메뉴 건너뛰기




Volumn 6, Issue , 2012, Pages

Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease

Author keywords

Gene regulatory network; Inflammation; Neurodegeneration; Perturbation; Prion disease; Stable states

Indexed keywords

ANIMAL; ARTICLE; CELL DEATH; DISEASE COURSE; GENE REGULATORY NETWORK; GENETICS; INFLAMMATION; MOUSE; NERVE CELL; PATHOLOGY; PRION DISEASE; SYSTEMS BIOLOGY;

EID: 84867352718     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-6-132     Document Type: Article
Times cited : (38)

References (56)
  • 2
    • 0037264120 scopus 로고    scopus 로고
    • Unfolding the role of protein misfolding in neurodegenerative diseases
    • 10.1038/nrn1007, 12511861
    • Soto C. Unfolding the role of protein misfolding in neurodegenerative diseases. Nat Rev Neurosci 2003, 4:49-60. 10.1038/nrn1007, 12511861.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 49-60
    • Soto, C.1
  • 3
    • 78650994378 scopus 로고    scopus 로고
    • The intricate mechanisms of neurodegeneration in prion diseases
    • Soto C, Satani N. The intricate mechanisms of neurodegeneration in prion diseases. Trends in molecular medicine 2010, 17:14-24.
    • (2010) Trends in molecular medicine , vol.17 , pp. 14-24
    • Soto, C.1    Satani, N.2
  • 5
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: too much or too little?
    • 10.1016/j.neuron.2009.08.039, 2834890, 19840553
    • Lucin KM, Wyss-Coray T. Immune activation in brain aging and neurodegeneration: too much or too little?. Neuron 2009, 64:110-122. 10.1016/j.neuron.2009.08.039, 2834890, 19840553.
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 6
    • 73949090103 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative diseases
    • 10.1111/j.1365-2567.2009.03225.x, 2814458, 20561356
    • Amor S, Puentes F, Baker D, van der Valk P. Inflammation in neurodegenerative diseases. Immunology 2010, 129:154-169. 10.1111/j.1365-2567.2009.03225.x, 2814458, 20561356.
    • (2010) Immunology , vol.129 , pp. 154-169
    • Amor, S.1    Puentes, F.2    Baker, D.3    van der Valk, P.4
  • 7
    • 78649434414 scopus 로고    scopus 로고
    • Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation
    • 10.1002/glia.21070, 3498730, 20878768
    • Hughes MM, Field RH, Perry VH, Murray CL, Cunningham C. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia 2010, 58:2017-2030. 10.1002/glia.21070, 3498730, 20878768.
    • (2010) Glia , vol.58 , pp. 2017-2030
    • Hughes, M.M.1    Field, R.H.2    Perry, V.H.3    Murray, C.L.4    Cunningham, C.5
  • 8
    • 0035098569 scopus 로고    scopus 로고
    • Microglia and the pathogenesis of spongiform encephalopathies
    • 10.1016/S0165-0173(01)00042-X, 11245886
    • Rezaie P, Lantos PL. Microglia and the pathogenesis of spongiform encephalopathies. Brain Res Brain Res Rev 2001, 35:55-72. 10.1016/S0165-0173(01)00042-X, 11245886.
    • (2001) Brain Res Brain Res Rev , vol.35 , pp. 55-72
    • Rezaie, P.1    Lantos, P.L.2
  • 10
    • 0031127379 scopus 로고    scopus 로고
    • PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie
    • 10.1006/exnr.1997.6424, 9168844
    • Williams A, Lucassen PJ, Ritchie D, Bruce M. PrP deposition, microglial activation, and neuronal apoptosis in murine scrapie. Exp Neurol 1997, 144:433-438. 10.1006/exnr.1997.6424, 9168844.
    • (1997) Exp Neurol , vol.144 , pp. 433-438
    • Williams, A.1    Lucassen, P.J.2    Ritchie, D.3    Bruce, M.4
  • 11
    • 84859720222 scopus 로고    scopus 로고
    • A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition
    • 10.1371/journal.pone.0035440, 3325969, 22514743
    • Moes M, Le Bechec A, Crespo I, Laurini C, Halavatyi A, et al. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLoS One 2012, 7:e35440. 10.1371/journal.pone.0035440, 3325969, 22514743.
    • (2012) PLoS One , vol.7
    • Moes, M.1    Le Bechec, A.2    Crespo, I.3    Laurini, C.4    Halavatyi, A.5
  • 12
    • 78049263544 scopus 로고    scopus 로고
    • Large-scale analysis of network bistability for human cancers
    • 10.1371/journal.pcbi.1000851, 2900289, 20628618
    • Shiraishi T, Matsuyama S, Kitano H. Large-scale analysis of network bistability for human cancers. PLoS Comput Biol 2010, 6:e1000851. 10.1371/journal.pcbi.1000851, 2900289, 20628618.
    • (2010) PLoS Comput Biol , vol.6
    • Shiraishi, T.1    Matsuyama, S.2    Kitano, H.3
  • 13
    • 84865285586 scopus 로고    scopus 로고
    • Topological effects of data incompleteness of gene regulatory networks
    • 10.1186/1752-0509-6-110, 3543246, 22920968
    • Sanz J, Cozzo E, Borge-Holthoefer J, Moreno Y. Topological effects of data incompleteness of gene regulatory networks. BMC Syst Biol 2012, 6:110. 10.1186/1752-0509-6-110, 3543246, 22920968.
    • (2012) BMC Syst Biol , vol.6 , pp. 110
    • Sanz, J.1    Cozzo, E.2    Borge-Holthoefer, J.3    Moreno, Y.4
  • 14
    • 33845262280 scopus 로고    scopus 로고
    • The effects of incomplete protein interaction data on structural and evolutionary inferences
    • 10.1186/1741-7007-4-39, 1665463, 17081312
    • de Silva E, Thorne T, Ingram P, Agrafioti I, Swire J, et al. The effects of incomplete protein interaction data on structural and evolutionary inferences. BMC Biol 2006, 4:39. 10.1186/1741-7007-4-39, 1665463, 17081312.
    • (2006) BMC Biol , vol.4 , pp. 39
    • de Silva, E.1    Thorne, T.2    Ingram, P.3    Agrafioti, I.4    Swire, J.5
  • 15
    • 78650994378 scopus 로고    scopus 로고
    • The intricate mechanisms of neurodegeneration in prion diseases
    • Soto C, Satani N. The intricate mechanisms of neurodegeneration in prion diseases. Trends Mol Med 2010, 17:14-24.
    • (2010) Trends Mol Med , vol.17 , pp. 14-24
    • Soto, C.1    Satani, N.2
  • 16
    • 33646533330 scopus 로고    scopus 로고
    • Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms
    • 10.1007/s00125-006-0214-7, 16604358
    • Pirot P, Eizirik DL, Cardozo AK. Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms. Diabetologia 2006, 49:1229-1236. 10.1007/s00125-006-0214-7, 16604358.
    • (2006) Diabetologia , vol.49 , pp. 1229-1236
    • Pirot, P.1    Eizirik, D.L.2    Cardozo, A.K.3
  • 17
    • 36248949141 scopus 로고    scopus 로고
    • The endoplasmic reticulum and the unfolded protein response
    • 10.1016/j.semcdb.2007.09.003, 2706143, 18023214
    • Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007, 18:716-731. 10.1016/j.semcdb.2007.09.003, 2706143, 18023214.
    • (2007) Semin Cell Dev Biol , vol.18 , pp. 716-731
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 18
    • 57049117856 scopus 로고    scopus 로고
    • Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities
    • 10.1038/nrd2755, 19043451
    • Kim I, Xu W, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008, 7:1013-1030. 10.1038/nrd2755, 19043451.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 1013-1030
    • Kim, I.1    Xu, W.2    Reed, J.C.3
  • 20
    • 77951868857 scopus 로고    scopus 로고
    • Redox control of prion and disease pathogenesis
    • 10.1089/ars.2009.2628, 2864664, 19803746
    • Singh N, Singh A, Das D, Mohan ML. Redox control of prion and disease pathogenesis. Antioxid Redox Signal 2010, 12:1271-1294. 10.1089/ars.2009.2628, 2864664, 19803746.
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1271-1294
    • Singh, N.1    Singh, A.2    Das, D.3    Mohan, M.L.4
  • 21
    • 70349705441 scopus 로고    scopus 로고
    • Prions: protein aggregation and infectious diseases
    • 10.1152/physrev.00006.2009, 19789378
    • Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009, 89:1105-1152. 10.1152/physrev.00006.2009, 19789378.
    • (2009) Physiol Rev , vol.89 , pp. 1105-1152
    • Aguzzi, A.1    Calella, A.M.2
  • 22
    • 0033802516 scopus 로고    scopus 로고
    • Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines
    • 10.1006/cyto.2000.0711, 10976009
    • Tengku-Muhammad TS, Hughes TR, Ranki H, Cryer A, Ramji DP. Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines. Cytokine 2000, 12:1430-1436. 10.1006/cyto.2000.0711, 10976009.
    • (2000) Cytokine , vol.12 , pp. 1430-1436
    • Tengku-Muhammad, T.S.1    Hughes, T.R.2    Ranki, H.3    Cryer, A.4    Ramji, D.P.5
  • 23
    • 67651210577 scopus 로고    scopus 로고
    • C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia
    • 10.1152/ajplung.00094.2009, 2742785, 19465518
    • Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, et al. C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia. Am J Physiol Lung Cell Mol Physiol 2009, 297:L286-L298. 10.1152/ajplung.00094.2009, 2742785, 19465518.
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Xu, Y.1    Saegusa, C.2    Schehr, A.3    Grant, S.4    Whitsett, J.A.5
  • 24
    • 2942741013 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease
    • 10.1016/j.neurobiolaging.2003.10.016, 15212823
    • Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Neurobiol Aging 2004, 25:991-999. 10.1016/j.neurobiolaging.2003.10.016, 15212823.
    • (2004) Neurobiol Aging , vol.25 , pp. 991-999
    • Li, R.1    Strohmeyer, R.2    Liang, Z.3    Lue, L.F.4    Rogers, J.5
  • 25
    • 42149186322 scopus 로고    scopus 로고
    • Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes
    • 10.1186/1471-2164-9-114, 2294129, 18315872
    • Sorensen G, Medina S, Parchaliuk D, Phillipson C, Robertson C, et al. Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes. BMC Genomics 2008, 9:114. 10.1186/1471-2164-9-114, 2294129, 18315872.
    • (2008) BMC Genomics , vol.9 , pp. 114
    • Sorensen, G.1    Medina, S.2    Parchaliuk, D.3    Phillipson, C.4    Robertson, C.5
  • 26
    • 0037076817 scopus 로고    scopus 로고
    • Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)
    • 10.1016/S0006-8993(02)02589-1, 12020874
    • Hamilton JA, Whitty G, White AR, Jobling MF, Thompson A, et al. Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF). Brain Res 2002, 940:49-54. 10.1016/S0006-8993(02)02589-1, 12020874.
    • (2002) Brain Res , vol.940 , pp. 49-54
    • Hamilton, J.A.1    Whitty, G.2    White, A.R.3    Jobling, M.F.4    Thompson, A.5
  • 27
    • 28444497402 scopus 로고    scopus 로고
    • Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process
    • 10.1016/j.jneuroim.2005.08.021, 16225933
    • Bate C, Boshuizen R, Williams A. Microglial cells kill prion-damaged neurons in vitro by a CD14-dependent process. J Neuroimmunol 2005, 170:62-70. 10.1016/j.jneuroim.2005.08.021, 16225933.
    • (2005) J Neuroimmunol , vol.170 , pp. 62-70
    • Bate, C.1    Boshuizen, R.2    Williams, A.3
  • 28
    • 13544252480 scopus 로고    scopus 로고
    • Covalent blocking of fibril formation and aggregation of intracellular amyloidgenic proteins by transglutaminase-catalyzed intramolecular cross-linking
    • 10.1021/bi047722d, 15697232
    • Konno T, Morii T, Hirata A, Sato S, Oiki S, et al. Covalent blocking of fibril formation and aggregation of intracellular amyloidgenic proteins by transglutaminase-catalyzed intramolecular cross-linking. Biochemistry 2005, 44:2072-2079. 10.1021/bi047722d, 15697232.
    • (2005) Biochemistry , vol.44 , pp. 2072-2079
    • Konno, T.1    Morii, T.2    Hirata, A.3    Sato, S.4    Oiki, S.5
  • 29
    • 67651071286 scopus 로고    scopus 로고
    • Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders
    • 10.1152/physrev.00044.2008, 19584319
    • Iismaa SE, Mearns BM, Lorand L, Graham RM. Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders. Physiol Rev 2009, 89:991-1023. 10.1152/physrev.00044.2008, 19584319.
    • (2009) Physiol Rev , vol.89 , pp. 991-1023
    • Iismaa, S.E.1    Mearns, B.M.2    Lorand, L.3    Graham, R.M.4
  • 30
    • 24644523661 scopus 로고    scopus 로고
    • Role of chemokines in ischemic neuronal stress
    • 10.1385/NMM:7:1-2:149, 16052043
    • Minami M, Satoh M. Role of chemokines in ischemic neuronal stress. Neuromolecular Med 2005, 7:149-155. 10.1385/NMM:7:1-2:149, 16052043.
    • (2005) Neuromolecular Med , vol.7 , pp. 149-155
    • Minami, M.1    Satoh, M.2
  • 32
    • 0036230262 scopus 로고    scopus 로고
    • Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix
    • 10.1046/j.1365-2990.2002.00383.x, 11972797
    • Cunningham C, Boche D, Perry VH. Transforming growth factor beta1, the dominant cytokine in murine prion disease: influence on inflammatory cytokine synthesis and alteration of vascular extracellular matrix. Neuropathol Appl Neurobiol 2002, 28:107-119. 10.1046/j.1365-2990.2002.00383.x, 11972797.
    • (2002) Neuropathol Appl Neurobiol , vol.28 , pp. 107-119
    • Cunningham, C.1    Boche, D.2    Perry, V.H.3
  • 33
    • 33846195361 scopus 로고    scopus 로고
    • Altered prion protein glycosylation in the aging mouse brain
    • 10.1111/j.1471-4159.2006.04268.x, 17144900
    • Goh AX, Li C, Sy MS, Wong BS. Altered prion protein glycosylation in the aging mouse brain. J Neurochem 2007, 100:841-854. 10.1111/j.1471-4159.2006.04268.x, 17144900.
    • (2007) J Neurochem , vol.100 , pp. 841-854
    • Goh, A.X.1    Li, C.2    Sy, M.S.3    Wong, B.S.4
  • 34
    • 26944462341 scopus 로고    scopus 로고
    • Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1
    • 10.1016/j.nbd.2005.04.002, 15893468
    • Spudich A, Frigg R, Kilic E, Kilic U, Oesch B, et al. Aggravation of ischemic brain injury by prion protein deficiency: role of ERK-1/-2 and STAT-1. Neurobiol Dis 2005, 20:442-449. 10.1016/j.nbd.2005.04.002, 15893468.
    • (2005) Neurobiol Dis , vol.20 , pp. 442-449
    • Spudich, A.1    Frigg, R.2    Kilic, E.3    Kilic, U.4    Oesch, B.5
  • 35
    • 33751034377 scopus 로고    scopus 로고
    • The prion protein is neuroprotective against retinal degeneration in vivo
    • 10.1016/j.exer.2006.07.010, 16952355
    • Frigg R, Wenzel A, Samardzija M, Oesch B, Wariwoda H, et al. The prion protein is neuroprotective against retinal degeneration in vivo. Exp Eye Res 2006, 83:1350-1358. 10.1016/j.exer.2006.07.010, 16952355.
    • (2006) Exp Eye Res , vol.83 , pp. 1350-1358
    • Frigg, R.1    Wenzel, A.2    Samardzija, M.3    Oesch, B.4    Wariwoda, H.5
  • 36
    • 26444463390 scopus 로고    scopus 로고
    • Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection
    • 10.1016/j.lfs.2005.03.031, 16005025
    • Hashimoto Y, Suzuki H, Aiso S, Niikura T, Nishimoto I, et al. Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. Life Sci 2005, 77:3092-3104. 10.1016/j.lfs.2005.03.031, 16005025.
    • (2005) Life Sci , vol.77 , pp. 3092-3104
    • Hashimoto, Y.1    Suzuki, H.2    Aiso, S.3    Niikura, T.4    Nishimoto, I.5
  • 37
    • 1242316262 scopus 로고    scopus 로고
    • Humanin rescues cortical neurons from prion-peptide-induced apoptosis
    • 10.1016/j.mcn.2003.09.017, 14962743
    • Sponne I, Fifre A, Koziel V, Kriem B, Oster T, et al. Humanin rescues cortical neurons from prion-peptide-induced apoptosis. Mol Cell Neurosci 2004, 25:95-102. 10.1016/j.mcn.2003.09.017, 14962743.
    • (2004) Mol Cell Neurosci , vol.25 , pp. 95-102
    • Sponne, I.1    Fifre, A.2    Koziel, V.3    Kriem, B.4    Oster, T.5
  • 40
    • 77956802559 scopus 로고    scopus 로고
    • Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application
    • 497987
    • Trudler D, Farfara D, Frenkel D. Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application. Mediators Inflamm 2010, 497987:12.
    • (2010) Mediators Inflamm , pp. 12
    • Trudler, D.1    Farfara, D.2    Frenkel, D.3
  • 41
    • 77950542752 scopus 로고    scopus 로고
    • Targeting toll-like receptors: emerging therapeutics?
    • 10.1038/nrd3203, 20380038
    • Hennessy EJ, Parker AE, O'Neill LA. Targeting toll-like receptors: emerging therapeutics?. Nature reviews Drug discovery 2010, 9:293-307. 10.1038/nrd3203, 20380038.
    • (2010) Nature reviews Drug discovery , vol.9 , pp. 293-307
    • Hennessy, E.J.1    Parker, A.E.2    O'Neill, L.A.3
  • 42
    • 0037082101 scopus 로고    scopus 로고
    • The neutrophil NADPH oxidase
    • 10.1006/abbi.2001.2642, 11795892
    • Babior BM, Lambeth JD, Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys 2002, 397:342-344. 10.1006/abbi.2001.2642, 11795892.
    • (2002) Arch Biochem Biophys , vol.397 , pp. 342-344
    • Babior, B.M.1    Lambeth, J.D.2    Nauseef, W.3
  • 43
    • 34748831102 scopus 로고    scopus 로고
    • The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury
    • 2515712, 17647198
    • Chong ZZ, Maiese K. The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol 2007, 22:1251-1267. 2515712, 17647198.
    • (2007) Histol Histopathol , vol.22 , pp. 1251-1267
    • Chong, Z.Z.1    Maiese, K.2
  • 44
    • 36849040619 scopus 로고    scopus 로고
    • MHC class I expression and synaptic plasticity after nerve lesion
    • 10.1016/j.brainresrev.2007.06.016, 17764750
    • Thams S, Oliveira A, Cullheim S. MHC class I expression and synaptic plasticity after nerve lesion. Brain Res Rev 2008, 57:265-269. 10.1016/j.brainresrev.2007.06.016, 17764750.
    • (2008) Brain Res Rev , vol.57 , pp. 265-269
    • Thams, S.1    Oliveira, A.2    Cullheim, S.3
  • 45
    • 4444311806 scopus 로고    scopus 로고
    • A proposal for using the ensemble approach to understand genetic regulatory networks
    • 10.1016/j.jtbi.2003.12.017, 15363677
    • Kauffman S. A proposal for using the ensemble approach to understand genetic regulatory networks. J Theor Biol 2004, 230:581-590. 10.1016/j.jtbi.2003.12.017, 15363677.
    • (2004) J Theor Biol , vol.230 , pp. 581-590
    • Kauffman, S.1
  • 46
    • 0141515736 scopus 로고    scopus 로고
    • MedScan, a natural language processing engine for MEDLINE abstracts
    • 10.1093/bioinformatics/btg207, 12967967
    • Novichkova S, Egorov S, Daraselia N. MedScan, a natural language processing engine for MEDLINE abstracts. Bioinformatics 2003, 19:1699-1706. 10.1093/bioinformatics/btg207, 12967967.
    • (2003) Bioinformatics , vol.19 , pp. 1699-1706
    • Novichkova, S.1    Egorov, S.2    Daraselia, N.3
  • 47
    • 1842559914 scopus 로고    scopus 로고
    • Extracting human protein interactions from MEDLINE using a full-sentence parser
    • 10.1093/bioinformatics/btg452, 15033866
    • Daraselia N, Yuryev A, Egorov S, Novichkova S, Nikitin A, et al. Extracting human protein interactions from MEDLINE using a full-sentence parser. Bioinformatics 2004, 20:604-611. 10.1093/bioinformatics/btg452, 15033866.
    • (2004) Bioinformatics , vol.20 , pp. 604-611
    • Daraselia, N.1    Yuryev, A.2    Egorov, S.3    Novichkova, S.4    Nikitin, A.5
  • 48
    • 40749087306 scopus 로고    scopus 로고
    • BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks
    • 10.1093/bioinformatics/btm553, 18024474
    • Zinovyev A, Viara E, Calzone L, Barillot E. BiNoM: a Cytoscape plugin for manipulating and analyzing biological networks. Bioinformatics 2008, 24:876-877. 10.1093/bioinformatics/btm553, 18024474.
    • (2008) Bioinformatics , vol.24 , pp. 876-877
    • Zinovyev, A.1    Viara, E.2    Calzone, L.3    Barillot, E.4
  • 49
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: new features for data integration and network visualization
    • 10.1093/bioinformatics/btq675, 3031041, 21149340
    • Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T. Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 2011, 27:431-432. 10.1093/bioinformatics/btq675, 3031041, 21149340.
    • (2011) Bioinformatics , vol.27 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3    Wang, P.L.4    Ideker, T.5
  • 51
    • 50549088838 scopus 로고    scopus 로고
    • Synchronous versus asynchronous modeling of gene regulatory networks
    • 10.1093/bioinformatics/btn336, 2519162, 18614585
    • Garg A, Di Cara A, Xenarios I, Mendoza L, De Micheli G. Synchronous versus asynchronous modeling of gene regulatory networks. Bioinformatics 2008, 24:1917-1925. 10.1093/bioinformatics/btn336, 2519162, 18614585.
    • (2008) Bioinformatics , vol.24 , pp. 1917-1925
    • Garg, A.1    Di Cara, A.2    Xenarios, I.3    Mendoza, L.4    De Micheli, G.5
  • 52
    • 84871766785 scopus 로고    scopus 로고
    • An efficient method for dynamic analysis of gene regulatory networks and in silico gene perturbation experiments research in computational molecular biology
    • Springer Berlin, Heidelberg, Speed T, Huang H
    • Garg A, Xenarios I, Mendoza L, DeMicheli G. An efficient method for dynamic analysis of gene regulatory networks and in silico gene perturbation experiments research in computational molecular biology. Lecture Notes in Computer Science, Vol. 4453 2007, 76. Springer Berlin, Heidelberg, Speed T, Huang H.
    • (2007) Lecture Notes in Computer Science, Vol. 4453 , pp. 76
    • Garg, A.1    Xenarios, I.2    Mendoza, L.3    DeMicheli, G.4
  • 53
    • 33646346114 scopus 로고    scopus 로고
    • A method for the generation of standardized qualitative dynamical systems of regulatory networks
    • 10.1186/1742-4682-3-13, 23516553
    • Mendoza L, Xenarios I. A method for the generation of standardized qualitative dynamical systems of regulatory networks. Theoretical biology & medical modelling 2006, 3:13. 10.1186/1742-4682-3-13, 23516553.
    • (2006) Theoretical biology & medical modelling , vol.3 , pp. 13
    • Mendoza, L.1    Xenarios, I.2
  • 55
    • 2942552376 scopus 로고    scopus 로고
    • Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network
    • Dobrin R, Beg QK, Barabasi AL, Oltvai ZN. Aggregation of topological motifs in the Escherichia coli transcriptional regulatory network. BMC Bioinforma 2004, 5:10.
    • (2004) BMC Bioinforma , vol.5 , pp. 10
    • Dobrin, R.1    Beg, Q.K.2    Barabasi, A.L.3    Oltvai, Z.N.4
  • 56
    • 33845969217 scopus 로고    scopus 로고
    • Classes of complex networks defined by role-to-role connectivity profiles
    • 10.1038/nphys489, 2447920, 18618010
    • Guimera R, Sales-Pardo M, Amaral LA. Classes of complex networks defined by role-to-role connectivity profiles. Nat Phys 2007, 3:63-69. 10.1038/nphys489, 2447920, 18618010.
    • (2007) Nat Phys , vol.3 , pp. 63-69
    • Guimera, R.1    Sales-Pardo, M.2    Amaral, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.