Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mren-2 transgenic rats

British Journal of Pharmacology

Volumn 135, Issue 7, 2002, Pages 1743-1748

  Lemos, Virgínia S ^a   Côrtes, Steyner F ^a   Silva, Denise M R ^a   Campagnole Santos, Maria J ^a   Santos, Robson A S ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Angiotensin (1 7); Bradykinin; Contractile responses; Endothelial receptors; Nitric oxide; Phenylephrine; Renin angiotensin system

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; A 779; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN RECEPTOR; ANGIOTENSIN RECEPTOR ANTAGONIST; ANGIOTENSIN[1-7]; BRADYKININ ANTAGONIST; BRADYKININ RECEPTOR; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; ICATIBANT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; UNCLASSIFIED DRUG; ALPHA ADRENERGIC RECEPTOR; ANGIOTENSIN I; ANGIOTENSIN I (1 7); ANGIOTENSIN I (1-7); ANTIHYPERTENSIVE AGENT; PEPTIDE FRAGMENT;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; MALE; MODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRAIN DIFFERENCE; TRANSGENIC ANIMAL; ANALYSIS OF VARIANCE; ANIMAL; AORTA; DRUG ANTAGONISM; DRUG INTERACTION; IN VITRO STUDY; MOUSE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANALYSIS OF VARIANCE; ANGIOTENSIN I; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIHYPERTENSIVE AGENTS; AORTA; CAPTOPRIL; DRUG INTERACTIONS; ENDOTHELIUM, VASCULAR; MALE; MICE; PEPTIDE FRAGMENTS; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, ANGIOTENSIN; RECEPTORS, BRADYKININ; VASOCONSTRICTION;

EID: 0036546371     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704630     Document Type: Article

References (36)

1. ABAS, A., GORELIK, G., CARHINI, L.A. & SCICLI, A.G. (1997). Angiotensin-(1-7) induces bradykinin-mediated hypotensive responses in anesthetized rats. Hypertension, 30, 217-221.
2. ARNET, H.A., NOVOSEL, D., BARTON, M., NOLL, G., GANTEN, O. & LÜCHER, T.F. (1999). Endothelium dysfunction in the aorta of transgenic rats harboring the mouse Ren-2 gene. Endothelium, 6, 175-184.
3. ARRIBAS, S., SANCHEZ-FERRER, C.F., PIERO, C., PONTE, A., SALAICES, M. & MARIN, J. (1994). Functional vascular rennin-angiotensin system in hypertensive transgenic rats for the mouse renin gene Ren-2. Gen. Pharmacol., 25, 1163-1170.
4. HADER, M., ZHAO, Y.I., SANDER, M., LEE, M.A., BACHMANN, J., BOHM, M., DJAVIDANI, B., PETERS, J., MULLINS, J.J. & GANTEN, D. (1992). Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27 rats. Hypertension, 19, 681-686.
5. BENTER, I.F., FERRARIO, C.M., MORRIS, M. & DIZ, D.I. (1995). Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats. Am. J. Physiol., 269, H313-H319.
6. BROSNIHAN, K.B., LI, P. & FERRARIO, C.M. (1996). Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide. Hypertension, 27, 523-528.
7. CAMPBELL, D.J., KONG, P., KLADIS, A., REES, B., GANTEN, D. & SKINNER, S.L. (1995). Angiotensin and BK peptides in the TGR(mRen-2)27 rat. Hypertension, 25, 1014-1020.
8. CHAPPELL, M.C., TALLANT, E.A., BROSNIHAN, K.B. & FERRARIO, C.M. (1994). Conversion of angiotensin I to angiontensin-(1-7) by thunnel oligopeptidase (EC 3.4.24.15) in vascular smooth muscle cells. J. Vasc. Med. Biol., 5, 129-137.
9. DONOGHUE, M., HSIEH, F., BARONAS, C., GODBOUT, K., GOSSELIN, M., STAGLIANO, N., DONOVAN, M., WOOLF, B., ROBISON, K., JEYASSELAN, R., BREITBART, R.E. & ACTON, S. (2000). A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res., 87, E1-E9.
10. DZAU, V.J. (1993). Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart. Basic Res. Cardiol., 88, 1-14.
11. FERNANDES, L., FORTES, Z.B., NIGRO, D., TOSTES, R.C.A., SANTOS, R.A.S. & CARVALHO, M.H.C. (2001). Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo. Hypertension, 37, 703-709.
12. GANTEN, D. (1993). The transition from experimental to clinical pharmacology: the renin-angiotensin paradigm. J. Cardiovasc. Pharmacol., 22, 514-529.
13. GORELIK, G., CARBINI, L.A. & SCICLI, A.G. (1998). Angiotensin 1-7 induces bradykinin-mediated relaxation in procine coronary artery. J. Pharmacol. Exp. Ther., 286, 403-410.
14. GROSS, V., LIPPOLDT, A., SCHNEIDER, W. & LUFT, F.C. (1995). Effect of captopril and angiotensin II receptor blockade on-pressure natrioresis in transgenic TGR(mRen-2)27 rats. Hypertension, 26, 471-479.
15. HILGERS, H., BROVKOVYCH, S., MALINSKI, T. & WIEMER, O. (2001). Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells. Hypertension, 37, 72-76.
16. HILGERS, K.F., PETERS, J., VEELKEN, R., SOMMER, M., RUPRECHT, G., GANTEN, D., LUFT, F.C. & MANN, J.F.E. (1997). Increased vascular angiotensin formation in female rats harboring the mouse Ren-2 gene. Hypertension, 19, 687-691.
17. JACKE, K., WITTE, K., HUSER, L., BEHRENDS, H., & LEMMER, H. (2000). Contribution of the renin-angiotensin system to sub-sensitivity of soluble glumylyl cyclase in TGR(mRen2)27 rats. Eur. J. Pharmacol., 403, 27-35.
18. LEE, M.A., BOHM, M., KIM, S., BACHMANN, S., BACHMANN, J., HADER, M. & GANTEN, D. (1995). Differential gene expression of renin and angiotensin in the RGR(mREN-2)27 transgenic rat. Hypertension, 25, 570-580.
19. MOMBOULI, I.-V. & VANHOUTTE, P.M. (1999). Endothelial dysfunction: from physiology to therapy. J. Mol. Cell Cardiol., 31, 61-74.
20. MORIGUCHI, A., TALLANT, E.A., MATSUMURA, K., REILLY, T.M., WALTON, H., GANTEN, D. & FERRARIO, C.M. (1995). Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats. Hypertension, 25, 1260-1265.
21. MULLER, C., ENDLICH, K., and HELWIG, U. (1998). Role of cicosanoids in renal angiotensin II vasoconstriction during nitric oxide blockade. Kidney Int. Suppl., 67, S234-S237.
22. MULLINS, J.J., PETERS, J. & GANTEN, D. (1990). Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature, 344, 541-544.
23. MUTHALIF, M.M., BENTER, I.F., UDDIN, M.R., HARPER, J.L. & MALIK, K.U. (1998). Signal transduction mechanisms involved in angiotensin-(1-7) -stimulated arachidonic acid release and prostanoid synthesis in rabbit aortic smooth muscle cells. J. Pharmacol. Exp. Ther., 284, 388-398.
24. NAKAMOTO, H., FERRARIO, C.M., FULLER, S.B., ROBACZEWSKI, D.L., WINICOV, E. & DEAN, R.P. (1995). Angiontensin-(1-7) and nitric oxide interactions in renovascular hypertension. Hypertension, 25, 796-802.
25. NEVES, L.A.A., ALMEIDA, A.P., KHOSLA, M.C. & SANTOS, R.A.S. (1995). Metabolism of angiotensin I in isolated rat hearts. Effect of angiotensin converting enzyme inhibitors. Biochem. Pharmacol., 50, 1451-1459.
26. 1 receptor gene expression in transgenic (mRen-2) 27 rats. Br. J. Pharmacol., 121, 134-140.
27. OLIVEIRA, M.A., FORTES, Z.B., SANTOS, R.A.S., KHOSLA, M.C. & GARVALHO, M.H.C. (1999). Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilatation in vivo. Peptides, 20, 1195-1201.
28. PUEYO, M.E. & MICHEL, J.-B. (1997). Angiotensin II receptors in endothelial cells. Gen. Pharmac., 29, 691-696.
29. RURDY, R.E. & WEBER, M.A. (1988). Angiotensin amplification of α-adrenergic vasoconstriction, role of receptor reserve. Circ. Res., 63, 748-757.
30. SANTOS, R.A.S., BROSHIHANN, K.B., JACOBSEN, D.W., DICORLETO, P.E. & FERRARIO, C.M. (1992). Production of angiotensin-(1-7) by human vascular endothelium. Hypertension, 19, II-56-II-61.
31. SANTOS, R.A.S., CAMPAGNOLE-SANTOS, M.J. & ANDRADE, S.P. (2000). Angiotensin-(1-7): an update. Regul. Pept., 91, 45-62.
32. TALLANT, E.A., LU, X., WEISS, R.B., CHAPPELI, M.C. & FERRARIO, C.M. (1997). Bovine aortic endothelial cells contain an angiotensin-(1-7) receptor. Hypertension, 29, 388-393.
33. UNGER, T.H., GOHLKE, P., PAUL, M. & BETTIG, R. (1991). Tissue renin-angiotensin systems: fact or fiction? J. Cardiovasc. Pharmac., 18, S20-S25.
34. WEISHAAR, R.E., PANEK, R.L, MAJOR, T.C., SIMMERMAN, J. RAPUNDALO, S.T. & TAYLOR, D.G. (1991). Evidence for a functional tissue renin-angiotensin system in the rat mesenteric vasculature and its involvement in regulating blood pressure. J. Pharmacol. Exp. Ther., 256, 568-574.
35. YAMADA, K., IYER, S.N., CHAPPELI., M.C., BROSNIHAN, K.B., FUKUHARA, M. & FERRARIO, C.M. (1999). Differential response of angiotensin peptides in the urine of hypertensive animals. Regul. Pept., 80, 57-66.
36. 2 receptors in the hypertensive Ren-2 gene transgenic rat kidney. Hypertension, 33, 347-353.