Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice

Journal of Virology

Volumn 86, Issue 16, 2012, Pages 8568-8580

  Yao, Hui Wen ^a   Chen, Shih Heng ^a   Li, Ching ^b   Tung, Yuk Ying ^c   Chena, Shun Hua ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c Institute of Education   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENIC FACTOR; EARLY GROWTH RESPONSE FACTOR 1; FIBROBLAST GROWTH FACTOR 2; VASCULOTROPIN; VASCULOTROPIN A; EGR1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA INJURY; CORNEA NEOVASCULARIZATION; CORNEA OPACITY; DISEASE SEVERITY; EARLY GROWTH RESPONSE FACTOR 1 GENE; FEMALE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; GENETIC ANALYSIS; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS GENE; VIRUS LOAD; VIRUS REPLICATION; VIRUS VIRULENCE; CORNEA DISEASE; EGR 1 GENE; GENE; HERPES SIMPLEX; HERPETIC STROMAL KERATITIS; NEOVASCULARIZATION (PATHOLOGY); PROTEIN FUNCTION; ANIMAL; C57BL MOUSE; CORNEA; DISEASE MODEL; DRUG ANTAGONISM; GENE DELETION; HOST PATHOGEN INTERACTION; MOUSE MUTANT; PATHOGENICITY; PATHOLOGY; VIROLOGY;

ANIMALS; CORNEA; DISEASE MODELS, ANIMAL; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; HERPESVIRUS 1, HUMAN; HOST-PATHOGEN INTERACTIONS; KERATITIS, HERPETIC; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; TRANSCRIPTION FACTORS; VIRUS REPLICATION;

EID: 84867294947     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.07020-11     Document Type: Article

References (47)

1. Aicher WK, Sakamoto KM, Hack A, Eibel H. 1999. Analysis of functional elements in the human Egr-1 gene promoter. Rheumatol. Int. 18: 207-214.
2. Babu JS, et al. 1996. Viral replication is required for induction of ocular immunopathology by herpes simplex virus. J. Virol. 70:101-107.
3. Bacon TH, Levin MJ, Leary JJ, Sarisky RT, Sutton D. 2003. Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin. Microbiol. Rev. 16:114-128.
4. Biswas PS, Banerjee K, Kim B, Smith J, Rouse BT. 2005. A novel flow cytometry based assay for quantification of corneal angiogenesis in the mouse model of herpetic stromal keratitis. Exp. Eye Res. 80:73-81.
5. Biswas PS, Rouse BT. 2005. Early events in HSV keratitis-setting the stage for a blinding disease. Microbes Infect. 7:799-810.
6. Bittlingmaier K, Schneider D, Falke D. 1977. Influence of dibutyryl cyclicAMPon thymidine uptake by herpes simplex virus infected cells and the intracellular level of cyclic AMP. Biochim. Biophys. Acta 477:228-238.
7. Carr DJ, Chodosh J, Ash J, Lane TE. 2003. Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. J. Virol. 77:10037-10046.
8. Chang Y, et al. 2006. Induction of the early growth response 1 gene by Epstein-Barr virus lytic transactivator Zta. J. Virol. 80:7748-7755.
9. Chauhan D, et al. 1994. Involvement of serum response element in okadaic acid-induced EGR-1 transcription in human T-cells. Cancer Res. 54:2234-2239.
10. Chen SH, et al. 2008. Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice. J. Clin. Invest. 118:3470-3477.
11. Dana MR, Zhu SN, Yamada J. 1998. Topical modulation of interleukin-1 activity in corneal neovascularization. Cornea 17:403-409.
12. Davar G, et al. 1994. Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J. Comp. Neurol. 339:3-11.
13. Duan R, de Vries RD, Osterhaus AD, Remeijer L, Verjans GM. 2008. Acyclovir-resistant corneal HSV-1 isolates from patients with herpetic keratitis. J. Infect. Dis. 198:659-663.
14. Duan R, et al. 2009. Acyclovir susceptibility and genetic characteristics of sequential herpes simplex virus type 1 corneal isolates from patients with recurrent herpetic keratitis. J. Infect. Dis. 200:1402-1414.
15. Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM. 2003. Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nat. Med. 9:1026-1032.
16. Haas TL, Stitelman D, Davis SJ, Apte SS, Madri JA. 1999. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J. Biol. Chem. 274:22679-22685.
17. Herpetic Eye Disease Study Group. 2000. Oral acyclovir for herpes simplex virus eye disease: effect on prevention of epithelial keratitis and stromal keratitis. Arch. Ophthalmol. 118:1030-1036.
18. Jang KL, Pulverer B, Woodgett JR, Latchman DS. 1991. Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO. Nucleic Acids Res. 19:4879-4883.
19. Jin Y, Sheikh F, Detillieux KA, Cattini PA. 2000. Role for early growth response-1 protein in alpha(1)-adrenergic stimulation of fibroblast growth factor-2 promoter activity in cardiac myocytes. Mol. Pharmacol. 57:984-990.
20. Kim B, et al. 2004. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am. J. Pathol. 165:2177-2185.
21. Kim DB, DeLuca NA. 2002. Phosphorylation of transcription factor Sp1 during herpes simplex virus type 1 infection. J. Virol. 76:6473-6479.
22. Knickelbein JE, Hendricks RL, Charukamnoetkanok P. 2009. Management of herpes simplex virus stromal keratitis: an evidence-based review. Surv. Ophthalmol. 54:226-234.
23. Kundumani-Sridharan V, et al. 2010. 15(S)-Hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression. Blood 115:2105-2116.
24. Lee SL, et al. 1996. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273: 1219-1221.
25. Lee SL, Tourtellotte LC, Wesselschmidt RL, Milbrandt J. 1995. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J. Biol. Chem. 270:9971-9977.
26. Liesegang TJ. 2001. Herpes simplex virus epidemiology and ocular importance. Cornea 20:1-13.
27. Liu L, Tsai JC, Aird WC. 2000. Egr-1 gene is induced by the systemic administration of the vascular endothelial growth factor and the epidermal growth factor. Blood 96:1772-1781.
28. Metcalf JF, Koga J, Chatterjee S, Whitley RJ. 1987. Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease. Curr. Eye Res. 6:173-177.
29. Naesens L, De Clercq E. 2001. Recent developments in herpesvirus therapy. Herpes 8:12-16.
30. O'Donovan KJ, Tourtellotte WG, Millbrandt J, Baraban JM. 1999. The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience. Trends Neurosci. 22:167-173.
31. Pepose JS. 1996. Herpes simplex virus disease: anterior segment of the eye, p 905-932. In Pepose JS, Holland GN, Whilhelmus KR (ed), Ocular infection and immunity, 1st ed. C. V. Mosby, St. Louis, MO.
32. Remeijer L, Osterhaus A, Verjans G. 2004. Human herpes simplex virus keratitis: the pathogenesis revisited. Ocul. Immunol. Inflamm. 12:255-285.
33. Rezende RA, et al. 2006. Efficacy of oral antiviral prophylaxis in preventing ocular herpes simplex virus recurrences in patients with and without self-reported atopy. Am. J. Ophthalmol. 142:563-567.
34. Roizman B, Knipe DM, Whitley RJ. 2007. Herpes simplex viruses, p 2501-2601. In Knipe DM, et al. (ed), Fields virology, 5th ed, vol 2. Lippincott Williams & Wilkins, Philadelphia, PA.
35. Santiago FS, Lowe HC, Day FL, Chesterman CN, Khachigian LM. 1999. Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Am. J. Pathol. 154: 937-944.
36. Santiago FS, et al. 1999. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat. Med. 5:1264-1269.
37. Saravia M, Zapata G, Ferraiolo P, Racca L, Berra A. 2009. Anti-VEGF monoclonal antibody-induced regression of corneal neovascularization and inflammation in a rabbit model of herpetic stromal keratitis. Graefe's Arch. Clin. Exp. Ophthalmol. 247:1409-1416.
38. Shimoyamada H, et al. 2010. Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells. Am. J. Pathol. 177:70-83.
39. Su YH, Yan XT, Oakes JE, Lausch RN. 1996. Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection. J. Virol. 70:1277-1281.
40. Thomas J, Gangappa S, Kanangat S, Rouse BT. 1997. On the essential involvement of neutrophils in the immunopathologic disease: herpetic stromal keratitis. J. Immunol. 158:1383-1391.
41. Tumpey TM, Chen SH, Oakes JE, Lausch RN. 1996. Neutrophilmediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J. Virol. 70:898-904.
42. Vidal F, Aragones J, Alfranca A, de Landazuri MO. 2000. Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1. Blood 95:3387-3395.
43. Wang D, Mayo MW, Baldwin AS, Jr. 1997. Basic fibroblast growth factor transcriptional autoregulation requires EGR-1. Oncogene 14:2291-2299.
44. Wuest T, Zheng M, Efstathiou S, Halford WP, Carr DJ. 2011. The herpes simplex virus-1 transactivator infected cell protein-4 drives VEGF-A dependent neovascularization. PLoS Pathog. 7:e1002278. doi: 10.1371/journal.ppat.1002278.
45. Yan SF, et al. 2000. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 6:1355-1361.
46. Yan XT, Tumpey TM, Kunkel SL, Oakes JE, Lausch RN. 1998. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest. Ophthalmol. Vis. Sci. 39:1854-1862.
47. Zheng M, Deshpande S, Lee S, Ferrara N, Rouse BT. 2001. Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis. J. Virol. 75:9828-9835.