-
1
-
-
0015523596
-
Broad-spectrum antiviral activity of virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide
-
Sidwell RW, Huffman JH, Khare GP, Allen LB, Witkowski JT, Robins RK. Broad-spectrum antiviral activity of virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. Science 1972; 177:705-706.
-
(1972)
Science
, vol.177
, pp. 705-706
-
-
Sidwell, R.W.1
Huffman, J.H.2
Khare, G.P.3
Allen, L.B.4
Witkowski, J.T.5
Robins, R.K.6
-
2
-
-
84944969395
-
Ribavirin treatment of experimental respiratory syncytial viral infection. A controlled double-blind study in young adults
-
Hall CB, Walsh EE, Hruska JF, Betts RF, Hall WJ. Ribavirin treatment of experimental respiratory syncytial viral infection. A controlled double-blind study in young adults. JAMA 1983; 249:2666-2670.
-
(1983)
JAMA
, vol.249
, pp. 2666-2670
-
-
Hall, C.B.1
Walsh, E.E.2
Hruska, J.F.3
Betts, R.F.4
Hall, W.J.5
-
3
-
-
33645454876
-
Ribavirin therapy for chronic type C hepatitis
-
Buti M, Esteban R, Rodriguez-Frias F, Jardi R, Guardia J. Ribavirin therapy for chronic type C hepatitis. J Hepatol 1991; 13 SUPPL 2:S103.
-
(1991)
J Hepatol
, vol.13
, Issue.SUPPL. 2
-
-
Buti, M.1
Esteban, R.2
Rodriguez-Frias, F.3
Jardi, R.4
Guardia, J.5
-
4
-
-
23944462641
-
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
-
Feld JJ, Hoofnagle JH. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature 2005; 436:967-972.
-
(2005)
Nature
, vol.436
, pp. 967-972
-
-
Feld, J.J.1
Hoofnagle, J.H.2
-
5
-
-
33646560284
-
The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus
-
Dixit NM, Perelson AS. The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. Cell Mol Life Sci 2006; 63:832-842.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 832-842
-
-
Dixit, N.M.1
Perelson, A.S.2
-
6
-
-
0034532953
-
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen
-
Crotty S, Maag D, Arnold JJ, et al. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med 2000; 6:1375-1379.
-
(2000)
Nat Med
, vol.6
, pp. 1375-1379
-
-
Crotty, S.1
Maag, D.2
Arnold, J.J.3
-
7
-
-
11844282166
-
Metabolism and antiviral activity of ribavirin
-
Parker WB. Metabolism and antiviral activity of ribavirin. Virus Res 2005; 107:165-171.
-
(2005)
Virus Res
, vol.107
, pp. 165-171
-
-
Parker, W.B.1
-
8
-
-
0023361116
-
Ribavirin aerosol treatment of serious respiratory syncytial virus infection in infants
-
Rodriguez WJ, Parrott RH. Ribavirin aerosol treatment of serious respiratory syncytial virus infection in infants. Infect Dis Clin North Am 1987; 1:425-439.
-
(1987)
Infect Dis Clin North Am
, vol.1
, pp. 425-439
-
-
Rodriguez, W.J.1
Parrott, R.H.2
-
9
-
-
0022630892
-
Lassa fever Effective therapy with ribavirin
-
McCormick JB, King IJ, Webb PA, et al. Lassa fever. Effective therapy with ribavirin. N Engl J Med 1986; 314:20-26.
-
(1986)
N Engl J Med
, vol.314
, pp. 20-26
-
-
McCormick, J.B.1
King, I.J.2
Webb, P.A.3
-
10
-
-
0029677207
-
Intravenous ribavirin by constant infusion for serious influenza and parainfuenzavirus infection
-
Hayden FG, Sable CA, Connor JD, Lane J. Intravenous ribavirin by constant infusion for serious influenza and parainfuenzavirus infection. Antivir Ther 1996; 1:51-56.
-
(1996)
Antivir Ther
, vol.1
, pp. 51-56
-
-
Hayden, F.G.1
Sable, C.A.2
Connor, J.D.3
Lane, J.4
-
11
-
-
0038122772
-
Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin
-
Hoofnagle JH, Ghany MG, Kleiner DE, et al. Maintenance therapy with ribavirin in patients with chronic hepatitis C who fail to respond to combination therapy with interferon alfa and ribavirin. Hepatology 2003; 38:66-74.
-
(2003)
Hepatology
, vol.38
, pp. 66-74
-
-
Hoofnagle, J.H.1
Ghany, M.G.2
Kleiner, D.E.3
-
12
-
-
0032949443
-
The clinical pharmacology of ribavirin
-
Glue P. The clinical pharmacology of ribavirin. Semin Liver Dis 1999; 19 SUPPL 1:17-24.
-
(1999)
Semin Liver Dis
, vol.19
, Issue.SUPPL. 1
, pp. 17-24
-
-
Glue, P.1
-
13
-
-
0032862514
-
Pharmacokinetics and absolute bioavailability of ribavirin in healthy volunteers as determined by stable-isotope methodology
-
Preston SL, Drusano GL, Glue P, Nash J, Gupta SK, McNamara P. Pharmacokinetics and absolute bioavailability of ribavirin in healthy volunteers as determined by stable-isotope methodology. Antimicrob Agents Chemother 1999; 43:2451-2456.
-
(1999)
Antimicrob Agents Chemother
, vol.43
, pp. 2451-2456
-
-
Preston, S.L.1
Drusano, G.L.2
Glue, P.3
Nash, J.4
Gupta, S.K.5
McNamara, P.6
-
15
-
-
33745889935
-
Nucleoside transporters: From scavengers to novel therapeutic targets
-
King AE, Ackley MA, Cass CE, Young JD, Baldwin SA. Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci 2006; 27:416-425.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 416-425
-
-
King, A.E.1
Ackley, M.A.2
Cass, C.E.3
Young, J.D.4
Baldwin, S.A.5
-
16
-
-
77949657465
-
Characterization of ribavirin uptake systems in human hepatocytes
-
Fukuchi Y, Furihata T, Hashizume M, Iikura M, Chiba K. Characterization of ribavirin uptake systems in human hepatocytes. J Hepatol 2010; 52:486-492.
-
(2010)
J Hepatol
, vol.52
, pp. 486-492
-
-
Fukuchi, Y.1
Furihata, T.2
Hashizume, M.3
Iikura, M.4
Chiba, K.5
-
17
-
-
33846373423
-
Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters
-
Yamamoto T, Kuniki K, Takekuma Y, Hirano T, Iseki K, Sugawara M. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters. Eur J Pharmacol 2007; 557:1-8.
-
(2007)
Eur J Pharmacol
, vol.557
, pp. 1-8
-
-
Yamamoto, T.1
Kuniki, K.2
Takekuma, Y.3
Hirano, T.4
Iseki, K.5
Sugawara, M.6
-
18
-
-
77957002540
-
Infuence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection
-
Morello J, Cuenca L, Soriano V, et al. Infuence of a single nucleotide polymorphism at the main ribavirin transporter gene on the rapid virological response to pegylated interferon-ribavirin therapy in patients with chronic hepatitis C virus infection. J Infect Dis 2010; 202:1185-1191.
-
(2010)
J Infect Dis
, vol.202
, pp. 1185-1191
-
-
Morello, J.1
Cuenca, L.2
Soriano, V.3
-
19
-
-
79955482297
-
Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: Protection against anemia in patients with chronic hepatitis C
-
Doehring A, Hofmann WP, Schlecker C, et al. Role of nucleoside transporters SLC28A2/3 and SLC29A1/2 genetics in ribavirin therapy: protection against anemia in patients with chronic hepatitis C. Pharmacogenet Genomics 2011; 21:289-296.
-
(2011)
Pharmacogenet Genomics
, vol.21
, pp. 289-296
-
-
Doehring, A.1
Hofmann, W.P.2
Schlecker, C.3
-
20
-
-
2442744266
-
Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line
-
Willis RC, Carson DA, Seegmiller JE. Adenosine kinase initiates the major route of ribavirin activation in a cultured human cell line. Proc Natl Acad Sci USA 1978; 75:3042-3044.
-
(1978)
Proc Natl Acad Sci USA
, vol.75
, pp. 3042-3044
-
-
Willis, R.C.1
Carson, D.A.2
Seegmiller, J.E.3
-
21
-
-
34247893961
-
Structural effects on the phosphorylation of 3-substituted 1-beta-D-ribofuranosyl-1,2,4-triazoles by human adenosine kinase
-
Kumarapperuma SC, Sun Y, Jeselnik M, et al. Structural effects on the phosphorylation of 3-substituted 1-beta-D-ribofuranosyl-1,2,4-triazoles by human adenosine kinase. Bioorg Med Chem Lett 2007; 17:3203-3207.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 3203-3207
-
-
Kumarapperuma, S.C.1
Sun, Y.2
Jeselnik, M.3
-
22
-
-
0015609404
-
Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent
-
Streeter DG, Witkowski JT, Khare GP, et al. Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc Natl Acad Sci USA 1973; 70:1174-1178.
-
(1973)
Proc Natl Acad Sci USA
, vol.70
, pp. 1174-1178
-
-
Streeter, D.G.1
Witkowski, J.T.2
Khare, G.P.3
-
23
-
-
0042318456
-
Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase
-
Vo NV, Young KC, Lai MM. Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase. Biochemistry 2003; 42:10462-10471.
-
(2003)
Biochemistry
, vol.42
, pp. 10462-10471
-
-
Vo, N.V.1
Young, K.C.2
Lai, M.M.3
-
24
-
-
0346101769
-
Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase
-
Bougie I, Bisaillon M. Initial binding of the broad spectrum antiviral nucleoside ribavirin to the hepatitis C virus RNA polymerase. J Biol Chem 2003; 278:52471-52478.
-
(2003)
J Biol Chem
, vol.278
, pp. 52471-52478
-
-
Bougie, I.1
Bisaillon, M.2
-
25
-
-
0025236704
-
The metabolism of ribavirin in erythrocytes and nucleated cells
-
Page T, Connor JD. The metabolism of ribavirin in erythrocytes and nucleated cells. Int J Biochem 1990; 22:379-383.
-
(1990)
Int J Biochem
, vol.22
, pp. 379-383
-
-
Page, T.1
Connor, J.D.2
-
26
-
-
0036890967
-
Dosage of ribavirin in patients with hepatitis C should be based on renal function: A population pharmacokinetic analysis
-
Bruchfeld A, Lindahl K, Schvarcz R, Stahle L. Dosage of ribavirin in patients with hepatitis C should be based on renal function: a population pharmacokinetic analysis. Ther Drug Monit 2002; 24:701-708.
-
(2002)
Ther Drug Monit
, vol.24
, pp. 701-708
-
-
Bruchfeld, A.1
Lindahl, K.2
Schvarcz, R.3
Stahle, L.4
-
27
-
-
0033806292
-
Population pharmacokinetic and pharmacodynamic analysis of ribavirin in patients with chronic hepatitis C
-
Jen JF, Glue P, Gupta S, Zambas D, Hajian G. Population pharmacokinetic and pharmacodynamic analysis of ribavirin in patients with chronic hepatitis C. Ther Drug Monit 2000; 22:555-565.
-
(2000)
Ther Drug Monit
, vol.22
, pp. 555-565
-
-
Jen, J.F.1
Glue, P.2
Gupta, S.3
Zambas, D.4
Hajian, G.5
-
28
-
-
0019799031
-
Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys
-
Ferrara EA, Oishi JS, Wannemacher RW, Stephen EL. Plasma disappearance, urine excretion, and tissue distribution of ribavirin in rats and rhesus monkeys. Antimicrob Agents Chemother 1981; 19:1042-1049.
-
(1981)
Antimicrob Agents Chemother
, vol.19
, pp. 1042-1049
-
-
Ferrara, E.A.1
Oishi, J.S.2
Wannemacher, R.W.3
Stephen, E.L.4
-
29
-
-
0024363993
-
Pharmacokinetics of ribavirin and urinary excretion of the major metabolite 1,2,4-triazole-3-carboxamide in normal volunteers
-
Paroni R, Del Puppo M, Borghi C, Sirtori CR, Galli Kienle M. Pharmacokinetics of ribavirin and urinary excretion of the major metabolite 1,2,4-triazole-3-carboxamide in normal volunteers. Int J Clin Pharmacol Ther Toxicol 1989; 27:302-307.
-
(1989)
Int J Clin Pharmacol Ther Toxicol
, vol.27
, pp. 302-307
-
-
Paroni, R.1
Del Puppo, M.2
Borghi, C.3
Sirtori, C.R.4
Galli Kienle, M.5
-
30
-
-
3042595904
-
The role of ribavirin in the combination therapy of hepatitis C virus infection
-
Picardi A, Gentilucci UV, Zardi EM, D'Avola D, Amoroso A, Afeltra A. The role of ribavirin in the combination therapy of hepatitis C virus infection. Curr Pharm Des 2004; 10:2081-2092.
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2081-2092
-
-
Picardi, A.1
Gentilucci, U.V.2
Zardi, E.M.3
D'Avola, D.4
Amoroso, A.5
Afeltra, A.6
-
31
-
-
78751621217
-
Evolving epidemiology of hepatitis C virus
-
Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect 2011; 17:107-115.
-
(2011)
Clin Microbiol Infect
, vol.17
, pp. 107-115
-
-
Lavanchy, D.1
-
32
-
-
24344503816
-
HCV natural history: The retrospective and prospective in perspective
-
Alter HJ. HCV natural history: the retrospective and prospective in perspective. J Hepatol 2005; 43:550-552.
-
(2005)
J Hepatol
, vol.43
, pp. 550-552
-
-
Alter, H.J.1
-
33
-
-
75149163334
-
Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression
-
Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings L W. Aging of hepatitis C virus (HCV)-infected persons in the United States: a multiple cohort model of HCV prevalence and disease progression. Gastroenterology 2010; 138:513-521.
-
(2010)
Gastroenterology
, vol.138
, pp. 513-521
-
-
Davis, G.L.1
Alter, M.J.2
El-Serag, H.3
Poynard, T.4
Jennings, L.W.5
-
34
-
-
77249172808
-
Role of ribavirin in HCV treatment response: Now and in the future
-
Jain MK, Zoellner C. Role of ribavirin in HCV treatment response: now and in the future. Expert Opin Pharmacother 2010; 11:673-683.
-
(2010)
Expert Opin Pharmacother
, vol.11
, pp. 673-683
-
-
Jain, M.K.1
Zoellner, C.2
-
36
-
-
0026733674
-
A pilot study of ribavirin therapy for chronic hepatitis C
-
di Bisceglie AM, Shindo M, Fong TL, et al. A pilot study of ribavirin therapy for chronic hepatitis C. Hepatology 1992; 16:649-654.
-
(1992)
Hepatology
, vol.16
, pp. 649-654
-
-
di Bisceglie, A.M.1
Shindo, M.2
Fong, T.L.3
-
37
-
-
33645458986
-
Ribavirin monotherapy for chronic hepatitis C infection: A Cochrane Hepato-Biliary Group systematic review and meta-analysis of randomized trials
-
Brok J, Gluud LL, Gluud C. Ribavirin monotherapy for chronic hepatitis C infection: a Cochrane Hepato-Biliary Group systematic review and meta-analysis of randomized trials. Am J Gastroenterol 2006; 101:842-847.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 842-847
-
-
Brok, J.1
Gluud, L.L.2
Gluud, C.3
-
38
-
-
1542377471
-
Antiviral action of ribavirin in chronic hepatitis C
-
Pawlotsky JM, Dahari H, Neumann AU, et al. Antiviral action of ribavirin in chronic hepatitis C. Gastroenterology 2004; 126:703-714.
-
(2004)
Gastroenterology
, vol.126
, pp. 703-714
-
-
Pawlotsky, J.M.1
Dahari, H.2
Neumann, A.U.3
-
39
-
-
0022868893
-
Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. A preliminary report
-
Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. A preliminary report. N Engl J Med 1986; 315:1575-1578.
-
(1986)
N Engl J Med
, vol.315
, pp. 1575-1578
-
-
Hoofnagle, J.H.1
Mullen, K.D.2
Jones, D.B.3
-
40
-
-
0024981607
-
Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial
-
di Bisceglie AM, Martin P, Kassianides C, et al. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med 1989; 321:1506-1510.
-
(1989)
N Engl J Med
, vol.321
, pp. 1506-1510
-
-
di Bisceglie, A.M.1
Martin, P.2
Kassianides, C.3
-
41
-
-
0029564107
-
The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C
-
Chemello L, Cavalletto L, Bernardinello E, Guido M, Pontisso P, Alberti A. The effect of interferon alfa and ribavirin combination therapy in naive patients with chronic hepatitis C. J Hepatol 1995; 23 SUPPL 2:8-12.
-
(1995)
J Hepatol
, vol.23
, Issue.SUPPL. 2
, pp. 8-12
-
-
Chemello, L.1
Cavalletto, L.2
Bernardinello, E.3
Guido, M.4
Pontisso, P.5
Alberti, A.6
-
42
-
-
0032547938
-
Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
-
McHutchison JG, Gordon SC, Schiff ER, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N Engl J Med 1998; 339:1485-1492.
-
(1998)
N Engl J Med
, vol.339
, pp. 1485-1492
-
-
McHutchison, J.G.1
Gordon, S.C.2
Schiff, E.R.3
-
43
-
-
0032585237
-
Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
-
Poynard T, Marcellin P, Lee SS, et al. Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet 1998; 352:1426-1432.
-
(1998)
Lancet
, vol.352
, pp. 1426-1432
-
-
Poynard, T.1
Marcellin, P.2
Lee, S.S.3
-
44
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002; 347:975-982.
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
45
-
-
11144330097
-
Modelling how ribavirin improves interferon response rates in hepatitis C virus infection
-
Dixit NM, Layden-Almer JE, Layden TJ, Perelson AS. Modelling how ribavirin improves interferon response rates in hepatitis C virus infection. Nature 2004; 432:922-924.
-
(2004)
Nature
, vol.432
, pp. 922-924
-
-
Dixit, N.M.1
Layden-Almer, J.E.2
Layden, T.J.3
Perelson, A.S.4
-
46
-
-
78649715862
-
Induction pegylated interferon alfa-2a and high dose ribavirin do not increase SVR in heavy patients with HCV genotype 1 and high viral loads
-
Reddy KR, Shiffman ML, Rodriguez-Torres M, et al. Induction pegylated interferon alfa-2a and high dose ribavirin do not increase SVR in heavy patients with HCV genotype 1 and high viral loads. Gastroenterology 2010; 139:1972-1983.
-
(2010)
Gastroenterology
, vol.139
, pp. 1972-1983
-
-
Reddy, K.R.1
Shiffman, M.L.2
Rodriguez-Torres, M.3
-
47
-
-
51549111262
-
Hepatitis C: Current options for nonresponders to peginterferon and ribavirin
-
Thomas E, Fried MW. Hepatitis C: current options for nonresponders to peginterferon and ribavirin. Curr Gastroenterol Rep 2008; 10:53-59.
-
(2008)
Curr Gastroenterol Rep
, vol.10
, pp. 53-59
-
-
Thomas, E.1
Fried, M.W.2
-
48
-
-
33746564989
-
Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable hepatitis C virus RNA at week 4 of treatment
-
Sánchez-Tapias JM, Diago M, Escartin P, et al. Peginterferon-alfa2a plus ribavirin for 48 versus 72 weeks in patients with detectable hepatitis C virus RNA at week 4 of treatment. Gastroenterology 2006; 131:451-460.
-
(2006)
Gastroenterology
, vol.131
, pp. 451-460
-
-
Sánchez-Tapias, J.M.1
Diago, M.2
Escartin, P.3
-
49
-
-
12844279849
-
High-dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C
-
Lindahl K, Stahle L, Bruchfeld A, Schvarcz R. High-dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C. Hepatology 2005; 41:275-279.
-
(2005)
Hepatology
, vol.41
, pp. 275-279
-
-
Lindahl, K.1
Stahle, L.2
Bruchfeld, A.3
Schvarcz, R.4
-
50
-
-
48249086484
-
Serum concentrations of ribavirin and pegylated interferon and viral responses in patients infected with HIV and HCV
-
Nicot F, Legrand-Abravanel F, Lafont T, et al. Serum concentrations of ribavirin and pegylated interferon and viral responses in patients infected with HIV and HCV. J Med Virol 2008; 80:1523-1529.
-
(2008)
J Med Virol
, vol.80
, pp. 1523-1529
-
-
Nicot, F.1
Legrand-Abravanel, F.2
Lafont, T.3
-
51
-
-
33746239300
-
Plasma ribavirin concentrations during treatment of recurrent hepatitis C with peginterferon alpha-2b and ribavirin combination after liver transplantation
-
Dumortier J, Ducos E, Scoazec J Y, Chevallier P, Boillot O, Gagnieu MC. Plasma ribavirin concentrations during treatment of recurrent hepatitis C with peginterferon alpha-2b and ribavirin combination after liver transplantation. J Viral Hepat 2006; 13:538-543.
-
(2006)
J Viral Hepat
, vol.13
, pp. 538-543
-
-
Dumortier, J.1
Ducos, E.2
Scoazec, J.Y.3
Chevallier, P.4
Boillot, O.5
Gagnieu, M.C.6
-
52
-
-
23844449765
-
Signifcance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C
-
Arase Y, Ikeda K, Tsubota A, et al. Signifcance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C. Intervirology 2005; 48:138-144.
-
(2005)
Intervirology
, vol.48
, pp. 138-144
-
-
Arase, Y.1
Ikeda, K.2
Tsubota, A.3
-
53
-
-
0037226397
-
Ribavirin quantification in combination treatment of chronic hepatitis C
-
Larrat S, Stanke-Labesque F, Plages A, Zarski J P, Bessard G, Souvignet C. Ribavirin quantification in combination treatment of chronic hepatitis C. Antimicrob Agents Chemother 2003; 47:124-129.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 124-129
-
-
Larrat, S.1
Stanke-Labesque, F.2
Plages, A.3
Zarski, J.P.4
Bessard, G.5
Souvignet, C.6
-
54
-
-
0034038791
-
Determination of ribavirin in serum using highly selective solid-phase extraction and high-performance liquid chromatography
-
Svensson JO, Bruchfeld A, Schvarcz R, Stahle L. Determination of ribavirin in serum using highly selective solid-phase extraction and high-performance liquid chromatography. Ther Drug Monit 2000; 22:215-218.
-
(2000)
Ther Drug Monit
, vol.22
, pp. 215-218
-
-
Svensson, J.O.1
Bruchfeld, A.2
Schvarcz, R.3
Stahle, L.4
-
55
-
-
68249154875
-
Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection
-
McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med 2009; 361:580-593.
-
(2009)
N Engl J Med
, vol.361
, pp. 580-593
-
-
McHutchison, J.G.1
Lawitz, E.J.2
Shiffman, M.L.3
-
56
-
-
79953173221
-
Boceprevir for untreated chronic HCV genotype 1 infection
-
Poordad F, McCone J, Bacon BR, et al. Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med 2011; 364:1195-1206.
-
(2011)
N Engl J Med
, vol.364
, pp. 1195-1206
-
-
Poordad, F.1
McCone, J.2
Bacon, B.R.3
-
57
-
-
65449152185
-
Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
-
McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med 2009; 360:1827-1838.
-
(2009)
N Engl J Med
, vol.360
, pp. 1827-1838
-
-
McHutchison, J.G.1
Everson, G.T.2
Gordon, S.C.3
-
58
-
-
73149113353
-
Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients
-
Susser S, Welsch C, Wang Y, et al. Characterization of resistance to the protease inhibitor boceprevir in hepatitis C virus-infected patients. Hepatology 2009; 50:1709-1718.
-
(2009)
Hepatology
, vol.50
, pp. 1709-1718
-
-
Susser, S.1
Welsch, C.2
Wang, Y.3
-
59
-
-
34247594930
-
Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir
-
Sarrazin C, Kieffer TL, Bartels D, et al. Dynamic hepatitis C virus genotypic and phenotypic changes in patients treated with the protease inhibitor telaprevir. Gastroenterology 2007; 132:1767-1777.
-
(2007)
Gastroenterology
, vol.132
, pp. 1767-1777
-
-
Sarrazin, C.1
Kieffer, T.L.2
Bartels, D.3
-
60
-
-
65449171953
-
Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
-
Hézode C, Forestier N, Dusheiko G, et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N Engl J Med 2009; 360:1839-1850.
-
(2009)
N Engl J Med
, vol.360
, pp. 1839-1850
-
-
Hézode, C.1
Forestier, N.2
Dusheiko, G.3
-
61
-
-
33750571888
-
Ribavirin-induced anemia: Mechanisms, risk factors and related targets for future research
-
Russmann S, Grattagliano I, Portincasa P, Palmieri VO, Palasciano G. Ribavirin-induced anemia: mechanisms, risk factors and related targets for future research. Curr Med Chem 2006; 13:3351-3357.
-
(2006)
Curr Med Chem
, vol.13
, pp. 3351-3357
-
-
Russmann, S.1
Grattagliano, I.2
Portincasa, P.3
Palmieri, V.O.4
Palasciano, G.5
-
62
-
-
77956817303
-
Plasma/erythrocyte ribavirin ×100 ratio as an indicator of sustained virological response in HCV genotype 1 patients with early virological response
-
Baiocchi L, De Leonardis F, Delle Monache M, et al. Plasma/erythrocyte ribavirin ×100 ratio as an indicator of sustained virological response in HCV genotype 1 patients with early virological response. Antivir Ther 2010; 15:633-639.
-
(2010)
Antivir Ther
, vol.15
, pp. 633-639
-
-
Baiocchi, L.1
de Leonardis, F.2
Delle Monache, M.3
-
63
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial
-
Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001; 358:958-965.
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchison, J.G.2
Gordon, S.C.3
-
64
-
-
33947633587
-
Strategies for managing anemia in hepatitis C patients undergoing antiviral therapy
-
McHutchison JG, Manns MP, Brown RS, Reddy KR, Shiffman ML, Wong JB. Strategies for managing anemia in hepatitis C patients undergoing antiviral therapy. Am J Gastroenterol 2007; 102:880-889.
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 880-889
-
-
McHutchison, J.G.1
Manns, M.P.2
Brown, R.S.3
Reddy, K.R.4
Shiffman, M.L.5
Wong, J.B.6
-
65
-
-
84855856255
-
Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C
-
Stickel F, Helbling B, Heim M, et al. Critical review of the use of erythropoietin in the treatment of anaemia during therapy for chronic hepatitis C. J Viral Hepat 2012; 19:77-87.
-
(2012)
J Viral Hepat
, vol.19
, pp. 77-87
-
-
Stickel, F.1
Helbling, B.2
Heim, M.3
-
66
-
-
84855833690
-
Impact of erythropoietin on sustained virological response to peginterferon and ribavirin therapy for HCV infection: A systematic review and meta-analysis
-
Alavian SM, Tabatabaei SV, Behnava B. Impact of erythropoietin on sustained virological response to peginterferon and ribavirin therapy for HCV infection: a systematic review and meta-analysis. J Viral Hepat 2012; 19:88-93.
-
(2012)
J Viral Hepat
, vol.19
, pp. 88-93
-
-
Alavian, S.M.1
Tabatabaei, S.V.2
Behnava, B.3
-
67
-
-
79953176289
-
Boceprevir for previously treated chronic HCV genotype 1 infection
-
Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011; 364:1207-1217.
-
(2011)
N Engl J Med
, vol.364
, pp. 1207-1217
-
-
Bacon, B.R.1
Gordon, S.C.2
Lawitz, E.3
-
68
-
-
84857635616
-
Management of hepatitis C in patients with chronic kidney disease
-
Al-Freah MA, Zeino Z, Heneghan MA. Management of hepatitis C in patients with chronic kidney disease. Curr Gastroenterol Rep 2012; 14:78-86.
-
(2012)
Curr Gastroenterol Rep
, vol.14
, pp. 78-86
-
-
Al-Freah, M.A.1
Zeino, Z.2
Heneghan, M.A.3
-
69
-
-
0013297123
-
-
Copegus (ribavirin), Genentech, San Francisco, CA, USA
-
Copegus (ribavirin). Package insert 2011. Genentech, San Francisco, CA, USA.
-
(2011)
Package Insert
-
-
-
70
-
-
77954753594
-
The Ribavirin Pregnancy Registry: Fndings after 5 years of enrollment, 2003- 2009
-
Roberts SS, Miller RK, Jones JK, et al. The Ribavirin Pregnancy Registry: fndings after 5 years of enrollment, 2003- 2009. Birth Defects Res A Clin Mol Teratol 2010; 88:551-559.
-
(2010)
Birth Defects Res a Clin Mol Teratol
, vol.88
, pp. 551-559
-
-
Roberts, S.S.1
Miller, R.K.2
Jones, J.K.3
-
71
-
-
77952427109
-
Seminal fluid ribavirin level and functional semen parameters in patients with chronic hepatitis C on antiviral combination therapy
-
Hofer H, Donnerer J, Sator K, et al. Seminal fluid ribavirin level and functional semen parameters in patients with chronic hepatitis C on antiviral combination therapy. J Hepatol 2010; 52:812-816.
-
(2010)
J Hepatol
, vol.52
, pp. 812-816
-
-
Hofer, H.1
Donnerer, J.2
Sator, K.3
-
72
-
-
77949773445
-
ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C
-
Fellay J, Thompson AJ, Ge D, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature 2010; 464:405-408.
-
(2010)
Nature
, vol.464
, pp. 405-408
-
-
Fellay, J.1
Thompson, A.J.2
Ge, D.3
-
73
-
-
77957326039
-
Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction
-
Thompson AJ, Fellay J, Patel K, et al. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology 2010; 139:1181-1189.
-
(2010)
Gastroenterology
, vol.139
, pp. 1181-1189
-
-
Thompson, A.J.1
Fellay, J.2
Patel, K.3
-
74
-
-
79953208979
-
Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function
-
Hitomi Y, Cirulli ET, Fellay J, et al. Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. Gastroenterology 2011; 140:1314-1321.
-
(2011)
Gastroenterology
, vol.140
, pp. 1314-1321
-
-
Hitomi, Y.1
Cirulli, E.T.2
Fellay, J.3
-
75
-
-
0024455619
-
Molecular analysis of the inhibitory effect of phosphorylated ribavirin on the vesicular stomatitis virus in vitro polymerase reaction
-
Fernandez-Larsson R, O'Connell K, Koumans E, Patterson JL. Molecular analysis of the inhibitory effect of phosphorylated ribavirin on the vesicular stomatitis virus in vitro polymerase reaction. Antimicrob Agents Chemother 1989; 33:1668-1673.
-
(1989)
Antimicrob Agents Chemother
, vol.33
, pp. 1668-1673
-
-
Fernandez-Larsson, R.1
O'Connell, K.2
Koumans, E.3
Patterson, J.L.4
-
76
-
-
0035824671
-
Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin
-
Maag D, Castro C, Hong Z, Cameron CE. Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J Biol Chem 2001; 276:46094-46098.
-
(2001)
J Biol Chem
, vol.276
, pp. 46094-46098
-
-
Maag, D.1
Castro, C.2
Hong, Z.3
Cameron, C.E.4
-
77
-
-
0141755411
-
Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy
-
Young KC, Lindsay KL, Lee KJ, et al. Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy. Hepatology 2003; 38:869-878.
-
(2003)
Hepatology
, vol.38
, pp. 869-878
-
-
Young, K.C.1
Lindsay, K.L.2
Lee, K.J.3
-
78
-
-
50949134232
-
Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796
-
Howe AY, Cheng H, Johann S, et al. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796. Antimicrob Agents Chemother 2008; 52:3327-3338.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 3327-3338
-
-
Howe, A.Y.1
Cheng, H.2
Johann, S.3
-
79
-
-
40549128699
-
Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment
-
Nakamura M, Saito H, Ikeda M, et al. Possible molecular mechanism of the relationship between NS5B polymorphisms and early clearance of hepatitis C virus during interferon plus ribavirin treatment. J Med Virol 2008; 80:632-639.
-
(2008)
J Med Virol
, vol.80
, pp. 632-639
-
-
Nakamura, M.1
Saito, H.2
Ikeda, M.3
-
80
-
-
34247552260
-
Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy
-
Lutchman G, Danehower S, Song BC, et al. Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy. Gastroenterology 2007; 132:1757-1766.
-
(2007)
Gastroenterology
, vol.132
, pp. 1757-1766
-
-
Lutchman, G.1
Danehower, S.2
Song, B.C.3
-
81
-
-
0035811016
-
RNA virus error catastrophe: Direct molecular test by using ribavirin
-
Crotty S, Cameron CE, Andino R. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc Natl Acad Sci USA 2001; 98:6895-6900.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6895-6900
-
-
Crotty, S.1
Cameron, C.E.2
Andino, R.3
-
82
-
-
33947320164
-
Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy
-
Hofmann WP, Polta A, Herrmann E, et al. Mutagenic effect of ribavirin on hepatitis C nonstructural 5B quasispecies in vitro and during antiviral therapy. Gastroenterology 2007; 132:921-930.
-
(2007)
Gastroenterology
, vol.132
, pp. 921-930
-
-
Hofmann, W.P.1
Polta, A.2
Herrmann, E.3
-
83
-
-
0037228023
-
Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons
-
Lanford RE, Guerra B, Lee H, et al. Antiviral effect and virus-host interactions in response to alpha interferon, gamma interferon, poly(i)-poly(c), tumor necrosis factor alpha, and ribavirin in hepatitis C virus subgenomic replicons. J Virol 2003; 77:1092-1104.
-
(2003)
J Virol
, vol.77
, pp. 1092-1104
-
-
Lanford, R.E.1
Guerra, B.2
Lee, H.3
-
84
-
-
0347594123
-
The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: Lack of evidence for ribavirin-induced viral mutagenesis
-
Schinkel J, de Jong MD, Bruning B, van Hoek B, Spaan WJ, Kroes AC. The potentiating effect of ribavirin on interferon in the treatment of hepatitis C: lack of evidence for ribavirin-induced viral mutagenesis. Antivir Ther 2003; 8:535-540.
-
(2003)
Antivir Ther
, vol.8
, pp. 535-540
-
-
Schinkel, J.1
de Jong, M.D.2
Bruning, B.3
van Hoek, B.4
Spaan, W.J.5
Kroes, A.C.6
-
85
-
-
13444310882
-
Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA
-
Pfeiffer JK, Kirkegaard K. Ribavirin resistance in hepatitis C virus replicon-containing cell lines conferred by changes in the cell line or mutations in the replicon RNA. J Virol 2005; 79:2346-2355.
-
(2005)
J Virol
, vol.79
, pp. 2346-2355
-
-
Pfeiffer, J.K.1
Kirkegaard, K.2
-
87
-
-
33846207539
-
A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication
-
Kim SS, Peng L F, Lin W, et al. A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication. Gastroenterology 2007; 132:311-320.
-
(2007)
Gastroenterology
, vol.132
, pp. 311-320
-
-
Kim, S.S.1
Peng, L.F.2
Lin, W.3
-
88
-
-
78751545582
-
Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models
-
Thomas E, Feld JJ, Li Q, Hu Z, Fried MW, Liang TJ. Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology 2011; 53:32-41.
-
(2011)
Hepatology
, vol.53
, pp. 32-41
-
-
Thomas, E.1
Feld, J.J.2
Li, Q.3
Hu, Z.4
Fried, M.W.5
Liang, T.J.6
-
89
-
-
84871731074
-
Ribavirin exerts a weak interferon-like effect on gene expression in the liver of patients with chronic hepatitis C
-
Rotman Y, Noureddin M, Feld JJ, et al. Ribavirin exerts a weak interferon-like effect on gene expression in the liver of patients with chronic hepatitis C. Hepatology 2011; 54 SUPPL 1:1327A-1328A.
-
(2011)
Hepatology
, vol.54
, Issue.SUPPL. 1
-
-
Rotman, Y.1
Noureddin, M.2
Feld, J.J.3
-
90
-
-
79952311505
-
S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders
-
Feld JJ, Modi AA, El-Diwany R, et al. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology 2011; 140:830-839.
-
(2011)
Gastroenterology
, vol.140
, pp. 830-839
-
-
Feld, J.J.1
Modi, A.A.2
El-Diwany, R.3
-
91
-
-
0019471668
-
Inhibitors of IMP dehydrogenase prevent sindbis virus replication and reduce GTP levels in Aedes albopictus cells
-
Malinoski F, Stollar V. Inhibitors of IMP dehydrogenase prevent sindbis virus replication and reduce GTP levels in Aedes albopictus cells. Virology 1981; 110:281-291.
-
(1981)
Virology
, vol.110
, pp. 281-291
-
-
Malinoski, F.1
Stollar, V.2
-
92
-
-
85047692907
-
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA
-
Zhou S, Liu R, Baroudy BM, Malcolm BA, Reyes GR. The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology 2003; 310:333-342.
-
(2003)
Virology
, vol.310
, pp. 333-342
-
-
Zhou, S.1
Liu, R.2
Baroudy, B.M.3
Malcolm, B.A.4
Reyes, G.R.5
-
93
-
-
0032775451
-
Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents
-
Franchetti P, Grifantini M. Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents. Curr Med Chem 1999; 6:599-614.
-
(1999)
Curr Med Chem
, vol.6
, pp. 599-614
-
-
Franchetti, P.1
Grifantini, M.2
-
94
-
-
0034102651
-
Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: A comparison with ribavirin and demonstration of antiviral additivity with alpha interferon
-
Markland W, McQuaid TJ, Jain J, Kwong AD. Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon. Antimicrob Agents Chemother 2000; 44:859-866.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 859-866
-
-
Markland, W.1
McQuaid, T.J.2
Jain, J.3
Kwong, A.D.4
-
95
-
-
24044538303
-
A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C
-
McHutchison JG, Shiffman ML, Cheung RC, et al. A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. Antivir Ther 2005; 10:635-643.
-
(2005)
Antivir Ther
, vol.10
, pp. 635-643
-
-
McHutchison, J.G.1
Shiffman, M.L.2
Cheung, R.C.3
-
96
-
-
0033024781
-
Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile
-
Tam RC, Pai B, Bard J, et al. Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol 1999; 30:376-382.
-
(1999)
J Hepatol
, vol.30
, pp. 376-382
-
-
Tam, R.C.1
Pai, B.2
Bard, J.3
-
97
-
-
0032055507
-
Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response
-
Ning Q, Brown D, Parodo J, et al. Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. J Immunol 1998; 160:3487-3493.
-
(1998)
J Immunol
, vol.160
, pp. 3487-3493
-
-
Ning, Q.1
Brown, D.2
Parodo, J.3
-
98
-
-
0031663638
-
The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses
-
Hultgren C, Milich DR, Weiland O, Sallberg M. The antiviral compound ribavirin modulates the T helper (Th) 1/Th2 subset balance in hepatitis B and C virus-specific immune responses. J Gen Virol 1998; 79:2381-2391.
-
(1998)
J Gen Virol
, vol.79
, pp. 2381-2391
-
-
Hultgren, C.1
Milich, D.R.2
Weiland, O.3
Sallberg, M.4
-
99
-
-
14944375587
-
Immunology of hepatitis B virus and hepatitis C virus infection
-
Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005; 5:215-229.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 215-229
-
-
Rehermann, B.1
Nascimbeni, M.2
-
100
-
-
3042780965
-
Effects of antiviral therapy on the cellular immune response in acute hepatitis C
-
Rahman F, Heller T, Sobao Y, et al. Effects of antiviral therapy on the cellular immune response in acute hepatitis C. Hepatology 2004; 40:87-97.
-
(2004)
Hepatology
, vol.40
, pp. 87-97
-
-
Rahman, F.1
Heller, T.2
Sobao, Y.3
-
101
-
-
36749069393
-
Interferons at age 50: Past, current and future impact on biomedicine
-
Borden EC, Sen GC, Uze G, et al. Interferons at age 50: past, current and future impact on biomedicine. Nat Rev Drug Discov 2007; 6:975-990.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 975-990
-
-
Borden, E.C.1
Sen, G.C.2
Uze, G.3
-
102
-
-
36348960622
-
Hepatic gene expression during treatment with peginterferon and ribavirin: Identifying molecular pathways for treatment response
-
Feld JJ, Nanda S, Huang Y, et al. Hepatic gene expression during treatment with peginterferon and ribavirin: identifying molecular pathways for treatment response. Hepatology 2007; 46:1548-1563.
-
(2007)
Hepatology
, vol.46
, pp. 1548-1563
-
-
Feld, J.J.1
Nanda, S.2
Huang, Y.3
-
103
-
-
77953893773
-
Ribavirin improves early responses to peginterferon through improved interferon signaling
-
Feld JJ, Lutchman GA, Heller T, et al. Ribavirin improves early responses to peginterferon through improved interferon signaling. Gastroenterology, 2010; 139:154-162.
-
(2010)
Gastroenterology
, vol.139
, pp. 154-162
-
-
Feld, J.J.1
Lutchman, G.A.2
Heller, T.3
-
104
-
-
0038032916
-
Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells
-
Zhang Y, Jamaluddin M, Wang S, et al. Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. J Virol 2003; 77:5933-5947.
-
(2003)
J Virol
, vol.77
, pp. 5933-5947
-
-
Zhang, Y.1
Jamaluddin, M.2
Wang, S.3
-
105
-
-
34447618973
-
Ribavirin up-regulates the activity of double-stranded RNA-activated protein kinase and enhances the action of interferon-alpha against hepatitis C virus
-
Liu WL, Su WC, Cheng CW, et al. Ribavirin up-regulates the activity of double-stranded RNA-activated protein kinase and enhances the action of interferon-alpha against hepatitis C virus. J Infect Dis 2007; 196:425-434.
-
(2007)
J Infect Dis
, vol.196
, pp. 425-434
-
-
Liu, W.L.1
Su, W.C.2
Cheng, C.W.3
-
106
-
-
69249234626
-
Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities
-
Su WC, Liu WL, Cheng CW, et al. Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities. FEBS Lett 2009; 583:2793-2798.
-
(2009)
FEBS Lett
, vol.583
, pp. 2793-2798
-
-
Su, W.C.1
Liu, W.L.2
Cheng, C.W.3
-
107
-
-
84863251369
-
Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8
-
Tokumoto Y, Hiasa Y, Uesugi K, et al. Ribavirin regulates hepatitis C virus replication through enhancing interferon-stimulated genes and interleukin 8. J Infect Dis 2012; 205:1121-1130.
-
(2012)
J Infect Dis
, vol.205
, pp. 1121-1130
-
-
Tokumoto, Y.1
Hiasa, Y.2
Uesugi, K.3
-
108
-
-
79958059274
-
Negative regulation of interferon-beta gene expression during acute and persistent virus infections
-
Ye J, Maniatis T. Negative regulation of interferon-beta gene expression during acute and persistent virus infections. PLoS ONE 2011; 6:e20681.
-
(2011)
PLoS ONE
, vol.6
-
-
Ye, J.1
Maniatis, T.2
-
109
-
-
0038651180
-
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
-
Lee J, Chuang TH, Redecke V, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci USA 2003; 100:6646-6651.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 6646-6651
-
-
Lee, J.1
Chuang, T.H.2
Redecke, V.3
-
110
-
-
84861658289
-
Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7
-
Boonstra A, Liu BS, Groothuismink ZM, et al. Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7. Antivir Ther 2012; 17:657-667.
-
(2012)
Antivir Ther
, vol.17
, pp. 657-667
-
-
Boonstra, A.1
Liu, B.S.2
Groothuismink, Z.M.3
-
111
-
-
84859735305
-
An orally available, small-molecule interferon inhibits viral replication
-
Konishi H, Okamoto K, Ohmori Y, et al. An orally available, small-molecule interferon inhibits viral replication. Sci Rep 2012; 2:259.
-
(2012)
Sci Rep
, vol.2
, pp. 259
-
-
Konishi, H.1
Okamoto, K.2
Ohmori, Y.3
-
112
-
-
84855211921
-
Treatment of chronic hepatitis C - are interferons really necessary?
-
Ferenci P. Treatment of chronic hepatitis C - are interferons really necessary? Liver Int 2012; 32 SUPPL 1:108-112.
-
(2012)
Liver Int
, vol.32
, Issue.SUPPL. 1
, pp. 108-112
-
-
Ferenci, P.1
-
113
-
-
71149099686
-
Safety and efficacy of viramidine versus ribavirin in ViSER2: Randomized, double-blind study in therapy-naive hepatitis C patients
-
Marcellin P, Gish RG, Gitlin N, et al. Safety and efficacy of viramidine versus ribavirin in ViSER2: randomized, double-blind study in therapy-naive hepatitis C patients. J Hepatol 2010; 52:32-38.
-
(2010)
J Hepatol
, vol.52
, pp. 32-38
-
-
Marcellin, P.1
Gish, R.G.2
Gitlin, N.3
-
114
-
-
84855248040
-
Once daily PSI-7977 plus RBV: Pegylated interferon alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3
-
Gane EJ, Stedman CA, Hyland RH, et al. Once daily PSI-7977 plus RBV: pegylated interferon alfa not required for complete rapid viral response in treatment-naive patients with HCV GT2 or GT3. Hepatology 2011; 54 SUPPL 1:377A.
-
(2011)
Hepatology
, vol.54
, Issue.SUPPL. 1
-
-
Gane, E.J.1
Stedman, C.A.2
Hyland, R.H.3
-
115
-
-
80051920720
-
Second-wave protease inhibitors: Choosing an heir
-
Ciesek S, von Hahn T, Manns MP. Second-wave protease inhibitors: choosing an heir. Clin Liver Dis 2011; 15:597-609.
-
(2011)
Clin Liver Dis
, vol.15
, pp. 597-609
-
-
Ciesek, S.1
von Hahn, T.2
Manns, M.P.3
-
116
-
-
80055076797
-
Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: A randomized trial
-
Manns M, Reesink H, Berg T, et al. Rapid viral response of once-daily TMC435 plus pegylated interferon/ribavirin in hepatitis C genotype-1 patients: a randomized trial. Antivir Ther 2011; 16:1021-1033.
-
(2011)
Antivir Ther
, vol.16
, pp. 1021-1033
-
-
Manns, M.1
Reesink, H.2
Berg, T.3
-
117
-
-
84856159009
-
Preliminary study of two antiviral agents for hepatitis C genotype 1
-
Lok AS, Gardiner DF, Lawitz E, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med 2012; 366:216-224.
-
(2012)
N Engl J Med
, vol.366
, pp. 216-224
-
-
Lok, A.S.1
Gardiner, D.F.2
Lawitz, E.3
-
118
-
-
84864281382
-
Cyclophilin inhibitors: A novel class of promising host-targeting anti-HCV agents
-
Gallay PA. Cyclophilin inhibitors: a novel class of promising host-targeting anti-HCV agents. Immunol Res 2012; 52:200-210.
-
(2012)
Immunol Res
, vol.52
, pp. 200-210
-
-
Gallay, P.A.1
-
120
-
-
34447320468
-
Quasispecies and its impact on viral hepatitis
-
Domingo E, Gomez J. Quasispecies and its impact on viral hepatitis. Virus Res 2007; 127:131-150.
-
(2007)
Virus Res
, vol.127
, pp. 131-150
-
-
Domingo, E.1
Gomez, J.2
-
121
-
-
84855242440
-
The role of ribavirin in direct acting antiviral drug regimens for chronic hepatitis C
-
Clark V, Nelson DR. The role of ribavirin in direct acting antiviral drug regimens for chronic hepatitis C. Liver Int 2012; 32 SUPPL 1:103-107.
-
(2012)
Liver Int
, vol.32
, Issue.SUPPL. 1
, pp. 103-107
-
-
Clark, V.1
Nelson, D.R.2
-
122
-
-
84857415002
-
The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C
-
Zeuzem S, Buggisch P, Agarwal K, et al. The protease inhibitor, GS-9256, and non-nucleoside polymerase inhibitor tegobuvir alone, with ribavirin, or pegylated interferon plus ribavirin in hepatitis C. Hepatology 2012; 55:749-758.
-
(2012)
Hepatology
, vol.55
, pp. 749-758
-
-
Zeuzem, S.1
Buggisch, P.2
Agarwal, K.3
-
123
-
-
81855228070
-
Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection
-
Zeuzem S, Asselah T, Angus P et al. Efficacy of the protease inhibitor BI 201335, polymerase inhibitor BI 207127, and ribavirin in patients with chronic HCV infection. Gastroenterology 2011; 141:2047-2055.
-
(2011)
Gastroenterology
, vol.141
, pp. 2047-2055
-
-
Zeuzem, S.1
Asselah, T.2
Angus, P.3
-
124
-
-
0037381591
-
Threshold for neutropenia in the adjustment of interferon treatment in HCV infection
-
Renou C, Harafa A, Cummins C, et al. Threshold for neutropenia in the adjustment of interferon treatment in HCV infection. Hepatology 2003; 37:949-950.
-
(2003)
Hepatology
, vol.37
, pp. 949-950
-
-
Renou, C.1
Harafa, A.2
Cummins, C.3
-
125
-
-
85058202409
-
Treatment of hepatitis C virus genotype 2 and 3 with pegylated interferon plus ribavirin
-
Rizzetto M. Treatment of hepatitis C virus genotype 2 and 3 with pegylated interferon plus ribavirin. J Hepatol 2005; 42:275-276.
-
(2005)
J Hepatol
, vol.42
, pp. 275-276
-
-
Rizzetto, M.1
-
126
-
-
33846356749
-
Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C
-
Shiffman ML, Ghany MG, Morgan TR, et al. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. Gastroenterology 2007; 132:103-112.
-
(2007)
Gastroenterology
, vol.132
, pp. 103-112
-
-
Shiffman, M.L.1
Ghany, M.G.2
Morgan, T.R.3
-
127
-
-
77957945298
-
The next step for taribavirin
-
Kwo PY, Vinayek R. The next step for taribavirin. Hepatology 2010; 52:1185-1188.
-
(2010)
Hepatology
, vol.52
, pp. 1185-1188
-
-
Kwo, P.Y.1
Vinayek, R.2
|