Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit

Journal of Pharmacological Sciences

Volumn 118, Issue 4, 2012, Pages 447-454

  Ma, Juan ^a   Liang, He ^a   Jin, Hong Ri ^b   Dat, Nguyen Tien ^c   Zhang, Shan Yu ^a   Jiang, Ying Zi ^a   Nan, Ji Xing ^a   Li, Donghao ^a   Wu, Xue ^a   Lee, Jung Joon ^a,b   Jin, Xuejun ^a  

^a YANBIAN UNIVERSITY   (China)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Viet Nam)

Author keywords

Inflammation; Nuclear factor B (NF B); RelA p65; Transactivation; Yangonin

Indexed keywords

C JUN NH2 TERMINAL KINASE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG; YANGONIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; DNA BINDING; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INTERLEUKIN 6 GENE; INTERLEUKIN 8 GENE; MONOCYTE CHEMOTACTIC PROTEIN 1 GENE; MOUSE; NONHUMAN; NUCLEAR FACTOR KAPPA B GENE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

EID: 84867215612     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11215FP     Document Type: Article

References (24)

1. Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell. 2004;6:203-208.
2. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683.
3. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of nf-[kappa]B activity. Annu Rev Immunol. 2000;18:621-663.
4. Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 2006;25:6706-6716.
5. Sethi G, Sung B, Aggarwal BB. Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood). 2008;233:21-31.
6. Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994;12:141-179.
7. Wu D, Yu L, Nair MG, DeWitt DL, Ramsewak RS. Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from piper methysticum (kava kava) roots. Phytomedicine. 2002;9:41-47.
8. Folmer F, Blasius R, Morceau F, Tabudravu J, Dicato M, Jaspars M, et al. Inhibition of tnfalpha-induced activation of nuclear factor kappaB by kava (piper methysticum) derivatives. Biochem Pharmacol. 2006;71:1206-1218.
9. Zhou P, Gross S, Liu JH, Yu BY, Feng LL, Nolta J, et al. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. FASEB J. 2010;24:4722-4732.
10. Takei H, Baba Y, Hisatsune A, Katsuki H, Miyata T, Yokomizo K, et al. Glycyrrhizin inhibits interleukin-8 production and nuclear factor-kappaB activity in lung epithelial cells, but not through glucocorticoid receptors. J Pharmacol Sci. 2008;106:460-468.
11. Lee JH, Koo TH, Yoon H, Jung HS, Jin HZ, Lee K, et al. Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid. Biochem Pharmacol. 2006;72:1311-1321.
12. Jin X, Jin HR, Jung HS, Lee SJ, Lee JH, Lee JJ. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010;285:30539-30547.
13. Zhang G, Ghosh S. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest. 2001;107:13-19.
14. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 2002;109 Suppl:S81-S96.
15. Ballard DW, Dixon EP, Peffer NJ, Bogerd H, Doerre S, Stein B, et al. The 65-kda subunit of human NF-kappa B functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc Natl Acad Sci U S A. 1992;89:1875-1879.
16. Schmitz ML, Baeuerle PA. The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO J. 1991;10:3805-3817.
17. Sizemore N, Leung S, Stark GR. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/rela subunit. Mol Cell Biol. 1999;19:4798-4805.
18. Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, Yagita H, et al. Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci U S A. 1998;95:3537-3542.
19. Zhang Y, Dong C. Regulatory mechanisms of mitogen-activated kinase signaling. Cell Mol Life Sci. 2007;64:2771-2789.
20. Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ. Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis. 2003;24:1515-1524.
21. Gingery A, Bradley E, Shaw A, Oursler MJ. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/ NFkappaB pathways to maintain osteoclast survival. J Cell Biochem. 2003;89:165-179.
22. Noman AS, Koide N, Hassan F, I-E-Khuda I, Dagvadorj J, Tumurkhuu G, et al. Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of Myd88 expression. Innate Immun. 2009;15:33-41.
23. Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature. 1999;401:86-90.
24. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004;431:461-466.