Involvement of the BLT 2 receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice

British Journal of Pharmacology

Volumn 154, Issue 5, 2008, Pages 1073-1078

  Kim, H J ^a   Kim, D K ^a   Kim, H ^a   Koh, J Y ^a   Kim, K M ^a   Noh, M S ^a   Lee, S ^b   Kim, S ^b   Park, S H ^c   Kim, J J ^a   Kim, S Y ^d   Lee, C H ^d  

^a AmorePacific Corporation   (South Korea)

^b Seoul National University   (South Korea)

^c Inha University School of Medicine   (South Korea)

^d National Cancer Center   (South Korea)

Author keywords

12(R) HETE; 12(S,R) HETE; BLT 2 receptor; Compound A; LY255283; Scratching

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 2 (2,6 DIHYDROXYHEXYL) 6 (3 HYDROXY 1,5 UNDECADIENYL)PYRIDINE; 4' [[PENTANOYL(PHENYL)AMINO]METHYL] 1,1' BIPHENYL 2 CARBOXYLIC ACID; 5 ETHYL 2 HYDROXY 4 [6 METHYL 6 (1H TETRAZOL 5 YL)HEPTYLOXY]ACETOPHENONE; ARACHIDONATE 12 LIPOXYGENASE; CAPSAICIN; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE BLT2 RECEPTOR; LEUKOTRIENE RECEPTOR STIMULATING AGENT; NALTREXONE; ANTIPRURITIC AGENT; FATTY ALCOHOL; GLYCOL; LTB4R2 PROTEIN, MOUSE; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PRURITUS; SCRATCHING; VIDEORECORDING; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; DRUG SCREENING; METABOLISM; METHODOLOGY; SIGNAL TRANSDUCTION;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ANIMALS; ANTIPRURITICS; ARACHIDONATE 12-LIPOXYGENASE; BEHAVIOR, ANIMAL; CAPSAICIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FATTY ALCOHOLS; GLYCOLS; MALE; MICE; MICE, INBRED ICR; NALTREXONE; PRURITUS; RECEPTORS, LEUKOTRIENE B4; SIGNAL TRANSDUCTION; TETRAZOLES; VIDEO RECORDING;

EID: 46249119396     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.220     Document Type: Article

References (34)

1. Alexander SPH, Mathie A, Peters JA (2007). Guide to Receptors and Channels (GRAC), 2nd edition (2007 revision). Br J Pharmacol 150 (Suppl 1): S1-S168.
2. 4 in substance P-induced itch-associated response in mice. J Invest Dermatol 117: 1621-1626.
3. 2 induces itch-associated responses in mice. Eur J Pharmacol 353: 93-96.
4. 4 receptor on the dorsal root ganglion neurons in mice. Brain Res Mol Brain Res 137: 263-266.
5. 2 induces itch-associated responses through TP receptors in the skin in mice. J Invest Dermatol 127: 2042-2047.
6. Antonipillai I, Nadler J, Vu EJ, Bughi S, Natarajan R, Horton R (1996). A 12-lipoxygenase product, 12-hydroxyeicosatetraenoic acid, is increased in diabetics with incipient and early renal disease. J Clin Endocrinol Metab 81: 1940-1945.
7. Bevan S, Szolcsányi J (1990). Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol Sci 11: 330-333.
8. Bienkowski P, Kostowski W, Koros E (1999). Ethanol-reinforced behaviour in the rat: effects of naltrexone. Eur J Pharmacol 374: 321-327.
9. Boeglin WE, Kim RB, Brash AR (1998). A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. Proc Natl Acad Sci USA 95: 6744-6799.
10. 4-like material in biologically active amounts from the lesional skin of patients with psoriasis. J Invest Dermatol 83: 70-73.
11. 4. Br J Pharmacol 80: 497-502.
12. 4 receptors on guinea pig lung membranes by sulfhydryl modifying reagents. J Pharmacol Exp Ther 255: 565-571.
13. Fjellner B, Hagermark Q (1979). Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement. Acta Deratovener 59: 505-512.
14. Gonzalez-Nunez D, Claria J, Rivera F, Poch E (2001). Increased levels of 12(S)-HETE in patients with essential hypertension. Hypertension 37: 334-338.
15. 2. Acta Dermatovener 57: 37-43.
16. Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J et al. (2000). Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97: 6155-6160.
17. 2 -dependent Erk activation and cell migration of primary mouse keratinocytes. J Biol Chem 280: 24816-24823.
18. Kim DK, Kim HJ, Sung KS, Kim H, Cho SA, Kim KM et al. (2007). 12(S)-HPETE induces itch-associated scratchings in mice. Eur J Pharmacol 554: 30-33.
19. Kuraishi Y, Nagasawa T, Hayashi K, Satoh M (1995). Scratching behavior induced by pruritogenic but not algesiogenic agents in mice. Eur J Pharmacol 275: 229-233.
20. 2: expression and function in human and murine mast cells. J Immunol 177: 3439-3447.
21. Neuber K, Hilger RA, Konig W (1992). Differential increase in 12-HETE release and CD29/CD49f expression of platelets from normal donors and from patients with atopic dermatitis. Int Arch Allergy Immunol 98: 339-342.
22. Piomelli D, Volterra A, Dale N, Siegelbaum SA, Kandel ER, Schwartz JH et al. (1987). Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells. Nature 328: 38-43.
23. Pock E (2003). Role of lipoxygenase metabolites in cardiovascular disease. Curr Hypertens Rep 5: 1-2.
24. Ruzicka T, Simmet T, Peskar BA, Ring J (1986). Skin levels of arachidonic acid-derived inflammatory mediators and histamine in atopic dermatitis and psoriasis. J Invest Dermatol 86: 105-108.
25. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE (1997). Specific C-receptors for itch in human skin. J Neurosci 17: 8003-8008.
26. Souza DG, Coutinho SF, Silveira MR, Cara DC, Teixeira MM (2000). Effects of a BLT receptor antagonist on local and remote reperfusion injuries after transient ischemia of the superior mesenteric artery in rats. Eur J Pharmacol 403: 121-128.
27. Stander S, Steinhoff M (2002). Pathophysiology of pruritus in atopic dermatitis: overview. Exp Dermatol 11: 12-24.
28. Tang K, Honn KV (1999). 12(S)-HETE in Cancer Metastasis. Lipoxygenases and Their Metabolites. Pienum Press: New York.
29. Wahlgren CF (1991). Itch and atopic dermatitis: clinical and experimental studies. Acta Derm Venereol Suppl (Stockh) 165: 1-53.
30. Weisshaar E, Kucenic MJ, Fleischer Jr AB (2003). Pruritus: a review. Acta Derm Venereol Suppl 213: 5-32.
31. Yao Y, Clark CM, Trojanowski JQ, Lee VMY, Pratico D (2005). Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Annal Neurol 58: 623-626.
32. 2. J Biol Chem 276: 12454-12459.
33. 2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 192: 421-432.
34. Ziboh V, Cho Y, Mani I, Xi S (2002). Biological significance of essential fatty acids/prostanoids/lipoxygenase-derived monohydroxy fatty acids in the skin. Arch Pharm Res 25: 747-758.