Onset and distribution of tissue PrP accumulation in scrapie-affected Suffolk sheep as demonstrated by sequential necropsies and tonsillar biopsies

Journal of Comparative Pathology

Volumn 125, Issue 1, 2001, Pages 48-57

  Jeffrey, M ^a   Martin, S ^a   Thomson, J R ^b   Dingwall, W S ^b   Begara McGorum, I ^b   Gonzalez L ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

^b SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

AGE; ARTICLE; AUTOPSY; BIOPSY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DENDRITIC CELL; GANGLION; GENOTYPE; IMMUNOHISTOCHEMISTRY; INFECTION; LYMPHATIC SYSTEM; MACROPHAGE; MESENTERY LYMPH NODE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; SCRAPIE; SHEEP; SHEEP DISEASE; TISSUE DISTRIBUTION; TONSIL;

EID: 0034934355     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1053/jcpa.2001.0476     Document Type: Article

References (23)

1. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord
2. Prognostic value of follicular dendritic cells in nodular sclerosing Hodgkin's disease
3. Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie
4. Transmissions to mice indicates that 'new variant' CJD is caused by the BSE agent
5. Natural infection of Suffolk sheep with scrapie virus
6. A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies
7. Hydrated autoclave pretreatment enhancement of prion protein immunoreactivity in formalin-fixed bovine spongiform encephalopathy-affected brain
8. Experimentally induced bovine spongiform encephalopathy in cattle in Mission, Tex, and the control of scrapie
9. PrP genetics in sheep and the implications for scrapie and BSE
10. Natural scrapie and PrP genotype: Case control studies in British sheep
11. Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland
12. Sites of prion protein accumulation in scrapie infected mouse spleen revealed by immuno-gold electron microscopy
13. Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie
14. PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie-infected mice
15. PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States
16. Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie infected sheep
17. Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph-node - Implications for transmission and antemortem diagnosis
18. Preclinical test for prion diseases
19. SC detection in the preclinical diagnosis of scrapie
20. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie
21. Scrapie-associated prion-protein in the gastro-intestinal tract of sheep with natural scrapie
22. Homozygosity for prion protein alleles encoding flutamine-171 renders sheep susceptible to natural scrapie
23. Infectivity of scrapie prions bound to a stainless steel surface