-
1
-
-
0016439429
-
DNA modification mechanisms and gene activity during development
-
R. Holliday, and J.E. Pugh DNA modification mechanisms and gene activity during development Science 187 1975 226 232
-
(1975)
Science
, vol.187
, pp. 226-232
-
-
Holliday, R.1
Pugh, J.E.2
-
2
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat. Rev. Genet. 3 2002 415 428
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
3
-
-
2642531973
-
Epigenetics in human disease and prospects for epigenetic therapy
-
G. Egger, G. Liang, A. Aparicio, and P.A. Jones Epigenetics in human disease and prospects for epigenetic therapy Nature 429 2004 457 463
-
(2004)
Nature
, vol.429
, pp. 457-463
-
-
Egger, G.1
Liang, G.2
Aparicio, A.3
Jones, P.A.4
-
4
-
-
33644856123
-
Epigenetic therapy of cancer: Past, present and future
-
C.B. Yoo, and P.A. Jones Epigenetic therapy of cancer: past, present and future Nat. Rev. Drug Discov. 5 2006 37 50
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
5
-
-
0020582853
-
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs
-
D.V. Santi, C.E. Garrett, and P.J. Barr On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs Cell 33 1983 9 10
-
(1983)
Cell
, vol.33
, pp. 9-10
-
-
Santi, D.V.1
Garrett, C.E.2
Barr, P.J.3
-
6
-
-
0000418476
-
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
-
D.V. Santi, A. Norment, and C.E. Garrett Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine Proc. Natl. Acad. Sci. U S A 81 1984 6993 6997
-
(1984)
Proc. Natl. Acad. Sci. U S A
, vol.81
, pp. 6993-6997
-
-
Santi, D.V.1
Norment, A.2
Garrett, C.E.3
-
8
-
-
21044439177
-
Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
-
E. Kaminskas, A. Farrell, S. Abraham, A. Baird, L.S. Hsieh, S.L. Lee, J.K. Leighton, H. Patel, A. Rahman, R. Sridhara, Y.C. Wang, and R. Pazdur Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes Clin. Cancer Res. 11 2005 3604 3608
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 3604-3608
-
-
Kaminskas, E.1
Farrell, A.2
Abraham, S.3
Baird, A.4
Hsieh, L.S.5
Lee, S.L.6
Leighton, J.K.7
Patel, H.8
Rahman, A.9
Sridhara, R.10
Wang, Y.C.11
Pazdur, R.12
-
9
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
J.P. Issa, G. Garcia-Manero, F.J. Giles, R. Mannari, D. Thomas, S. Faderl, E. Bayar, J. Lyons, C.S. Rosenfeld, J. Cortes, and H.M. Kantarjian Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies Blood 103 2004 1635 1640
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
Mannari, R.4
Thomas, D.5
Faderl, S.6
Bayar, E.7
Lyons, J.8
Rosenfeld, C.S.9
Cortes, J.10
Kantarjian, H.M.11
-
10
-
-
80051604949
-
Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
-
J.M. Scandura, G.J. Roboz, M. Moh, E. Morawa, F. Brenet, J.R. Bose, L. Villegas, U.S. Gergis, S.A. Mayer, C.M. Ippoliti, T.J. Curcio, E.K. Ritchie, and E.J. Feldman Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML Blood 118 2011 1472 1480
-
(2011)
Blood
, vol.118
, pp. 1472-1480
-
-
Scandura, J.M.1
Roboz, G.J.2
Moh, M.3
Morawa, E.4
Brenet, F.5
Bose, J.R.6
Villegas, L.7
Gergis, U.S.8
Mayer, S.A.9
Ippoliti, C.M.10
Curcio, T.J.11
Ritchie, E.K.12
Feldman, E.J.13
-
11
-
-
79953108690
-
Epigenetics in cancer: What's the future?
-
228
-
Y. Boumber, and J.P. Issa Epigenetics in cancer: what's the future? Oncol. (Williston Park) 25 2011 220 226 228
-
(2011)
Oncol. (Williston Park)
, vol.25
, pp. 220-226
-
-
Boumber, Y.1
Issa, J.P.2
-
12
-
-
79251624478
-
Anaplastic large cell lymphoma: Twenty-five years of discovery
-
M.C. Kinney, R.A. Higgins, and E.A. Medina Anaplastic large cell lymphoma: twenty-five years of discovery Arch. Pathol. Lab. Med. 135 2011 19 43
-
(2011)
Arch. Pathol. Lab. Med.
, vol.135
, pp. 19-43
-
-
Kinney, M.C.1
Higgins, R.A.2
Medina, E.A.3
-
13
-
-
0024583779
-
A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis
-
Y. Kaneko, G. Frizzera, S. Edamura, N. Maseki, M. Sakurai, Y. Komada, H. Tanaka, M. Sasaki, and T. Suchi A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis Blood 73 1989 806 813
-
(1989)
Blood
, vol.73
, pp. 806-813
-
-
Kaneko, Y.1
Frizzera, G.2
Edamura, S.3
Maseki, N.4
Sakurai, M.5
Komada, Y.6
Tanaka, H.7
Sasaki, M.8
Suchi, T.9
-
14
-
-
0024350583
-
The t(2;5)(p23;q35): A recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma
-
M.M. Le Beau, M.A. Bitter, R.A. Larson, L.A. Doane, E.D. Ellis, W.A. Franklin, C.M. Rubin, M.E. Kadin, and J.W. Vardiman The t(2;5)(p23;q35): a recurring chromosomal abnormality in Ki-1-positive anaplastic large cell lymphoma Leukemia 3 1989 866 870
-
(1989)
Leukemia
, vol.3
, pp. 866-870
-
-
Le Beau, M.M.1
Bitter, M.A.2
Larson, R.A.3
Doane, L.A.4
Ellis, E.D.5
Franklin, W.A.6
Rubin, C.M.7
Kadin, M.E.8
Vardiman, J.W.9
-
15
-
-
0024509152
-
A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma ('Ki-1 lymphoma')
-
R. Rimokh, J.P. Magaud, F. Berger, J. Samarut, B. Coiffier, D. Germain, and D.Y. Mason A translocation involving a specific breakpoint (q35) on chromosome 5 is characteristic of anaplastic large cell lymphoma ('Ki-1 lymphoma') Br. J. Haematol. 71 1989 31 36
-
(1989)
Br. J. Haematol.
, vol.71
, pp. 31-36
-
-
Rimokh, R.1
Magaud, J.P.2
Berger, F.3
Samarut, J.4
Coiffier, B.5
Germain, D.6
Mason, D.Y.7
-
16
-
-
34948834758
-
Pathobiology of ALK+anaplastic large-cell lymphoma
-
H.M. Amin, and R. Lai Pathobiology of ALK+anaplastic large-cell lymphoma Blood 110 2007 2259 2267
-
(2007)
Blood
, vol.110
, pp. 2259-2267
-
-
Amin, H.M.1
Lai, R.2
-
17
-
-
37549057005
-
The anaplastic lymphoma kinase in the pathogenesis of cancer
-
R. Chiarle, C. Voena, C. Ambrogio, R. Piva, and G. Inghirami The anaplastic lymphoma kinase in the pathogenesis of cancer Nat. Rev. Cancer 8 2008 11 23
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 11-23
-
-
Chiarle, R.1
Voena, C.2
Ambrogio, C.3
Piva, R.4
Inghirami, G.5
-
18
-
-
66949152073
-
Anaplastic lymphoma kinase: Signalling in development and disease
-
R.H. Palmer, E. Vernersson, C. Grabbe, and B. Hallberg Anaplastic lymphoma kinase: signalling in development and disease Biochem. J. 420 2009 345 361
-
(2009)
Biochem. J.
, vol.420
, pp. 345-361
-
-
Palmer, R.H.1
Vernersson, E.2
Grabbe, C.3
Hallberg, B.4
-
19
-
-
30144437752
-
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; Delayed expression of the p16 protein upon reversal of the silencing
-
T. Nagasawa, Q. Zhang, P.N. Raghunath, H.Y. Wong, M. El-Salem, A. Szallasi, M. Marzec, P. Gimotty, A.H. Rook, E.C. Vonderheid, N. Odum, and M.A. Wasik Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing Leuk. Res. 30 2006 303 312
-
(2006)
Leuk. Res.
, vol.30
, pp. 303-312
-
-
Nagasawa, T.1
Zhang, Q.2
Raghunath, P.N.3
Wong, H.Y.4
El-Salem, M.5
Szallasi, A.6
Marzec, M.7
Gimotty, P.8
Rook, A.H.9
Vonderheid, E.C.10
Odum, N.11
Wasik, M.A.12
-
20
-
-
72249085328
-
NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells
-
C. Ambrogio, C. Martinengo, C. Voena, F. Tondat, L. Riera, P.F. di Celle, G. Inghirami, and R. Chiarle NPM-ALK oncogenic tyrosine kinase controls T-cell identity by transcriptional regulation and epigenetic silencing in lymphoma cells Cancer Res. 69 2009 8611 8619
-
(2009)
Cancer Res.
, vol.69
, pp. 8611-8619
-
-
Ambrogio, C.1
Martinengo, C.2
Voena, C.3
Tondat, F.4
Riera, L.5
Di Celle, P.F.6
Inghirami, G.7
Chiarle, R.8
-
21
-
-
4444257905
-
Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma
-
J.D. Khoury, G.Z. Rassidakis, L.J. Medeiros, H.M. Amin, and R. Lai Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma Blood 104 2004 1580 1581
-
(2004)
Blood
, vol.104
, pp. 1580-1581
-
-
Khoury, J.D.1
Rassidakis, G.Z.2
Medeiros, L.J.3
Amin, H.M.4
Lai, R.5
-
22
-
-
70349459928
-
Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+TCL) cells from apoptosis
-
Q. Zhang, H.Y. Wang, G. Bhutani, X. Liu, M. Paessler, J.W. Tobias, D. Baldwin, K. Swaminathan, M.C. Milone, and M.A. Wasik Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+TCL) cells from apoptosis Proc. Natl. Acad. Sci. U S A 106 2009 15843 15848
-
(2009)
Proc. Natl. Acad. Sci. U S A
, vol.106
, pp. 15843-15848
-
-
Zhang, Q.1
Wang, H.Y.2
Bhutani, G.3
Liu, X.4
Paessler, M.5
Tobias, J.W.6
Baldwin, D.7
Swaminathan, K.8
Milone, M.C.9
Wasik, M.A.10
-
23
-
-
38749141374
-
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling
-
A. Akimzhanov, L. Krenacs, T. Schlegel, S. Klein-Hessling, E. Bagdi, E. Stelkovics, E. Kondo, S. Chuvpilo, P. Wilke, A. Avots, S. Gattenlohner, H.K. Muller-Hermelink, A. Palmetshofer, and E. Serfling Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling Am. J. Pathol. 172 2008 215 224
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 215-224
-
-
Akimzhanov, A.1
Krenacs, L.2
Schlegel, T.3
Klein-Hessling, S.4
Bagdi, E.5
Stelkovics, E.6
Kondo, E.7
Chuvpilo, S.8
Wilke, P.9
Avots, A.10
Gattenlohner, S.11
Muller-Hermelink, H.K.12
Palmetshofer, A.13
Serfling, E.14
-
24
-
-
33746651038
-
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes
-
Q. Zhang, H.Y. Wang, A. Woetmann, P.N. Raghunath, N. Odum, and M.A. Wasik STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes Blood 108 2006 1058 1064
-
(2006)
Blood
, vol.108
, pp. 1058-1064
-
-
Zhang, Q.1
Wang, H.Y.2
Woetmann, A.3
Raghunath, P.N.4
Odum, N.5
Wasik, M.A.6
-
25
-
-
38949085902
-
Prognostic factors in childhood anaplastic large cell lymphoma: Results of a large European intergroup study
-
M.C. Le Deley, A. Reiter, D. Williams, G. Delsol, I. Oschlies, K. McCarthy, M. Zimmermann, and L. Brugieres Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study Blood 111 2008 1560 1566
-
(2008)
Blood
, vol.111
, pp. 1560-1566
-
-
Le Deley, M.C.1
Reiter, A.2
Williams, D.3
Delsol, G.4
Oschlies, I.5
McCarthy, K.6
Zimmermann, M.7
Brugieres, L.8
-
27
-
-
4544341015
-
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
-
Article3
-
G.K. Smyth Linear models and empirical bayes methods for assessing differential expression in microarray experiments Stat. Appl. Genet. Mol. Biol. 3 2004 Article3
-
(2004)
Stat. Appl. Genet. Mol. Biol.
, vol.3
-
-
Smyth, G.K.1
-
28
-
-
28744458859
-
Bioconductor: Open software development for computational biology and bioinformatics
-
R.C. Gentleman, V.J. Carey, D.M. Bates, B. Bolstad, M. Dettling, S. Dudoit, B. Ellis, L. Gautier, Y. Ge, J. Gentry, K. Hornik, T. Hothorn, W. Huber, S. Iacus, R. Irizarry, F. Leisch, C. Li, M. Maechler, A.J. Rossini, G. Sawitzki, C. Smith, G. Smyth, L. Tierney, J.Y. Yang, and J. Zhang Bioconductor: open software development for computational biology and bioinformatics Genome Biol. 5 2004 R80
-
(2004)
Genome Biol.
, vol.5
, pp. 80
-
-
Gentleman, R.C.1
Carey, V.J.2
Bates, D.M.3
Bolstad, B.4
Dettling, M.5
Dudoit, S.6
Ellis, B.7
Gautier, L.8
Ge, Y.9
Gentry, J.10
Hornik, K.11
Hothorn, T.12
Huber, W.13
Iacus, S.14
Irizarry, R.15
Leisch, F.16
Li, C.17
Maechler, M.18
Rossini, A.J.19
Sawitzki, G.20
Smith, C.21
Smyth, G.22
Tierney, L.23
Yang, J.Y.24
Zhang, J.25
more..
-
29
-
-
5444227862
-
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
-
D. Gius, H. Cui, C.M. Bradbury, J. Cook, D.K. Smart, S. Zhao, L. Young, S.A. Brandenburg, Y. Hu, K.S. Bisht, A.S. Ho, D. Mattson, L. Sun, P.J. Munson, E.Y. Chuang, J.B. Mitchell, and A.P. Feinberg Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach Cancer Cell 6 2004 361 371
-
(2004)
Cancer Cell
, vol.6
, pp. 361-371
-
-
Gius, D.1
Cui, H.2
Bradbury, C.M.3
Cook, J.4
Smart, D.K.5
Zhao, S.6
Young, L.7
Brandenburg, S.A.8
Hu, Y.9
Bisht, K.S.10
Ho, A.S.11
Mattson, D.12
Sun, L.13
Munson, P.J.14
Chuang, E.Y.15
Mitchell, J.B.16
Feinberg, A.P.17
-
30
-
-
79751526520
-
Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma
-
H. Caren, A. Djos, M. Nethander, R.M. Sjoberg, P. Kogner, C. Enstrom, S. Nilsson, and T. Martinsson Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma BMC Cancer 11 2011 66
-
(2011)
BMC Cancer
, vol.11
, pp. 66
-
-
Caren, H.1
Djos, A.2
Nethander, M.3
Sjoberg, R.M.4
Kogner, P.5
Enstrom, C.6
Nilsson, S.7
Martinsson, T.8
-
31
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
R. Jaenisch, and A. Bird Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals Nat. Genet. 33 2003 245 254
-
(2003)
Nat. Genet.
, vol.33
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
32
-
-
33847293264
-
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
-
T. Chen, S. Hevi, F. Gay, N. Tsujimoto, T. He, B. Zhang, Y. Ueda, and E. Li Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells Nat. Genet. 39 2007 391 396
-
(2007)
Nat. Genet.
, vol.39
, pp. 391-396
-
-
Chen, T.1
Hevi, S.2
Gay, F.3
Tsujimoto, N.4
He, T.5
Zhang, B.6
Ueda, Y.7
Li, E.8
-
33
-
-
33748998743
-
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
-
G. Egger, S. Jeong, S.G. Escobar, C.C. Cortez, T.W. Li, Y. Saito, C.B. Yoo, P.A. Jones, and G. Liang Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival Proc. Natl. Acad. Sci. U S A 103 2006 14080 14085
-
(2006)
Proc. Natl. Acad. Sci. U S A
, vol.103
, pp. 14080-14085
-
-
Egger, G.1
Jeong, S.2
Escobar, S.G.3
Cortez, C.C.4
Li, T.W.5
Saito, Y.6
Yoo, C.B.7
Jones, P.A.8
Liang, G.9
-
34
-
-
77749302093
-
A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
-
P.W. Hollenbach, A.N. Nguyen, H. Brady, M. Williams, Y. Ning, N. Richard, L. Krushel, S.L. Aukerman, C. Heise, and K.J. MacBeth A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines PLoS One 5 2010 e9001
-
(2010)
PLoS One
, vol.5
, pp. 9001
-
-
Hollenbach, P.W.1
Nguyen, A.N.2
Brady, H.3
Williams, M.4
Ning, Y.5
Richard, N.6
Krushel, L.7
Aukerman, S.L.8
Heise, C.9
MacBeth, K.J.10
-
35
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
P.A. Jones, and S.M. Taylor Cellular differentiation, cytidine analogs and DNA methylation Cell 20 1980 85 93
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
36
-
-
0018581647
-
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
-
S.M. Taylor, and P.A. Jones Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine Cell 17 1979 771 779
-
(1979)
Cell
, vol.17
, pp. 771-779
-
-
Taylor, S.M.1
Jones, P.A.2
-
37
-
-
79959231353
-
The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway
-
P. Martinelli, P. Bonetti, C. Sironi, G. Pruneri, C. Fumagalli, P.R. Raviele, S. Volorio, S. Pileri, R. Chiarle, F.K. McDuff, B.K. Tusi, S.D. Turner, G. Inghirami, P.G. Pelicci, and E. Colombo The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway Blood 117 2011 6617 6626
-
(2011)
Blood
, vol.117
, pp. 6617-6626
-
-
Martinelli, P.1
Bonetti, P.2
Sironi, C.3
Pruneri, G.4
Fumagalli, C.5
Raviele, P.R.6
Volorio, S.7
Pileri, S.8
Chiarle, R.9
McDuff, F.K.10
Tusi, B.K.11
Turner, S.D.12
Inghirami, G.13
Pelicci, P.G.14
Colombo, E.15
-
38
-
-
77952952304
-
The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells
-
M. Almstedt, N. Blagitko-Dorfs, J. Duque-Afonso, J. Karbach, D. Pfeifer, E. Jager, and M. Lubbert The DNA demethylating agent 5-aza-2'-deoxycytidine induces expression of NY-ESO-1 and other cancer/testis antigens in myeloid leukemia cells Leuk. Res. 34 2010 899 905
-
(2010)
Leuk. Res.
, vol.34
, pp. 899-905
-
-
Almstedt, M.1
Blagitko-Dorfs, N.2
Duque-Afonso, J.3
Karbach, J.4
Pfeifer, D.5
Jager, E.6
Lubbert, M.7
-
39
-
-
0037962005
-
Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia
-
H.M. Kantarjian, S. O'Brien, J. Cortes, F.J. Giles, S. Faderl, J.P. Issa, G. Garcia-Manero, M.B. Rios, J. Shan, M. Andreeff, M. Keating, and M. Talpaz Results of decitabine (5-aza-2′deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia Cancer 98 2003 522 528
-
(2003)
Cancer
, vol.98
, pp. 522-528
-
-
Kantarjian, H.M.1
O'Brien, S.2
Cortes, J.3
Giles, F.J.4
Faderl, S.5
Issa, J.P.6
Garcia-Manero, G.7
Rios, M.B.8
Shan, J.9
Andreeff, M.10
Keating, M.11
Talpaz, M.12
-
40
-
-
33847395041
-
Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia
-
Y. Oki, H.M. Kantarjian, V. Gharibyan, D. Jones, S. O'Brien, S. Verstovsek, J. Cortes, G.M. Morris, G. Garcia-Manero, and J.P. Issa Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia Cancer 109 2007 899 906
-
(2007)
Cancer
, vol.109
, pp. 899-906
-
-
Oki, Y.1
Kantarjian, H.M.2
Gharibyan, V.3
Jones, D.4
O'Brien, S.5
Verstovsek, S.6
Cortes, J.7
Morris, G.M.8
Garcia-Manero, G.9
Issa, J.P.10
-
41
-
-
34548529948
-
Phase i study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
-
W. Blum, R.B. Klisovic, B. Hackanson, Z. Liu, S. Liu, H. Devine, T. Vukosavljevic, L. Huynh, G. Lozanski, C. Kefauver, C. Plass, S.M. Devine, N.A. Heerema, A. Murgo, K.K. Chan, M.R. Grever, J.C. Byrd, and G. Marcucci Phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia J. Clin. Oncol. 25 2007 3884 3891
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3884-3891
-
-
Blum, W.1
Klisovic, R.B.2
Hackanson, B.3
Liu, Z.4
Liu, S.5
Devine, H.6
Vukosavljevic, T.7
Huynh, L.8
Lozanski, G.9
Kefauver, C.10
Plass, C.11
Devine, S.M.12
Heerema, N.A.13
Murgo, A.14
Chan, K.K.15
Grever, M.R.16
Byrd, J.C.17
Marcucci, G.18
-
42
-
-
39749155114
-
Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)
-
A.F. Cashen, A.K. Shah, L. Todt, N. Fisher, and J. DiPersio Pharmacokinetics of decitabine administered as a 3-h infusion to patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) Cancer Chemother. Pharmacol. 61 2008 759 766
-
(2008)
Cancer Chemother. Pharmacol.
, vol.61
, pp. 759-766
-
-
Cashen, A.F.1
Shah, A.K.2
Todt, L.3
Fisher, N.4
Dipersio, J.5
-
43
-
-
33644990380
-
Angiostatic activity of DNA methyltransferase inhibitors
-
D.M. Hellebrekers, K.W. Jair, E. Vire, S. Eguchi, N.T. Hoebers, M.F. Fraga, M. Esteller, F. Fuks, S.B. Baylin, M. van Engeland, and A.W. Griffioen Angiostatic activity of DNA methyltransferase inhibitors Mol. Cancer Ther. 5 2006 467 475
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 467-475
-
-
Hellebrekers, D.M.1
Jair, K.W.2
Vire, E.3
Eguchi, S.4
Hoebers, N.T.5
Fraga, M.F.6
Esteller, M.7
Fuks, F.8
Baylin, S.B.9
Van Engeland, M.10
Griffioen, A.W.11
-
44
-
-
84887212492
-
Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: Clinical implications
-
R. Halaban, M. Krauthammer, M. Pelizzola, E. Cheng, D. Kovacs, M. Sznol, S. Ariyan, D. Narayan, A. Bacchiocchi, A. Molinaro, Y. Kluger, M. Deng, N. Tran, W. Zhang, M. Picardo, and J.J. Enghild Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications PLoS One 4 2009 e4563
-
(2009)
PLoS One
, vol.4
, pp. 4563
-
-
Halaban, R.1
Krauthammer, M.2
Pelizzola, M.3
Cheng, E.4
Kovacs, D.5
Sznol, M.6
Ariyan, S.7
Narayan, D.8
Bacchiocchi, A.9
Molinaro, A.10
Kluger, Y.11
Deng, M.12
Tran, N.13
Zhang, W.14
Picardo, M.15
Enghild, J.J.16
-
45
-
-
33745587303
-
Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3
-
M. Kasprzycka, M. Marzec, X. Liu, Q. Zhang, and M.A. Wasik Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3 Proc. Natl. Acad. Sci. U S A 103 2006 9964 9969
-
(2006)
Proc. Natl. Acad. Sci. U S A
, vol.103
, pp. 9964-9969
-
-
Kasprzycka, M.1
Marzec, M.2
Liu, X.3
Zhang, Q.4
Wasik, M.A.5
-
46
-
-
80054043545
-
Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia
-
D. Atanackovic, T. Luetkens, B. Kloth, G. Fuchs, Y. Cao, Y. Hildebrandt, S. Meyer, K. Bartels, H. Reinhard, N. Lajmi, S. Hegewisch-Becker, G. Schilling, U. Platzbecker, G. Kobbe, T. Schroeder, C. Bokemeyer, and N. Kroger Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia Am. J. Hematol. 86 2011 918 922
-
(2011)
Am. J. Hematol.
, vol.86
, pp. 918-922
-
-
Atanackovic, D.1
Luetkens, T.2
Kloth, B.3
Fuchs, G.4
Cao, Y.5
Hildebrandt, Y.6
Meyer, S.7
Bartels, K.8
Reinhard, H.9
Lajmi, N.10
Hegewisch-Becker, S.11
Schilling, G.12
Platzbecker, U.13
Kobbe, G.14
Schroeder, T.15
Bokemeyer, C.16
Kroger, N.17
-
47
-
-
25844482087
-
Epigenetic treatment of hematopoietic malignancies: In vivo targets of demethylating agents
-
R. Claus, M. Almstedt, and M. Lubbert Epigenetic treatment of hematopoietic malignancies: in vivo targets of demethylating agents Semin. Oncol. 32 2005 511 520
-
(2005)
Semin. Oncol.
, vol.32
, pp. 511-520
-
-
Claus, R.1
Almstedt, M.2
Lubbert, M.3
-
48
-
-
43949136445
-
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
-
C. Stresemann, and F. Lyko Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine Int. J. Cancer 123 2008 8 13
-
(2008)
Int. J. Cancer
, vol.123
, pp. 8-13
-
-
Stresemann, C.1
Lyko, F.2
-
49
-
-
18744395503
-
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes
-
Q. Zhang, H.Y. Wang, M. Marzec, P.N. Raghunath, T. Nagasawa, and M.A. Wasik STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes Proc. Natl. Acad. Sci. U S A 102 2005 6948 6953
-
(2005)
Proc. Natl. Acad. Sci. U S A
, vol.102
, pp. 6948-6953
-
-
Zhang, Q.1
Wang, H.Y.2
Marzec, M.3
Raghunath, P.N.4
Nagasawa, T.5
Wasik, M.A.6
-
50
-
-
35948966315
-
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
-
Q. Zhang, H.Y. Wang, X. Liu, and M.A. Wasik STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression Nat. Med. 13 2007 1341 1348
-
(2007)
Nat. Med.
, vol.13
, pp. 1341-1348
-
-
Zhang, Q.1
Wang, H.Y.2
Liu, X.3
Wasik, M.A.4
-
51
-
-
79961041326
-
IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK
-
Q. Zhang, H.Y. Wang, X. Liu, G. Bhutani, K. Kantekure, and M. Wasik IL-2R common gamma-chain is epigenetically silenced by nucleophosphin-anaplastic lymphoma kinase (NPM-ALK) and acts as a tumor suppressor by targeting NPM-ALK Proc. Natl. Acad. Sci. U S A 108 2011 11977 11982
-
(2011)
Proc. Natl. Acad. Sci. U S A
, vol.108
, pp. 11977-11982
-
-
Zhang, Q.1
Wang, H.Y.2
Liu, X.3
Bhutani, G.4
Kantekure, K.5
Wasik, M.6
-
52
-
-
27944485366
-
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
-
M. Marzec, M. Kasprzycka, A. Ptasznik, P. Wlodarski, Q. Zhang, N. Odum, and M.A. Wasik Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3 Lab. Invest. 85 2005 1544 1554
-
(2005)
Lab. Invest.
, vol.85
, pp. 1544-1554
-
-
Marzec, M.1
Kasprzycka, M.2
Ptasznik, A.3
Wlodarski, P.4
Zhang, Q.5
Odum, N.6
Wasik, M.A.7
-
53
-
-
32644442671
-
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
-
W. Wan, M.S. Albom, L. Lu, M.R. Quail, N.C. Becknell, L.R. Weinberg, D.R. Reddy, B.P. Holskin, T.S. Angeles, T.L. Underiner, S.L. Meyer, R.L. Hudkins, B.D. Dorsey, M.A. Ator, B.A. Ruggeri, and M. Cheng Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells Blood 107 2006 1617 1623
-
(2006)
Blood
, vol.107
, pp. 1617-1623
-
-
Wan, W.1
Albom, M.S.2
Lu, L.3
Quail, M.R.4
Becknell, N.C.5
Weinberg, L.R.6
Reddy, D.R.7
Holskin, B.P.8
Angeles, T.S.9
Underiner, T.L.10
Meyer, S.L.11
Hudkins, R.L.12
Dorsey, B.D.13
Ator, M.A.14
Ruggeri, B.A.15
Cheng, M.16
-
54
-
-
33846110366
-
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK
-
A.V. Galkin, J.S. Melnick, S. Kim, T.L. Hood, N. Li, L. Li, G. Xia, R. Steensma, G. Chopiuk, J. Jiang, Y. Wan, P. Ding, Y. Liu, F. Sun, P.G. Schultz, N.S. Gray, and M. Warmuth Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK Proc. Natl. Acad. Sci. U S A 104 2007 270 275
-
(2007)
Proc. Natl. Acad. Sci. U S A
, vol.104
, pp. 270-275
-
-
Galkin, A.V.1
Melnick, J.S.2
Kim, S.3
Hood, T.L.4
Li, N.5
Li, L.6
Xia, G.7
Steensma, R.8
Chopiuk, G.9
Jiang, J.10
Wan, Y.11
Ding, P.12
Liu, Y.13
Sun, F.14
Schultz, P.G.15
Gray, N.S.16
Warmuth, M.17
-
55
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
B.J. Druker, S. Tamura, E. Buchdunger, S. Ohno, G.M. Segal, S. Fanning, J. Zimmermann, and N.B. Lydon Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells Nat. Med. 2 1996 561 566
-
(1996)
Nat. Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
56
-
-
79960142158
-
Novel therapeutic options in anaplastic large cell lymphoma: Molecular targets and immunological tools
-
O. Merkel, F. Hamacher, E. Sifft, L. Kenner, and R. Greil Novel therapeutic options in anaplastic large cell lymphoma: molecular targets and immunological tools Mol. Cancer Ther. 10 2011 1127 1136
-
(2011)
Mol. Cancer Ther.
, vol.10
, pp. 1127-1136
-
-
Merkel, O.1
Hamacher, F.2
Sifft, E.3
Kenner, L.4
Greil, R.5
-
57
-
-
80055023013
-
Managing resistance in chronic myeloid leukemia
-
S. Roychowdhury, and M. Talpaz Managing resistance in chronic myeloid leukemia Blood Rev. 25 2011 279 290
-
(2011)
Blood Rev.
, vol.25
, pp. 279-290
-
-
Roychowdhury, S.1
Talpaz, M.2
|