Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator

Journal of Medicinal Chemistry

Volumn 55, Issue 19, 2012, Pages 8236-8247

  Nique, François ^a   Hebbe, Séverine ^a   Triballeau, Nicolas ^a   Peixoto, Christophe ^a   Lefrançois, Jean Michel ^a   Jary, Hélène ^a   Alvey, Luke ^a   Manioc, Murielle ^a   Housseman, Christopher ^a   Klaassen, Hugo ^a   Van Beeck, Kris ^a   Guédin, Denis ^a   Namour, Florence ^a   Minet, Dominque ^a   Van Der Aar, Ellen ^a   Feyen, Jean ^a   Fletcher, Stephen ^a   Blanqué, Roland ^a   Robin Jagerschmidt, Catherine ^a   Deprez, Pierre ^a  

^a Galapagos   (France)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 (HYDROXYMETHYL) 3 METHYL 2,5 DIOXO 4 PHENYLIMIDAZOLIDIN 1 YL) 2 (TRIFLUOROMETHYL)BENZONITRILE; 4 (HYDROXYMETHYL)DIARYLHYDANTOIN; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; DRUG BIOAVAILABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; ORCHIECTOMY; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANABOLIC AGENTS; ANDROGEN RECEPTOR ANTAGONISTS; ANDROGENS; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG PARTIAL AGONISM; HELA CELLS; HUMANS; HYDANTOINS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUSCLE, SKELETAL; ORCHIECTOMY; ORGAN SIZE; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANDROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTIONAL ACTIVATION;

EID: 84867369654     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300281x     Document Type: Article

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