Post-transcriptional control of gene expression during mouse oogenesis

Results and Problems in Cell Differentiation

Volumn 55, Issue , 2012, Pages 1-21

  Clarke, Hugh J ^a  

^a ROYAL VICTORIA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84867206116     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/978-3-642-30406-4_1     Document Type: Review

References (123)

1. Abaza I, Gebauer F (2008) Trading translation with RNA-binding proteins. RNA 14:404-409
2. Arnold DR, Francon P, Zhang J, Martin K, Clarke HJ (2008) Stem-loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouse. Dev Biol 313:347-358
3. Audic Y, Omilli F, Osborne HB (1997) Postfertilization deadenylation of mRNAs in Xenopus laevis embryos is sufficient to cause their degradation at the blastula stage. Mol Cell Biol 17:209-218
4. Bachvarova R, De Leon V (1977) Stored and polysomal ribosomes of mouse ova. Dev Biol 58:248-254
5. Bachvarova R, De Leon V, Johnson A, Kaplan G, Paynton BV (1985) Changes in total RNA, polyadenylated RNA, and actin mRNA during meiotic maturation of mouse oocytes. Dev Biol 108:325-331
6. Balagopal V, Parker R (2009) Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs. Curr Opin Cell Biol 21:403-408
7. Barnard DC, Cao Q, Richter JD (2005) Differential phosphorylation controls Maskin association with eukaryotic translation initiation factor 4E and localization on the mitotic apparatus. Mol Cell Biol 25:7605-7615
8. Belloc E, Mendez R (2008) A deadenylation negative feedback mechanism governs meiotic metaphase arrest. Nature 452:1017-1021
9. Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK (2008) Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis. J Cell Biol 182:543-557
10. Braun JE, Huntzinger E, Fauser M, Izaurralde E (2011) GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell 44:120-133
11. Brook M, Smith JWS, Gray NK (2009) The DAZL and PABP families: RNA-binding proteins with interrelated roles in translational control in oocytes. Reproduction 137:595-617
12. Brower PT, Gizang E, Boreen SM, Schultz RM (1981) Biochemical studies of mammalian oogenesis: synthesis and stability of various classes of RNA during growth of the mouse oocyte in vitro. Dev Biol 86:373-383
13. Burns DM, D'Ambrogio A, Nottrott S, Richter JD (2011) CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation. Nature 473:105-108
14. Cai C, Tamai K, Molyneaux K (2010) KHDC1B is a novel CPEB binding partner specifically expressed in mouse oocytes and early embryos. Mol Biol Cell 21:3137-3148
15. Capco DG, Gallicano GI, McGaughey RW, Downing KH, Larabell CA (1993) Cytoskeletal sheets of mammalian eggs and embryos: a lattice-like network of intermediate filaments. Cell Motil Cytoskeleton 24:85-99
16. Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM (2006) Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J 25:2792-2801
17. Chekulaeva M, Mathys H, Zipprich JT, Attig J, Colic M, Parker R, Filipowicz W (2011) miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol 18:1218-1226
18. Chen J, Melton C, Suh N, Oh JS, Horner K, Xie F, Sette C, Blelloch R, Conti M (2011) Genomewide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Genes Dev 25:755-766
19. Colgan DF, Murthy KG, Prives C, Manley JL (1996) Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Nature 384:282-285
20. Copeland PR, Wormington M (2001) The mechanism and regulation of deadenylation: identification and characterization of Xenopus PARN. RNA 7:875-886
21. Cowling VH (2009) Regulation of mRNA cap methylation. Biochem J 425:295-302
22. Dai Y, Newman B, Moor R (2005) Translational regulation of MOS messenger RNA in pig oocytes. Biol Reprod 73:997-1003
23. De La Fuente R (2006) Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes. Dev Biol 292:1-12
24. Detivaud L, Pascreau G, Karaiskou A, Osborne HB, Kubiak JZ (2003) Regulation of EDENdependent deadenylation of Aurora A/Eg2-derived mRNA via phosphorylation and dephosphorylation in Xenopus laevis egg extracts. J Cell Sci 116:2697-2705
25. Eliscovich C, Peset I, Vernos I, Mendez R (2008) Spindle-localized CPE-mediated translation controls meiotic chromosome segregation. Nat Cell Biol 10:858-865
26. Eulalio A, Behm-Ansmant I, Izaurralde E (2007) P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol 8:9-22
27. Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB (2006) Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Genes Dev 20:2713-2727
28. Fabian MR, Cieplak MK, Frank F, Morita M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF, Sonenberg N (2011) miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol 18:1211-1217
29. Flemr M, Ma J, Schultz RM, Svoboda P (2010) P-body loss is concomitant with formation of a messenger RNA storage domain in mouse oocytes. Biol Reprod 82:1008-1017
30. Fox CA, Sheets MD, Wickens MP (1989) Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU. Genes Dev 3:2151-2162
31. Franks TM, Lykke-Andersen J (2008) The control of mRNA decapping and P-body formation. Mol Cell 32:605-615
32. Garneau NL, Wilusz J, Wilusz CJ (2007) The highways and byways of mRNA decay. Nat Rev Mol Cell Biol 8:113-126
33. Gebauer F, Richter JD (1996) Mouse cytoplasmic polyadenylylation element binding protein: an evolutionarily conserved protein that interacts with the cytoplasmic polyadenylylation elements of c-mos mRNA. Proc Natl Acad Sci USA 93:14602-14607
34. Gebauer F, Xu WH, Cooper GM, Richter JD (1994) Translational control by cytoplasmic polyadenylation of c-mos messenger-RNA is necessary for oocyte maturation in the mouse. EMBO J 13:5712-5720
35. Gershon E, Galiani D, Dekel N (2006) Cytoplasmic polyadenylation controls cdc25B mRNA translation in rat oocytes resuming meiosis. Reproduction 132:21-31
36. Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, Van Dongen S, Inoue K, Enright AJ, Schier AF (2006) Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312:75-79
37. Goldstrohm AC, Wickens M (2008) Multifunctional deadenylase complexes diversify mRNA control. Nat Rev Mol Cell Biol 9:337-344
38. Goldstrohm AC, Hook BA, Seay DJ, Wickens M (2006) PUF proteins bind Pop2p to regulate messenger RNAs. Nat Struct Mol Biol 13:533-539
39. Groppo R, Richter JD (2009) Translational control from head to tail. Curr Opin Cell Biol 21:444-451
40. Hodgman R, Tay J, Mendez R, Richter JD (2001) CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes. Development 128:2815-2822
41. Holt JE, Weaver J, Jones KT (2010) Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes. Development 137:1297-1304
42. Huarte J, Belin D, Vassalli A, Strickland S, Vassalli JD (1987) Meiotic maturation of mouse oocytes triggers the translation and polyadenylation of dormant tissue-type plasminogen activator mRNA. Genes Dev 1:1201-1211
43. Huarte J, Stutz A, Oconnell ML, Gubler P, Belin D, Darrow AL, Strickland S, Vassalli JD (1992) Transient translational silencing by reversible mRNA deadenylation. Cell 69:1021-1030
44. Jackson RJ, Hellen CU, Pestova TV (2010) The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11:113-127
45. Jung MY, Lorenz L, Richter JD (2006) Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein. Mol Cell Biol 26:4277-4287
46. Kaneda M, Tang F, O'Carroll D, Lao K, Surani MA (2009) Essential role for Argonaute2 protein in mouse oogenesis. Epigenetics Chromatin 2:9
47. Kang MK, Han SJ (2011) Post-transcriptional and post-translational regulation during mouse oocyte maturation. BMB Rep 44:147-157
48. Kim JH, Richter JD (2006) Opposing polymerase-deadenylase activities regulate cytoplasmic polyadenylation. Mol Cell 24:173-183
49. Kleene KC, Distel RJ, Hecht NB (1984) Translational regulation and deadenylation of a protamine mRNA during spermiogenesis in the mouse. Dev Biol 105:71-79
50. Korner CG, Wormington M, Muckenthaler M, Schneider S, Dehlin E, Wahle E (1998) The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes. EMBO J 17:5427-5437
51. Kulkarni M, Ozgur S, Stoecklin G (2010) On track with P-bodies. Biochem Soc Trans 38:242-251
52. Lehtonen E, Lehto VP, Vartio T, Badley RA, Virtanen I (1983) Expression of cytokeratin polypeptides in mouse oocytes and preimplantation embryos. Dev Biol 100:158-165
53. Li L, Baibakov B, Dean J (2008) A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell 15:416-425
54. Liu J, Linher K, Li J (2009) Porcine DAZL messenger RNA: its expression and regulation during oocyte maturation. Mol Cell Endocrinol 311:101-108
55. Ma J, Flemr M, Stein P, Berninger P, Malik R, Zavolan M, Svoboda P, Schultz RM (2010) MicroRNA activity is suppressed in mouse oocytes. Curr Biol 20:265-270
56. Marangos P, Carroll J (2008) Securin regulates entry into M-phase by modulating the stability of cyclin B. Nat Cell Biol 10:445-451
57. McGrew LL, Dworkin-Rastl E, Dworkin MB, Richter JD (1989) Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element. Genes Dev 3:803-815
58. Medvedev S, Yang J, Hecht NB, Schultz RM (2008) CDC2A (CDK1)-mediated phosphorylation of MSY2 triggers maternal mRNA degradation during mouse oocyte maturation. Dev Biol 321:205-215
59. Medvedev S, Pan H, Schultz RM (2011) Absence of MSY2 in mouse oocytes perturbs oocyte growth and maturation, RNA stability, and the transcriptome. Biol Reprod 85:575-583
60. Mendez R, Hake LE, Andresson T, Littlepage LE, Ruderman JV, Richter JD (2000a) Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA. Nature 404:302-307
61. Mendez R, Murthy KG, Ryan K, Manley JL, Richter JD (2000b) Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Mol Cell 6:1253-1259
62. Mendez R, Barnard D, Richter JD (2002) Differential mRNA translation and meiotic progression require Cdc2-mediated CPEB destruction. EMBO J 21:1833-1844
63. Millevoi S, Vagner S (2010) Molecular mechanisms of eukaryotic pre-mRNA 30 end processing regulation. Nucleic Acids Res 38:2757-2774
64. Minshall N, Reiter M.H., Weil D, Standart N (2007) CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes. J Biol Chem 282:37389-37401
65. Moore FL, Jaruzelska J, Fox MS, Urano J, Firpo MT, Turek PJ, Dorfman DM, Pera RAR (2003) Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins. Proc Natl Acad Sci USA 100:538-543
66. Morris AR, Mukherjee N, Keene JD (2008) Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. Mol Cell Biol 28:4093-4103
67. Murai S, Stein P, Buffone MG, Yamashita S, Schultz RM (2010) Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos. Dev Biol 341:205-212
68. Murchison EP, Stein P, Xuan Z, Pan H, Zhang MQ, Schultz RM, Hannon GJ (2007) Critical roles for Dicer in the female germline. Genes Dev 21:682-693
69. Nakahata S, Katsu Y, Mita K, Inoue K, Nagahama Y, Yamashita M (2001) Biochemical identification of Xenopus pumilio as a sequence-specific cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein. J Biol Chem 276:20945-20953
70. Nakahata S, Kotani T, Mita K, Kawasaki T, Katsu Y, Nagahama Y, Yamashita M (2003) Involvement of Xenopus pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation. Mech Dev 120:865-880
71. Nakanishi T, Kubota H, Ishibashi N, Kumagai S, Watanabe H, Yamashita M, S-i K, Miyado K, Baba T (2006) Possible role of mouse poly(A) polymerase mGLD-2 during oocyte maturation. Dev Biol 289:115-126
72. Nakanishi T, Kumagai S, Kimura M, Watanabe H, Sakurai T, Kashiwabara S, Baba T (2007) Disruption of mouse poly(A) polymerase mGLD-2 does not alter polyadenylation status in oocytes and somatic cells. Biochem Biophys Res Commun 364:14-19
73. Oh B, Hwang SY, McLaughlin J, Solter D, Knowles BB (2000) Timely translation during the mouse oocyte-to-embryo transition. Development 127:3795-3803
74. Paillard L, Omilli F, Legagneux V, Bassez T, Maniey D, Osborne HB (1998) EDEN and EDENBP, a cis element and an associated factor that mediate sequence-specific mRNA deadenylation in Xenopus embryos. EMBO J 17:278-287
75. Pan H, O'Brien MJ, Wigglesworth K, Eppig JJ, Schultz RM (2005) Transcript profiling during mouse oocyte development and the effect of gonadotropin priming and development in vitro. Dev Biol 286:493-506
76. Parker R, Sheth U (2007) P bodies and the control of mRNA translation and degradation. Mol Cell 25:635-646
77. Paynton BV, Rempel R, Bachvarova R (1988) Changes in state of adenylation and time course of degradation of maternal mRNAs during oocyte maturation and early embryonic development in the mouse. Dev Biol 129:304-314
78. Piqué M, López JM, Foissac S, Guigó R, Méndez R (2008) A combinatorial code for CPEmediated translational control. Cell 132:434-448
79. Racki WJ, Richter JD (2006) CPEB controls oocyte growth and follicle development in the mouse. Development 133:4527-4537
80. Radford HE, Meijer HA, de Moor CH (2008) Translational control by cytoplasmic polyadenylation in Xenopus oocytes. Biochim Biophys Acta 1779:217-229
81. Reverte CG, Ahearn MD, Hake LE (2001) CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome. Dev Biol 231:447-458
82. Richter JD, Sonenberg N (2005) Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 433:477-480
83. Rouget C, Papin C, Boureux A, Meunier AC, Franco B, Robine N, Lai EC, Pelisson A, Simonelig M (2010) Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo. Nature 467:1128-1132
84. Salles FJ, Darrow AL, O'Connell ML, Strickland S (1992) Isolation of novel murine maternal mRNAs regulated by cytoplasmic polyadenylation. Genes Dev 6:1202-1212
85. Schmid M, Kuchler B, Eckmann CR (2009) Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans. Genes Dev 23:824-836
86. Setoyama D, Yamashita M, Sagata N (2007) Mechanism of degradation of CPEB during Xenopus oocyte maturation. Proc Natl Acad Sci USA 104:18001-18006
87. Standart N, Jackson RJ (2007) MicroRNAs repress translation of m7G ppp-capped target mRNAs in vitro by inhibiting initiation and promoting deadenylation. Genes Dev 21:1975-1982
88. Standart N, Minshall N (2008) Translational control in early development: CPEB, P-bodies and germinal granules. Biochem Soc Trans 36:671-676
89. Strickland S, Huarte J, Belin D, Vassalli A, Rickles RJ, Vassalli JD (1988) Antisense RNA directed against the 30 noncoding region prevents dormant mRNA activation in mouse oocytes. Science 241:680-684
90. Stutz A, Huarte J, Gubler P, Conne B, Belin D, Vassalli JD (1997) In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes. Mol Cell Biol 17:1759-1767
91. Stutz A, Conne B, Huarte J, Gubler P, Volkel V, Flandin P, Vassalli JD (1998) Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev 12:2535-2548
92. Su Y-Q, Sugiura K, Woo Y, Wigglesworth K, Kamdar S, Affourtit J, Eppig JJ (2007) Selective degradation of transcripts during meiotic maturation of mouse oocytes. Dev Biol 302:104-117
93. Sugimura I, Lilly MA (2006) Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Dev Cell 10:127-135
94. Suh N, Blelloch R (2011) Small RNAs in early mammalian development: from gametes to gastrulation. Development 138:1653-1661
95. Suh N, Baehner L, Moltzahn F, Melton C, Shenoy A, Chen J, Blelloch R (2010) MicroRNA function Is globally suppressed in mouse oocytes and early embryos. Curr Biol 20:271-277
96. Swetloff A, Conne B, Huarte J, Pitetti J-L, Nef S, Vassalli J-D (2009) Dcp1-bodies in mouse oocytes. Mol Biol Cell 20:4951-4961
97. Tadros W, Lipshitz HD (2009) The maternal-to-zygotic transition: a play in two acts. Development 136:3033-3042
98. Tadros W, Goldman AL, Babak T, Menzies F, Vardy L, Orr-Weaver T, Hughes TR, Westwood JT, Smibert CA, Lipshitz HD (2007) SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase. Dev Cell 12:143-155
99. Tam OH, Aravin AA, Stein P, Girard A, Murchison EP, Cheloufi S, Hodges E, Anger M, Sachidanandam R, Schultz RM, Hannon GJ (2008) Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453:534-538
100. Tang F (2010) Small RNAs in mammalian germline: tiny for immortal. Differentiation 79:141-146
101. Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA (2007) Maternal microRNAs are essential for mouse zygotic development. Genes Dev 21:644-648
102. Tay J, Hodgman R, Richter JD (2000) The control of cyclin B1 mRNA translation during mouse oocyte maturation. Dev Biol 221:1-9
103. Thelie A, Papillier P, Pennetier S, Perreau C, Traverso JM, Uzbekova S, Mermillod P, Joly C, Humblot P, Dalbies-Tran R (2007) Differential regulation of abundance and deadenylation of maternal transcripts during bovine oocyte maturation in vitro and in vivo. BMC Dev Biol 7:125
104. Tremblay K, Vigneault C, McGraw S, Sirard MA (2005) Expression of cyclin B1 messenger RNA isoforms and initiation of cytoplasmic polyadenylation in the bovine oocyte. Biol Reprod 72:1037-1044
105. Tritschler F, Huntzinger E, Izaurralde E (2010) Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of deja vu. Nat Rev Mol Cell Biol 11:379-384
106. Uzbekova S, Arlot-Bonnemains Y, Dupont J, Dalbies-Tran R, Papillier P, Pennetier S, Thelie A, Perreau C, Mermillod P, Prigent C, Uzbekov R (2008) Spatio-temporal expression patterns of Aurora kinases A, B, and C and cytoplasmic polyadenylation-element-binding protein in bovine oocytes during meiotic maturation. Biol Reprod 78:218-233
107. Vardy L, Orr-Weaver TL (2007a) The Drosophila PNG kinase complex regulates the translation of cyclin B. Dev Cell 12:157-166
108. Vardy L, Orr-Weaver TL (2007b) Regulating translation of maternal messages: multiple repression mechanisms. Trends Cell Biol 17:547-554
109. Vassalli JD, Huarte J, Belin D, Gubler P, Vassalli A, O'Connell ML, Parton LA, Rickles RJ, Strickland S (1989) Regulated polyadenylation controls mRNA translation during meiotic maturation of mouse oocytes. Genes Dev 3:2163-2171
110. VerMilyea MD, Maneck M, Yoshida N, Blochberger I, Suzuki E, Suzuki T, Spang R, Klein CA, Perry ACF (2011) Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. EMBO J 30:1841-1851
111. Villaescusa JC, Allard P, Carminati E, Kontogiannea M, Talarico D, Blasi F, Farookhi R, Verrotti AC (2006) Clast4, the murine homologue of human eIF4E-Transporter, is highly expressed in developing oocytes and post-translationally modified at meiotic maturation. Gene 367:101-109
112. von Roretz C, Gallouzi IE (2008) Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol 181:189-194
113. Watanabe T, Totoki Y, Toyoda A, Kaneda M, Kuramochi-Miyagawa S, Obata Y, Chiba H, Kohara Y, Kono T, Nakano T, Surani MA, Sakaki Y, Sasaki H (2008) Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453:539-543
114. Welk JF, Charlesworth A, Smith GD, MacNicol AM (2001) Identification and characterization of the gene encoding human cytoplasmic polyadenylation element binding protein. Gene 263:113-120
115. Wickens M, Bernstein DS, Kimble J, Parker R (2002) A PUF family portrait: 30UTR regulation as a way of life. Trends Genet 18:150-157
116. Wright PW, Bolling LC, Calvert ME, Sarmento OF, Berkeley EV, Shea MC, Hao Z, Jayes FC, Bush LA, Shetty J, Shore AN, Reddi PP, Tung KS, Samy E, Allietta MM, Sherman NE, Herr JC, Coonrod SA (2003) ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. Dev Biol 256:74-89
117. Xu EY, Chang R, Salmon NA, Reijo Pera RA (2007) A gene trap mutation of a murine homolog of the Drosophila stem cell factor Pumilio results in smaller testes but does not affect litter size or fertility. Mol Reprod Dev 74:912-921
118. Yamashita A, Chang TC, Yamashita Y, Zhu W, Zhong Z, Chen CY, Shyu AB (2005) Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover. Nat Struct Mol Biol 12:1054-1063
119. Yang Q, Allard P, Huang M, Zhang W, Clarke HJ (2010) Proteasomal activity is required to initiate and to sustain translational activation of messenger RNA encoding the stem-loopbinding protein during meiotic maturation in mice. Biol Reprod 82:123-131
120. Yu J, Hecht NB, Schultz RM (2001) Expression of MSY2 in mouse oocytes and preimplantation embryos. Biol Reprod 65:1260-1270
121. Yu JY, Hecht NB, Schultz RM (2002) RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein. Biol Reprod 67:1093-1098
122. Yu J, Deng M, Medvedev S, Yang J, Hecht NB, Schultz RM (2004) Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility. Dev Biol 268:195-206
123. Yurttas P, Vitale AM, Fitzhenry RJ, Cohen-Gould L, Wu W, Gossen JA, Coonrod SA (2008) Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo. Development 135:2627-2636