Ablation of angiotensin (1-7) receptor Mas in C57Bl/6 mice causes endothelial dysfunction

Journal of the American Society of Hypertension

Volumn 2, Issue 6, 2008, Pages 418-424

  Rabelo, Luiza A ^a,b   Xu, Ping ^c   Todiras, Mihail ^c   Sampaio, Walkyria O ^a   Buttgereit, Jens ^c   Bader, Michael ^c   Santos, Robson A S ^a   Alenina, Natalia ^c  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b Instituto de Ciências Biológicas e da Saúde   (Brazil)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

endothelial function; Mas deficient mice; nitric oxide; reactive oxygen species

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN RECEPTOR; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; HYPERTENSION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; STRAIN DIFFERENCE; VASODILATATION;

EID: 57149117137     PISSN: 19331711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jash.2008.05.003     Document Type: Article

References (31)

1. Jackson T.R., Blair L.A., Marshall J., Goedert M., and Hanley M.R. The Mas oncogene encodes an angiotensin receptor. Nature 335 (1988) 437-440
2. Santos R.A., Simoes e Silva A.C., Maric C., Silva D.M., Machado R.P., de Buhr I., et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A 100 (2003) 8258-8263
3. Benter I.F., Yousif M.H., Anim J.T., Cojocel C., and Diz D.I. Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME. Am J Physiol 290 (2006) H684-H691
4. Grobe J.L., Mecca A.P., Lingis M., Shenoy V., Bolton T.A., Machado J.M., et al. Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). Am J Physiol 292 (2007) H736-H742
5. Iwata M., Cowling R.T., Gurantz D., Moore C., Zhang S., Yuan J.X., et al. Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects. Am J Physiol 289 (2005) H2356-H2363
6. Iyer S.N., Ferrario C.M., and Chappell M.C. Angiotensin-(1-7) contributes to the antihypertensive effects of blockade of the renin-angiotensin system. Hypertension 31 (1998) 356-361
7. Santos R.A., Ferreira A.J., Nadu A.P., Braga A.N., de Almeida A.P., Campagnole-Santos M.J., et al. Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats. Physiol Genom 17 (2004) 292-299
8. Kostenis E., Milligan G., Christopoulos A., Sanchez-Ferrer C.F., Heringer-Walther S., Sexton P.M., et al. G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation 111 (2005) 1806-1813
9. Heitsch H., Brovkovych S., Malinski T., and Wiemer G. Angiotensin-(1-7)-stimulated nitric oxide and superoxide release from endothelial cells. Hypertension 37 (2001) 72-76
10. Alenina N., Xu P., Rentzsch B., Patkin E.L., and Bader M. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol 93 (2008) 528-537
11. da Costa Goncalves A.C., Leite R., Fraga-Silva R.A., Pinheiro S.V., Reis A.B., Reis F.M., et al. Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function. Am J Physiol 293 (2007) H2588-H2596
12. Sampaio W.O., Souza dos Santos R.A., Faria-Silva R., da Mata Machado L.T., Schiffrin E.L., and Touyz R.M. Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways. Hypertension 49 (2007) 185-192
13. Kumar M., Grammas P., Giacomelli F., and Wiener J. Selective expression of c-Mas proto-oncogene in rat cerebral endothelial cells. Neuroreport 8 (1996) 93-96
14. Xu P., Costa-Goncalves A.C., Todiras M., Rabelo L.A., Sampaio W.O., Moura M.M., et al. Endothelial dysfunction and elevated blood pressure in Mas gene-deleted mice. Hypertension 51 (2008) 574-580
15. Hartner A., Cordasic N., Klanke B., Veelken R., and Hilgers K.F. Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice. Nephrol Dial Transplant 18 (2003) 1999-2004
16. Pillebout E., Burtin M., Yuan H.T., Briand P., Woolf A.S., Friedlander G., et al. Proliferation and remodeling of the peritubular microcirculation after nephron reduction: association with the progression of renal lesions. Am J Pathol 159 (2001) 547-560
17. Xu P., Santos R.A., Bader M., and Alenina N. Alterations in gene expression in the testis of angiotensin-(1-7)-receptor Mas-deficient mice. Regul Pept 138 (2007) 51-55
18. Bohlender J., Menard J., Wagner J., Luft F.C., and Ganten D. Human renin-dependent hypertension in rats transgenic for human angiotensinogen. Hypertension 27 (1996) 535-540
19. Bohlender J., Menard J., Edling O., Ganten D., and Luft F.C. Mouse and rat plasma renin concentration and gene expression in (mRen2)27 transgenic rats. Am J Physiol 274 (1998) H1450-H1456
20. Langenickel T.H., Pagel I., Buttgereit J., Tenner K., Lindner M., Dietz R., et al. Rat corin gene: molecular cloning and reduced expression in experimental heart failure. Am J Physiol 287 (2004) H1516-H1521
21. Gerzer R., Bohme E., Hofmann F., and Schultz G. Soluble guanylate cyclase purified from bovine lung contains heme and copper. FEBS Lett 132 (1981) 71-74
22. Walther T., Balschun D., Voigt J.P., Fink H., Zuschratter W., Birchmeier C., et al. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. J Biol Chem 273 (1998) 11867-11873
23. Wu L., Iwai M., Nakagami H., Chen R., Suzuki J., Akishita M., et al. Effect of angiotensin II type 1 receptor blockade on cardiac remodeling in angiotensin II type 2 receptor null mice. Arterioscler Thromb Vasc Biol 22 (2002) 49-54
24. Gurley S.B., Allred A., Le T.H., Griffiths R., Mao L., Philip N., et al. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest 116 (2006) 2218-2225
25. Bendall J.K., Heymes C., Wright T.J., Wheatcroft S., Grieve D.J., Shah A.M., et al. Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. J Mol Cell Cardiol 34 (2002) 1325-1333
26. Lum C., Shesely E.G., Potter D.L., and Beierwaltes W.H. Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension 43 (2004) 79-86
27. Muller D.N., Schmidt C., Barbosa-Sicard E., Wellner M., Gross V., Hercule H., et al. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J 403 (2007) 109-118
28. Peiro C., Vallejo S., Gembardt F., Azcutia V., Heringer-Walther S., Rodriguez-Manas L., et al. Endothelial dysfunction through genetic deletion or inhibition of the G protein-coupled receptor Mas: a new target to improve endothelial function. J Hypertens 25 (2007) 2421-2425
29. Lykkesfeldt J. Malondialdehyde as biomarker of oxidative damage to lipids caused by smoking. Clin Chim Acta 380 (2007) 50-58
30. Meagher E.A., and FitzGerald G.A. Indices of lipid peroxidation in vivo: strengths and limitations. Free Radic Biol Med 28 (2000) 1745-1750
31. Faria-Silva R., Duarte F.V., and Santos R.A. Short-term angiotensin(1-7) receptor Mas stimulation improves endothelial function in normotensive rats. Hypertension 46 (2005) 948-952