Quantification of iron concentration in the liver by MRI

Insights into Imaging

Volumn 3, Issue 2, 2012, Pages 173-180

  Alústiza Echeverría, José María ^a   Castiella, Agustín ^b   Emparanza, José Ignacio ^a  

^a HOSPITAL DONOSTIA   (Spain)

^b HOSPITAL DE MENDARO   (Spain)

Author keywords

Haemochromatosis; Iron overload; Liver iron; MRI; Quantification; Relaxometry; Signal intensity ratio

Indexed keywords

EID: 84867203068     PISSN: None     EISSN: 18694101     Source Type: Journal    
DOI: 10.1007/s13244-011-0132-1     Document Type: Review

References (32)

1. Brittenham GM, Badman DG (2003) Non invasive measurement of iron: report of an NIDDK workshop. Blood 101:15-19
2. Pietrangelo A, Deugnier Y, Dooley J et al (2010) EASL clinical practice guidelines for HFE haemochromatosis. European Association for the Study of the Liver. J Hepatol 53:3-22
3. Allen KJ, Gurrin LC, Constantine CC et al (2008) Iron-overloadrelated disease in HFE hereditary haemochromatosis. N Engl J Med 358:221-230
4. Villeneuve JP, Bilofdeau M, Lepage R et al (1996) Variability in hepatic iron concentration measurement from needle-biopsy specimens. J Hepatol 25:172-177
5. Ambu R, Crisponi G, Sciot R et al (1995) Uneven hepatic iron and phosphorus distribution in beta-thalassemia. J Hepatol 23:544-549
6. Crisponi G, Ambu R, Cristiani F et al (2000) Does iron concentration in a liver needle biopsy accurately reflect hepatic iron burden in beta-thalassemia? Clin Chem 46:1185-1188
7. Emond MJ, Bronner MP, Carlson TH et al (1999) Quantitative study of the variability of hepatic iron concentrations. Clin Chem 45:340-346
8. St Pierre TG, Clark PR, Chua-Anusorn W. et al (2005) Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 105:855-861
9. Alexopoulou E, Stripeli F, Baras P et al (2006) R2 relaxometry with MRI for the quantification of tissue iron overload in betathalassemic patients. J Magn Reson Imaging 23:163-170
10. Anderson LJ, Holden S, Davis B et al (2001) Cardiovascular T2- star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J 22:2171-2179
11. Wood JC, Enriquez C, Ghugre N et al (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106:1460-1465
12. Westwood MA, Anderson LJ, Firmin DN et al (2003) A single breath-hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload. J Magn Reson Imaging 18:33-39
13. Hankins JS, McCarville MB, Loeffler RB et al (2009) R2* magnetic resonance imaging of the liver in patients with iron overload. Blood 113:4853-4855
14. St Pierre TG, Clark PR, Chua-Anusorn W (2004) Single spinecho proton transverse relaxometry of iron loaded-liver. NMR Biomed 17:446-448
15. Wood JC (2007) Magnetic resonance imaging measurement of iron overload. Curr Opin Hematol 14:183-190
16. Argyropoulou MI, Astrakas L (2007) MRI evaluation of tissue iron burden in patients with beta-thalassaemia major. Pediatr Radiol 37:1191-1200
17. Papakonstantinou O, Kostaridou S, Man's T (1999) Quantification of liver iron overload by T2 quantitative magnetic resonance imaging in thalassemia: impact of chronic hepatitis C on measurements. J Pediatr Hematol Oncol 21:142-148
18. Christoforidis A, Perifanis V, Spanos G et al (2009) MRI assessment of liver iron content in thalassamic patients with three different protocols: comparisons and correlations. Eur J Haematol 82:388-392
19. Positano V, Salani B, Pepe A et al (2009) Improved T2* assessment in liver iron overload by magnetic resonance imaging. Magn Reson Imaging 27:188-197
20. Sirlin CB, Reeder SB (2010) Magnetic resonance imaging quantification of liver iron. Magn Reson Imaging Clin N Am 18:359-381
21. Taouli B, Ehman RL, Reeder SB (2009)MRI methods for assessment of chronic liver disease. AJR Am J Roentgenol 193:14-27
22. Wood JC (2009) History and current impact of cardiac magnetic resonance imaging on the management of iron overload. Circulation 120:1937-1939
23. Meloni A, Ramazzotti A, Positano V et al (2009) Evaluation of a web-based network for reproducible T2* MRI assessment of iron overload in thalassemia. Int J Med Inform 78:503-512
24. Gandon Y, Olivié D, Guyader D et al (2004) Non-invasive assessment of hepatic iron stores by MRI. Lancet 363:357-362
25. Alústiza JM, Artetxe J, Castiella A et al (2004) MR quantification of hepatic iron concentration. Radiology 230:479-484
26. Ernst O, Sergent G, Bonvarlet P et al (1997) Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol 168:1205-1208
27. Ernst O, Rose C, Sergent G et al (1999) Hepatic iron overload: quantification with MR imaging at 1.5 T. AJR Am J Roentgenol 172:1141-1142
28. Bonkovsky HL, Rubin RB, Cable EE et al (1999) Hepatic iron concentration: non-invasive estimation by means of MR imaging techniques. Radiology 212:227-232
29. Gandon Y. Iron and liver. Available at: www.radio.univ-rennes1.fr
30. Rose C, Vandevenne P, Bourgeois E et al (2006) Liver iron content assessment by routine and simple magnetic resonance imaging procedure in highly transfused patients. Eur J Haematol 77:145-149
31. Castiella A, Alústiza JM, Emparanza JI et al (2011) Liver iron concentration quantification by MRI. Are recommended protocols accurate enough for clinical practice? Eur Radiol 21:137-141
32. Alústiza JM. Sedia investiga. Cálculo Hierro Hepático. Available at: www.sedia.es