Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

Biochimie

Volumn 94, Issue 11, 2012, Pages 2457-2460

  Zhong, Hai Jing ^a,b   Pui Yan Ma, Victor ^c   Cheng, Zhen ^c   Shiu Hin Chan, Daniel ^c   He, Hong Zhang ^c   Leung, Ka Ho ^c   Ma, Dik Lung ^c   Leung, Chung Hang ^a,b  

^a University of Macau   (Macao)

^b UNIVERSITY OF MACAU   (Macao)

^c HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Drug discovery; Natural product; NEDD8 activating enzyme; Ubiquitin like protein; Virtual screening

Indexed keywords

[4 [4 [(2,3 DIHYDRO 1H INDEN 1 YL)AMINO] 7H PYRROLO[2,3 D]PYRIMIDIN 7 YL] 2 HYDROXYCYCLOPENTYLMETHYL] SULFAMATE; DEOXYVASICINONE; NATURAL PRODUCT; NEDD8 PROTEIN; QUINAZOLINE DERIVATIVE; SUMO PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MODEL; NEDDYLATION; NUCLEOPHILICITY; VIRTUAL REALITY;

BIOLOGICAL AGENTS; CACO-2 CELLS; COMPUTATIONAL BIOLOGY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; UBIQUITIN-ACTIVATING ENZYMES; UBIQUITINATION; USER-COMPUTER INTERFACE;

EID: 84867397251     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.06.004     Document Type: Article

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