Aortic Atherosclerosis, Hypercoagulability, and Stroke. The APRIS (Aortic Plaque and Risk of Ischemic Stroke) Study

Journal of the American College of Cardiology

Volumn 52, Issue 10, 2008, Pages 855-861

  Di Tullio, Marco R ^a   Homma, Shunichi ^a   Jin, Zhezhen ^a   Sacco, Ralph L ^b  

^a NewYork Presbyterian Hospital   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

aorta; atherosclerosis; coagulation; stroke

Indexed keywords

PROTHROMBIN; PROTHROMBIN FRAGMENT F 1.2; THROMBIN; UNCLASSIFIED DRUG;

ADULT; AGED; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROSCLEROTIC PLAQUE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DEATH; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; HYPERCOAGULABILITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECURRENCE RISK; RECURRENT DISEASE; RISK FACTOR; STROKE; THROMBUS; TRANSESOPHAGEAL ECHOCARDIOGRAPHY;

AGED; AORTIC VALVE STENOSIS; CASE-CONTROL STUDIES; CONFIDENCE INTERVALS; ECHOCARDIOGRAPHY, TRANSESOPHAGEAL; FEMALE; HUMANS; MALE; ODDS RATIO; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; STROKE; THROMBOPHILIA;

EID: 49849089139     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2008.04.062     Document Type: Article

References (29)

1. Amarenco P., Duyckaerts C., Tzourio C., Henin D., Bousser M.G., and Hauw J.J. The frequency of ulcerated plaques in the aortic arch in patients with stroke. N Engl J Med 326 (1992) 221-225
2. Amarenco P., Cohen A., Tzourio C., et al. Atherosclerotic disease of the aortic arch and the risk of ischemic stroke. N Eng J Med 331 (1994) 1474-1479
3. Jones E.F., Kalman J.M., Calafiore P., Tonkin A.M., and Donnan G.A. Proximal aortic atheroma: an independent risk factor for cerebral ischemia. Stroke 26 (1995) 218-224
4. Di Tullio M.R., Sacco R.L., Gersony D., et al. Aortic atheromas and acute ischemic stroke: a transesophageal echocardiographic study in an ethnically mixed population. Neurology 46 (1996) 1560-1566
5. Tunick P.A., Rosenzweig B.P., Katz E.S., Freedberg R.S., Peres J.L., and Kronzon I. High risk for vascular events in patients with protruding aortic atheromas: a prospective study. J Am Coll Cardiol 23 (1994) 1085-1090
6. The French Study of Aortic Plaques in Stroke Group. Atherosclerotic disease of the aortic arch as a risk factor for recurrent ischemic stroke. N Engl J Med 334 (1996) 1216-1221
7. Cohen A., Tzourio C., Bertrand B., Chauvel C., Bousser M.G., and Amaranco P. Aortic plaque morphology and vascular events-a follow-up study in patients with ischemic stroke. Circulation 96 (1997) 3838-3841
8. Kronzon I., and Tunick P.A. Aortic atherosclerotic disease and stroke. Circulation 114 (2006) 63-75
9. Stone D.A., Hawke M.W., LaMonte M., et al. Ulcerated atherosclerotic plaques in the thoracic aorta are associated with cryptogenic stroke: a multiplane transesophageal echocardiographic study. Am Heart J 130 (1995) 105-108
10. Agmon Y., Khandheria B.K., Meissner I., et al. Relation of coronary artery disease and cerebrovascular disease with atherosclerosis of the thoracic aorta in the general population. Am J Cardiol 89 (2002) 262-267
11. Di Tullio M.R., Sacco R.L., Savoia M.T., Sciacca R.R., and Homma S. Aortic atheroma morphology and the risk of ischemic stroke in a multiethnic population. Am Heart J 139 (2000) 329-336
12. Dressler F.A., Craig W.R., Castello R., and Labovitz A.J. Mobile aortic atheroma and systemic emboli: efficacy of anticoagulation and influence of plaque morphology on recurrent stroke. J Am Coll Cardiol 31 (1998) 134-138
13. The Stroke Prevention in Atrial Fibrillation Investigators Committee on Echocardiography. Transesophageal echocardiographic correlates of thromboembolism in high-risk patients with nonvalvular atrial fibrillation. Ann Intern Med 128 (1998) 639-647
14. Adams Jr. H.P., Bendixen B.H., Kappelle L.J., et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24 (1993) 35-41
15. Di Tullio M.R., Sacco R.L., and Homma S. Ultrasound examination of the aortic arch in stroke. In: Primer on Cerebrovascular Diseases (1996), Academic Press, New York, NY 628-634
16. Rundek T., Di Tullio M.R., Sciacca R.R., et al. Association between large aortic arch atheromas and high-intensity transient signals in elderly stroke patients. Stroke 30 (1999) 2683-2686
17. Tunick P.A., Culliford A.T., Lamparello P.J., and Kronzon I. Atheromatosis of the aortic arch as an occult source of multiple systemic emboli. Ann Intern Med 114 (1991) 391-392
18. Tunick P.A., Lackner H., Katz E.S., Culliford A.T., Giangola G., and Kronzon I. Multiple emboli due to a large aortic arch thrombus in a patient with thrombotic diathesis. Am Heart J 124 (1992) 239-241
19. Vaduganathan P., Ewton A., Nagueh S.F., Weilbaecher D.G., Safi H.J., and Zoghbi W.A. Pathologic correlates of aortic plaques, thrombi and mobile "aortic debris" imaged in vivo with transesophageal echocardiography. J Am Coll Cardiol 30 (1997) 357-363
20. Khatibzadeh M., Mitusch R., Stierle U., Gromoll B., and Sheikhzadeh A. Aortic atherosclerotic plaque as a source of systemic embolism. J Am Coll Cardiol 27 (1996) 664-669
21. Sen S., Hinderliter A., Sen P.K., et al. Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attacks. Circulation 116 (2007) 928-935
22. Coppola A., Davi G., De Stefano V., Mancini F.P., Cerbone A.M., and Di Minno G. Homocysteine, coagulation, platelet function, and thrombosis. Semin Thromb Hemost 26 (2000) 243-254
23. Di Tullio M., Sacco R.L., Santoni-Rugiu F., et al. Increased frequency of lupus anticoagulant in stroke patients with aortic arch atheromas (abstr). Neurology 45 (1995) 409S
24. Triboulloy C., Peltier M., Colas L., et al. Fibrinogen is an independent marker for thoracic atherosclerosis. Am J Cardiol 81 (1998) 321-326
25. Bauer K.A. Laboratory markers of coagulation activation. Arch Pathol Lab Med 117 (1993) 71-77
26. Kargman D.E., Hurlet-Jensen A., Gu Q., and Sacco R.L. Prothrombin fragment F 1+2: a risk factor for ischemic stroke. Ann Neurol 38 (1995) 320-321
27. Berge E., Fris P., and Sandset P.M. Hemostatic activation in acute ischemic stroke. Thromb Res 101 (2002) 13-21
28. Sacco R.L., Adams R., Albers G., et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke, co-sponsored by the Council on Cardiovascular Radiology and Intervention. Circulation 113 (2006) e409-e449
29. Ferrari E., Vidal R., Chevallier T., and Baudouy M. Atherosclerosis of the thoracic aorta and aortic debris as a marker of poor prognosis: benefit of oral anticoagulants. J Am Coll Cardiol 33 (1999) 1317-1322