메뉴 건너뛰기




Volumn 53, Issue 8, 2012, Pages 608-618

DNA-PKcs-dependent NHEJ pathway supports the progression of topoisomerase II poison-induced chromosome aberrant cells

Author keywords

Chinese hamster cell lines; Chromosome integrity; Double strand break repair; Etoposide; Idarubicin; Micronucleus

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; ETOPOSIDE; IDARUBICIN; PROTEIN KINASE C;

EID: 84867362456     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21729     Document Type: Article
Times cited : (5)

References (55)
  • 1
    • 20144367619 scopus 로고    scopus 로고
    • BRCA2 regulates homologous recombination in response to DNA damage: Implications for genome stability and carcinogenesis
    • Abaji C, Cousineau I, Belmaaza A. 2005. BRCA2 regulates homologous recombination in response to DNA damage: Implications for genome stability and carcinogenesis. Cancer Res 65: 4117-4125.
    • (2005) Cancer Res , vol.65 , pp. 4117-4125
    • Abaji, C.1    Cousineau, I.2    Belmaaza, A.3
  • 2
    • 0032126029 scopus 로고    scopus 로고
    • Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells
    • Abbott DW, Freeman ML, Holt JT. 1998. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J Natl Cancer Inst 90: 978-985.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 978-985
    • Abbott, D.W.1    Freeman, M.L.2    Holt, J.T.3
  • 3
    • 0033847847 scopus 로고    scopus 로고
    • Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations
    • Ahuja HG, Felix CA, Aplan PD. 2000. Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations. Genes Chromosomes Cancer 29: 96-105.
    • (2000) Genes Chromosomes Cancer , vol.29 , pp. 96-105
    • Ahuja, H.G.1    Felix, C.A.2    Aplan, P.D.3
  • 6
    • 0027251059 scopus 로고
    • Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II
    • Burden DA, Goldsmith LJ, Sullivan DM. 1993. Cell-cycle-dependent phosphorylation and activity of Chinese-hamster ovary topoisomerase II. Biochem J 293: 297-304.
    • (1993) Biochem J , vol.293 , pp. 297-304
    • Burden, D.A.1    Goldsmith, L.J.2    Sullivan, D.M.3
  • 7
    • 0030751965 scopus 로고    scopus 로고
    • The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair
    • Chaung W, Mi LJ, Boorstein RJ. 1997. The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair. Nucleic Acids Res 25: 992-994.
    • (1997) Nucleic Acids Res , vol.25 , pp. 992-994
    • Chaung, W.1    Mi, L.J.2    Boorstein, R.J.3
  • 8
    • 0024393707 scopus 로고
    • Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells, xrs 5 and xrs 6. IV. Study of chromosomal aberrations and sister-chromatid exchanges by restriction endonucleases and inhibitors of DNA topoisomerase II
    • Darroudi F, Natarajan AT. 1989. Cytogenetical characterization of Chinese hamster ovary X-ray-sensitive mutant cells, xrs 5 and xrs 6. IV. Study of chromosomal aberrations and sister-chromatid exchanges by restriction endonucleases and inhibitors of DNA topoisomerase II. Mutat Res 212: 137-148.
    • (1989) Mutat Res , vol.212 , pp. 137-148
    • Darroudi, F.1    Natarajan, A.T.2
  • 9
    • 55749111365 scopus 로고    scopus 로고
    • Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells
    • de Campos-Nebel M, Larripa I, González-Cid M. 2008. Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells. Mutat Res 646: 8-16.
    • (2008) Mutat Res , vol.646 , pp. 8-16
    • de Campos-Nebel, M.1    Larripa, I.2    González-Cid, M.3
  • 10
    • 77958551737 scopus 로고    scopus 로고
    • Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination
    • de Campos-Nebel M, Larripa I, González-Cid M. 2010. Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination. PLoS ONE 5: e12541.
    • (2010) PLoS ONE , vol.5
    • de Campos-Nebel, M.1    Larripa, I.2    González-Cid, M.3
  • 11
    • 3142761931 scopus 로고    scopus 로고
    • Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugs. Review
    • Degrassi F, Fiore M, Palitti F. 2004. Chromosomal aberrations and genomic instability induced by topoisomerase-targeted antitumour drugs. Review. Curr Med Chem Anticancer Agents 4: 317-325.
    • (2004) Curr Med Chem Anticancer Agents , vol.4 , pp. 317-325
    • Degrassi, F.1    Fiore, M.2    Palitti, F.3
  • 12
    • 0036682122 scopus 로고    scopus 로고
    • An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    • Delacôte F, Han M, Stamato TD, Jasin M, Lopez BS. 2002. An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res 30: 3454-3463.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3454-3463
    • Delacôte, F.1    Han, M.2    Stamato, T.D.3    Jasin, M.4    Lopez, B.S.5
  • 13
    • 38349145553 scopus 로고    scopus 로고
    • Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: The trans-S double-strand break repair model
    • Delacôte F, Lopez BS. 2008. Importance of the cell cycle phase for the choice of the appropriate DSB repair pathway, for genome stability maintenance: The trans-S double-strand break repair model. Cell Cycle 7: 33-38.
    • (2008) Cell Cycle , vol.7 , pp. 33-38
    • Delacôte, F.1    Lopez, B.S.2
  • 15
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 97: 6630-6633.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    DePinho, R.A.6    Alt, F.W.7
  • 16
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice. Review
    • Fortune JM, Osheroff N. 2000. Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice. Review. Prog Nucleic Acid Res Mol Biol 64: 221-253.
    • (2000) Prog Nucleic Acid Res Mol Biol , vol.64 , pp. 221-253
    • Fortune, J.M.1    Osheroff, N.2
  • 17
    • 61849132198 scopus 로고    scopus 로고
    • Single-strand annealing, conservative homologous recombination, nonhomologous DNA end joining, and the cell cycle-dependent repair of DNA double-strand breaks induced by sparsely or densely ionizing radiation
    • Frankenberg-Schwager M, Gebauer A, Koppe C, Wolf H, Pralle E, Frankenberg D. 2009. Single-strand annealing, conservative homologous recombination, nonhomologous DNA end joining, and the cell cycle-dependent repair of DNA double-strand breaks induced by sparsely or densely ionizing radiation. Radiat Res 171: 265-273.
    • (2009) Radiat Res , vol.171 , pp. 265-273
    • Frankenberg-Schwager, M.1    Gebauer, A.2    Koppe, C.3    Wolf, H.4    Pralle, E.5    Frankenberg, D.6
  • 18
    • 0037506012 scopus 로고    scopus 로고
    • Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: A multigenic study on cancer susceptibility
    • Fu YP, Yu JC, Cheng TC, Lou MA, Hsu GC, Wu CY, Chen ST, Wu HS, Wu PE, Shen CY. 2003. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: A multigenic study on cancer susceptibility. Cancer Res 63: 2440-2446.
    • (2003) Cancer Res , vol.63 , pp. 2440-2446
    • Fu, Y.P.1    Yu, J.C.2    Cheng, T.C.3    Lou, M.A.4    Hsu, G.C.5    Wu, C.Y.6    Chen, S.T.7    Wu, H.S.8    Wu, P.E.9    Shen, C.Y.10
  • 19
    • 34249945536 scopus 로고    scopus 로고
    • DNA double-strand break repair: From mechanistic understanding to cancer treatment
    • Helleday T, Lo J, van Gent DC, Engelward BP. 2007. DNA double-strand break repair: From mechanistic understanding to cancer treatment. DNA Repair 6: 923-935.
    • (2007) DNA Repair , vol.6 , pp. 923-935
    • Helleday, T.1    Lo, J.2    van Gent, D.C.3    Engelward, B.P.4
  • 20
    • 0032965702 scopus 로고    scopus 로고
    • Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: Implications for genotoxicity testing
    • Hu T, Miller CM, Ridder GM, Aardema MJ. 1999. Characterization of p53 in Chinese hamster cell lines CHO-K1, CHO-WBL, and CHL: Implications for genotoxicity testing. Mutat Res 426: 51-62.
    • (1999) Mutat Res , vol.426 , pp. 51-62
    • Hu, T.1    Miller, C.M.2    Ridder, G.M.3    Aardema, M.J.4
  • 21
    • 1942534150 scopus 로고    scopus 로고
    • Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin
    • Huang X, Okafuji M, Traganos F, Luther E, Holden E, Darzynkiewicz Z. 2004. Assessment of histone H2AX phosphorylation induced by DNA topoisomerase I and II inhibitors topotecan and mitoxantrone and by the DNA cross-linking agent cisplatin. Cytometry A 58: 99-110.
    • (2004) Cytometry A , vol.58 , pp. 99-110
    • Huang, X.1    Okafuji, M.2    Traganos, F.3    Luther, E.4    Holden, E.5    Darzynkiewicz, Z.6
  • 23
    • 69949173301 scopus 로고    scopus 로고
    • Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence. Review
    • Iliakis G. 2009. Backup pathways of NHEJ in cells of higher eukaryotes: Cell cycle dependence. Review. Radiother Oncol 92: 310-315.
    • (2009) Radiother Oncol , vol.92 , pp. 310-315
    • Iliakis, G.1
  • 24
    • 12944265309 scopus 로고    scopus 로고
    • Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells
    • Jensen LH, Dejligbjerg M, Hansen LT, Grauslund M, Jensen PB, Sehested M. 2004. Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells. BMC Pharmacol 4: 31.
    • (2004) BMC Pharmacol , vol.4 , pp. 31
    • Jensen, L.H.1    Dejligbjerg, M.2    Hansen, L.T.3    Grauslund, M.4    Jensen, P.B.5    Sehested, M.6
  • 25
    • 0031794286 scopus 로고    scopus 로고
    • Molecular mechanisms of DNA double strand break repair. Review
    • Kanaar R, Hoeijmakers JH, van Gent DC. 1998. Molecular mechanisms of DNA double strand break repair. Review. Trends Cell Biol 8: 483-489.
    • (1998) Trends Cell Biol , vol.8 , pp. 483-489
    • Kanaar, R.1    Hoeijmakers, J.H.2    van Gent, D.C.3
  • 26
    • 64549100748 scopus 로고    scopus 로고
    • Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis
    • Kato TA, Okayasu R, Bedford JS. 2009. Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis. J Cell Physiol 219: 760-765.
    • (2009) J Cell Physiol , vol.219 , pp. 760-765
    • Kato, T.A.1    Okayasu, R.2    Bedford, J.S.3
  • 28
    • 34547845825 scopus 로고    scopus 로고
    • The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV
    • Kuhfittig-Kulle S, Feldmann E, Odersky A, Kuliczkowska A, Goedecke W, Eggert A, Pfeiffer P. 2007. The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV. Mutagenesis 22: 217-233.
    • (2007) Mutagenesis , vol.22 , pp. 217-233
    • Kuhfittig-Kulle, S.1    Feldmann, E.2    Odersky, A.3    Kuliczkowska, A.4    Goedecke, W.5    Eggert, A.6    Pfeiffer, P.7
  • 29
    • 0036673956 scopus 로고    scopus 로고
    • Deficiency in BRCA2 leads to increase in non-conservative homologous recombination
    • Larminat F, Germanier M, Papouli E, Defais M. 2002. Deficiency in BRCA2 leads to increase in non-conservative homologous recombination. Oncogene 21: 5188-5192.
    • (2002) Oncogene , vol.21 , pp. 5188-5192
    • Larminat, F.1    Germanier, M.2    Papouli, E.3    Defais, M.4
  • 30
    • 35848954749 scopus 로고    scopus 로고
    • Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer
    • Lee HS, Choe G, Park KU, Park do J, Yang HK, Lee BL, Kim WH. 2007. Altered expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) during gastric carcinogenesis and its clinical implications on gastric cancer. Int J Oncol 31: 859-866.
    • (2007) Int J Oncol , vol.31 , pp. 859-866
    • Lee, H.S.1    Choe, G.2    Park, K.U.3    Park do, J.4    Yang, H.K.5    Lee, B.L.6    Kim, W.H.7
  • 31
    • 0037198145 scopus 로고    scopus 로고
    • DNA-dependent protein kinase complex: A multifunctional protein in DNA repair and damage checkpoint. Review
    • Lee SH, Kim CH. 2002. DNA-dependent protein kinase complex: A multifunctional protein in DNA repair and damage checkpoint. Review. Mol Cells 13: 159-166.
    • (2002) Mol Cells , vol.13 , pp. 159-166
    • Lee, S.H.1    Kim, C.H.2
  • 32
    • 77950630063 scopus 로고    scopus 로고
    • Incidence and susceptibility to therapy-related myeloid neoplasms
    • Leone G, Fianchi L, Pagano L, Voso MT. 2010. Incidence and susceptibility to therapy-related myeloid neoplasms. Chem Biol Interact 184: 39-45.
    • (2010) Chem Biol Interact , vol.184 , pp. 39-45
    • Leone, G.1    Fianchi, L.2    Pagano, L.3    Voso, M.T.4
  • 33
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining. Review
    • Lieber MR. 2008. The mechanism of human nonhomologous DNA end joining. Review. J Biol Chem 283: 1-5.
    • (2008) J Biol Chem , vol.283 , pp. 1-5
    • Lieber, M.R.1
  • 34
    • 51849121635 scopus 로고    scopus 로고
    • DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
    • Mao Z, Bozzella M, Seluanov A, Gorbunova V. 2008. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 7: 2902-2906.
    • (2008) Cell Cycle , vol.7 , pp. 2902-2906
    • Mao, Z.1    Bozzella, M.2    Seluanov, A.3    Gorbunova, V.4
  • 35
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • McClendon AK, Osheroff N. 2007. DNA topoisomerase II, genotoxicity, and cancer. Mutat Res 623: 83-97.
    • (2007) Mutat Res , vol.623 , pp. 83-97
    • McClendon, A.K.1    Osheroff, N.2
  • 36
    • 0031962350 scopus 로고    scopus 로고
    • Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques
    • Mosesso P, Darroudi F, van den Berg M, Vermeulen S, Palitti F, Natarajan AT. 1998. Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. Mutagenesis 13: 39-43.
    • (1998) Mutagenesis , vol.13 , pp. 39-43
    • Mosesso, P.1    Darroudi, F.2    van den Berg, M.3    Vermeulen, S.4    Palitti, F.5    Natarajan, A.T.6
  • 37
    • 49649114192 scopus 로고    scopus 로고
    • The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells
    • Natarajan AT, Berni A, Marimuthu KM, Palitti F. 2008. The type and yield of ionising radiation induced chromosomal aberrations depend on the efficiency of different DSB repair pathways in mammalian cells. Mutat Res 642: 80-85.
    • (2008) Mutat Res , vol.642 , pp. 80-85
    • Natarajan, A.T.1    Berni, A.2    Marimuthu, K.M.3    Palitti, F.4
  • 38
    • 0038393167 scopus 로고    scopus 로고
    • What do human micronuclei contain?
    • Norppa H, Falck GC. 2003. What do human micronuclei contain? Mutagenesis 18: 221-233.
    • (2003) Mutagenesis , vol.18 , pp. 221-233
    • Norppa, H.1    Falck, G.C.2
  • 40
    • 79959709844 scopus 로고    scopus 로고
    • Different DNA-PKcs functions in the repair of radiation-induced and spontaneous DSBs within interstitial telomeric sequences
    • Revaud D, Martins LM, Boussin FD, Sabatier L, Desmaze C. 2011. Different DNA-PKcs functions in the repair of radiation-induced and spontaneous DSBs within interstitial telomeric sequences. Chromosoma 120: 309-319.
    • (2011) Chromosoma , vol.120 , pp. 309-319
    • Revaud, D.1    Martins, L.M.2    Boussin, F.D.3    Sabatier, L.4    Desmaze, C.5
  • 41
    • 50849141104 scopus 로고    scopus 로고
    • Early events in the mammalian response to DNA double-strand breaks. Review
    • Riches LC, Lynch AM, Gooderham NJ. 2008. Early events in the mammalian response to DNA double-strand breaks. Review. Mutagenesis 23: 331-339.
    • (2008) Mutagenesis , vol.23 , pp. 331-339
    • Riches, L.C.1    Lynch, A.M.2    Gooderham, N.J.3
  • 42
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K, Krüger I, Thompson LH, Löbrich M. 2003. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 23: 5706-5715.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Krüger, I.2    Thompson, L.H.3    Löbrich, M.4
  • 43
    • 34247497770 scopus 로고    scopus 로고
    • XRCC4 in G1 suppresses homologous recombination in S/G2, in G1 checkpoint-defective cells
    • Saintigny Y, Delacôte F, Boucher D, Averbeck D, Lopez BS. 2007. XRCC4 in G1 suppresses homologous recombination in S/G2, in G1 checkpoint-defective cells. Oncogene 26: 2769-2780.
    • (2007) Oncogene , vol.26 , pp. 2769-2780
    • Saintigny, Y.1    Delacôte, F.2    Boucher, D.3    Averbeck, D.4    Lopez, B.S.5
  • 44
    • 3142768860 scopus 로고    scopus 로고
    • Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells
    • Saleh-Gohari N, Helleday T. 2004. Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells. Nucleic Acids Res 32: 3683-3688.
    • (2004) Nucleic Acids Res , vol.32 , pp. 3683-3688
    • Saleh-Gohari, N.1    Helleday, T.2
  • 45
    • 0031879187 scopus 로고    scopus 로고
    • Increased expression of DNA-dependent protein kinase confers resistance to adriamycin
    • Shen H, Schultz M, Kruh GD, Tew KD. 1998. Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochim Biophys Acta 1381: 131-138.
    • (1998) Biochim Biophys Acta , vol.1381 , pp. 131-138
    • Shen, H.1    Schultz, M.2    Kruh, G.D.3    Tew, K.D.4
  • 46
    • 42649130001 scopus 로고    scopus 로고
    • Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone
    • Smart DJ, Halicka HD, Schmuck G, Traganos F, Darzynkiewicz Z, Williams GM. 2008. Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone. Mutat Res 641: 43-47.
    • (2008) Mutat Res , vol.641 , pp. 43-47
    • Smart, D.J.1    Halicka, H.D.2    Schmuck, G.3    Traganos, F.4    Darzynkiewicz, Z.5    Williams, G.M.6
  • 47
    • 38449107978 scopus 로고    scopus 로고
    • Breast cancer risk among male BRCA1 and BRCA2 mutation carriers
    • Tai YC, Domchek S, Parmigiani G, Chen S. 2007. Breast cancer risk among male BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 99: 1811-1814.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1811-1814
    • Tai, Y.C.1    Domchek, S.2    Parmigiani, G.3    Chen, S.4
  • 48
    • 73249137148 scopus 로고    scopus 로고
    • Dependence of DNA double strand break repair pathways on cell cycle phase in human lymphoblastoid cells
    • Takashima Y, Sakuraba M, Koizumi T, Sakamoto H, Hayashi M, Honma M. 2009. Dependence of DNA double strand break repair pathways on cell cycle phase in human lymphoblastoid cells. Environ Mol Mutagen 50: 815-822.
    • (2009) Environ Mol Mutagen , vol.50 , pp. 815-822
    • Takashima, Y.1    Sakuraba, M.2    Koizumi, T.3    Sakamoto, H.4    Hayashi, M.5    Honma, M.6
  • 49
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S. 1998. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. EMBO J 17: 5497-5508.
    • (1998) EMBO J , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 50
    • 34547617889 scopus 로고    scopus 로고
    • BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II
    • Treszezamsky AD, Kachnic LA, Feng Z, Zhang J, Tokadjian C, Powell SN. 2007. BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II. Cancer Res 67: 7078-7081.
    • (2007) Cancer Res , vol.67 , pp. 7078-7081
    • Treszezamsky, A.D.1    Kachnic, L.A.2    Feng, Z.3    Zhang, J.4    Tokadjian, C.5    Powell, S.N.6
  • 51
    • 27144456829 scopus 로고    scopus 로고
    • Genetic predisposition to cancer
    • Turnbull C, Hodgson S. 2005. Genetic predisposition to cancer. Clin Med 5: 491-498.
    • (2005) Clin Med , vol.5 , pp. 491-498
    • Turnbull, C.1    Hodgson, S.2
  • 52
    • 0035136283 scopus 로고    scopus 로고
    • Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2
    • Wang H, Zeng ZC, Bui TA, DiBiase SJ, Qin W, Xia F, Powell SN, Iliakis G. 2001. Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2. Cancer Res 61: 270-277.
    • (2001) Cancer Res , vol.61 , pp. 270-277
    • Wang, H.1    Zeng, Z.C.2    Bui, T.A.3    DiBiase, S.J.4    Qin, W.5    Xia, F.6    Powell, S.N.7    Iliakis, G.8
  • 53
    • 33846705754 scopus 로고    scopus 로고
    • Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells
    • Wang L, Roy SK, Eastmond DA. 2007. Differential cell cycle-specificity for chromosomal damage induced by merbarone and etoposide in V79 cells. Mutat Res 616: 70-82.
    • (2007) Mutat Res , vol.616 , pp. 70-82
    • Wang, L.1    Roy, S.K.2    Eastmond, D.A.3
  • 54
    • 77953322110 scopus 로고    scopus 로고
    • Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cells
    • Wilson PF, Hinz JM, Urbin SS, Nham PB, Thompson LH. 2010. Influence of homologous recombinational repair on cell survival and chromosomal aberration induction during the cell cycle in gamma-irradiated CHO cells. DNA Repair 9: 737-744.
    • (2010) DNA Repair , vol.9 , pp. 737-744
    • Wilson, P.F.1    Hinz, J.M.2    Urbin, S.S.3    Nham, P.B.4    Thompson, L.H.5
  • 55
    • 37549006429 scopus 로고    scopus 로고
    • Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2
    • Wu W, Wang M, Wu W, Singh SK, Mussfeldt T, Iliakis G. 2008. Repair of radiation induced DNA double strand breaks by backup NHEJ is enhanced in G2. DNA Repair 7: 329-338.
    • (2008) DNA Repair , vol.7 , pp. 329-338
    • Wu, W.1    Wang, M.2    Wu, W.3    Singh, S.K.4    Mussfeldt, T.5    Iliakis, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.