 40663719)
24. Litonjua AA, Lasky-Su J, Schneiter K et al (2008) ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med 178:688-694
25. Sohn MH, Lee JH, Kim KW (2009) Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy. Am J Respir Crit Care Med 179:449-456
26. Smit LA, Siroux V, Bouzigon E et al (2009) CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 179:363-368
27. Gudbjartsson DF, Bjornsdottir US, Halapi E et al (2009) Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 41:342-347
28. Prefontaine D, Lajoie-Kadoch S, Foley S et al (2009) Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J Immunol 183:5094-5103
29. Israel E, Chinchilliyn V, Ford JG et al (2004) Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomized, placebo-controlled cross-over trial. Lancet 364:1505-1512 (Pubitemid 39410416)
30. Miranda C, Busacker A, Balzar S et al (2004) Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol 113:101-108 (Pubitemid 38096168)
31. Schneider A, Tilemann L, Schermer T et al (2009) Diagnosing asthma in general practice with portable exhaled nitric oxide measurement - results of a prospective diagnostic study. Respir Res 10:15-25
32. Travers J, Marsh S, Aldington S et al (2007) Reference ranges for exhaled nitric oxide derived from a random community survey of adults. Am J Respir Crit Care Med 176:238-242 (Pubitemid 47195873)
33. National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma: Full Report. Bethesda, MD: National Institutes of Health, US Dept of Health and Human Services, National Heart, Lung, and Blood Institute., 2007. Available at: (http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm.).
34. Peters SP, Kunselman SJ, Icitovic N et al (2010) Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med 363:1715-1726
35. Szefler SJ, Martin RJ, King TS et al (2002) Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol 109(3):410-418 (Pubitemid 34234189)
36. Rabe KF, Pizzichini E, Stallberg B et al (2006) Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Chest 129:246-256 (Pubitemid 43289841)
37. Salpeter SR, Ormiston TM, Salpeter EE (2004) Meta-analysis: respiratory tolerance to regular β2-agonist use in patients with asthma. Ann Intern Med 140:802-813
38. Lazarus SC, Boushey HA, Fahy JV et al (2001) Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA 285:2583-2593 (Pubitemid 32479898)
39. Nelson HS, Weiss ST, Bleecker ER, the SMART Study Group et al (2006) The salmeterol multicenter asthma research trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest 129:15-26 (Pubitemid 43265239)
40. Busse W, Corren J, Lanier BQ et al (2001) Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma. J Allergy Clin Immunol 108(2):184-190 (Pubitemid 32735398)
41. Vaquerizo MJ, Casan P, Castillo J et al (2003) Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma. Thorax 58(3):204-210 (Pubitemid 36307997)
42. Bjermer L, Bisgaard H, Bousquet J et al (2003) Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial. BMJ 327(7420):891-896
43. Sims EJ, Jackson CM, Lipworth BJ (2003) Add-on therapy with montelukast or formoterol in patients with the glycine-16 beta2-receptor genotype. Br J Clin Pharmacol 56:104-111 (Pubitemid 36886495)
44. Haldar P, Brightling CE, Hargadon B et al (2009) Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 360:973-984
45. Nair P, Pizzichini MM, Kjarsgaard M, Efthimiadis A, Pizzichini E, Hargreave FE, O'Byrne PM et al (2009) Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 360:985-993
46. Denning DW, O'Driscoll BR, Powell G et al (2009) Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: the Fungal Asthma Sensitization Trial (FAST) Study. Am J Respir Crit Care Med 179:11-18
47. Simpson JL, Powell H, Boyle MJ et al (2008) Clarithromycin targets neutrophilic airway inflammation in refractory asthma. Am J Respir Crit Care Med 177:148-155
48. Sutherland ER, King TS, Icitovic N, for the National Heart, Lung and Blood Institute's Asthma Clinical Research Network et al (2010) A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol 126:747-753
49. Daoud A, Gloria CJ, Taningco G et al (2008) Minocycline treatment results in reduced oral steroid requirements in adult asthma. Allergy Asthma Proc 29(3):286-294
50. Castro M, Rubin A, Laviolette M, AIR2 Trial Study Group et al (2010) Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med 181 (2):116-124
51. Miller JD, Cox G, Vincic L et al (2005) A prospective feasibility study of bronchial thermoplasty in the human airway. Chest 127:1999-2006
52. Cox G, Thomason NC, Rubin AS, AIR Trial Study Group et al (2007) Asthma control during the year after bronchial thermoplasty. N Engl J Med 356(13):1327-1337 (Pubitemid 46513298)
53. Pavord ID, Cox G, Thomson NC, RISA Trial Study Group et al (2007) Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med 176(12):1185-1191 (Pubitemid 350256471)
54. Cox MB, Laviollette M, Rubin A et al (2010) 5-year safety of bronchial thermoplasty demonstrated in patients with moderate to severe asthma: Asthma Intervention Research (AIR) Trial. Am J Respir Crit Care Med 181:A6839
55. Barnes P (2010) New therapies for asthma: is there any progress? Trends Pharmacol Sci 31(7):335-343
56. Sutherland ER, Goleva E, Jackson LP et al (2010) Vitamin D levels, lung function, and steroid response in adult asthma. Am J Respir Crit Care Med 181:699-704
57. Grootendorst DC, Gauw SA, Verhoosel RM et al (2007) Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax 62:1081-1087 (Pubitemid 350206202)
58. Lu S, Liu N, Dass SB et al (2009) Randomized, placebo-controlled study of a selective PDE4 inhibitor in the treatment of asthma. Respir Med 103:342-347
59. Liao JK, Laufs U (2005) Pleiotropic effects of statins. Annu Rev Pharmacol Toxicol 45:89-118 (Pubitemid 40261799)
60. Alexeeff SE, Litonjua AA, Sparrow D et al (2007) Statin use reduces decline in lung function: VA Normative Aging Study. Am J Respir Crit Care Med 176:742-747 (Pubitemid 47598474)
61. Blamoun AI, Batty GN, DeBari VA et al (2008) Statins may reduce episodes of exacerbation and the requirement for intubation in patients with COPD: evidence from a retrospective cohort study. Int J Clin Pract 62(9):1373-1378
62. Soyseth V, Brekke PH, Smith P et al (2007) Statin use is associated with reduced mortality in COPD. Eur Respir J 29(2):279-283 (Pubitemid 46237383)
63. Hothersall EJ, Chaudhuri RS, McSharry C et al (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax 63:1070-1075
64. Menzies D, Nair A, Meldrum KT et al (2007) Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma. J Allergy Clin Immunol 119:328-335 (Pubitemid 46204809)
65. Cowan DC, Cowan JO, Palmay R et al (2010) Simvastatin in the treatment of asthma: lack of steroid-sparing effect. Thorax 65:891-896
66. Maneechotesuwan K, Ekjiratrakui W, Kasetsinsombat K et al (2010) Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2,3-dioxygenase. J Allergy Clin Immunol 126:754-762
67. Drazen JM, Boccuzzi SJ, Wogen J et al (2000) Adherence to prescribed treatment for asthma. Am J Respir Crit Care Med 161: A402
68. Sundberg R, Toren K, Franklin KA et al (2010) Asthma in men and women: treatment adherence, anxiety, and quality of sleep. Respir Med 104:337-344
69. Bateman ED, Hurd SS, Barnes PJ et al (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 31(1):143-178
70. Wenzel SE, Fahy JV, Irvin C et al (2000) Proceedings of the ATS workshop on refractory asthma current understanding, recommendations, and unanswered questions. Am J Respir Crit Care Med 162:2341-2351 (Pubitemid 32051710)
71. Barnes P (2009) Intrinsic asthma: not so different from allergic asthma but driven by superantigens? Clin Exp Allergy 39:1145-1151
72. Wenzel SE, Schwartz LB, Langmack EL et al (1999) Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 160:1001-1008 (Pubitemid 29442043)
73. Simpson JL, Scott R, Boyle MJ et al (2006) Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 11:54-61
74. Woodruff PG, Modrek B, Choy DF et al (2009) T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 180:388-395
75. Melgert BN, Ray A, Hylkema MN et al (2007) Are there reasons why adult asthma is more common in females? Curr Allergy Asthma Rep 7:143-150 (Pubitemid 46736336)
76. Holgate ST, Polosa R (2006) The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 368:780-793 (Pubitemid 44279056)
77. Schleimer RP, Kato A, Kern R et al (2007) Epithelium: at the interface of innate and adaptive immune responses. J Allergy Clin Immunol 120:1279-1284 (Pubitemid 350216601)
78. Sciurba F (2004) Physiologic similarities and differences between COPD and asthma. Chest 126:117S-124S (Pubitemid 39093401)