Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2α, p38-MAPK and NF-κB in advanced glycation end products stimulated human chondrocytes

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 12, 2012, Pages 2179-2189

  Rasheed, Zafar ^a   Haqqi, Tariq M ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

Author keywords

AGEs; Bag 1; Chondrocyte; COX 2; EIF2 ; ER stress; GRP78; NF B; OA; P38 MAPK; PGE2; RAGE

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BAG 1 PROTEIN; BOVINE SERUM ALBUMIN; CYCLOOXYGENASE 2; GLUCOSE REGULATED PROTEIN 78; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 2ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PD 98051; PROSTAGLANDIN E2; SMALL INTERFERING RNA; TUNICAMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CELL STIMULATION; CHONDROGENESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENDOPLASMIC RETICULUM STRESS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELL PROLIFERATION; CHONDROCYTES; CYCLOOXYGENASE 2; ENDOPLASMIC RETICULUM STRESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUKARYOTIC INITIATION FACTOR-2; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; MALE; MIDDLE AGED; NF-KAPPA B; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERUM ALBUMIN, BOVINE; SIGNAL TRANSDUCTION;

EUKARYOTA;

EID: 84867370364     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.08.021     Document Type: Article

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