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Volumn 7, Issue 10, 2012, Pages

Correction of Liver Steatosis by a Hydrophobic Iminosugar Modulating Glycosphingolipids Metabolism

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLYCOSPHINGOLIPID; IMINOSUGAR;

EID: 84867327154     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038520     Document Type: Article
Times cited : (14)

References (42)
  • 1
    • 59649095416 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis and animal models: understanding the human disease
    • Varela-Rey M, Embade N, Ariz U, Lu SC, Mato JM, et al. (2009) Non-alcoholic steatohepatitis and animal models: understanding the human disease. Int J Biochem Cell Biol 41: 969-976.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 969-976
    • Varela-Rey, M.1    Embade, N.2    Ariz, U.3    Lu, S.C.4    Mato, J.M.5
  • 2
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • McCullough AJ, (2006) Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 40 Suppl 1: S17-S29.
    • (2006) J Clin Gastroenterol , vol.40 , Issue.SUPPL. 1
    • McCullough, A.J.1
  • 3
    • 33646831000 scopus 로고    scopus 로고
    • Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations
    • Solga SF, Alkhuraishe A, Cope K, Tabesh A, Clark JM, et al. (2006) Breath biomarkers and non-alcoholic fatty liver disease: preliminary observations. Biomarkers 11: 174-183.
    • (2006) Biomarkers , vol.11 , pp. 174-183
    • Solga, S.F.1    Alkhuraishe, A.2    Cope, K.3    Tabesh, A.4    Clark, J.M.5
  • 5
    • 77949311823 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a review and update
    • Lewis JR, Mohanty SR, (2010) Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci 55: 560-578.
    • (2010) Dig Dis Sci , vol.55 , pp. 560-578
    • Lewis, J.R.1    Mohanty, S.R.2
  • 6
    • 49649110937 scopus 로고    scopus 로고
    • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis
    • Wouters K, van Gorp PJ, Bieghs V, Gijbels MJ, Duimel H, et al. (2008) Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis. Hepatology 48: 474-486.
    • (2008) Hepatology , vol.48 , pp. 474-486
    • Wouters, K.1    van Gorp, P.J.2    Bieghs, V.3    Gijbels, M.J.4    Duimel, H.5
  • 7
    • 77952013674 scopus 로고    scopus 로고
    • Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease
    • Vinaixa M, Rodriguez MA, Rull A, Beltran R, Blade C, et al. (2010) Metabolomic assessment of the effect of dietary cholesterol in the progressive development of fatty liver disease. J Proteome Res 9: 2527-2538.
    • (2010) J Proteome Res , vol.9 , pp. 2527-2538
    • Vinaixa, M.1    Rodriguez, M.A.2    Rull, A.3    Beltran, R.4    Blade, C.5
  • 8
    • 34248228704 scopus 로고    scopus 로고
    • Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes
    • Zhao H, Przybylska M, Wu IH, Zhang J, Siegel C, et al. (2007) Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes 56: 1210-1218.
    • (2007) Diabetes , vol.56 , pp. 1210-1218
    • Zhao, H.1    Przybylska, M.2    Wu, I.H.3    Zhang, J.4    Siegel, C.5
  • 9
    • 72949117677 scopus 로고    scopus 로고
    • Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice
    • Bijl N, Sokolovic M, Vrins C, Langeveld M, Moerland PD, et al. (2009) Modulation of glycosphingolipid metabolism significantly improves hepatic insulin sensitivity and reverses hepatic steatosis in mice. Hepatology 50: 1431-1441.
    • (2009) Hepatology , vol.50 , pp. 1431-1441
    • Bijl, N.1    Sokolovic, M.2    Vrins, C.3    Langeveld, M.4    Moerland, P.D.5
  • 10
    • 77955300117 scopus 로고    scopus 로고
    • Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase
    • Yew NS, Zhao H, Hong EG, Wu IH, Przybylska M, et al. (2010) Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase. PLoS One 5: e11239.
    • (2010) PLoS One , vol.5
    • Yew, N.S.1    Zhao, H.2    Hong, E.G.3    Wu, I.H.4    Przybylska, M.5
  • 11
    • 34248205140 scopus 로고    scopus 로고
    • Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity
    • Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, et al. (2007) Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes 56: 1341-1349.
    • (2007) Diabetes , vol.56 , pp. 1341-1349
    • Aerts, J.M.1    Ottenhoff, R.2    Powlson, A.S.3    Grefhorst, A.4    van Eijk, M.5
  • 12
    • 63349110943 scopus 로고    scopus 로고
    • Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation
    • van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, et al. (2009) Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. PLoS One 4: e4723.
    • (2009) PLoS One , vol.4
    • van Eijk, M.1    Aten, J.2    Bijl, N.3    Ottenhoff, R.4    van Roomen, C.P.5
  • 13
    • 67651165606 scopus 로고    scopus 로고
    • Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice
    • Zhao H, Przybylska M, Wu IH, Zhang J, Maniatis P, et al. (2009) Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice. Hepatology 50: 85-93.
    • (2009) Hepatology , vol.50 , pp. 85-93
    • Zhao, H.1    Przybylska, M.2    Wu, I.H.3    Zhang, J.4    Maniatis, P.5
  • 15
    • 35348926769 scopus 로고    scopus 로고
    • Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance
    • Kabayama K, Sato T, Saito K, Loberto N, Prinetti A, et al. (2007) Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A 104: 13678-13683.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13678-13683
    • Kabayama, K.1    Sato, T.2    Saito, K.3    Loberto, N.4    Prinetti, A.5
  • 17
    • 67349130083 scopus 로고    scopus 로고
    • Glycosphingolipids and insulin resistance
    • Langeveld M, Aerts JM, (2009) Glycosphingolipids and insulin resistance. Prog Lipid Res 48: 196-205.
    • (2009) Prog Lipid Res , vol.48 , pp. 196-205
    • Langeveld, M.1    Aerts, J.M.2
  • 18
    • 77149141692 scopus 로고    scopus 로고
    • Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation
    • Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, et al. (2010) Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem 53: 689-698.
    • (2010) J Med Chem , vol.53 , pp. 689-698
    • Wennekes, T.1    Meijer, A.J.2    Groen, A.K.3    Boot, R.G.4    Groener, J.E.5
  • 19
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: a pathogenic paradox
    • Brown MS, Goldstein JL, (2008) Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7: 95-96.
    • (2008) Cell Metab , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 20
    • 34248226374 scopus 로고    scopus 로고
    • Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses
    • Ripoll VM, Irvine KM, Ravasi T, Sweet MJ, Hume DA, (2007) Gpnmb is induced in macrophages by IFN-gamma and lipopolysaccharide and acts as a feedback regulator of proinflammatory responses. J Immunol 178: 6557-6566.
    • (2007) J Immunol , vol.178 , pp. 6557-6566
    • Ripoll, V.M.1    Irvine, K.M.2    Ravasi, T.3    Sweet, M.J.4    Hume, D.A.5
  • 21
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: getting both pathology and metabolic context right
    • Larter CZ, Yeh MM, (2008) Animal models of NASH: getting both pathology and metabolic context right. J Gastroenterol Hepatol 23: 1635-1648.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 22
    • 70350018324 scopus 로고    scopus 로고
    • Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis
    • Rull A, Rodriguez F, Aragones G, Marsillach J, Beltran R, et al. (2009) Hepatic monocyte chemoattractant protein-1 is upregulated by dietary cholesterol and contributes to liver steatosis. Cytokine 48: 273-279.
    • (2009) Cytokine , vol.48 , pp. 273-279
    • Rull, A.1    Rodriguez, F.2    Aragones, G.3    Marsillach, J.4    Beltran, R.5
  • 23
    • 77951475260 scopus 로고    scopus 로고
    • Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice
    • Bietrix F, Lombardo E, van Roomen CP, Ottenhoff R, Vos M, et al. (2010) Inhibition of glycosphingolipid synthesis induces a profound reduction of plasma cholesterol and inhibits atherosclerosis development in APOE*3 Leiden and low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 30: 931-937.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 931-937
    • Bietrix, F.1    Lombardo, E.2    van Roomen, C.P.3    Ottenhoff, R.4    Vos, M.5
  • 25
    • 82955248096 scopus 로고    scopus 로고
    • Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation
    • Langeveld M, van den Berg SA, Bijl N, Bijland S, van Roomen CP, et al. (2012) Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation. Metabolism 61: 99-107.
    • (2012) Metabolism , vol.61 , pp. 99-107
    • Langeveld, M.1    van den Berg, S.A.2    Bijl, N.3    Bijland, S.4    van Roomen, C.P.5
  • 26
    • 72449194752 scopus 로고    scopus 로고
    • Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver
    • Tsuduki T, Nakamura Y, Honma T, Nakagawa K, Kimura T, et al. (2009) Intake of 1-deoxynojirimycin suppresses lipid accumulation through activation of the beta-oxidation system in rat liver. J Agric Food Chem 57: 11024-11029.
    • (2009) J Agric Food Chem , vol.57 , pp. 11024-11029
    • Tsuduki, T.1    Nakamura, Y.2    Honma, T.3    Nakagawa, K.4    Kimura, T.5
  • 27
    • 78650665645 scopus 로고    scopus 로고
    • Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress
    • Kobayashi Y, Miyazawa M, Kamei A, Abe K, Kojima T, (2010) Ameliorative effects of mulberry (Morus alba L.) leaves on hyperlipidemia in rats fed a high-fat diet: induction of fatty acid oxidation, inhibition of lipogenesis, and suppression of oxidative stress. Biosci Biotechnol Biochem 74: 2385-2395.
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 2385-2395
    • Kobayashi, Y.1    Miyazawa, M.2    Kamei, A.3    Abe, K.4    Kojima, T.5
  • 28
    • 77951433803 scopus 로고    scopus 로고
    • Hepatic glycosphingolipid deficiency and liver function in mice
    • Jennemann R, Rothermel U, Wang S, Sandhoff R, Kaden S, et al. (2010) Hepatic glycosphingolipid deficiency and liver function in mice. Hepatology 51: 1799-1809.
    • (2010) Hepatology , vol.51 , pp. 1799-1809
    • Jennemann, R.1    Rothermel, U.2    Wang, S.3    Sandhoff, R.4    Kaden, S.5
  • 29
    • 2942577575 scopus 로고    scopus 로고
    • Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis
    • Shen C, Bullens D, Kasran A, Maerten P, Boon L, et al. (2004) Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis. Int Immunopharmacol 4: 939-951.
    • (2004) Int Immunopharmacol , vol.4 , pp. 939-951
    • Shen, C.1    Bullens, D.2    Kasran, A.3    Maerten, P.4    Boon, L.5
  • 30
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH, (2008) Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 31
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, et al. (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5
  • 32
    • 84855966721 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in metabolic disease and other disorders
    • Ozcan L, Tabas I, (2012) Role of endoplasmic reticulum stress in metabolic disease and other disorders. Annu Rev Med 63: 317-328.
    • (2012) Annu Rev Med , vol.63 , pp. 317-328
    • Ozcan, L.1    Tabas, I.2
  • 33
    • 79952836464 scopus 로고    scopus 로고
    • A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
    • Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, et al. (2011) A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Biochem J 435: 267-76.
    • (2011) Biochem J , vol.435 , pp. 267-276
    • Boslem, E.1    MacIntosh, G.2    Preston, A.M.3    Bartley, C.4    Busch, A.K.5
  • 34
    • 25844437136 scopus 로고    scopus 로고
    • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease
    • Li Z, Soloski MJ, Diehl AM, (2005) Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. Hepatology 42: 880-885.
    • (2005) Hepatology , vol.42 , pp. 880-885
    • Li, Z.1    Soloski, M.J.2    Diehl, A.M.3
  • 35
    • 73449142810 scopus 로고    scopus 로고
    • Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis
    • Kremer M, Thomas E, Milton RJ, Perry AW, van RN, et al. (2010) Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology 51: 130-141.
    • (2010) Hepatology , vol.51 , pp. 130-141
    • Kremer, M.1    Thomas, E.2    Milton, R.J.3    Perry, A.W.4    van, R.N.5
  • 36
    • 33747626511 scopus 로고    scopus 로고
    • Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis
    • Marí M, Caballero F, Colell A, Morales A, Caballeria J, et al. (2006) Mitochondrial free cholesterol loading sensitizes to TNF- and Fas-mediated steatohepatitis. Cell Metab 4: 185-198.
    • (2006) Cell Metab , vol.4 , pp. 185-198
    • Marí, M.1    Caballero, F.2    Colell, A.3    Morales, A.4    Caballeria, J.5
  • 37
    • 80053612479 scopus 로고    scopus 로고
    • Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis
    • Van Rooyen DM, Larter CZ, Haigh WG, Yeh MM, Ioannou G, et al. (2011) Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis. Gastroenterology 141: 1393-1403.
    • (2011) Gastroenterology , vol.141 , pp. 1393-1403
    • Van Rooyen, D.M.1    Larter, C.Z.2    Haigh, W.G.3    Yeh, M.M.4    Ioannou, G.5
  • 38
    • 77952717393 scopus 로고    scopus 로고
    • Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice
    • Bieghs V, Wouters K, van Gorp PJ, Gijbels MJ, de Winther MP, et al. (2010) Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice. Gastroenterology 138: 2477-2486, 2477-86-2486.
    • (2010) Gastroenterology , vol.138 , pp. 2477-2486
    • Bieghs, V.1    Wouters, K.2    van Gorp, P.J.3    Gijbels, M.J.4    de Winther, M.P.5
  • 39
    • 15644367080 scopus 로고    scopus 로고
    • Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase
    • Overkleeft HS, Renkema GH, Neele J, Vianello P, Hung IO, et al. (1998) Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase. J Biol Chem 273: 26522-26527.
    • (1998) J Biol Chem , vol.273 , pp. 26522-26527
    • Overkleeft, H.S.1    Renkema, G.H.2    Neele, J.3    Vianello, P.4    Hung, I.O.5
  • 40
    • 33846964923 scopus 로고    scopus 로고
    • Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man
    • Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, et al. (2007) Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man. J Org Chem 72: 1088-1097.
    • (2007) J Org Chem , vol.72 , pp. 1088-1097
    • Wennekes, T.1    van den Berg, R.J.2    Donker, W.3    van der Marel, G.A.4    Strijland, A.5
  • 41
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH, (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 42
    • 0038468462 scopus 로고    scopus 로고
    • Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure
    • Levels JH, Lemaire LC, van den Ende AE, van Deventer SJ, van Lanschot JJ, (2003) Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure. Crit Care Med 31: 1647-1653.
    • (2003) Crit Care Med , vol.31 , pp. 1647-1653
    • Levels, J.H.1    Lemaire, L.C.2    van den Ende, A.E.3    van Deventer, S.J.4    van Lanschot, J.J.5


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