Infectious titres of sheep scrapie and bovine spongiform encephalopathy agents cannot be accurately predicted from quantitative laboratory test results

Journal of General Virology

Volumn 93, Issue PART 11, 2012, Pages 2518-2527

  González, Lorenzo ^a   Thorne, Leigh ^a   Jeffrey, Martin ^a   Martin, Stuart ^a   Spiropoulos, John ^a   Beck, Katy E ^a   Lockey, Richard W ^a,b   Vickery, Christopher M ^a   Holder, Thomas ^a   Terry, Linda ^a,c  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE ASSOCIATED PRION PROTEIN; PRION PROTEIN; PROTEASE RESISTANT PRION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN TISSUE; CHEMICAL ANALYSIS; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; LABORATORY TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCRAPIE; SHEEP; VIRUS INFECTIVITY; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL ASSAY; BRAIN; CATTLE; ENCEPHALOPATHY, BOVINE SPONGIFORM; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICE; PRIONS; SCRAPIE; SHEEP;

EID: 84867522062     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.045849-0     Document Type: Article

References (36)

1. Screplication, stability and processing in neurons is predictive of the incubation period of disease. PLoS Pathog 7, e1001317.
2. Scaccumulation in the tongue and nasal mucosa of terminally diseased cattle. J Gen Virol 92, 467-476.
3. Barron, R.M. & Manson, J. C. (2003). A gene-targeted mousemodel of P102L Gerstmann-Sträussler-Scheinker syndrome. Clin Lab Med 23, 161-173.
4. Scin vivo. J Biol Chem 282, 35878-35886.
5. Beck, K. E., Sallis, R. E., Lockey, R., Simmons, M. M. & Spiropoulos, J. (2010). Ovine PrP genotype is linked with lesion profile and immunohistochemistry patterns after primary transmission of classical scrapie to wild-type mice. J Neuropathol Exp Neurol 69, 483-497.
6. Bruce, M. E., Boyle, A., Cousens, S., McConnell, I., Foster, J., Goldmann, W. & Fraser, H. (2002). Strain characterization of natural sheep scrapie and comparison with BSE. J Gen Virol 83, 695-704.
7. Caughey, B., Raymond, G. J., Kocisko, D. A. & Lansbury, P. T., Jr (1997). Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies. J Virol 71, 4107-4110.
8. EFSA Panel on Biological Hazards (2009). Scientific opinion on analytical sensitivity of approved TSE rapid tests. EFSA Journal 7, 1436.
9. Gambetti, P., Dong, Z., Yuan, J., Xiao, X., Zheng, M., Alshekhlee, A., Castellani, R., Cohen, M., Barria, M. A. & other authors (2008). A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol 63, 697-708.
10. González, L., Martin, S., Begara-McGorum, I., Hunter, N., Houston, F., Simmons, M. & Jeffrey, M. (2002). Effects of agent strain and host genotype on PrP accumulation in the brain of sheep naturally and experimentally affected with scrapie. J Comp Pathol 126, 17-29.
11. dimmunoreactivity in the brain of scrapie-and BSE-infected sheep: implications for differential cell targeting and PrP processing. J Gen Virol 84, 1339-1350.
12. González, L., Martin, S., Houston, F. E., Hunter, N., Reid, H. W., Bellworthy, S. J. & Jeffrey, M. (2005a). Phenotype of disease-associated PrP accumulation in the brain of bovine spongiform encephalopathy experimentally infected sheep. J Gen Virol 86, 827-838.
13. Gonzá lez, L., Terry, L. & Jeffrey, M. (2005b). Expression of prion protein in the gut of mice infected orally with the 301V murine strain of the bovine spongiform encephalopathy agent. J Comp Pathol 132, 273-282.
14. González, L., Chianini, F., Martin, S., Sisó, S., Gibbard, L., Reid, H. W. & Jeffrey, M. (2007). Comparative titration of experimental ovine BSE infectivity in sheep and mice. J Gen Virol 88, 714-717.
15. González, L., Martin, S., Hawkins, S. A. C., Goldmann, W., Jeffrey, M. & Sisó, S. (2010a). Pathogenesis of natural goat scrapie: modulation by host PRNP genotype and effect of co-existent conditions. Vet Res 41, 48.
16. González, L., Sisó, S., Monleón, E., Casalone, C., van Keulen, L. J. M., Balkema-Buschmann, A., Ortiz-Peláez, A., Iulini, B., Langeveld, J. P. M. & other authors (2010b). Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe. J Gen Virol 91, 2630-2641.
17. González, L., Jeffrey, M., Dagleish, M. P., Goldmann, W., Sisó, S., Eaton, S. L., Martin, S., Finlayson, J., Stewart, P. & other authors (2012). Susceptibility to scrapie and disease phenotype in sheep: cross-Prnp genotype experimental transmissions with natural sources. Vet Res 43, 55.
18. Hamilton, M. A., Russo, R. C. & Thurston, R. V. (1977). Trimmed Spearman-Kärber method for estimating median lethal concentrations in toxicity bioassays. Environ Sci Technol 11, 714-719.
19. Head, M. W., Knight, R., Zeidler, M., Yull, H., Barlow, A. & Ironside, J. W. (2009). A case of protease sensitive prionopathy in a patient in the UK. Neuropathol Appl Neurobiol 35, 628-632.
20. Jeffrey, M., Martin, S., Barr, J., Chong, A. & Fraser, J. R. (2001a). Onset of accumulation of PrPres in murineME7 scrapie in relation to pathological and PrP immunohistochemical changes. J Comp Pathol 124, 20-28.
21. Jeffrey, M., Martin, S., Thomson, J. R., Dingwall, W. S., Begara-McGorum, I. & Gonzá lez, L. (2001b). Onset and distribution of tissue PrP accumulation in scrapie-affected suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies. J Comp Pathol 125, 48-57.
22. Jeffrey, M., Gonzá lez, L., Chong, A., Foster, J., Goldmann, W., Hunter, N. & Martin, S. (2006). Ovine infection with the agents of scrapie (CH1641 isolate) and bovine spongiform encephalopathy: immunochemical similarities can be resolved by immunohistochemistry. J Comp Pathol 134, 17-29.
23. Jeffrey, M., McGovern, G., Sisó, S. & Gonzá lez, L. (2011). Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease. Acta Neuropathol 121, 113-134.
24. Jeffrey, M., McGovern, G., Chambers, E. V., King, D., González, L., Manson, J. C., Ghetti, B., Piccardo, P. & Barron, R. M. (2012). Mechanism of PrP-amyloid formation in mice without transmissible spongiform encephalopathy. Brain Pathol 22, 58-66.
25. Konold, T., Bone, G. E., Phelan, L. J., Simmons, M. M., González, L., Sisó, S., Goldmann, W., Cawthraw, S. & Hawkins, S. A. C. (2010). Monitoring of clinical signs in goats with transmissible spongiform encephalopathies. BMC Vet Res 6, 13.
26. Kupfer, L., Eiden, M., Buschmann, A. & Groschup, M. H. (2007). Amino acid sequence and prion strain specific effects on the in vitro and in vivo convertibility of ovine/murine and bovine/murine prion protein chimeras. Biochim Biophys Acta 1772, 704-713.
27. Lasmézas, C. I., Deslys, J. P., Robain, O., Jaegly, A., Beringue, V., Peyrin, J. M., Fournier, J. G., Hauw, J. J., Rossier, J. & Dormont, D. (1997). Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein. Science 275, 402-404.
28. McKinley, M. P., Bolton, D. C. & Prusiner, S. B. (1983). A protease-resistant protein is a structural component of the scrapie prion. Cell 35, 57-62.
29. Miyazawa, K., Emmerling, K. & Manuelidis, L. (2011). High CJD infectivity remains after prion protein is destroyed. J Cell Biochem 112, 3630-3637.
30. Mould, D. L., Dawson, A. M. & Smith, W. (1967). Determination of the dosage-response curve of mice inoculated with scrapie. J Comp Pathol 77, 387-391.
31. Piccardo, P., Manson, J. C., King, D., Ghetti, B. & Barron, R. M. (2007). Accumulation of prion protein in the brain that is not associated with transmissible disease. Proc Natl Acad Sci U S A 104, 4712-4717.
32. Rohwer, R. G. (1991). The scrapie agent: "a virus by any other name". Curr Top Microbiol Immunol 172, 195-232.
33. Safar, J. G., Geschwind, M. D., Deering, C., Didorenko, S., Sattavat, M., Sanchez, H., Serban, A., Vey, M., Baron, H. & other authors (2005). Diagnosis of human prion disease. Proc Natl Acad Sci US A 102, 3501-3506.
34. Silveira, J. R., Raymond, G. J., Hughson, A. G., Race, R. E., Sim, V. L., Hayes, S. F. & Caughey, B. (2005). The most infectious prion protein particles. Nature 437, 257-261.
35. Sisó, S., Jeffrey, M. & González, L. (2009). Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route. Neuropathol Appl Neurobiol 35, 232-246.
36. Sisó, S., Jeffrey, M., Martin, S., Chianini, F., Dagleish, M. P. & González, L. (2010). Characterization of strains of ovine transmissible spongiform encephalopathy with a short PrPd profiling method. J Comp Pathol 142, 300-310.