Prothrombin fragment 1+2 is associated with carotid intima-media thickness in subjects free of clinical cardiovascular disease

Stroke

Volumn 35, Issue 5, 2004, Pages 1085-1089

  Paramo J A ^a,b   Orbe, J ^a   Beloqui, O ^a   Benito, A ^a   Colina, I ^a   Martinez Vila, E ^a   Diez, J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b University Clinic   (Spain)

Author keywords

Atherosclerosis; Carotid arteries; Intima media thickness; Prothrombin; Thrombin

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTHROMBIN; THROMBIN;

ADULT; AGE DISTRIBUTION; AGED; ARTERY INTIMA PROLIFERATION; ARTICLE; ASSOCIATION; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEALTH STATUS; HUMAN; IN VIVO CULTURE; INTIMA; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; MULTIVARIATE ANALYSIS; PATHOGENESIS; PLASMA; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; THROMBIN TIME;

ARTERIOSCLEROSIS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROTHROMBIN; REGRESSION ANALYSIS; RISK FACTORS; TUNICA INTIMA; ULTRASONOGRAPHY, DOPPLER, DUPLEX;

EID: 2142718287     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000124927.38723.f2     Document Type: Article

References (37)

1. Folsom AR. Hemostatic risk factors for atherothrombotic disease: an epidemiologic view. Thromb Haemost. 2001;86:366-373.
2. Small M, Lowe GD, Douglas JT, Hutton I, Lorimer AR, Forbes CD. Thrombin and plasmin activity in coronary artery disease. Br Heart J. 1988;60:201-203.
3. Meade TW, Mellows S, Miller GJ, Chakrabarti RR, North WR, Haines HP, Stirling Y, Imeson JD, Thompson SG. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet. 1986;2:533-538.
4. Folsom A, Wu K, Rosamond W, Sharrett A, Chambless L. Prospective study of hemostatic factors and incidence of coronary heart disease: the Atherosclerotic Risk in Communities (ARIC) study. Circulation. 1997; 96:1102-1108.
5. Tracy RP, Arnold AM, Ettinger W, Fried C, Meilahn E, Savage P. The relationship of fibrinogen and factors VII and VIII to incident cardiovascular disease and death in the elderly. Results from the Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 1999;19:1776-1783.
6. Conway DSG, Heeringa J, Van der Kuip DAM, Chin BSP, Hofman A, Witteman JCM, Lip GYH. Atrial fibrillation and the prothrombotic state in the elderly. The Rotterdam Study. Stroke. 2003;34:413-417.
7. Bauer KA, Broekmans AW, Bertina RM, Conard J, Horellou MH, Samama MM, Rosenberg RD. Hemostatic enzyme generation in the blood of patients with hereditary protein C deficiency. Blood. 1988;71: 1418-1426.
8. Van der Poll T, Buller HR, ten Cate H, Worterl CH, Bauer KA, van Deventer SJ, Hack CE, Sauwervein HP, Rosenberg RD, ten Cate JW. Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med. 1990;322:1622-1627.
9. Kienast J, Thompson SG, Raskino C, Pelzer H, Fechtrup C, Osterman H, van de Loo J. Prothrombin activation fragment 1+2 and thrombin antithrombin complexes in patients with angina pectoris. Relation to the presence and severity of coronary atherosclerosis. Thromb Haemost. 1993;70:550-553.
10. Cushman M, Psaty BM, Macy E, Bovill EG, Cornell ES, Kuller LH, Tracy RP. Correlates of thrombin markers in an elderly cohort free of clinical cardiovascular disease. Arterioscler Thromb Vasc Biol. 1996;16: 1163-1169.
11. Musial J, Pajal A, Undas A, Kavalec E, Topoi-Madry R, Pazucha T, Grzywacz M, Szczeklik A. Thrombin generation markers and coronary heart disease risk factors in a Polish population sample. Thromb Haemost. 1997;77:697-700.
12. Feinberg WM, Pearce LA, Hart RG, Cushman M, Cornell ES, Lip GY, Bovill EG. Markers of thrombin and platelet activity in patients with atrial fibrillation: correlation with stroke among 1531 participants in the stroke prevention in atrial fibrillation III study. Stroke. 1999;30:2547-2553.
13. Rifon J, Páramo JA, Prósper F, Collados MT, Sarrá J, Rocha E. Thrombin-antithrombin complexes and prothrombin fragment 1+2 in aorto-coronary bypass surgery. Relation to graft occlusion. Hematol Pathol. 1994;8:35-42.
14. Lowe GD, Rumley A, Sweetnam PM, Yarnell JW, Rumley J. Fibrin D-dimer, markers of coagulation activation and the risk of major ischemic heart disease in the Caerphilly study. Thromb Haemost. 2001;86: 822-827.
15. Bots ML, Hoes AW, Kondstaal PJ, Hofman A, Grobbe DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam study. Circulation. 1997;96:1432-1437.
16. Chambless LE, Folsom AR, Clegg LX, Sharrett AR, Shahar E, Nieto FJ, Rosamond WD, Evans G. Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol. 2000;151:478-487.
17. Longstreth WT Jr., Shemanski L, Lefkowitz D, O'Leary DH, Polak JF, Wolfson SK Jr. Asymptomatic internal carotid artery stenosis defined by ultrasound and the risk of subsequent stroke in the elderly. The Cardiovascular Health Study. Stroke. 1998;29:2371-2376.
18. Celermajer DS. Noninvasive detection of atherosclerosis. N Engl J Med. 1998;339:2014-2015.
19. Davis PH, Dawson JD, Riley WA, Lauer RM. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age. The Muscatine Study. Circulation. 2001; 104:2815-2820.
20. Gerhlick A. Are there markers of the blood-vessel all interaction and of thrombus formation that can be used clinically? Circulation. 1990;81: 128-134.
21. Pelzer H, Schwarz A, Stüber W. Determination of human prothrombin activation fragment 1+2 in plasma with an antibody against a synthetic peptide. Thromb Haemost. 1991;65:153-159.
22. Martínez-Vila E, Páramo JA, Beloqui O, Irimia P, Colina I, Monreal I, Benito A, Barba J, Zubieta JL, Diez J. Independent association of fibrinogen with carotid intima-media thickness in asymptomatic subjects. Cerebrovasc Dis. 2003;16:356-362.
23. López Y, Paloma MJ, Rifón J, Cuesta B, Páramo JA. Measurement of prethrombotic markers in the assessment of hypercoagulable states. Thromb Res. 1999;93:71-78.
24. Lopez Y, Páramo JA. Endothelial cell and hemostatic activation in relation to cytokines in patients with sepsis. Thromb Res. 1999;94: 95-101.
25. Giannitsis E, Siemens HJ, Mitush R, Tetterborn I, Wiegand U, Schmücker G, Sheikhzadeh A, Stierle U. Prothrombin fragments F1+2, thrombin-antithrombin complexes, fibrin monomers and fibrinogen in patients with coronary atherosclerosis. Int J Cardiol. 1999;68:269-274.
26. De Buyzere M, Philippe J, Duprez D, Baele G, Clement DL. Coagulation system activation and increase of D-dimer level in peripheral arterial occlusive disease. Am J Hematol. 1993;43:91-94.
27. Agewall S, Wikstrand J, Suurkula M, Tengborn L, Fagerberg B. Carotid artery wall morphology, haemostatic factors and cardiovascular disease. An ultrasound study in men at high and low risk for atherosclerotic disease. Blood Coagul Fibrinolysis. 1994;5:895-904.
28. Salonen JT, Salonen R. Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb. 1991;11:1245-1249.
29. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14-22.
30. Chambless LE, Folsom AR, Davis V, Sharrett R, Heiss G, Sorlie P, Szklo M, Howard G, Evans GW. Risk factors for progression of common carotid atherosclerosis: the Atherosclerosis Risk in Communities Study, 1987-1998. Am J Epidemiol. 2002;155:38-47.
31. Metcalf PA, Folsom AR, Davis CE, Wu KK, Heiss G. Haemostasis and carotid artery wall thickness in non-insulin dependent diabetes mellitus. Diabetes Res Clin Pract. 2000;47:25-35.
32. Cortellaro M, Badasarre D, Cofrancesco E, Tremoly E, Colombo A, Boschetti C, Paoletti R. Relation between hemostatic variables and increase of common carotid intima-media thickness in patients with peripheral arterial disease. Stroke. 1996;27:450-454.
33. Schmitz-Huebner U, Thompson SG, Balleisen L, Fechtrup C, Grosse-Heitmeyer W, Kirchhof B, Most E, Muller US, Seiffert C, Seiffert D. Lack of association between hemostatic variables and the presence or the extent of coronary atherosclerosis. Br Heart J. 1988;59:287-291.
34. Görög P, Ridler CD, Rees GM, Kovacs JB. Evidence against hypercoagulability in coronary artery disease. Thromb Res. 1995;79:377-385.
35. Millenson MM, Bauer KA, Kistler JP, Barzegar S, Tlin L, Rosenberg RD. Monitoring "mini-intensity" anticoagulation with warfarin: comparison of the prothrombin time using a sensitive thromboplastin with prothrombin fragment 1+2. Blood. 1992;79:2034-2038.
36. Byington RP, Evans GW, Espeland MA, Applegate WB, Hunninghak DB, Probstfield J, Furberg CD. Effects of lovastatin and warfarin on early carotid atherosclerosis: sex-specific analysis. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group. Circulation. 1999; 100:e14-e17.
37. Tracy RP. Thrombin, inflammation and cardiovascular disease. An epidemiologic perspective. Chest. 2003;124:49S-57S.