First-time comparison of the in vitro antimalarial activity of Artemisia annua herbal tea and artemisinin

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 106, Issue 11, 2012, Pages 696-700

  De Donno, Antonella ^a   Grassi, Tiziana ^a   Idolo, Adele ^a   Guido, Marcello ^a   Papadia, Paride ^a   Caccioppola, Alessandro ^a   Villanova, Luciano ^b   Merendino, Alessandro ^b   Bagordo, Francesco ^a   Fanizzi, Francesco Paolo ^a  

^a UNIVERSITY OF SALENTO   (Italy)

^b LachIfarma Srl ^*  (Italy)

Author keywords

Artemisia annua; Herbal tea; In vitro study; Nuclear magnetic resonance; Parasite lactate dehydrogenase test; Plasmodium falciparum

Indexed keywords

ARTEMISIA ANNUA EXTRACT; ARTEMISININ; HERBACEOUS AGENT; LACTATE DEHYDROGENASE;

ANTIMALARIAL ACTIVITY; ARTEMISIA ANNUA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; IC 50; IN VITRO STUDY; NONHUMAN; PLANT LEAF; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; TEA;

ANTIMALARIALS; ARTEMISIA; ARTEMISININS; BEVERAGES; COST-BENEFIT ANALYSIS; DRUG RESISTANCE, MICROBIAL; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MALARIA; MALE; PLANT EXTRACTS; PLASMODIUM FALCIPARUM; REPRODUCIBILITY OF RESULTS; SAPONINS; SOLUBILITY;

ARTEMISIA ANNUA; PLASMODIUM FALCIPARUM;

EID: 84867334558     PISSN: 00359203     EISSN: 18783503     Source Type: Journal    
DOI: 10.1016/j.trstmh.2012.07.008     Document Type: Article

References (29)

1. WHO World malaria report 2010 2010, World Health Organization, Geneva, [accessed 18 April 2011]. http://www.who.int/malaria/world_malaria_report_2010/en/index.html.
2. Basilico N., Parapini S., Sisto F., et al. The lipid moiety of haemozoin (malaria pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1. J Biomed Biotechnol 2010, 2010:854927.
3. Taylor S.M., Molyneux M.E., Simel D.L., Meshnick S.R., Jiuliano J.J. Does this patient have malaria?. JAMA 2010, 304:2048-2056.
4. WHO Guidelines for the treatment of malaria 2006, World Health Organization, Geneva, WHO/HTM/MAL/2006.1108.
5. Guerin P.J., Olliaro P., Nosten F., et al. Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development. Lancet Infect Dis 2002, 2:564-573.
6. WHO Roll Back Malaria: the global malaria action plan for a malaria-free world 2008, World Health Organization, Geneva, [accessed 10 July 2012]. http://www.rollbackmalaria.org/gmap/index.html.
7. Omodeo-Salè F., Cortelezzi L., Basilico N., Casagrande M., Sparatore A., Taramelli D. Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes. Antimicrob Agents Chemother 2009, 53:4339-4344.
8. De Ridder S., van der Kooy F., Verpoorte R. Artemisia annua as a self-reliant treatment for malaria in developing countries. J Ethnopharmacol 2008, 120:302-314.
9. Ramazani A., Zakeri S., Sardari S., Khodakarim N., Djadidt N.D. In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense. Malar J 2010, 9:124.
10. 1H-NMR. Phytochem Anal 2008, 19:329-334.
11. Hsu E. The history of qing hao in the Chinese materia medica. Trans R Soc Trop Med Hyg 2006, 100:505-508.
12. Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 1985, 228:1049-1055.
13. Balint G.A. Artemisinin and its derivatives: an important new class of antimalarial agents. Pharmacol Ther 2001, 90:261-265.
14. Mutabingwa T.K. Artemisinin-based combination therapies (ACTs): best hope for malaria treatment but inaccessible to the needy!. Acta Trop 2005, 95:305-315.
15. Ashton M., Duy Sy N., Van Huong N., et al. Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria. Clin Pharmacol Ther 1998, 63:482-493.
16. Titulaer H.A.C., Zuidema J., Kager P.A., Wetsteyn J.C.F.M., Lugt C.H.B., Merkus F.W.H.M. The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers. J Pharm Pharmacol 1990, 42:810-813.
17. Van Agtmael M.A., Cheng-Qi S., Qing J.X., Mull R., van Boxtel C.J. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int J Antimicrob Agents 1999, 12:151-158.
18. Blanke C.H., Naisabha G.B., Balema M.B., Mbaruku G.M., Heide L., Muller M.S. Herba Artemisiae annuae tea preparation compared to sulfadoxine-pyrimethamine in the treatment of uncomplicated falciparum malaria in adults: a randomized double-blind clinical trial. Trop Doct 2008, 38:113-116.
19. Mueller M.S., Runyambo N., Wagner I., Borrmann S., Dietz K., Heide L. Randomized controlled trial of a traditional preparation of Artemisia annua L. (annual wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg 2004, 98:318-321.
20. Räth K., Taxis K., Waltz G., Gleiter C.H., Li S.M., Heide L. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004, 70:128-132.
21. Mueller M.S., Karhagomba I.B., Hirt H.M., Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000, 73:487-493.
22. Carbonara T., Pascale R., Argentieri M.P., et al. Phytochemical analysis of a herbal tea from Artemisia annua L. J Pharm Biomed Anal 2012, 62:79-86.
23. Liu N.Q., Cao M., Frédérich M., Choi Y.H., Verpoorte R., van der Kooy F. Metabolomic investigation of the ethnopharmacological use of Artemisia afra with NMR spectroscopy and multivariate analysis. J Ethnopharmacol 2010, 128:230-235.
24. 1H NMR spectroscopy and chemometrics. J Pharm Biomed Anal 2004, 35:117-126.
25. Trager W., Jensen J.B. Human malaria parasites in continuous culture. Science 1976, 193:673-675.
26. Makler M.T., Ries J.M., Williams J.A., et al. Parasite lactate dehydrogenase as an assay for Plasmodium falciparum drug sensitivity. Am J Trop Med Hyg 1993, 48:739-741.
27. Willcox M., Benoit-Vical F., Fowler D., et al. Do ethnobotanical and laboratory data predict clinical safety and efficacy of anti-malarial plants?. Malaria J 2011, 10(Suppl 1):S7.
28. Elford B.C., Roberts M.F., Phillipson J.D., Wilson R.J. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Trans R Soc Trop Med Hyg 1987, 81:434-436.
29. Willcox M., Bodeker G., Bourdy G., et al. Artemisia annua as a traditional antimalarial medicine. Traditional medicinal plants and malaria 2004, 43-60. CRC Press, Boca Raton, FL. M.L. Willcox, G. Bodeker, P. Rasoanaivo (Eds.).