Carbamoylation of amino acids and proteins in uremia

Kidney International, Supplement

Volumn 59, Issue 78, 2001, Pages

  Kraus, L M ^a   Kraus A P , Jr ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Carbamoyl amino acids; Cyanate; Urea; Uremic toxin

Indexed keywords

AMINO ACID; ANTIBODY; ASPARAGINE; CARRIER PROTEIN; CYANIC ACID; HEMOGLOBIN; HOMOCITRULLINE; HORMONE; LOW DENSITY LIPOPROTEIN; LYSINE; OSTEOCALCIN; PROTEIN DERIVATIVE; RECEPTOR; CARBAMIC ACID DERIVATIVE; CYANIC ACID DERIVATIVE; ENZYME; GLUCOSE; INSULIN; PROTEIN; TOXIN;

ANIMAL TISSUE; CONFERENCE PAPER; DIABETES MELLITUS; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HEMODIALYSIS; HEMOGLOBIN SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY FAILURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; RAT; UREMIA; ANIMAL; CHRONIC KIDNEY FAILURE; DIABETIC NEPHROPATHY; METABOLISM; RENAL REPLACEMENT THERAPY; REVIEW;

AMINO ACIDS; ANIMALS; CARBAMATES; CYANATES; DIABETIC NEPHROPATHIES; ENZYMES; GLUCOSE; HORMONES; HUMANS; INSULIN; KIDNEY FAILURE, CHRONIC; LIPOPROTEINS, LDL; PROTEINS; RENAL DIALYSIS; TOXINS, BIOLOGICAL; UREMIA;

EID: 0035128720     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2001.59780102.x     Document Type: Conference Paper

References (31)

1. Genesis of the uraemic syndrome: Role of uraemic toxins
2. The search for the uremic toxin: The case for carbamoylation of amino acids and proteins
3. The isomeric transformation of urea into ammonium cyanate in aqueous solution
4. Reactions of cyanate with functional groups of proteins. III. Reactions with amino and carboxyl groups
5. 2-terminal residues in proteins
6. Modification of proteins with cyanate
7. 2-terminal cysteine and cystine in proteins
8. Cyanate-induced cataracts in patients with sickle-cell hemoglobinopathies
9. Sodium cyanate induced polyneuropathy in patients with sickle-cell disease
10. Urea-derived cyanate forms ε-amino-carbamoyl-lysine (homocitrulline) in leukocyte proteins in patients with end-stage renal disease on peritoneal dialysis
11. Carbamoylation of hemoglobin in uremic patients determined by antibody specific for homocitrulline (carbamoylated ε-N-Lysine)
12. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamoylation: Generation of antibodies specific for derivatized lysine
13. Matrix metalloproteinase 2 (gelatinase A) regulates glomerular cell proliferation and differentiation
14. Reactions of cyanate present in aqueous urea with amino acids and proteins
15. The inhibition of rat liver threonine dehydratase by carbamoylphosphate: The formation of carbamoylpyridoxal 5′-phosphate
16. On the pyridoxal 5′-phosphate stimulation of aspartate aminotransferase and alanine aminotransferase in serum and erythrocytes of patients undergoing haemodialysis and with kidney transplants
17. Inhibition of coenzyme activation of aspartate aminotransferase
18. Carbamylation of apo-aspartate aminotransferase: A possible mechanism for enzyme inactivation in uremic patients
19. Inactivation of chymotrypsin by cyanate
20. Physiological and clinical implications of protein carbamoylation
21. Carbamylation of insulin and its biological activity
22. Carbamylation of amino and tyrosine hydroxyl groups: Separation of an inhibitor of oxytocin with no intrinsic activity on the isolated uterus
23. Chemical modification of erythropoietin: An increase in in vitro activity by guanidination
24. Role of the lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts
25. Carbamoylation induced alterations in low-density lipoprotein metabolism
26. Decreased clearance of uraemic and mildly carbamoylated low-density lipoprotein
27. Plasma amino acid levels and amino acid losses during continuous ambulatory peritoneal dialysis
28. Plasma and muscle free amino acids during continuous ambulatory peritoneal dialysis
29. Essential carbamoyl-amino acids formed in vivo in patients with end-stage renal disease managed by continuous ambulatory peritoneal dialysis: Isolation, identification, and quantitation
30. Tyrosine and N-carbamoyl-tyrosine in end stage renal disease during continuous ambulatory peritoneal dialysis
31. epsi;-(carboxymethyl) lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins