Single amino acid residue in the M4 domain of GluN1 subunit regulates the surface delivery of NMDA receptors

Journal of Neurochemistry

Volumn 123, Issue 3, 2012, Pages 385-395

  Kaniakova, Martina ^a   Lichnerova, Katarina ^a   Vyklicky, Ladislav ^a   Horak, Martin ^a  

^a INSTITUTE OF MATHEMATICS   (Czech Republic)

Author keywords

assembly; electrophysiology; glutamate receptor; ion channel; membrane domain; trafficking

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ENDOPLASMIC RETICULUM; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GLUN1 GENE; GLUN2 GENE; IMMUNOPRECIPITATION; MOLECULAR MECHANICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; STRUCTURE ANALYSIS;

AMINO ACIDS; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOPLASMIC RETICULUM; HEK293 CELLS; HUMANS; MUTAGENESIS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, CELL SURFACE; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 84867334376     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12002     Document Type: Article

References (26)

1. Cais O., Sedlacek M., Horak M., Dittert I., and, Vyklicky L. Jr, (2008) Temperature dependence of NR1/NR2B NMDA receptor channels. Neuroscience 151, 428-438.
2. Cao J. Y., Qiu S., Zhang J., Wang J. J., Zhang X. M., and, Luo J. H., (2011) Transmembrane region of N-methyl-D-aspartate receptor (NMDAR) subunit is required for receptor subunit assembly. J. Biol. Chem. 286, 27698-27705.
3. Fukaya M., Kato A., Lovett C., Tonegawa S., and, Watanabe M., (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc. Natl Acad. Sci. USA 100, 4855-4860. (Pubitemid 36457818)
4. Hawkins L. M., Prybylowski K., Chang K., Moussan C., Stephenson F. A., and, Wenthold R. J., (2004) Export from the endoplasmic reticulum of assembled N-methyl-d-aspartic acid receptors is controlled by a motif in the c terminus of the NR2 subunit. J. Biol. Chem. 279, 28903-28910. (Pubitemid 38915758)
5. Horak M., and, Wenthold R. J., (2009) Different roles of C-terminal cassettes in the trafficking of full-length NR1 subunits to the cell surface. J. Biol. Chem. 284, 9683-9691.
6. Horak M., Chang K., and, Wenthold R. J., (2008) Masking of the endoplasmic reticulum retention signals during assembly of the NMDA receptor. J. Neurosci. 28, 3500-3509. (Pubitemid 351469313)
7. Ishii T., Moriyoshi K., Sugihara H., et al,. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843. (Pubitemid 23057917)
8. Kaniakova M., Krausova B., Vyklicky V., Korinek M., Lichnerova K., Vyklicky L., and, Horak M., (2012) Key amino acid residues within the third membrane domains of NR1 and NR2 subunits contribute to the regulation of the surface delivery of NMDA receptors. J. Biol. Chem. 287, 26423-26434. doi: 10.1074/jbc.M112.339085.
9. Kenny A. V., Cousins S. L., Pinho L., and, Stephenson F. A., (2009) The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J. Biol. Chem. 284, 324-333.
10. Lau C. G., and, Zukin R. S., (2007) NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat. Rev. Neurosci. 8, 413-426. (Pubitemid 46789232)
11. McIlhinney R. A., Le Bourdelles B., Molnar E., Tricaud N., Streit P., and, Whiting P. J., (1998) Assembly intracellular targeting and cell surface expression of the human N-methyl-D-aspartate receptor subunits NR1a and NR2A in transfected cells. Neuropharmacology 37, 1355-1367. (Pubitemid 28511289)
12. Okabe S., Miwa A., and, Okado H., (1999) Alternative splicing of the C-terminal domain regulates cell surface expression of the NMDA receptor NR1 subunit. J. Neurosci. 19, 7781-7792. (Pubitemid 30225777)
13. Penn A. C., Williams S. R., and, Greger I. H., (2008) Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum. EMBO J. 27, 3056-3068.
14. Petralia R. S., Al-Hallaq R. A., and, Wenthold R. J., (2009) Trafficking and Targeting of NMDA Receptors, in Biology of the NMDA Receptor, (, Van Dongen A. M., ed.). CRC Press, Boca Raton, FL.
15. Petrovic M., Sedlacek M., Cais O., Horak M., Chodounska H., and, Vyklicky L. Jr, (2009) Pregnenolone sulfate modulation of N-methyl-D-aspartate receptors is phosphorylation dependent. Neuroscience 160, 616-628.
16. Qiu S., Zhang X. M., Cao J. Y., Yang W., Yan Y. G., Shan L., Zheng J., and, Luo J. H., (2009) An endoplasmic reticulum retention signal located in the extracellular amino-terminal domain of the NR2A subunit of N-Methyl-D-aspartate receptors. J. Biol. Chem. 284, 20285-20298.
17. Ren H., Salous A. K., Paul J. M., Lipsky R. H., and, Peoples R. W., (2007) Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action. Br. J. Pharmacol. 151, 749-757. (Pubitemid 47075312)
18. Salous A. K., Ren H., Lamb K. A., Hu X. Q., Lipsky R. H., and, Peoples R. W., (2009) Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit. Br. J. Pharmacol. 158, 1395-1404.
19. Salussolia C. L., Corrales A., Talukder I., Kazi R., Akgul G., Bowen M., and, Wollmuth L. P., (2011) Interaction of the M4 segment with other transmembrane segments is required for surface expression of mammalian AMPA receptors. J. Biol. Chem. 286, 40205-40218.
20. Schorge S., and, Colquhoun D., (2003) Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits. J. Neurosci. 23, 1151-1158. (Pubitemid 36258894)
21. Sobolevsky A. I., Rosconi M. P., and, Gouaux E., (2009) X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462, 745-756.
22. Standley S., Roche K. W., McCallum J., Sans N., and, Wenthold R. J., (2000) PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron 28, 887-898. (Pubitemid 32038079)
23. Stephenson F. A., Cousins S. L., and, Kenny A. V., (2008) Assembly and forward trafficking of NMDA receptors (Review). Mol. Membr. Biol. 25, 311-320. (Pubitemid 351620416)
24. Traynelis S. F., Wollmuth L. P., McBain C. J., Menniti F. S., Vance K. M., Ogden K. K., Hansen K. B., Yuan H., Myers S. J., and, Dingledine R., (2010) Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405-496.
25. Vicini S., Wang J. F., Li J. H., Zhu W. J., Wang Y. H., Luo J. H., Wolfe B. B., and, Grayson D. R., (1998) Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J. Neurophysiol. 79, 555-566. (Pubitemid 28095877)
26. Wang J. M., Zhang L., Yao Y., Viroonchatapan N., Rothe E., and, Wang Z. Z., (2002) A transmembrane motif governs the surface trafficking of nicotinic acetylcholine receptors. Nat. Neurosci. 5, 963-970.