Tacrolimus strongly inhibits multiple human UDP-glucuronosyltransferase (UGT) isoforms

Pharmazie

Volumn 67, Issue 9, 2012, Pages 804-808

  Liu, Xiao You ^a   Fang, Zhong Ze ^c   Dong, Pei Pei ^d   Shi, Xiang Hua ^a   Teng, Yan Jie ^e   Sun, Xu Yong ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b 303 Hospital of PLA   (China)

^c NATIONAL CANCER INSTITUTE   (United States)

^d DALIAN MEDICAL UNIVERSITY   (China)

^e MUDANJIANG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B7; HYMECROMONE; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; DRUG METABOLISM; ENZYME INHIBITION; GLUCURONIDATION; IN VITRO STUDY;

BIOTRANSFORMATION; ENZYME INHIBITORS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; HYMECROMONE; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; ISOENZYMES; KINETICS; LIVER; RECOMBINANT PROTEINS; TACROLIMUS;

EID: 84867194734     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.2509     Document Type: Article

References (23)

1. Dong RH, Fang ZZ, Zhu LL, Liang SC, Ge GB, Yang L, Liu ZY (2012) Investigation of UDP-glucuronosyltransferases (UGTs) inhibitory properties of carvacrol. Phytother Res 26: 86-90.
2. Fang ZZ, Zhang YY, Ge GB, Huo H, Liang SC, Yang L (2010) Time-dependent inhibition (TDI) of CYP3A4 and CYP2C9 by noscapine potentially explains clinical noscapine-warfarin interaction. Br J Clin Pharmacol 69: 193-199.
3. Fang ZZ, Zhang YY, Ge GB, Liang SC, Sun DX, Zhu LL, Dong PP, Cao YF, Yang L (2011) Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions. Phytother Res 25: 256-263.
4. Green MD, Oturu EM, Tephly TR (1994) Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab Dispos 22: 799-805. (Pubitemid 24307496)
5. Halloran PF (2004) Immunosuppressive drugs for kidney transplantation. N Eng J Med 351: 2715-2729.
6. Hara Y, Nakajima M, Miyamoto K, Yokoi T (2007) Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine. Drug Metab Pharmacokinet 22: 103-112.
7. Hosohata K, Masuda S, Ogura Y, Oike F, Takada Y, Katsura T, Uemoto S, Inui K (2008) Interaction between tacrolimus and lansoprazole, but not rabeprazole in living-donor liver transplant patients with defects of CYP2C19 and CYP3A5. Drug Metab Pharmacokinet 23: 134-138.
8. Huang T, Fang ZZ, Yang L (2010) Strong inhibitory effect of medroxyprogesterone acetate (MPA) on UDP-glucuronosyltransferase (UGT) 2B7 might induce drug-drug interactions. Pharmazie 65: 919-921.
9. Huang T, Fang ZZ, Zhang YY, Zhu LL, Feng LL, Zheng W, Cao YF, Sun DX, Yang L (2011) Inhibitory potential of chlormadinone acetate (CMA) on five important UDP-glucuronosyltransferases in human liver. Pharmazie 66: 212-215.
10. Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51: 4187-4191.
11. Kiang TK, Ensom MH, Chang TK (2005) UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacol Ther 106: 97-132. (Pubitemid 40386722)
12. Knights KM, Bowalgaha K, Miners JO. (2010) Spironolactone and canrenone inhibit UGT2B7-catalyzed human liver and kidney microsomal aldosterone 18β-glucuronidation: A potential drug interaction. Drug Metab Disp 36: 1056-1062.
13. Laverdiere I, Caron P, Harvey M, Lévesque É, Guillemette C (2011) In vitro investigation of human UDP-glucuronosyltransferase isoforms responsible for tacrolimus glucuronidation: predominant contribution of UGT1A4. Drug Metab Dispos 39: 1127-1130.
14. Lertora JJ, Rege AB, Greenspan DL, Akula S, George WJ, Hyslop NE Jr, Agrawal KC (1994) Pharmacokinetic interaction between zidovudine and valproic acid in patients infected with human immunodeficiency virus. Clin Pharmacol Ther 56: 272-278. (Pubitemid 24323918)
15. Lin JH, Lu AYH (1997) Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev 49: 403-449. (Pubitemid 28030947)
16. Michalets EL (1998) Update: clinically significant cytochrome P450 drug interactions. Pharmacotherapy 18: 84-112.
17. Sahai J, Gallicano K, Pakuts A, Cameron DW (1994) Effect of fluconazole on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus. J Infect Dis 169: 1103-1107. (Pubitemid 24303236)
18. Sun DX, Fang ZZ, Zhang YY, Cao YF, Yang L, Yin J (2010a) Inhibitory effects of curcumenol on human liver cytochrome P450 enzymes. Phytother Res 24: 1213-1216.
19. Sun DX, Lu JC, Fang ZZ, Zhang YY, Cao YF, Mao YX, Zhu LL, Yin J, Yang L (2010b) Reversible inhibition of three important human liver cytochrome P450 enzymes by tiliroside. Phytother Res 24: 1670-1675.
20. Tanaka E (1998) Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes. J Clin Pharm Ther 23: 403-416.
21. Wallemacq P, Armstrong VW, Brunet M, Haufroid V, Holt DW, Johnston A, Kuypers D, Le Meur Y, Marquet P, Oellerich M, Thervet E, Toenshoff B, Undre N, Weber LT, Westley IS, Mourad M (2009) Opportunities to optimize tacrolimus therapy in solid organ transplantation: report of the European consensus conference. Ther Drug Monit 31: 139-152.
22. Wen Z, Tallman MN, Ali SY, Smith PC (2007) UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos 35: 371-380. (Pubitemid 46333899)
23. Zhang D, Chando TJ, Everett DW, Patten CJ, Dehal SS, Humphreys WG (2005) In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos 33: 1729-1739. (Pubitemid 41539973)