Prediction of anti-plasmodial activity of Artemisia annua extracts: Application of 1H NMR spectroscopy and chemometrics

Journal of Pharmaceutical and Biomedical Analysis

Volumn 35, Issue 1, 2004, Pages 117-126

  Bailey, Nigel J C ^a   Wang, Yulan ^b   Sampson, Julia ^c,e   Davis, Wendy ^d   Whitcombe, Ian ^c,f   Hylands, Peter J ^c   Croft, Simon L ^d   Holmes, Elaine ^b  

^a SCYNEXIS Europe Ltd   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c Oxford Natural Products plc   (United Kingdom)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e Porton Down Science Park   (United Kingdom)

^f UCB PHARMA   (Belgium)

Author keywords

FID; Free induction decay; IC50; Measure of extract anti plasmodial activity; Measure of extract toxicity; NMR; Nuclear magnetic resonance; Partial least squares; PCA; PLS; PLS DA; Principal components analysis; ToxED50

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISIA ANNUA EXTRACT; ARTEMISIN;

ANALYSIS OF VARIANCE; ANTIMALARIAL ACTIVITY; ARTEMISIA ANNUA; ARTICLE; CHEMOMETRIC ANALYSIS; CORRELATION ANALYSIS; CYTOTOXICITY; PREDICTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VALIDATION PROCESS;

ANIMALS; ANTIPROTOZOAL AGENTS; ARTEMISIA ANNUA; ARTEMISININS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PLANT EXTRACTS; PLASMODIUM FALCIPARUM; PREDICTIVE VALUE OF TESTS; SESQUITERPENES;

EID: 1642379661     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2003.12.024     Document Type: Article

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