Carbamoylated free amino acids in uremia: HOCl generates volatile protein modifying and cytotoxic oxidant species from N-carbamoyl-threonine but not threonine

Biochimie

Volumn 94, Issue 11, 2012, Pages 2441-2447

  Schreier, Sabine M ^a   Hollaus, Marianne ^a   Hermann, Marcela ^b   Jirovetz, Leopold ^c   Exner, Markus ^d   Kapiotis, Stylianos ^e   Gmeiner, Bernhard M K ^a   Laggner, Hilde ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d Gruppenpraxis Labors   (Austria)

^e Hospital of the Divine Redeemer   (Austria)

Author keywords

Carbamoylation; Chloramine; Hypochlorite; Oxidative stress

Indexed keywords

ALDEHYDE; HUMAN SERUM ALBUMIN; HYPOCHLOROUS ACID; LOW DENSITY LIPOPROTEIN; MONOCHLORAMINE; N CARBAMOYL THREONINE; OXIDIZING AGENT; THREONINE; UNCLASSIFIED DRUG;

ARTERY ENDOTHELIUM; ARTICLE; CARBAMOYLATION; CHEMICAL REACTION; CONTROLLED STUDY; CORONARY ARTERY; CYTOTOXICITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR STABILITY; MONOCYTE; OXIDATIVE STRESS; PROTEIN MODIFICATION; UREMIA;

ALDEHYDES; CARBAMATES; CELL LINE; CYTOTOXINS; HUMANS; HYPOCHLOROUS ACID; LIPOPROTEINS, LDL; OXIDANTS; SERUM ALBUMIN; THREONINE; UREMIA; VOLATILIZATION;

EID: 84867403462     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.06.032     Document Type: Article

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