Bone as an endocrine organ

Endocrine Practice

Volumn 18, Issue 5, 2012, Pages 758-762

  Guntur, Anyonya R ^a   Rosen, Clifford J ^a  

^a MAINE MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GLUCOSE; INSULIN RECEPTOR; OSTEOCALCIN; TESTOSTERONE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR RUNX2;

BONE; BONE DENSITY; CELL PROLIFERATION; ENDOCRINE GLAND; ENERGY EXPENDITURE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; INSULIN SENSITIVITY; NONHUMAN; OSTEOLYSIS; PANCREAS ISLET BETA CELL; REVIEW; TRANSCRIPTION REGULATION; UPREGULATION; WNT SIGNALING PATHWAY;

BONE AND BONES; ENDOCRINE GLANDS; HUMANS; MODELS, BIOLOGICAL;

EID: 84867382199     PISSN: 1530891X     EISSN: 19342403     Source Type: Journal    
DOI: 10.4158/EP12141.RA     Document Type: Review

References (25)

1. Karsenty G, Wagner EF. Reaching a genetic and molecu-lar understanding of skeletal development. Dev Cell. 2002; 2:389-406.
2. Teitelbaum SL. Osteoclasts: What do they do and how do they do it? Am J Pathol. 2007;170:427-435.
3. Winkler DG, Sutherland MK, Geoghegan JC, et al. Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 2003;22:6267-6276.
4. Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004;113:561-568.
5. Grundy SM. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol. 1999;83:25F-29F.
6. Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: Vitamin K-dependent proteins in bone. Physiol Rev. 1989;69:990-1047.
7. Hauschka PV, Lian JB, Gallop PM. Direct identification of the calcium-binding amino acid, gamma-carboxyglu-Tamate, in mineralized tissue. Proc Natl Acad Sci U S A. 1975;72:3925-3929.
8. Ducy P, Desbois C, Boyce B, et al. Increased bone for-mation in osteocalcin-deficient mice. Nature. 1996;382: 448-452.
9. Lee NK, Sowa H, Hinoi E, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130: 456-469.
10. Cousin W, Courseaux A, Ladoux A, Dani C, Peraldi P. Cloning of hOST-PTP: The only example of a protein-Tyrosine-phosphatase the function of which has been lost between rodent and human. Biochem Biophys Res Commun. 2004;321:259-265.
11. Zee T, Settembre C, Levine RL, Karsenty G. T-cell pro-Tein tyrosine phosphatase regulates bone resorption and whole-body insulin sensitivity through its expression in osteoblasts. Mol Cell Biol. 2012;32:1080-1088.
12. Rached MT, Kode A, Silva BC, et al. FoxO1 expres-sion in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest. 2010;120: 357-368.
13. Kode A, Mosialou I, Silva BC, et al. FoxO1 protein coop-erates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem. 2012;287:8757-8768.
14. Ferron M, Wei J, Yoshizawa T, et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metab-olism. Cell. 2010;142:296-308.
15. Fulzele K, Riddle RC, DiGirolamo DJ, et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell. 2010;142:309-319.
16. Gu S, Boyer TG, Naski MC. Basic helix-loop-helix tran-scription factor twist1 inhibits the transactivator function of the master chondrogenic regulator Sox9. J Biol Chem. 2012;287:21082-21092.
17. Lecka-Czernik B. Bone loss in diabetes: Use of antidia-betic thiazolidinediones and secondary osteoporosis. Curr Osteoporos Rep. 2010;8:178-184.
18. Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernik B. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 2004;145:401-406.
19. Oishi K, Konishi M, Murata Y, Itoh N. Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice. Biochem Biophys Res Commun. 2011;412:396-400.
20. Wei W, Dutchak PA, Wang X, et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-Activated receptor ?. Proc Natl Acad Sci U S A. 2012;109:3143-3148.
21. Guntur AR, Kawai M, Le P. An essential role for the circadian-regulated gene nocturnin in osteogenesis: The importance of local timekeeping in skeletal homeostasis. Ann N Y Acad Sci. 2011;1237:58-63.
22. Pi M, Chen L, Huang MZ, et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One. 2008;3:e3858.
23. Oury F, Sumara G, Sumara O, et al. Endocrine regulation of male fertility by the skeleton. Cell. 2011;144:796-809.
24. Teplyuk NM, Zhang Y, Lou Y, et al. The osteogenic tran-scription factor runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1 in osteoblasts. Mol Endocrinol. 2009;23:849-861.
25. Jeong JH, Jin JS, Kim HN, et al. Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain. J Cell Physiol. 2008;217:511-517.