A βPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis

Journal of Neuroscience

Volumn 29, Issue 17, 2009, Pages 5666-5670

  Xu, Feng ^a   Previti, Mary Lou ^a   Nieman, Marvin T ^b   Davis, Judianne ^a   Schmaier, Alvin H ^b   Van Nostrand, William E ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR LIKE PROTEIN 2; AMYLOID PRECURSOR PROTEIN; HEMOGLOBIN; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; APLP2 PROTEIN, MOUSE; APROTININ;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLOOD CLOTTING; BRAIN HEMATOMA; BRAIN HEMORRHAGE; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PURIFICATION; REGULATORY MECHANISM; STRAIN DIFFERENCE; THROMBOCYTE FUNCTION; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; MULTIGENE FAMILY; PHYSIOLOGY; RISK FACTOR;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APROTININ; BLOOD COAGULATION; HUMANS; INTRACRANIAL THROMBOSIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIGENE FAMILY; RISK FACTORS;

EID: 65649118535     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0095-09.2009     Document Type: Article

References (46)

1. Chaanine A, Hugonenq C, Lena G, Mancini J (2008) Neurological complications in Down syndrome. Arch Pediatr 15:388-396.
2. Cheon MS, Dierssen M, Kim SH, Lubec G (2008) Protein expression of BACE1, BACE2 and APP in Down syndrome brains. Amino Acids 35:339-343.
3. Choudhri TF, Hoh BL, Solomon RA, Connolly ES Jr, Pinsky DJ (1997) Use of a spectrophotometric hemoglobin assay to objectively quantify intracerebral hemorrhage in mice. Stroke 28:2296-2302. (Pubitemid 27497937)
4. Clark W, Gunion-Rinker L, Lessov N, Hazel K (1998) Citicoline treatment for experimental intracerebral hemorrhage in mice. Stroke 29:2136-2140. (Pubitemid 28443531)
5. Crawley JT, Lane DA (2008) The haemostatic role of tissue factor pathway inhibitor. Arterioscler Thromb Vasc Biol 28:233-242.
6. Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE (1995) Alzheimer's amyloid β-protein induces its own production in cultured cerebrovascular smooth muscle cells. J Neurochem 65:931-934.
7. Donahue JE, Khurana JS, Adelman LS (1998) Intracerebral hemorrhage in two patient with Down's syndrome and cerebral amylod angiopathy. Acta Neuropathol 95:213-216. (Pubitemid 28076019)
8. Eitzman DT, Westrick RJ, Nabel EG, Ginsburg D (2000) Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood 95:577-580. (Pubitemid 30041672)
9. Esch FS, Keim PS, Beattie EC, Blacher RW, Culwell AR, Oltersdorf T, McClure D, Ward PJ (1990) Cleavage of amyloid β peptide during constitutive processing of its precursor. Science 248:1122-1124. (Pubitemid 20189868)
10. Feistritzer C, Wiedermann CJ (2007) Effects of anticoagulant strategies on activation of inflammation and coagulation. Expert Opin Biol Ther 7:855-870. (Pubitemid 46954432)
11. Griffin JH, Zlokovic B, Fernández JA (2002) Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol 39:197-205.
12. Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
13. Huang ZF, Wun TC, Broze GJ Jr (1993) Kinetics of factor Xa inhibition by tissue factor pathway inhibitor. J Biol Chem 268:26950-26955. (Pubitemid 24006403)
14. Huang ZF, Higuchi D, Lasky N, Broze GJ Jr (1997) Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood 90:944-951. (Pubitemid 27314126)
15. Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, Takeda N, Ito M, Yamamoto K, Matsushita T, Kusugami K, Muramatsu T, Saito H (2000) Complete antithrombin deficiency in mice results in embryonic lethality. J Clin Invest 106:873-878.
16. Jalbert LR, Rosen ED, Moons L, Chan JC, Carmeliet P, Collen D, Castellino FJ (1998) Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 102:1481-1488. (Pubitemid 28492214)
17. Jea A, Smith ER, Robertson R, Scott RM (2005) Moyamoya syndrome associated with Down syndrome: outcome after surgical revascularization. Pediatrics 116:694-701. (Pubitemid 46056402)
18. Leach R, Ko M, Krawetz SA (1999) Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization. Cytogenet Cell Genet 87:215-216. (Pubitemid 30103094)
19. Mahdi F, Van Nostrand WE, Schmaier AH (1995) Protease nexin-2/amyloid β-protein precursor inhibits Factor Xa in the prothrombinase complex. J Biol Chem 270:23468-23474.
20. Maruyama I, Bell CE, Majerus PW (1985) Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 101:363-371. (Pubitemid 15239110)
21. McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT (1998) Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res 804:45-51. (Pubitemid 28410477)
22. Ozturk AK, Nahed BV, Bydon M, Bilguvar K, Goksu E, Bademci G, Guclu B, Johnson MH, Amar A, Lifton RP, Gunel M (2006) Molecular genetic analysis of two large kindreds with intracranial aneurysms demonstrates linkage to 11q24-25 and 14q23-31. Stroke 37:1021-1027.
23. Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F, Cordell B (1988) Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature 331:525-527.
24. Pratt CW, Monroe DM (1992) Microplate coagulation assays. Biotechniques 13:430-433.
25. Rafay MF, Smith SE, Dirks P, Armstrong D, deVeber GA (2006) Hemorrhage predisposing to cerebral infarction in children with moyamoya disease. Pediatr Neurol 34:400-404.
26. Rozemuller AJ, Roos RA, Bots GT, Kamphorst W, Eikelenboom P, Van Nostrand WE (1993) Distribution of β/A4 and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease. Am J Pathol 142:1449-1457. (Pubitemid 24058132)
27. Saporito-Irwin SM, Thinakaran G, Ruffini L, Sisodia SS, Van Nostrand WE (1997) Amyloid β-protein stimulates parallel increases in the cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells. Amyloid 4:54-60. (Pubitemid 127497418)
28. Schmaier AH, Dahl LD, Rozemuller AJ, Roos RA, Wagner SL, Chung R, Van Nostrand WE (1993) Protease nexin-2/amyloid β-protein precursor: a tight binding inhibitor of coagulation factor IXa. J Clin Invest 92:2540-2545. (Pubitemid 23333565)
29. Sisodia SS, Thinakaran G, Slunt HH, Kitt CA, Von Koch CS, Reed RR, Zheng H, Price DL (1996) Studies on the metabolism and biological function of APLP2. Ann N Y Acad Sci 777:77-81. (Pubitemid 26149173)
30. Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS (1994) Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem 269:2637-2644. (Pubitemid 24978492)
31. Smith RP, Higuchi DA, Broze GJ Jr (1990) Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. Science 248:1126-1128. (Pubitemid 20189870)
32. Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL (1988) A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331:528-530.
33. Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD (1989) Protease nexin-II, a potent antichymotrypsin, shows identity to the amyloid β-protein precursor. Nature 341:546-549. (Pubitemid 19252530)
34. Van Nostrand WE, Wagner SL, Farrow JS, Cunningham DD (1990) Immunopurification and protease inhibitory properties of protease nexin-2/ amyloid β-protein precursor. J Biol Chem 265:9591-9594. (Pubitemid 20194291)
35. Van Nostrand WE, Schmaier AH, Neiditch BR, Siegel RS, Raschke WC, Sisodia SS, Wagner SL (1994) Expression, purification, and characterization of the Kunitz-type protease inhibitor domain of the amyloid β-protein precursor-like protein-2 (APLP-2). Biochem Biophys Acta 1209:165-170.
36. Van Nostrand WE, Melchor JP, Ruffini L (1998) Pathogenic cell surface amyloid β-protein fibril assembly in cultured human cerebrovascular smooth muscle cells. J Neurochem 70:216-223. (Pubitemid 28020846)
37. Van Nostrand WE, Melchor JP, Keane DM, Saporito-Irwin SM, Romanov G, Davis J, Xu F (2002) Localization of a fibrillar amyloid β-protein binding domain on its precursor. J Biol Chem 277:36392-36398.
38. Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, et al. (1999) β-secretase cleavage of the Alzheimer's precursor protein by the transmembrane aspartic protease BACE. Science 286:735-741. (Pubitemid 129515714)
39. von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS (1997) Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice. Neurobiol Aging 18:661-669. (Pubitemid 28046419)
40. Wagner MR, Keane DM, Melchor JP, Auspaker KR, Van Nostrand WE (2000) Fibrillar amyloid β-protein binds protease nexin-2/amyloid β-protein precursor: Stimulation of its inhibition of coagulation factor XIa. Biochemistry 39:7420-7427. (Pubitemid 30422059)
41. Wagner SL, Siegel RS, Vedvick TS, Raschke WC, Van Nostrand WE (1992) High level expression, purification, and characterization of the Kunitz protease inhibitor domain of protease nexin-2/amyloid β-protein precursor. Biochem Biophys Res Commun 186:1138-1145.
42. Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE (1993) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet 5:95-100. (Pubitemid 23261528)
43. Webster MT, Groome N, Francis PT, Pearce BR, Sherriff FE, Thinakaran G, Felsenstein KM, Wasco W, Tanzi RE, Bowen DM (1995) A novel protein, amyloid precursor-like protein 2, is present in human brain, cerebrospinal fluid and conditioned media. Biochem J 310:95-99.
44. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ (1999) Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398:513-517. (Pubitemid 129523589)
45. Xu F, Davis J, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE (2005) Protease nexin-2/amyloid β-protein precursor limits cerebral thrombosis. Proc Natl Acad Sci U S A 102:18135-18140. (Pubitemid 41798514)
46. Xu F, Previti ML, Van Nostrand WE (2007) Increased severity of hemorrhage in transgenic mice expressing cerebral protease nexin-2/amyloid β-protein precursor. Stroke 38:2598-2601. (Pubitemid 47329644)