One-pot three-component synthesis of novel heterocyclic steroids as a central antioxidant and anti-inflammatory agents

Steroids

Volumn 77, Issue 13, 2012, Pages 1469-1476

  Mohamed, Nadia R ^a,b   Abdelhalim, Mervat M ^a   Khadrawy, Yasser A ^a   Elmegeed, Gamal A ^a   Abdel Salam, Omar M E ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

^b PRINCE SATTAM BIN ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Anti neuroinflammatory; Antioxidant; Pyridine; Pyridopyrimidine

Indexed keywords

2' AMINO 3 BETA HYDROXY 4'H 4' PHENYL 5A ANDROSTAN[16,17 5',6']PYRAN 3' CARBONITRILE; 3 BETA HYDROXY 1',3',5',8' TETRAHYDRO 5' PHENYL 5A ANDROSTAN[16,17 6',7']PYRIDO[2',3' D]PYRIMIDIN 2',4' DITHIONE; 3 BETA HYDROXY 3',5',8' TRIHYDRO 2' METHYL 5' PHENYL 5A ANDROSTAN[16,17 6,7']PYRIDO[2',3' D]PYRIMIDIN 4' ONE; ACETYLCHOLINESTERASE; AMINO 3 BETA HYDROXY 4' IMINO 5' PHENYL 5A ANDROSTAN [16,17 6',7'] 5'H PYRIDO[2',3' D]PYRIMIDINE; ENDOTOXIN; GLUTATHIONE; HETEROCYCLIC STEROID; MALONALDEHYDE; N (3 BETA HYDROXY 3' CYANO 1',4' DIHYDRO 4' PHENYL 5A ANDROSTAN [16,17 5',6']PYRIDIN 2' YL)ETHOXYMETHANAMINE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; ONE POT SYNTHESIS; OXIDATIVE STRESS; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BRAIN; CHEMISTRY TECHNIQUES, SYNTHETIC; HETEROCYCLIC COMPOUNDS; NEURONS; OXIDATIVE STRESS; RATS; STEROIDS;

BACTERIA (MICROORGANISMS); RATTUS;

EID: 84867217897     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2012.09.001     Document Type: Article

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