Altered regional blood flow distribution in Mas-deficient mice

Therapeutic Advances in Cardiovascular Disease

Volumn 6, Issue 5, 2012, Pages 201-211

  Botelho Santos, Giancarla Aparecida ^a   Santos, Robson Augusto Souza ^a   Bader, Michael ^b   Alenina, Nathalia ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

blood flow; fluorescent microspheres; hemodynamics; knockout mice; Mas receptor; renin angiotensin system

Indexed keywords

ANGIOTENSIN RECEPTOR; ANGIOTENSIN[1-7]; MAS RECEPTOR; UNCLASSIFIED DRUG;

ADRENAL BLOOD FLOW; ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; HEART INDEX; HEART STROKE VOLUME; HEMODYNAMIC PARAMETERS; KIDNEY BLOOD FLOW; LUNG BLOOD FLOW; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN BLOOD FLOW; VASCULAR RESISTANCE;

ANIMALS; ARTERIAL PRESSURE; FLUORESCENCE; HEMODYNAMICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSPHERES; PROTO-ONCOGENE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; REGIONAL BLOOD FLOW; STROKE VOLUME; URETHANE; VASCULAR RESISTANCE;

EID: 84867313797     PISSN: 17539447     EISSN: 17539455     Source Type: Journal    
DOI: 10.1177/1753944712461164     Document Type: Article

References (74)

1. Alenina N. Baranova T. Smirnow E. Bader M. Lippoldt A. Patkin E. et al. (2002) Cell type-specific expression of the Mas proto-oncogene in testis. J Histochem Cytochem 50: 691–696.
2. Almeida A. Frábregas B. Madureira M. Santos R. Campagnole-Santos M. Santos R. (2000) Angiotensin-(1-7) potentiates the coronary vasodilatory effect bradykinin in the isolated rat heart. Braz J Med Biol Res 33: 709–713.
3. Barbee R. Perry B. Richard N. Murgo J. (1992) Microsphere and dilution techniques for the determination of blood flows and volumes in conscious mice. Am J Physiol 263: R728–R733.
4. Botelho-Santos G. Sampaio W. Reudelhuber T. Bader M. Campagnole-Santos M. Santos R. (2007) Expression of an angiotensin-(1-7)-producing fusion protein in rats induced marked changes in regional vascular resistance. Am J Physiol Heart Circ Physiol 292: H2485–H2490.
5. Braga A. Lemos M. da Silva J. Fontes W. Santos R. (2002) Effects of angiotensins on day–night fluctuations and stress-induced changes in blood pressure. Am J Physiol Regulat Integr Comp Physiol 282: R1663–R1671.
6. Brosnihan K. Li P. Ferrario C. (1996) Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension 27: 523–528.
7. Buczko W. Kucharewicz I. (2000) Angiotensin-(1-7). One step forward? Pol J Pharmacol 52: 75–81.
8. Bürgelová M. Vanourková Z. Thumová M. Dvorák P. Opocenský M. Kramer H. et al. (2009) Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension. J Hypertens 27: 1988–2000.
9. Canals M. Jenkins L. Kellett E. Milligan G. (2006) Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS. J Biol Chem 281: 16757–16767.
10. Castro C. Santos R. Ferreira A. Bader M. Alenina N. Almeida A. (2005) Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT 1 and AT 2 receptors in the mouse heart. Hypertension 46: 937–942.
11. Donoghue M. Hsieh F. Baronas E. Godbout K. Gosselin M. Stagliano N. et al. (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1. Circ Res 87: E1–E9.
12. Ehrhart-Bornstein M. Hinson J. Bornstein S. Scherbaum W. Vinson G. (1998) Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 19: 101–143.
13. Engeli S. Schling P. Gorzelniak K. Boschmann M. Janke J. Ailhaud G. et al. (2003) The adipose-tissue renin–angiotensin system: role in the metabolic syndrome? Int J Biochem Cell Biol 35: 807–825.
14. Fernandes L. Fortes Z. Nigro D. Tostes R. Santos R. Carvalho M. (2001) Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studies in vivo. Hypertension 37: 703–709.
15. Ferrario C. (1998) Angiotensin-(1-7) and antihypertensive mechanisms. J Nephrol 11: 278–283.
16. Ferrario C. (2010) New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 55: 445–452.
17. Ferrario C. Trask A. Jessup J. (2005) Advances in the biochemical and functional roles of angiotensin converting enzyme 2 and angiotensin-(1-7) in the regulation of cardiovascular function. Am Journal Physiol Heart Circ Physiol 289: H2281–H2290.
18. Ferreira A. Santos R. Almeida A. (2002) Angiotensin-(1-7) Improves the post-ischemic function in isolated perfused rat hearts. Braz J Med Biol Res 35: 1083–1090.
19. Feterik K. Smith L. Katusic Z. (2000) Angiotensin-(1-7) causes endothelium-dependent relaxation in canine middle cerebral artery. Brain Res 873: 75–82.
20. Freeman E. Chisolm G. Ferrario C. Tallant E. (1996) Angiotensin-(1-7) inhibits vascular smooth muscle cell growth. Hypertension 23: 104–108.
21. Gauthier K. Zhang D. Cui L. Nithipatikom K. Campbell W. (2008) Angiotensin II relaxations of bovine adrenal cortical arteries role of angiotensin ii metabolites and endothelial nitric oxide. Hypertension 52: 150–155.
22. Gervais M. Demolis P. Domergue V. Lesage M. Richer C. Giudicelli J. (1999) Systemic and regional hemodynamics assessment in rats with fluorescent microspheres. J Cardiovasc Pharmacol 33: 425–432.
23. Glenny R. Bernard S. Brinkley M. (1993) Validation of fluorescent-labeled microspheres for measurement of regional organ perfusion. Am Physiol Soc 93: 2585–2597.
24. Gomes E. Santos R. Guatimosim S. (2012) Angiotensin-(1-7)-mediated signaling in cardiomyocytes. Int J Hypertens 4 March (Epub ahead of print).
25. Gorelik G. Carbini L. Scicli A. (1998) Angiotensin 1–7 induces bradykinin-mediated relaxation in porcine coronary artery. Pharmacol Exp Ther 286: 403–410.
26. Guimarães G. Santos S. Oliveira M. Pimenta-Veloso E. Motta D. Martins A. et al. (2012) Exercise induces renin-angiotensin system unbalance and high collagen expression in the heart of Mas-deficient mice. Am J Physiol Heart Circ Physiol 1 June (Epub ahead of print).
27. Iusuf D. Henning R. van Gilst W. Roks A. (2008) Angiotensin-(1–7): pharmacological properties and pharmacotherapeutic perspectives. Eur J Pharmacol 585: 303–312.
28. Kostenis E. Milligan G. Christopoulos A. Sanchez-Ferrer C. Heringer-Walther S. Sexton P. et al. (2005) G-protein coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation 111: 1806–1813.
29. Kuba K. Imai Y. Penninger J. (2006) Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol 6: 271–276.
30. Kumagai H. Suzuki H. Ichikawa M. Matsumura Y. Jimbo M. Ryuzaki M. et al. (1993) Central and peripheral vasopressin interact differently with sympathetic nervous system and renin-angiotensin system in renal hypertensive rabbits. Circ Res 72: 1255–1265.
31. Leal M. Pinheiro S. Ferreira A. Santos R. Bordoni L. Alenina N. et al. (2009) The role of angiotensin-(1-7) receptor Mas in spermatogenesis in mice and rats. J Anatomy 214: 736–743.
32. Lemos V. Cortes S. Silva D. Campagnole-Santos M. Santos R. (2002) Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of m-Ren transgenic rats. Br J Pharmacol 135: 1743–1748.
33. Loot A. Roks A. Henning R. Tio R. Suumeijer A. Boomsma F. et al. (2002) Angiotensin-(1–7) attenuates the development of heart failure after myocardial infarction in rats. Circulation 105: 1548–1550.
34. Meng W. Busija D. (1993) Comparative effects of angiotensin-(1-7) and angiotensin II on piglet pial arterioles. Stroke 24: 2041–2045.
35. Morrell N. Upton P. Kotecha S. Huntley A. Yacoub M. Polak J. et al. (1999) Angiotensin II activates MAPK and stimulates growth of human pulmonary artery smooth muscle via AT 1 receptors. Am J Physiol 277: L440–L448.
36. Mulrow P. (1998) Renin–angiotensin system in the adrenal. Horm Metab Res 30: 346–349.
37. Neves L. Almeida A. Khosla M. Campagnole-Santos M. Santos R. (1997) Effect of angiotensin-(1-7) on reperfusion arrhythmias in isolated rat hearts. Braz J Med Biol Res 30: 801–809.
38. Oliveira M. Fortes Z. Santos R. Khosla M. de Carvalho M. (1999) Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo. Peptides 20: 1195–1201.
39. Orte C. Polak J. Haworth S. Yacoub M. Morrell N. (2000) Expression of pulmonary vascular angiotensin-converting enzyme in primary and secondary plexiform pulmonary hypertension. J Pathol 192: 379–384.
40. Osei S. Ahima R. Minkes R. Weaver J. Khosla M. Kadowitz P. (1993) Differential responses to Ang-(1-7) in the feline mesenteric and hindquarter vascular beds. Eur J Pharmacol 234: 35–42.
41. Peiró C. Vallejo S. Gembardt F. Azcutia V. Heringer-Walther S. Rodríguez-Mañas L. et al. (2007) Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function. J Hypertens 25: 2421–2425.
42. Porsti I. Bara A. Busse R. Hecker M. (1994) Release of nitric oxide by angiotensin-(1-7) from porcine coronary endothelium: implications for a novel angiotensin receptor. Br J Pharmacol 111: 652–654.
43. Probstfield J. O'Brien K. (2010) Progression of cardiovascular damage: the role of renin-angiotensin system blockade. Am J Cardiol 4: 10A-20A.
44. Rabelo L. Xu P. Todiras M. Sampaio W. Buttgereit J. Bader M. et al. (2008) Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction. J Am Soc Hypertens 2: 418–424.
45. Ren Y. Garvin J. Carretero O. (2002) Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles. Hypertension 39: 799–802.
46. Reudelhuber T. (2005) The renin–angiotensin system: peptides and enzymes beyond angiotensin II. Curr Opin Nephrol Hypertens 14: 155–159.
47. Richer C. Domergue V. Gervais M. Bruneval P. Giudicelli J. (2000) Fluospheres for cardiovascular phenotyping genetically modified mice. J Cardiovasc Pharmacol 36: 396–404.
48. Sampaio W. Castro C. Santos R. Schiffrin E. Touyz R. (2007 a) Angiotensin-(1-7) counterregulates angiotensin ii signaling in human endothelial cells. Hypertension 50: 1093–1098.
49. Sampaio W. Nascimento A. Santos R. (2003) Regulation of cardiovascular signaling by kinis and products of similar converting enzyme systems. systemic and regional hemodynamics effects of angiotensin-(1-7) in rats. Am J Physiol Heart Circ Physiol 284: H1985–H1994.
50. Sampaio W. Souza dos Santos R. Faria-Silva R. da Mata Machado L. Schiffrin E. Touyz R. (2007 b) Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49: 185–192.
51. Santos R. Campagnole-Santos M. Andrade S. (2000) Angiotensin-(1-7): an update. Regul Peptides 91: 45–62.
52. Santos R. Castro C. Gava E. Pinheiro S. Almeira A. Paula R. et al. (2006) Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor Mas knockout mice. Hypertension 47: 996–1002.
53. Santos S. Fernandes L. Mario E. Ferreira A. Pôrto L. Alvarez-Leite J. et al. (2008 a) Mas deficiency in FVB / N mice produces marked changes in lipid and glycemic metabolism. Diabetes 57: 340–347.
54. Santos R. Ferreira A. (2007) Angiotensin-(1–7) and the renin–angiotensin system. Curr Opin Nephrol Hypertension 16: 122–128.
55. Santos R. Ferreira A. Pinheiro S. Sampaio W. Touyz R. Campagnole-Santos M. (2005) Angiotensin-(1-7) and its receptor as a potential targets for new drugs. Expert Opin Investig Drugs 14: 1019–1031.
56. Santos R. Ferreira A. Simões E. Silva A. (2008 b) Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis. Exp Physiol 93: 519–527.
57. Santos RA. Simoes e Silva AC. Maric C. Silva DM. Machado RP. de Buhr I. et al. (2003) Angiotensin-(1–7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A 100 (14): 8258–63.
58. Sarin S. Sabba C. Groszmann R. (1990) Splanchnic and systemic hemodynamics in mice using a radioactive microsphere technique. AmJ Physiol 258: G365–G369.
59. Schmaier A. (2003) The kallikrein–kinin and the renin–angiotensin systems have a multilayered interaction. Am J Physiol Regul Integr Comp Physiol 285: R1–R13.
60. Shenoy U. Cassis L. (1997) Characterization of renin activity in brown adipose-tissue. Am J Physiol 272: C989–C999.
61. Shenoy V. Qi Y. Katovich M. Raizada M. (2011) ACE2, a promising therapeutic target for pulmonary hypertension. Curr Opin Pharmacology 11: 150–155.
62. Silva D. Vianna H. Cortes S. Campagnole-Santos M. Santos R. Lemos V. (2007) Evidence for a new angiotensin-(1–7) receptor subtype in the aorta of Sprague–Dawley rats. Peptides 28: 702–707.
63. Singh M. Mensah G. Bakris G. (2010) Pathogenesis and clinical physiology of hypertension. Cardiol Clin 28: 545–559.
64. Tallant E. Lu X. Weiss R. Chappell M. Ferrario C. (1997) Bovine aortic endothelial cells contain an angiotensina-(1-7) receptor. Hypertension 29: 388–393.
65. Tipnis S. Hooper N. Hyde R. Karran E. Christie G. Turner A. (2000) A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 275: 33238–33243.
66. Uhal B. Li X. Xue A. Gao X. Abdul-Hafez A. (2011) Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1-7/Mas axis. Am J Physiol Lung Cell Mol Physiol 301: L269–L274.
67. Unger T. Paulis L. Sica D. (2011) Therapeutic perspectives in hypertension: novel menas for renin–angiotensin–aldosterone system modulation and emerging device-based approaches. Eur Heart J 32: 2739–2747.
68. van der Wouden E. Ochodnicky P. van Dokkum R. Roks A. Deelman L. de Zeeuw D. Henning R. (2006) The role of angiotensin(1-7) in renal vasculature of the rat. J Hypertens 24: 1971–1978.
69. Varagic J. Trask A. Jessup J. Chappell M. Ferrario C. (2008) New angiotensins. J Mol Med 86: 663–671.
70. Wang Y. Qian C. Roks A. Westermann D. Schumacher S. Escher F. et al. (2010) Circulating rather than cardiac angiotensin-(1-7) stimulates cardioprotection post myocardial infarction. Circ Heart Fail 3: 286–293.
71. Watts J. Gellar M. Stuart L. Obraztsova M. Marchick M. Kline J. (2011) Effects of angiotensin (1-7) upon right ventricular function in experimental rat pulmonary embolism. Histol Histopathol 26: 1287–1294.
72. Welsh M. Sharpe R. Moffat L. Atanassova N. Saunders P. Kilter S. Bergh A. et al. (2010) Androgen action via testicular arteriole smooth muscle cells is important for leydig cell function, vasomotion and testicular fluid dynamics. PloS ONE 5: e13632.
73. Werner C. Baumhäkel M. Teo K. Schmieder R. Mann J. Unger T. et al. (2008) RAS blockade with ARB and ACE inhibitors: current perspective on rationale and patient selection. Clin Res Cardiol 97: 418–431.
74. Xu P. Costa-Goncalves A. Todiras M. Rabelo L. Sampaio W. Moura M. et al. (2008) Endothelial dysfunction and elevated blood pressure in Mas gene-deleted mice. Hypertension 51: 574–580.