Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum whereas neither MASP-1 nor MASP-3 is required for alternative pathway function

Journal of Immunology

Volumn 189, Issue 8, 2012, Pages 3957-3969

  Degn, Søren E ^a   Jensen, Lisbeth ^a   Hansen, Annette G ^a   Duman, Duygu ^b   Tekin, Mustafa ^b,c   Jensenius, Jens C ^a   Thiel, Steffen ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b ANKARA UNIVERSITY   (Turkey)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEASE 1; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEASE 2; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEASE 3; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CHILD; COMPLEMENT ACTIVATION; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT CLASSICAL PATHWAY; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENE; HUMAN; HUMAN CELL; MASP1 GENE; NONSENSE MUTATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

ABDOMINAL MUSCLES; ABNORMALITIES, MULTIPLE; ANIMALS; BLEPHAROPTOSIS; CODON, NONSENSE; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; CRANIOFACIAL ABNORMALITIES; CRANIOSYNOSTOSES; CRYPTORCHIDISM; DEVELOPMENTAL DISABILITIES; EYE ABNORMALITIES; HEART DEFECTS, CONGENITAL; HIP DISLOCATION, CONGENITAL; HUMANS; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; STRABISMUS; TRANSCRIPTIONAL ACTIVATION;

EID: 84867324414     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201736     Document Type: Article

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