Atrial fibrillation in pigs induces left atrial endocardial transcriptional remodelling

Thrombosis and Haemostasis

Volumn 108, Issue 4, 2012, Pages 742-749

  Cerveró, Jorge ^a   Segura, Víctor ^a   Macías, Alfonso ^b   Gavira, Juan José ^b   Montes, Ramón ^a   Hermida, José ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Animals models; Endothelial cells; Gene expression; Heart; Vascular remodelling

Indexed keywords

CASPASE 4; CHEMOKINE RECEPTOR CCR5; COMPLEMENT COMPONENT C3; CXCL2 CHEMOKINE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; D DIMER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; NOTCH1 RECEPTOR; PROTEIN BCL 2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; RGS PROTEIN; STROMAL CELL DERIVED FACTOR 1; THY 1 ANTIGEN; TOLL LIKE RECEPTOR 6; TRANSCRIPTION FACTOR JUND;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOTTING; BLOOD VESSEL PARAMETERS; CONTROLLED STUDY; DOPPLER ECHOCARDIOGRAPHY; DOWN REGULATION; ENDOCARDIUM; FEMALE; GENE EXPRESSION; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; HEART LEFT ATRIUM; INFLAMMATION; MICROARRAY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SWINE; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; ATRIAL FIBRILLATION; DISEASE MODELS, ANIMAL; ENDOCARDIUM; FEMALE; HEART ATRIA; NITRIC OXIDE SYNTHASE TYPE III; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUS SCROFA; THROMBOSIS; TRANSCRIPTOME;

EID: 84867280772     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH12-05-0285     Document Type: Article

References (37)

1. Hart RG, Halperin JL. Atrial fibrillation and stroke: Concepts and controversies. Stroke 2001; 32: 803-808.
2. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: The framingham study. Stroke 1991; 22: 983-988.
3. Steinberg JS. Atrial fibrillation: An emerging epidemic? Heart 2004; 90: 239-240.
4. Miyasaka Y, Barnes ME, Gersh BJ, et al. Secular trends in incidence of atrial fibrillation in olmsted county, minnesota, 1980 to 2000, and implications on the pro- jections for future prevalence. Circulation 2006; 114: 119-125.
5. Freestone B, Lip GY. The endothelium and atrial fibrillation. the prothrombotic state revisited. Hamostaseologie 2008; 28: 207-212.
6. Feng D, D'Agostino RB, Silbershatz H, et al. Hemostatic state and atrial fibrillation (the framingham offspring study). Am J Cardiol 2001; 87: 168-171.
7. Mitusch R, Siemens HJ, Garbe M, et al. Detection of a hypercoagulable state in nonvalvular atrial fibrillation and the effect of anticoagulant therapy. Thromb Haemost 1996; 75: 219-223.
8. Aird WC. Phenotypic heterogeneity of the endothelium: II. representative vascular beds. Circ Res 2007; 100: 174-190.
9. Ryan US, Mortara M, Whitaker C. Methods for microcarrier culture of bovine pulmonary artery endothelial cells avoiding the use of enzymes. Tissue Cell 1980; 12: 619-635.
10. Irizarry RA, Bolstad BM, Collin F, et al. Summaries of affymetrix GeneChip probe level data. Nucleic Acids Res 2003; 31: e15.
11. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 2004; 3: Article 3.
12. Gentleman R, Carey V, Huber W, et al. Bioinformatics and computational biology solutions using R and bioconductor. New York, Springer; 2005.
13. Draghici S. Data analysis tools for DNA microarrays. London, Chapman Hall/CRC; 2003.
14. Cai H, Li Z, Goette A, et al. Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: Potential mechanisms for atrial thrombosis and stroke. Circulation 2002; 106: 2854-2858.
15. Akar JG, Jeske W, Wilber DJ. Acute onset human atrial fibrillation is associated with local cardiac platelet activation and endothelial dysfunction. J Am Coll Cardiol 2008; 51: 1790-1793.
16. Sadanaga T, Sadanaga M, Ogawa S. Evidence that D-dimer levels predict subsequent thromboembolic and cardiovascular events in patients with atrial fibrillation during oral anticoagulant therapy. J Am Coll Cardiol 2010; 55: 2225-2231.
17. Wang J, Klysik E, Sood S, et al. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci USA 2010; 107: 9753-9758.
18. Lin CS, Lai LP, Lin JL, et al. Increased expression of extracellular matrix proteins in rapid atrial pacing-induced atrial fibrillation. Heart Rhythm 2007; 4: 938-949.
19. Lai LP, Lin JL, Lin CS, et al. Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain isoform reprogramming in atrial fibrillation. J Cardiovasc Electrophysiol 2004; 15: 214-223.
20. Kim NH, Ahn Y, Oh SK, et al. Altered patterns of gene expression in response to chronic atrial fibrillation. Int Heart J 2005; 46: 383-395.
21. Hua G, Zhang Q, Fan Z. Heat shock protein 75 (TRAP1) antagonizes reactive oxygen species generation and protects cells from granzyme M-mediated apoptosis. J Biol Chem 2007; 282: 20553-20560.
22. Mattiussi S, Turrini P, Testolin L, et al. p21(Waf1/Cip1/Sdi1) mediates shear stress-dependent antiapoptotic function. Cardiovasc Res 2004; 61: 693-704.
23. Conway DS, Buggins P, Hughes E, et al. Prognostic significance of raised plasma levels of interleukin-6 and C-reactive protein in atrial fibrillation. Am Heart J 2004; 148: 462-466.
24. Hermida J, Lopez FL, Montes R, et al. Usefulness of high-sensitivity C-reactive protein to predict mortality in patients with atrial fibrillation (from the atherosclerosis risk in communities [ARIC] study). Am J Cardiol 2012; 109: 95-99.
25. Patel P, Dokainish H, Tsai P, et al. Update on the association of inflammation and atrial fibrillation. J Cardiovasc Electrophysiol 2010; 21: 1064-1070.
26. Caposio P, Gugliesi F, Zannetti C, et al. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem 2007; 282: 33515-33529.
27. Okada M, Suzuki K, Takada K, et al. Detection of up-regulated genes in thrombinstimulated human umbilical vein endothelial cells. Thromb Res 2006; 118: 715-721.
28. Pullamsetti SS, Savai R, Schaefer MB, et al. cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases. Circulation 2011; 123: 1194-1204.
29. Gretarsdottir S, Thorleifsson G, Reynisdottir ST, et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat Genet 2003; 35: 131-138.
30. Pan H, Richards AA, Zhu X, et al. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death. Heart Rhythm 2009; 6: 707-710.
31. Davis ME, Cai H, Drummond GR, et al. Shear stress regulates endothelial nitric oxide synthase expression through c-src by divergent signaling pathways. Circ Res 2001; 89: 1073-1080.
32. Gu M, Brecher P. Nitric oxide-induced increase in p21(Sdi1/Cip1/Waf1) expression during the cell cycle in aortic adventitial fibroblasts. Arterioscler Thromb Vasc Biol 2000; 20: 27-34.
33. Cervero J, Montes R, Espana F, et al. Limited ability to activate protein C confers left atrial endocardium a thrombogenic phenotype: A role in cardioembolic stroke? Stroke 2011; 42: 2622-2624.
34. Ghanekar A, Mendicino M, Liu H, et al. Endothelial induction of fgl2 contributes to thrombosis during acute vascular xenograft rejection. J Immunol 2004; 172: 5693-5701.
35. Xu F, Previti ML, Nieman MT, et al. AbetaPP/APLP2 family of kunitz serine proteinase inhibitors regulate cerebral thrombosis. J Neurosci 2009; 29: 5666-5670.
36. Li Z, Nardi MA, Li YS, et al. C-terminal ADAMTS-18 fragment induces oxidative platelet fragmentation, dissolves platelet aggregates, and protects against carotid artery occlusion and cerebral stroke. Blood 2009; 113: 6051-6060.
37. Goette A, Bukowska A, Lendeckel U, et al. Angiotensin II receptor blockade reduces tachycardia-induced atrial adhesion molecule expression. Circulation 2008; 117: 732-742.