Cytokine production in the bone marrow microenvironment: Failure to demonstrate estrogen regulation in early postmenopausal women

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 2, 1996, Pages 513-518

  Kassem, Moustapha ^a   Khosla, Sundeep ^a   Spelsberg, Thomas C ^b   Riggs, B Lawrence ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MARKER; CYTOKINE; ESTRADIOL; ESTROGEN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; OSTEOCALCIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BONE DENSITY; BONE MARROW CULTURE; BONE TURNOVER; CLINICAL ARTICLE; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; HORMONAL THERAPY; HUMAN; IMMUNOMODULATION; MONONUCLEAR CELL; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; TRABECULAR BONE; TRANSDERMAL DRUG ADMINISTRATION;

ANTIGENS, CD; BONE MARROW; CULTURE MEDIA, CONDITIONED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MIDDLE AGED; OSTEOCLASTS; POSTMENOPAUSE; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; SIALOGLYCOPROTEINS;

EID: 0030064975     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.2.513     Document Type: Article

References (39)

1. Heaney RP, Recker RR, Saville PD. 1978 Menopausal changes in bone remodelling. J Lab Clin Med. 92:964-970.
2. Riggs BL, Melton III LJ. 1992 The prevention and treatment of osteoporosis. N Engl J Med. 327:620-627.
3. Raisz LG. 1988 Local and systemic factors in the pathogenesis of osteoporosis. N Engl J Med. 318:818-828.
4. Roddman GD. 1993 Role of cytokines in the regulation of bone resorption. Calcif Tissue Int. 53(Suppl 1):s94-s98.
5. Manolagas SC, Jilka RL. 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med. 332:305-311.
6. Girasole G, Jilka RL, Passeri G, et al. 1992 17β-Estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest. 89:883-891.
7. Pacifici R, Brown C, Puscheck E, et al. 1991 Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA. 88:5134-5138.
8. Pacifici R, Vannice JL, Rifas L, Kimble RB. 1993 Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: effects of menopause and estrogen/progesterone therapy. J Clin Endocrinol Metab. 77:1135-1141.
9. Kimble RB, Vannice JL, Bloedow DC, et al. 1994 Interleukin-1 receptor antagonist decrease bone loss and bone resorption in ovariectomized rats. J Clin Invest. 93:1959-1967.
10. Jilka RL, Hangoc G, Griasole G, et al. 1992 Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science. 257:88-91.
11. Passeri G, Girasole G, Jilka RL, Manolagas SC. 1993 Increased interleukin-6 production by murine bone marrow and bone cells after estrogen withdrawal. Endocrinology. 133:822-828.
12. Kitazawa R, Kimble RB, Vannice JL, Kung VT, Pacifici R. 1994 Interleukin-1 receptor antagonist and tumour necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest. 94:2397-2406.
13. Pioli G, Basini G, Pedrazzoni M, et al. 1992 Spontaneous release of interleukin-1 and interleukin-6 by peripheral blood mononuclear cells after oophorectomy. Clin Sci. 83:503-507.
14. Ralston SH, Russell RGG, Gowen M. 1990 Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J Bone Miner Res. 5:983-988.
15. Cohen-Solal ME, Graulet AM, Gueris DJ, Baylink D, De Vernejoul MC. 1993 Peripheral monocyte cultures supernatants of menopausal women can induce bone resorption: involvement of cytokines. J Clin Endocrinol Metab. 77:1648-1653.
16. Zarrabeitia MT, Riancho JA, Amado JA, Napal J, Gonzalez-Macias J. 1991 Cytokine production by peripheral blood cells in postmenopausal osteoporosis. Bone Miner. 14:161-167.
17. Hustmyer FG, Walker E, Yu XP, et al. 1993 Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis. J Bone Miner Res. 8:51-59.
18. McKane WR, Khosla S, Petersem JM, Egan K, Riggs BL. 1994 Circulating levels of cytokines that modulate bone resorption: effects of age and menopause in women. J Bone Miner Res. 9:1313-1318.
19. Khosla S, Peterson JM, Egan K, Jones JD, Riggs BL. 1994 Circulating cytokine levels in osteoporotic and normal women. J Clin Endocrinol Metab. 79:707-711.
20. Girasole G, Pedrazzoni M, Guiliani N, et al. 1995 Increased levels of human serum soluble interleukin-6 receptors in ovariectomized women: evidence of a relationship with parathyroid hormone and FSH. Bone. 16(Suppl 1):98s.
21. Kassem M, Mosekilde Li, Rungby J, Mosekilde Le, Melsen F, Eriksen EF. 1991 Formation of osteoclasts and osteoblast-like cells in long-term human bone marrow cultures. APMIS. 99:262-268.
22. Holdrinet RSG, Egmond JV, Wessels JMC, Haanen C. 1980 A method for quantification of peripheral blood admixture in bone marrow aspirates. Exp Hematol. 8:103-107.
23. Alderson MR, Tough TW, Ziegler SF, Grabstein KH. 1991 Interleukin-7 induces cytokine secretion and tumoricidal activity by human peripheral blood monocytes. J Exp Med. 173:923-930.
24. Duda RJ, O'Brien J, Katzmann JA, Peterson JM, Mann KG, Riggs BL. 1988 Concurrent assays of circulating bone gla-protein and bone alkaline phosphatase: effects of sex, age, and metabolic bone disease. J Clin Endocrinol Metab. 66:951-957.
25. Roodman GD, Kurihara N, Ohsaki Y, et al. 1992 Interleukin 6. A potential autocrine/paracrine factor in Paget's disease of bone. J Clin Invest. 89:46-52.
26. Tanabe M, Ochi T, Tomita T, et al. 1994 Remarkable elevation of interleukin 6 and interleukin 8 levels in the bone marrow serum of patients with rheumatoid arthritis. J Rheumatol. 21:830-835.
27. Copper SJ, Kalinka S, Mander TH. 1990 Specific radioimmunoassays for ILIα and ILIβ in plasma at physiological and acidic pH: determination of immunoreactive forms by gel filtration and radioligand binding studies. Cytokine. 2:182-189.
28. Pacifici R, Rifas L, McCracken R, et al. 1989 Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc Natl Acad Sci USA. 86:2398-2402.
29. Bismar H, Diel I, Ziegler R, Pfeilschifter J. 1994 Increased cytokine secretion by human bone marrow cells after menopause or discontinuation of extrogen replacement. J Bone Miner Res. 9(Suppl 1):S158.
30. Stock JL, Codene JA, McDonald B, Rosenwasser LJ. 1989 Effects of estrogen in vivo and in vitro on spontaneous interleukin-1 release by monocytes from postmenopausal women. J Clin Endocrinol Metab. 68:364-368.
31. Polan ML, Daniele A, Kuo A. 1988 Gonadal steroid modulate human monocyte interleukin-1 (IL-1) activity. Fertil Steril. 49:964-968.
32. Polan ML, Loukides J, Nelson P, et al. 1989 Progesterone and estradiol modulate interleukin-1β messenger ribonucleic acid levels in cultured human peripheral monocytes. J Clin Endocrinol Metab. 69:1200-1206.
33. Li ZG, Danis VA, Brooks PM. 1993 Effect of gonadal steroids on the production of IL-1 and JL-6 by blood mononuclear cells in vitro. Clin Exp Rheumatol. 11:157-162.
34. Kassem M, Harris SA, Spelsberg TC, Riggs BL. 1995 Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line expressing high levels of estrogen receptors. J Bone Miner Res. In press.
35. Rickard D, Russell G, Gowen M. 1992 Oestradiol inhibits the release of tumour necrosis factor but not interleukin 6 from adult human osteoblasts in vitro. Osteoporos Int. 2:94-102.
36. Oursler MJ, Cortese C, Keeting P, et al. 1991 Modulation of transforming growth factor-β production in normal Human osteoblast-like cells by 17β- estradiol and parathyroid hormone. Endocrinology. 129:3313-3320.
37. Ernst M, Heath JK, Rodan GA. 1989 Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology. 125:825-833.
38. Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg TC. 1994 Human giant cell tumors of the bone (osteoclastomas) as estrogen target cells. Proc Natl Acad Sci USA. 91:5227-5231.
39. Fiorelli G, Gori F, Petilli M, et al. 1995 Functional estrogen receptors in a human preosteoblastic cell line. Proc Natl Acad Sci USA. In press.