Activation of PAC1 and VPAC receptor subtypes elicits differential physiological responses from sympathetic preganglionic neurons in the anaesthetized rat

British Journal of Pharmacology

Volumn 167, Issue 5, 2012, Pages 1089-1098

  Inglott, Melissa A ^a   Lerner, Ethan A ^b   Pilowsky, Paul M ^a   Farnham, Melissa M J ^a  

^a MACQUARIE UNIVERSITY   (Australia)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

adrenal medulla; adrenaline; blood pressure; maxadilan; noradrenaline; PACAP; PACAP(6 38); sympathetic; vasoactive intestinal polypeptide

Indexed keywords

HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE RECEPTOR 1; URETHAN; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR EFFECT; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; MALE; MEAN ARTERIAL PRESSURE; NERVE POTENTIAL; NEUROPHYSIOLOGY; NEUROTRANSMISSION; NONHUMAN; PREGANGLIONIC NERVE CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; SYMPATHETIC NERVE CELL; VAGOTOMY;

ANESTHESIA; ANIMALS; BLOOD PRESSURE; MALE; NEURONS; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; SYMPATHETIC NERVOUS SYSTEM;

EID: 84867189101     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02045.x     Document Type: Article

References (34)

1. th Edition. Br J Pharmacol 164 (Suppl. 1): S1-S324.
2. DeHaven WI, Cuevas J, (2004). VPAC receptor modulation of neuroexcitability in intracardiac neurons: dependence on intracellular calcium mobilization and synergistic enhancement by PAC1 receptor activation. J Biol Chem 279: 40609-40621. (Pubitemid 39287653)
3. Dickson L, Finlayson K, (2009). VPAC and PAC receptors: from ligands to function. Pharmacol Ther 121: 294-316.
4. Eggenberger M, Born W, Zimmermann U, Lerner EA, Fischer JA, Muff R, (1999). Maxadilan interacts with receptors for pituitary adenylyl cyclase activating peptide in human SH-SY5Y and SK-N-MC neuroblastoma cells. Neuropeptides 33: 107-114. (Pubitemid 29254072)
5. Farnham MM, Li Q, Goodchild AK, Pilowsky PM, (2008). PACAP is expressed in sympathoexcitatory bulbospinal C1 neurons of the brain stem and increases sympathetic nerve activity in vivo. Am J Physiol 294: R1304-R1311. (Pubitemid 351490652)
6. Farnham MM, Inglott MA, Pilowsky PM, (2011). Intrathecal PACAP-38 causes increases in sympathetic nerve activity and heart rate but not blood pressure in the spontaneously hypertensive rat. Am J Physiol 300: H214-H222.
7. Fizanne L, Sigaudo-Roussel D, Saumet JL, Fromy B, (2004). Evidence for the involvement of VPAC1 and VPAC2 receptors in pressure-induced vasodilatation in rodents. J Physiol 554: 519-528. (Pubitemid 38181360)
8. Gaede AH, Lung MSY, Pilowsky PM, (2009). Catestatin attenuates the effects of intrathecal nicotine and isoproterenol. Brain Res 1305: 86-95.
9. Grevelink SA, Osborne J, Loscalzo J, Lerner EA, (1995). Vasorelaxant and second messenger effects of maxadilan. J Pharmacol Exp Ther 272: 33-37.
10. Harmar AJ, Arimura A, Gozes I, Journot L, Laburthe M, Pisegna JR, et al,. (1998). International union of pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol Rev 50: 265-270. (Pubitemid 28304027)
11. Igarashi H, Ito T, Kuwano-Kojima M, Takayanagi R, Coy DH, Jensen RT, (2008). Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats. Pancreas 37: 236-238.
12. Inglott MA, Farnham MM, Pilowsky PM, (2011). Intrathecal PACAP-38 causes prolonged widespread sympathoexcitation via a spinally mediated mechanism and increases in basal metabolic rate in anesthetized rat. Am J Physiol 300: H2300-H2307.
13. Jackson TS, Lerner E, Weisbrod RM, Tajima M, Loscalzo J, Keaney JF Jr, (1996). Vasodilatory properties of recombinant maxadilan. Am J Physiol 40: H924-H930.
14. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG, (2010). NC3Rs Reporting Guidelines Working Group. Br J Pharmacol 160: 1577-1579.
15. Krowicki ZK, Arimura A, Nathan NA, Hornby PJ, (1997). Hindbrain effects of PACAP on gastric motor function in the rat. Am J Physiol 272: G1221-G1229.
16. Kumar NN, Allen K, Parker L, Damanhuri H, Goodchild AK, (2010). Neuropeptide coding of sympathetic preganglionic neurons; focus on adrenally projecting populations. Neuroscience 170: 789-799.
17. Kuri BA, Chan SA, Smith CB, (2009). PACAP regulates immediate catecholamine release from adrenal chromaffin cells in an activity-dependent manner through a protein kinase C-dependent pathway. J Neurochem 110: 1214-1225.
18. Lai CC, Wu SY, Lin HH, Dun NJ, (1997). Excitatory action of pituitary adenylate cyclase activating polypeptide on rat sympathetic preganglionic neurons in vivo and in vitro. Brain Res 748: 189-194. (Pubitemid 27094899)
19. Le Mevel J-C, Lancien F, Mimassi N, Conlon JM, (2009). Ventilatory and cardiovascular actions of centrally and peripherally administered trout pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) in the unanaesthetized trout. J Exp Biol 212: 3919-3927.
20. Lerner EA, Shoemaker CB, (1992). Maxadilan. Cloning and functional expression of the gene encoding this potent vasodilator peptide. J Biol Chem 267: 1062-1066.
21. Lerner EA, Iuga AO, Reddy VB, (2007). Maxadilan, a PAC1 receptor agonist from sand flies. Peptides 28: 1651-1654. (Pubitemid 47361433)
22. McGrath J, Drummond G, McLachlan E, Kilkenny C, Wainwright C, (2010). Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol 160: 1573-1576.
23. Moro O, Lerner EA, (1997). Maxadilan, the vasodilator from sand flies, is a specific pituitary adenylate cyclase activating peptide type I receptor agonist. J Biol Chem 272: 966-970. (Pubitemid 27035014)
24. Morrison SF, Cao WH, (2000). Different adrenal sympathetic preganglionic neurons regulate epinephrine and norepinephrine secretion. Am J Physiol 279: R1763-R1775.
25. Murase T, Kondo K, Otake K, Oiso Y, (1993). Pituitary adenylate cyclase-activating polypeptide stimulates arginine vasopressin release in conscious rats. Neuroendocrinology 57: 1092-1096. (Pubitemid 23260787)
26. Ozawa M, Aono M, Mizuta K, Moriga M, Okuma M, (1997). Central administration of PACAP stimulates gastric secretion mediated through the vagal pathway in anesthetized rats. Digest Dis Sci 42: 2552-2559. (Pubitemid 28103795)
27. Payet MD, Bilodeau L, Breault L, Fournier A, Yon L, Vaudry H, et al,. (2003). PAC1 receptor activation by PACAP-38 mediates Ca2+ release from a cAMP-dependent pool in human fetal adrenal gland chromaffin cells. J Biol Chem 278: 1663-1670. (Pubitemid 36801398)
28. Pirger Z, Laszlo Z, Hiripi L, Hernadi L, Toth G, Lubics A, et al,. (2010). Pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors are present and biochemically active in the central nervous system of the pond snail lymnaea stagnalis. J Mol Neurosci 42: 464-471.
29. Robberecht P, Gourlet P, De Neef P, Woussen-Colle MC, Vandermeers-Piret MC, Vandermeers A, et al,. (1992). Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PAC-P) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. Eur J Biochem 207: 239-246.
30. Sawmiller DR, Ashtari M, Urueta H, Leschinsky M, Henning RJ, (2006). Mechanisms of vasoactive intestinal peptide-elicited coronary vasodilation in the isolated perfused rat heart. Neuropeptides 40: 349-355. (Pubitemid 44634709)
31. Seki Y, Suzuki Y, Baskaya MK, Saito K, Takayasu M, Shibuya M, et al,. (1995). Central cardiovascular effects induced by intracisternal PACAP in dogs. Am J Physiol 269: H135-H139.
32. Uddman R, Goadsby PJ, Jansen I, Edvinsson L, (1993). PACAP, a VIP-like peptide: immunohistochemical localization and effect upon cat pial arteries and cerebral blood flow. J Cereb Blood Flow Metab 13: 291-297. (Pubitemid 23067464)
33. Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, et al,. (2009). Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61: 283-357.
34. Widegren U, Hickner RC, Jorfeldt L, Henriksson J, (2010). Muscle blood flow response to mental stress and adrenaline infusion in man: microdialysis ethanol technique compared to (133)Xe clearance and venous occlusion plethysmography. Clin Physiol Funct Imaging 30: 152-161.