Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: First step to in vivo analysis

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 32, 2011, Pages 3781-3787

  Bojko, Barbara ^a,c   Vuckovic, Dajana ^a,d   Cudjoe, Erasmus ^a   Hoque, Md Ehsanul ^a,e   Mirnaghi, Fatemeh ^a   Wasowicz, Marcin ^b   Jerath, Angela ^b   Pawliszyn, Janusz ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c MEDICAL UNIVERSITY OF SILESIA   (Poland)

^d UNIVERSITY OF TORONTO   (Canada)

^e TRENT UNIVERSITY   (Canada)

Author keywords

Cardiopulmonary bypass; Liquid chromatography; Plasma; Solid phase microextraction; Tandem mass spectrometry; Tranexamic acid

Indexed keywords

ACCURACY AND PRECISION; BIOANALYTICAL METHODS; BIOLOGICAL SAMPLES; CARDIOPULMONARY BYPASS; CLINICAL PRACTICES; CONVENTIONAL TECHNIQUES; DIRECT EXTRACTION; IN-VIVO ANALYSIS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MATRIX EFFECTS; ON-SITE ANALYSIS; POLAR DRUGS; POLAR MOLECULES; PROTEIN PRECIPITATION; SAMPLE PREPARATION; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; TRANEXAMIC ACID;

COATINGS; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; PLASMAS; SKIN; ULTRAFILTRATION;

SOLVENT EXTRACTION;

TRANEXAMIC ACID;

ACCURACY; ARTICLE; BIOCOMPATIBILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; IN VIVO STUDY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; PRECIPITATION; PRIORITY JOURNAL; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION;

ANTIFIBRINOLYTIC AGENTS; CARDIOPULMONARY BYPASS; CHROMATOGRAPHY, LIQUID; DRUG MONITORING; HUMANS; LIMIT OF DETECTION; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SOLID PHASE MICROEXTRACTION; TANDEM MASS SPECTROMETRY; TRANEXAMIC ACID; ULTRAFILTRATION;

EID: 82955235537     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.08.003     Document Type: Article

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