Novel involvement of leukotriene B4 receptor 2 through ERK activation by PP2A down-regulation in leukotriene B4-induced keratin phosphorylation and reorganization of pancreatic cancer cells

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1823, Issue 12, 2012, Pages 2120-2129

  Park, Mi Kyung ^a   Park, Youngran ^a   Shim, Jaegal ^b   Lee, Hye Ja ^a   Kim, Sanghee ^c   Lee, Chang Hoon ^a  

^a Dongguk University   (South Korea)

^b National Cancer Center   (South Korea)

^c University of Seoul   (South Korea)

Author keywords

Leukotriene B4 Phosphorylation of keratin 8 Perinuclear reorganization of keratin LY255283 8 Leukotriene B4 receptor 2 PP2A

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; CYTOKERATIN 8; KERATIN; LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PANCREAS CANCER; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION;

ANESTHETICS, INHALATION; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; ENZYME ACTIVATION; ETHERS; FLAVONOIDS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYDROCARBONS, FLUORINATED; IMMUNOPRECIPITATION; KERATIN-8; LEUKOTRIENE B4; MITOGEN-ACTIVATED PROTEIN KINASE 3; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RECEPTORS, LEUKOTRIENE B4; RNA, MESSENGER; RNA, SMALL INTERFERING; SERINE; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84867298939     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2012.09.004     Document Type: Article

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