Normal ageing is associated with an increase in Th2 cells, MCP-1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF-AA between sexes

Clinical and Experimental Immunology

Volumn 170, Issue 2, 2012, Pages 186-193

  Mansfield, A S ^a   Nevala, W K ^a   Dronca, R S ^a   Leontovich, A A ^a   Shuster, L ^a   Markovic, S N ^a  

^a MAYO CLINIC   (United States)

Author keywords

Ageing; Immunity; MCP 1; RANTES; Th2 cells

Indexed keywords

CCL1 CHEMOKINE; CD40 LIGAND; CXCL1 CHEMOKINE; EOTAXIN; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 15; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 8; MACROPHAGE DERIVED CHEMOKINE; MELAN A; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR AB; RANTES; TETRAMER; VIRUS ANTIGEN;

ADULT; AGING; ARTICLE; B LYMPHOCYTE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOMEGALOVIRUS; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; INFLUENZA; LYMPHOCYTE DIFFERENTIATION; MALE; MELANOMA; NORMAL HUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SEX DIFFERENCE; T LYMPHOCYTE SUBPOPULATION; TH2 CELL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ANTIGENS, CD3; ANTIGENS, CD4; B-LYMPHOCYTE SUBSETS; CD40 LIGAND; CHEMOKINE CCL2; CHEMOKINE CCL5; CYTOKINES; HUMANS; MALE; MELANOMA; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SEX FACTORS; T-LYMPHOCYTE SUBSETS; TH2 CELLS; YOUNG ADULT;

EID: 84867201203     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2012.04644.x     Document Type: Article

References (35)

1. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965; 37:614-36.
2. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961; 25:585-621.
3. Cefalu CA. Theories and mechanisms of aging. Clin Geriatr Med 2011; 27:491-506.
4. Harman D. The aging process: major risk factor for disease and death. Proc Natl Acad Sci USA 1991; 88:5360-3.
5. Willimsky G, Blankenstein T. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance. Nature 2005; 437:141-6.
6. Fulop T, Kotb R, Fortin CF, Pawelec G, de Angelis F, Larbi A. Potential role of immunosenescence in cancer development. Ann NY Acad Sci 2010; 1197:158-65.
7. Nevala WK, Vachon CM, Leontovich AA, Scott CG, Thompson MA, Markovic SN. Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma. Clin Cancer Res 2009; 15:1931-9.
8. Mansfield AS, Holtan SG, Grotz TE etal. Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis. Mod Pathol 2011; 24:487-94.
9. Kawamoto N, Kaneko H, Takemura M etal. Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children. Pediatr Allergy Immunol 2006; 17:125-33.
10. Joosse A, de Vries E, Eckel R etal. Gender differences in melanoma survival: female patients have a decreased risk of metastasis. J Invest Dermatol 2011; 131:719-26.
11. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci USA 1994; 91:3652-6.
12. Buchholz VR, Neuenhahn M, Busch DH. CD8+ T cell differentiation in the aging immune system: until the last clone standing. Curr Opin Immunol 2011; 23:549-54.
13. Qiu L, Ding L, Huang J, Wang D, Zhang J, Guo B. Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages. Immunology 2009; 128:e325-34.
14. Maghazachi AA, Al-Aoukaty A, Schall TJ. CC chemokines induce the generation of killer cells from CD56+ cells. Eur J Immunol 1996; 26:315-9.
15. Taub DD, Turcovski-Corrales SM, Key ML, Longo DL, Murphy WJ. Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro. J Immunol 1996; 156:2095-103.
16. Godiska R, Chantry D, Raport CJ etal. Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells. J Exp Med 1997; 185:1595-604.
17. Andrew DP, Chang MS, McNinch J etal. STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13. J Immunol 1998; 161:5027-38.
18. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996; 184:747-52.
19. Vidalain PO, Azocar O, Yagita H, Rabourdin-Combe C, Servet-Delprat C. Cytotoxic activity of human dendritic cells is differentially regulated by double-stranded RNA and CD40 ligand. J Immunol 2001; 167:3765-72.
20. Heeschen C, Dimmeler S, Hamm CW etal. Soluble CD40 ligand in acute coronary syndromes. N Engl J Med 2003; 348:1104-11.
21. Roselli M, Mineo TC, Basili S etal. Soluble CD40 ligand plasma levels in lung cancer. Clin Cancer Res 2004; 10:610-4.
22. Barnhill RL, Xiao M, Graves D, Antoniades HN. Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo. Br J Dermatol 1996; 135:898-904.
23. Sansoni P, Vescovini R, Fagnoni F etal. The immune system in extreme longevity. Exp Gerontol 2008; 43:61-5.
24. Alberti S, Cevenini E, Ostan R etal. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech Ageing Dev 2006; 127:560-6.
25. Zanni F, Vescovini R, Biasini C etal. Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence. Exp Gerontol 2003; 38:981-7.
26. Stowe RP, Peek MK, Cutchin MP, Goodwin JS. Plasma cytokine levels in a population-based study: relation to age and ethnicity. J Gerontol A Biol Sci Med Sci 2010; 65:429-33.
27. Kim HO, Kim HS, Youn JC, Shin EC, Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med 2011; 9:113.
28. Gerli R, Monti D, Bistoni O etal. Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians. Mech Ageing Dev 2000; 121:37-46.
29. Inadera H, Egashira K, Takemoto M, Ouchi Y, Matsushima K. Increase in circulating levels of monocyte chemoattractant protein-1 with aging. J Interferon Cytokine Res 1999; 19:1179-82.
30. Mariani E, Pulsatelli L, Neri S etal. RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects. Exp Gerontol 2002; 37:219-26.
31. Yasui T, Maegawa M, Tomita J etal. Changes in serum cytokine concentrations during the menopausal transition. Maturitas 2007; 56:396-403.
32. Deguchi K, Kamada M, Irahara M etal. Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy. Menopause 2001; 8:266-73.
33. Verthelyi D, Klinman DM. Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo. Immunology 2000; 100:384-90.
34. Yang JH, Chen CD, Wu MY, Chao KH, Yang YS, Ho HN. Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women. Fertil Steril 2000; 74:261-7.
35. Kassem M, Khosla S, Spelsberg TC, Riggs BL. Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab 1996; 81:513-8.