Dermal Melanocortin Receptor Rebound in Diffuse Systemic Sclerosis after Anti-TGFβ1 Antibody Therapy

Scandinavian Journal of Immunology

Volumn 76, Issue 5, 2012, Pages 478-482

  Neumann Andersen, G ^a   Andersen, M ^a   Nagaeva, O ^b   Wikberg, J E S ^c   Mincheva Nilsson, L ^b  

^a NORTH DENMARK REGIONAL HOSPITAL   (Denmark)

^b UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; MELANIN; MELANOCORTIN RECEPTOR; MESSENGER RNA; PROOPIOMELANOCORTIN; PROTEIN PRECURSOR; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PUNCH BIOPSY; SKIN BIOPSY; SKIN DEFECT; SKIN PIGMENTATION; SKINFOLD THICKNESS; SYSTEMIC SCLEROSIS;

ANTIBODIES; FEMALE; HUMANS; MIDDLE AGED; PRO-OPIOMELANOCORTIN; RECEPTORS, MELANOCORTIN; RECOMBINANT PROTEINS; RNA, MESSENGER; SCLERODERMA, DIFFUSE; SKIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84867421619     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2012.02757.x     Document Type: Article

References (28)

1. Andersen GN, Caidahl K, Kazzam E et al. Correlation between increased nitric oxide production and markers of endothelial activation in systemic sclerosis: findings with the soluble adhesion molecules E-selectin, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1. Arthritis Rheum 2000;43:1085-93.
2. Gruschwitz MS, Vieth G. Up-regulation of class II major histocompatibility complex and intercellular adhesion molecule 1 expression on scleroderma fibroblasts and endothelial cells by interferon-gamma and tumor necrosis factor alpha in the early disease stage. Arthritis Rheum 1997;40:540-50.
3. Peltonen J, Kähäri L, Jaakola S et al. Evaluation of transforming growth factor beta and type 1 procollagen gene expression in fibrotic skin diseases by in situ hybridization. J Invest Dermatol 1990;94:365-71.
4. Kuroda K, Shinkai H. Gene expression of types I and III collagen, decorin, matrix metalloproteinases and tissue inhibitors of metalloproteinases in skin fibroblasts from patients with systemic sclerosis. Arch Dermatol Res 1997;289:567-72.
5. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991;88:6642-6.
6. Sargent JL, Milano A, Bhattacharyya S et al. A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. J Invest Dermatol 2010;130:694-705.
7. Denton CP, Merkel PA, Furst DE et al. CAT-192 Study Group; Scleroderma Clinical Trials Consortium. Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 2007;56:323-33.
8. Wikberg JE, Muceniece R, Mandrika I et al. New aspects on the melanocortins and their receptors. Pharmacol Res 2000;42:393-420.
9. Schiöth HB, Chhajlani V, Muceniece R, Klusa V, Wikberg JE. Major pharmacological distinction of the ACTH receptor from other melanocortin receptors. Life Sci 1996;59:797-801.
10. Böhm M, Raghunath M, Sunderkötter C et al. Collagen metabolism is a novel target of the neuropeptide alpha-melanocyte- stimulating hormone. J Biol Chem 2004;279:6959-66.
11. Lotti T, Teofoli P, Bianchi B, Mauviel A. POMC and fibroblast biology. Ann N Y Acad Sci 1999;885:262-7.
12. Schiller M, Raghunath M, Kubitscheck U et al. Human dermal fibroblasts express prohormone convertases 1 and 2 and produce proopiomelanocortin-derived peptides. J Invest Dermatol 2001;117:227-35.
13. Kokot A, Sindrilaru A, Schiller M et al. alpha-melanocyte-stimulating hormone suppresses bleomycin-induced collagen synthesis and reduces tissue fibrosis in a mouse model of scleroderma: melanocortin peptides as a novel treatment strategy for scleroderma?Arthritis Rheum 2009;60:592-603.
14. Dong L, Wen J, Pier E et al. Melanocyte-stimulating hormone directly enhances UV-induced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism. Cancer Res 2010;70:3547-56.
15. Chhajlani V, Wikberg JES. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett 1992;309:417-20.
16. Peters EM, Tobin DJ, Seidah NG, Schallreuter KU. Pro-opiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes. J Invest Dermatol 2000;114:430-7.
17. Spencer JD, Schallreuter KU. Regulation of pigmentation in human epidermal melanocytes by functional high-affinity beta-melanocyte-stimulating hormone/melanocortin-4 receptor signalling. Endocrinology 2009;150:1250-8.
18. Garcin G, Le Gallic L, Stoebner PE et al. Constitutive expression of MC1R in HaCaT keratinocytes inhibits basal and UVB-induced TNF-alpha production. Photochem Photobiol 2009;85:1440-50.
19. Hatta N, Dixon C, Ray AJ et al. Expression, candidate gene, and population studies of the melanocortin 5 receptor. J Invest Dermatol 2001;116:564-70.
20. Le Roy C, Li JY, Stocco DM, Langlois D, Saez JM. Regulation by adrenocorticotropin (ACTH), angiotensin II, transforming growth factor-beta, and insulin-like growth factor I of bovine adrenal cell steroidogenic capacity and expression of ACTH receptor, steroidogenic acute regulatory protein, cytochrome P450c17, and 3beta-hydroxysteroid dehydrogenase. Endocrinology 2000;141:1599-607.
21. Chakraborty A, Slominski A, Ermak G, Hwang J, Pawelek J. Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes. J Invest Dermatol 1995;105:655-9.
22. Liakos P, Chambaz EM, Feige JJ, Defaye G. Expression and regulation of melanocortin receptor-5 (MC5-R) in the bovine adrenal cortex. Mol Cell Endocrinol 2000;159:99-107.
23. Clements P, Lachenbruch P, Siebold J et al. Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995;22:1281-5.
24. Andersen GN, Nilsson K, Nagaeva O, Rantapää-Dahlqvist S, Sandström T, Mincheva-Nilsson L. Cytokine mRNA profile of alveolar T lymphocytes and macrophages in patients with systemic sclerosis suggests a local Tr1 response. Scand J Immunol 2011;74:272-81.
25. Andersen GN, Hägglund M, Nagaeva O et al. Quantitative measurement of the levels of melanocortin receptor subtype 1, 2, 3, and 5 and pro-opio-melanocortin peptide gene expression in subsets of human peripheral blood leukocytes. Scand J Immunol 2005;61:279-84.
26. Duncan MR, Frazier KS, Abramson S et al. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 1999;13:1774-86.
27. Hiramoto K, Kobayashi H, Ishii M, Sato E, Inoue M. Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis. Exp Dermatol 2010;19:132-6.
28. Ishida W, Mori Y, Lakos G et al. Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol 2006;126:1733-44.