Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice

Genes, Brain and Behavior

Volumn 11, Issue 7, 2012, Pages 794-805

  Huang, F L ^a   Huang, K P ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Cognitive deficit; Environmental enrichment; Methylphenidate; Neurogranin knockout mice

Indexed keywords

METHYLPHENIDATE; NEUROGRANIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BEHAVIOR DISORDER; COGNITION; COGNITIVE DEFECT; CONTEXTUAL FEAR CONDITIONING; CONTROLLED STUDY; FEMALE; FORCED SWIMMING TEST; GENE; GENE DELETION; HIPPOCAMPUS; HYPERACTIVITY; KNOCKOUT MOUSE; LEARNING DISORDER; LONG TERM POTENTIATION; MAZE TEST; MEMORY DISORDER; MOUSE; NG GENE; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SOCIAL ISOLATION; TREATMENT OUTCOME; WILD TYPE;

ANIMALS; COGNITION DISORDERS; FEMALE; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; INTERPERSONAL RELATIONS; MAZE LEARNING; MENTAL DISORDERS; METHYLPHENIDATE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROGRANIN; SWIMMING;

MUS;

EID: 84867328914     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00825.x     Document Type: Article

References (34)

1. Aman, M.G., Vamos, M. & Werry, J.S. (1984) Effects of methylphenidate in normal adults with reference to drug action in hyperactivity. Aust N Z J Psychiatry 18, 86-88.
2. Cavaliere, C., Cirillo, G., Bianco, M.R., Adriani, W., De Simone, A., Leo, D., Perrone-Capano, C. & Papa, M. (2012) Methylphenidate administration determines enduring changes in neuroglial network in rats. Eur Neuropsychopharmacol 22, 53-63.
3. Coldren, C.D., Lai, Z., Shragg, P., Rossi, E., Glidewell, S.C., Zuffardi, O., Mattina, T., Ivy, D.D., Curfs, L.M., Mattson, S.N., Riley, E.P., Treier, M. & Grossfeld, P.D. (2009) Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome). Neurogenetics 10, 89-95.
4. Dommett, E.J., Henderson, E.L., Westwell, M.S. & Greenfield, S.A. (2008) Methylphenidate amplifies long-term plasticity in the hippocampus via noradrenergic mechanisms. Learn Mem 15, 580-586.
5. Gage, F.H. (2000) Mammalian neural stem cells. Science 287, 1433-1438.
6. Gerendasy, D.D. & Sutcliffe, J.G. (1997) RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes. Mol Neurobiol 15, 131-163.
7. Grossfeld, P.D., Mattina, T., Lai, Z., Favier, R., Jones, K.L., Cotter, F. & Jones, C. (2004) The 11q terminal deletion disorder: a prospective study of 110 cases. Am J Med Genet A 129A, 51-61.
8. Hellwig-Brida, S., Daseking, M., Keller, F., Petermann, F. & Goldbeck, L. (2011) Effects of methylphenidate on intelligence and attention components in boys with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 21, 245-253.
9. Huang, F.L., Huang, K.P. & Boucheron, C. (2007) Long-term enrichment enhances the cognitive behavior of the aging neurogranin null mice without affecting their hippocampal LTP. Learn Mem 14, 512-519.
10. Huang, F.L., Huang, K.P., Wu, J. & Boucheron, C. (2006) Environmental enrichment enhances neurogranin expression and hippocampal learning and memory but fails to rescue the impairments of neurogranin null mutant mice. J Neurosci 26, 6230-6237.
11. Huang, K.P., Huang, F.L., Jager, T., Li, J., Reymann, K.G. & Balschun, D. (2004) Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. J Neurosci 24, 10660-10669.
12. Huang, K.P., Huang, F.L., Li, J., Schuck, P. & McPhie, P. (2000) Calcium-sensitive interaction between calmodulin and modified forms of rat brain neurogranin/RC3. Biochemistry 39, 7291-7299.
13. Huang, K.P., Huang, F.L. & Shetty, P.K. (2011) Stimulation-mediated translocation of calmodulin and neurogranin from soma to dendrites of mouse hippocampal CA1 pyramidal neurons. Neuroscience 178, 1-12.
14. Kebir, O., Tabbane, K., Sengupta, S. & Joober, R. (2009) Candidate genes and neuropsychological phenotypes in children with ADHD: review of association studies. J Psychiatry Neurosci 34, 88-101.
15. Kempermann, G. (2002) Why new neurons? Possible functions for adult hippocampal neurogenesis. J Neurosci 22, 635-638.
16. Kriegstein, A. & Alvarez-Buylla, A. (2009) The glial nature of embryonic and adult neural stem cells. Annu Rev Neurosci 32, 149-184.
17. Li, J., Pak, J.H., Huang, F.L. & Huang, K.P. (1999) N-methyl-d-aspartate induces neurogranin/RC3 oxidation in rat brain slices. J Biol Chem 274, 1294-1300.
18. Macbeth, A.H., Edds, J.S. & Young, W.S. 3rd (2009) Housing conditions and stimulus females: a robust social discrimination task for studying male rodent social recognition. Nat Protoc 4, 1574-1581.
19. Miyakawa, T., Yared, E., Pak, J.H., Huang, F.L., Huang, K.P. & Crawley, J.N. (2001) Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components. Hippocampus 11, 763-775.
20. Morris, R.G., Garrud, P., Rawlins, J.N. & O'Keefe, J. (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297, 681-683.
21. Overstreet, D.H., Friedman, E., Mathe, A.A. & Yadid, G. (2005) The Flinders Sensitive Line rat: a selectively bred putative animal model of depression. Neurosci Biobehav Rev 29, 739-759.
22. Pak, J.H., Huang, F.L., Li, J., Balschun, D., Reymann, K.G., Chiang, C., Westphal, H. & Huang, K.P. (2000) Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: a study with knockout mice. Proc Natl Acad Sci USA 97, 11232-11237.
23. Pires, V.A., Pamplona, F.A., Pandolfo, P., Fernandes, D., Prediger, R.D. & Takahashi, R.N. (2009) Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder. Behav Pharmacol 20, 134-145.
24. Prichard, L., Deloulme, J.C. & Storm, D.R. (1999) Interactions between neurogranin and calmodulin in vivo. J Biol Chem 274, 7689-7694.
25. Prut, L. & Belzung, C. (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol 463, 3-33.
26. Santarelli, L., Gobbi, G., Debs, P.C., Sibille, E.T., Blier, P., Hen, R. & Heath, M.J. (2001) Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci USA 98, 1912-1917.
27. Satoh, Y., Endo, S., Ikeda, T., Yamada, K., Ito, M., Kuroki, M., Hiramoto, T., Imamura, O., Kobayashi, Y., Watanabe, Y., Itohara, S. & Takishima, K. (2007) Extracellular signal-regulated kinase 2 (ERK2) knockdown mice show deficits in long-term memory; ERK2 has a specific function in learning and memory. J Neurosci 27, 10765-10776.
28. Schafe, G.E., Nadel, N.V., Sullivan, G.M., Harris, A. & LeDoux, J.E. (1999) Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn Mem 6, 97-110.
29. Seri, B., Garcia-Verdugo, J.M., Collado-Morente, L., McEwen, B.S. & Alvarez-Buylla, A. (2004) Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus. J Comp Neurol 478, 359-378.
30. Sheu, F.S., Mahoney, C.W., Seki, K. & Huang, K.P. (1996) Nitric oxide modification of rat brain neurogranin affects its phosphorylation by protein kinase C and affinity for calmodulin. J Biol Chem 271, 22407-22413.
31. Siesser, W.B., Zhao, J., Miller, L.R., Cheng, S.Y. & McDonald, M.P. (2006) Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive. Genes Brain Behav 5, 282-297.
32. Sofroniew, M.V. & Vinters, H.V. (2010) Astrocytes: biology and pathology. Acta Neuropathol 119, 7-35.
33. Yan, T.C., Hunt, S.P. & Stanford, S.C. (2009) Behavioural and neurochemical abnormalities in mice lacking functional tachykinin-1 (NK1) receptors: a model of attention deficit hyperactivity disorder. Neuropharmacology 57, 627-635.
34. Yan, T.C., McQuillin, A., Thapar, A., Asherson, P., Hunt, S.P., Stanford, S.C. & Gurling, H. (2010) NK1 (TACR1) receptor gene 'knockout' mouse phenotype predicts genetic association with ADHD. J Psychopharmacol 24, 27-38.