Accelerated in vivo thrombin formation independently predicts the presence and severity of CT angiographic coronary atherosclerosis

JACC: Cardiovascular Imaging

Volumn 5, Issue 12, 2012, Pages 1201-1210

  Borissoff, Julian I ^a   Joosen, Ivo A ^a   Versteylen, Mathijs O ^a   Spronk, Henri M ^a   Ten Cate, Hugo ^a   Hofstra, Leonard ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Cardiology Center Netherlands   (Netherlands)

Author keywords

atherosclerosis; atherothrombosis; coagulation; coronary computed tomography; imaging; thrombin

Indexed keywords

BIOLOGICAL MARKER; THROMBIN; THROMBIN ANTITHROMBIN COMPLEX;

ADULT; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; BLOOD CLOTTING; BLOOD LEVEL; CARDIOVASCULAR RISK; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY CALCIFICATION; DISEASE SEVERITY; FEMALE; HUMAN; IN VIVO STUDY; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; RISK ASSESSMENT; THORAX PAIN;

ADULT; AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; THROMBIN; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84867361758     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2012.01.023     Document Type: Article

References (47)

1. R. Ross Atherosclerosis: an inflammatory disease N Engl J Med 340 1999 115 126
2. D.R. Holmes Jr., D.J. Kereiakes, N.S. Kleiman, D.J. Moliterno, G. Patti, C.L. Grines Combining antiplatelet and anticoagulant therapies J Am Coll Cardiol 54 2009 95 109
3. J.I. Borissoff, H.M. Spronk, H. ten Cate The hemostatic system as a modulator of atherosclerosis N Engl J Med 364 2011 1746 1760
4. J.I. Borissoff, H.M. Spronk, S. Heeneman, H. ten Cate Is thrombin a key player in the 'coagulation-atherogenesis' maze? Cardiovasc Res 82 2009 392 403
5. J.I. Borissoff, S. Heeneman, E. Kilinc Early atherosclerosis exhibits an enhanced procoagulant state Circulation 122 2010 821 830
6. N.A. Nelken, S.J. Soifer, J. O'Keefe, T.K. Vu, I.F. Charo, S.R. Coughlin Thrombin receptor expression in normal and atherosclerotic human arteries J Clin Invest 90 1992 1614 1621
7. F. Bea, J. Kreuzer, M. Preusch Melagatran reduces advanced atherosclerotic lesion size and may promote plaque stability in apolipoprotein E-deficient mice Arterioscler Thromb Vasc Biol 26 2006 2787 2792
8. J.I. Borissoff, S.T. Loubele, P. Leenders Direct thrombin inhibition by dabigatran protects against severe atherosclerosis progression in prothrombotic mice Circulation 122 2010 A19384
9. M.J. Budoff, D. Dowe, J.G. Jollis Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography) trial J Am Coll Cardiol 52 2008 1724 1732
10. S. Voros, S. Rinehart, Z. Qian Coronary atherosclerosis imaging by coronary CT angiography: current status, correlation with intravascular interrogation and meta-analysis J Am Coll Cardiol Img 4 2011 537 548
11. R.B. D'Agostino Sr., R.S. Vasan, M.J. Pencina General cardiovascular risk profile for use in primary care: the Framingham Heart Study Circulation 117 2008 743 753
12. A.S. Agatston, W.R. Janowitz, F.J. Hildner, N.R. Zusmer, M. Viamonte Jr., R. Detrano Quantification of coronary artery calcium using ultrafast computed tomography J Am Coll Cardiol 15 1990 827 832
13. J. Hausleiter, T. Meyer, M. Hadamitzky Radiation dose estimates from cardiac multislice computed tomography in daily practice: impact of different scanning protocols on effective dose estimates Circulation 113 2006 1305 1310
14. E.M. Laufer, A.M. Mingels, M.H. Winkens The extent of coronary atherosclerosis is associated with increasing circulating levels of high sensitive cardiac troponin T Arteriosclerosis, thrombosis, and vascular biology 30 2010 1269 1275
15. W.G. Austen, J.E. Edwards, R.L. Frye A reporting system on patients evaluated for coronary artery disease Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association Circulation 51 1975 5 40
16. G.L. Raff, A. Abidov, S. Achenbach SCCT guidelines for the interpretation and reporting of coronary computed tomographic angiography J Cardiovasc Comput Tomogr 3 2009 122 136
17. M.J. Pletcher, J.A. Tice, M. Pignone, W.S. Browner Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis Arch Intern Med 164 2004 1285 1292
18. A.W. Dielis, E. Castoldi, H.M. Spronk Coagulation factors and the protein C system as determinants of thrombin generation in a normal population J Thromb Haemost 6 2008 125 131
19. M. Smid, A.W. Dielis, M. Winkens Thrombin generation in patients with a first acute myocardial infarction J Thromb Haemost 9 2011 450 456
20. H.M. Spronk, A.W. Dielis, E. De Smedt Assessment of thrombin generation II: Validation of the Calibrated Automated Thrombogram in platelet-poor plasma in a clinical laboratory Thromb Haemost 100 2008 362 364
21. B. Furie, B.C. Furie Mechanisms of thrombus formation N Engl J Med 359 2008 938 949
22. J. Danesh, S. Lewington, S.G. Thompson Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis JAMA 294 2005 1799 1809
23. M.R. Di Tullio, S. Homma, Z. Jin, R.L. Sacco Aortic atherosclerosis, hypercoagulability, and stroke the APRIS (Aortic Plaque and Risk of Ischemic Stroke) study J Am Coll Cardiol 52 2008 855 861
24. L. Henareh, T. Jogestrand, S. Agewall Prothrombin fragment 1 + 2 is associated with intima media thickness of the carotid artery in patients with myocardial infarction Thromb Res 124 2009 526 530
25. A. Undas, K. Szuldrzynski, K.E. Brummel-Ziedins, W. Tracz, K. Zmudka, K.G. Mann Systemic blood coagulation activation in acute coronary syndromes Blood 113 2009 2070 2078
26. J.G. van der Bom, M.L. Bots, H.H. van Vliet, H.A. Pols, A. Hofman, D.E. Grobbee Antithrombin and atherosclerosis in the Rotterdam Study Arteriosclerosis, thrombosis, and vascular biology 16 1996 864 867
27. M.M. McDermott, D. Green, P. Greenland Relation of levels of hemostatic factors and inflammatory markers to the ankle brachial index Am J Cardiol 92 2003 194 199
28. I. Tzoulaki, G.D. Murray, J.F. Price Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis: the Edinburgh Artery Study Am J Epidemiol 163 2006 334 341
29. J.A. Paramo, J. Orbe, O. Beloqui Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease Stroke 35 2004 1085 1089
30. H. Bernhard, P. Wipfler, B. Leschnik Relationship between thrombin generation and carotid intima-media thickness Hamostaseologie 30 Suppl 1 2010 S168 S171
31. S.Z. Rittersma, A.C. van der Wal, K.T. Koch Plaque instability frequently occurs days or weeks before occlusive coronary thrombosis: a pathological thrombectomy study in primary percutaneous coronary intervention Circulation 111 2005 1160 1165
32. M.C. Kramer, S.Z. Rittersma, R.J. de Winter Relationship of thrombus healing to underlying plaque morphology in sudden coronary death J Am Coll Cardiol 55 2010 122 132
33. J. Mann, M.J. Davies Mechanisms of progression in native coronary artery disease: role of healed plaque disruption Heart 82 1999 265 268
34. A.P. Burke, F.D. Kolodgie, A. Farb Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression Circulation 103 2001 934 940
35. A.V. Finn, M. Nakano, J. Narula, F.D. Kolodgie, R. Virmani Concept of vulnerable/unstable plaque Arterioscler Thromb Vasc Biol 30 2010 1282 1292
36. J.L. Degen, T.H. Bugge, J.D. Goguen Fibrin and fibrinolysis in infection and host defense J Thromb Haemost 5 Suppl 1 2007 24 31
37. S. Schulman, C. Kearon, A.K. Kakkar Dabigatran versus warfarin in the treatment of acute venous thromboembolism N Engl J Med 361 2009 2342 2352
38. S.J. Connolly, M.D. Ezekowitz, S. Yusuf Dabigatran versus warfarin in patients with atrial fibrillation N Engl J Med 361 2009 1139 1151
39. A. Naldini, C. Bernini, A. Pucci, F. Carraro Thrombin-mediated IL-10 up-regulation involves protease-activated receptor (PAR)-1 expression in human mononuclear leukocytes J Leukoc Biol 78 2005 736 744
40. J.S. Bae, Y.U. Kim, M.K. Park, A.R. Rezaie Concentration dependent dual effect of thrombin in endothelial cells via Par-1 and Pi3 Kinase J Cell Physiol 219 2009 744 751
41. J.S. Bae, A.R. Rezaie Thrombin inhibits nuclear factor kappaB and RhoA pathways in cytokine-stimulated vascular endothelial cells when EPCR is occupied by protein C Thromb Haemost 101 2009 513 520
42. L. Wang, M. Jerosch-Herold, D.R. Jacobs Jr., E. Shahar, R. Detrano, A.R. Folsom Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis) J Am Coll Cardiol 48 2006 1018 1026
43. J.C. Sluimer, J.M. Gasc, J.L. van Wanroij Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis J Am Coll Cardiol 51 2008 1258 1265
44. J.C. Sluimer, M.J. Daemen Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis J Pathol 218 2009 7 29
45. J.W. McEvoy, M.J. Blaha, A.P. Defilippis Coronary artery calcium progression: an important clinical measurement? A review of published reports J Am Coll Cardiol 56 2010 1613 1622
46. N. Alexopoulos, P. Raggi Calcification in atherosclerosis Nat Rev Cardiol 6 2009 681 688
47. J. Breyne, F. Juthier, D. Corseaux Atherosclerotic-like process in aortic stenosis: activation of the tissue factor-thrombin pathway and potential role through osteopontin alteration Atherosclerosis 213 2010 369 376